Translating tissue engineering technology platforms into cancer research

•  Introduction •  History of tissue engineering •  Physiological and structural aspects of 2D versus 3D culture in cancer research •  State of the art of 3D culture systems in cancer research •  New tissue engineering‐routed scaffolds for 3D culture •  Endothelial progenitor cells and tumour vasculature •  In vivo models •  Arteriovenous loop isolation chamber for tumour angiogenesis research •  Conclusion

• Publication year

  2009

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2009-07-20

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1111/j.1582-4934.2009.00853.xPMID 19627398PMCID 3828855
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integration column: artificial ECM: expanding the cell biology toolbox in 3D.

  2009cited by this paper
• Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement

  2009cited by this paper
• Dose-Finding Study of Fibrin Gel-Immobilized Vascular Endothelial Growth Factor 165 and Basic Fibroblast Growth Factor in the Arteriovenous Loop Rat Model

  2009cited by this paper
• The venous graft as an effector of early angiogenesis in a fibrin matrix.

  2008cited by this paper
• Designer self-assembling Peptide nanofiber scaffolds for study of 3-d cell biology and beyond.

  2008cited by this paper
• Ethical Issues in Cellular and Molecular Medicine and Tissue Engineering

  2008cited by this paper
• New dimensions in tumor immunology: what does 3D culture reveal?

  2008cited by this paper
• Unraveling the microenvironmental influences on the normal mammary gland and breast cancer.

  2008cited by this paper
• Synthetic Extracellular Matrix Enhances Tumor Growth and Metastasis in an Orthotopic Mouse Model of Pancreatic Adenocarcinoma

  2008cited by this paper
• Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications

  2008cited by this paper
• Titanium foam‐bioactive nanofiber hybrids for bone regeneration

  2008cited by this paper
• Evaluating drug efficacy and toxicology in three dimensions: using synthetic extracellular matrices in drug discovery.

  2008cited by this paper
• T17b murine embryonal endothelial progenitor cells can be induced towards both proliferation and differentiation in a fibrin matrix

  2008cited by this paper
• Foetal hepatocyte transplantation in a vascularized AV-Loop transplantation model in the rat

  2008cited by this paper
• Evaluation of blood vessel ingrowth in fibrin gel subject to type and concentration of growth factors

  2008cited by this paper
• Mechanisms that mediate stem cell self‐renewal and differentiation

  2008cited by this paper
• Use of Hyaluronan‐Derived Hydrogels for Three‐Dimensional Cell Culture and Tumor Xenografts

  2008cited by this paper
• Tumor Engineering: Orthotopic Cancer Models in Mice Using Cell-Loaded, Injectable, Cross-Linked Hyaluronan-Derived Hydrogels

  2007cited by this paper
• Gene modified cell transplantation for vascular regeneration.

  2007cited by this paper
• Cell-Based Bone Tissue Engineering

  2007cited by this paper
• Modeling tissue morphogenesis and cancer in 3D.

  2007cited by this paper
• Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model.

  2007cited by this paper
• Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science

  2007cited by this paper
• Concepts of scaffold-based tissue engineering—the rationale to use solid free-form fabrication techniques

  2007cited by this paper
• Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland.

  2007cited by this paper
• Engineering tumors with 3D scaffolds

  2007cited by this paper
• Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering.

  2007cited by this paper
• Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions.

  2007influential reference
• The third dimension bridges the gap between cell culture and live tissue

  2007cited by this paper
• Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.

  2007cited by this paper
• Three-dimensional culture models of normal and malignant breast epithelial cells

  2007cited by this paper
• Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?

  2007cited by this paper
• Materials science. Hydrogel cell cultures.

  2007cited by this paper
• Three-dimensional culturing of the Hodgkin lymphoma cell-line L1236 induces a HL tissue-like gene expression pattern

  2007cited by this paper
• A microfluidic platform for 3-dimensional cell culture and cell-based assays

  2007cited by this paper
• Hydrogel Cell Cultures

  2007cited by this paper
• Capturing complex 3D tissue physiology in vitro

  2006cited by this paper
• Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo.

  2006cited by this paper
• Engineering of Vascularized Transplantable Bone Tissues: Induction of Axial Vascularization in an Osteoconductive Matrix Using an Arteriovenous Loop

  2006cited by this paper
• IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

  2006cited by this paper
• Designer Self-Assembling Peptide Nanofiber Scaffolds for Adult Mouse Neural Stem Cell 3-Dimensional Cultures

  2006cited by this paper
• Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

  2005cited by this paper
• Tensional homeostasis and the malignant phenotype.

  2005cited by this paper
• Designer self-assembling peptide nanofiber scaffolds for 3D tissue cell cultures.

  2005cited by this paper
• Modelling glandular epithelial cancers in three-dimensional cultures

  2005cited by this paper
• Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration.

  2005cited by this paper
• Three-dimensional tissue culture models in cancer biology.

  2005cited by this paper
• Embryonic endothelial progenitor cells expressing a broad range of proangiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemia

  2005cited by this paper
• Use of three-dimensional collagen gels to study mechanotransduction in T47D breast epithelial cells

  2005cited by this paper
• Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers

  2004cited by this paper
• Designing materials for biology and medicine

  2004cited by this paper
• Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.

  2004cited by this paper
• Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.

  2004influential reference
• The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid Model

  2004cited by this paper
• Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

  2003cited by this paper
• Assembling a lasing hybrid material with supramolecular polymers and nanocrystals

  2003cited by this paper
• Animal models of bone metastasis

  2003cited by this paper
• Cell culture: Biology's new dimension

  2003cited by this paper
• Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.

  2002cited by this paper
• Putting tumours in context

  2001cited by this paper
• Multicellular resistance: a paradigm for clinical resistance?

  2000cited by this paper
• Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids.

  2000cited by this paper
• Xenograft Models of Premalignant Breast Disease

  2000cited by this paper
• Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

  1999cited by this paper
• Tissue engineering.

  1998cited by this paper
• Solid stress inhibits the growth of multicellular tumor spheroids

  1997cited by this paper
• Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

  1997cited by this paper
• Tissue engineering.

  1993cited by this paper
• Tissue engineering : Frontiers in biotechnology

  1993cited by this paper
• Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

  1992cited by this paper
• Cell and environment interactions in tumor microregions: the multicell spheroid model.

  1988cited by this paper
• Factors affecting growth and drug sensitivity of mouse mammary tumor lines in collagen gel cultures.

  1985cited by this paper
• Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.

  1982cited by this paper
• Resistance to adriamycin in multicellular spheroids.

  1979cited by this paper
• Materials science.

  1973cited by this paper
• Radiation-resistant tumor cells may be more sensitive in vitro.

  1972cited by this paper
• Growth of multicell spheroids in tissue culture as a model of nodular carcinomas.

  1971cited by this paper

• Scaffolds Mimicking the Tumor Microenvironment for In Vitro Malignancy Models

  2025cites this paper
• Exploring bone-tumor interactions through 3D in vitro models: Implications for primary and metastatic cancers

  2025cites this paper
• Human preclinical multiple myeloma in vitro models for disease modeling and therapy screening

  2025cites this paper
• Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics

  2024cites this paper
• 3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds

  2022cites this paper
• Patient-Derived Multiple Myeloma 3D Models for Personalized Medicine—Are We There Yet?

  2022cites this paper
• Extracellular Matrix Mechanobiologyin Cancer Cell Migration.

  2022cites this paper
• Role of targeted drug delivery in cancer therapeutics

  2021cites this paper
• Hydrogels of engineered bacterial fimbriae can finely tune 2D human cell culture.

  2021cites this paper
• In Vitro Assays for Nanoparticle-Cancer Cell Interaction Studies.

  2021cites this paper
• 3D scaffold materials for skin cancer modeling

  2020cites this paper
• Tissue engineering applications in breast cancer

  2020cites this paper
• Mapping the Radiogenome of Human Cancers

  2020cites this paper
• 3D Electrophysiological Measurements on Cells Embedded within Fiber‐Reinforced Matrigel

  2019cites this paper
• Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment

  2019cites this paper
• Liver Cancer: Current and Future Trends Using Biomaterials

  2019cites this paper
• Bioengineered Microtissue Models of the Human Bone Metastatic Microenvironment: A Novel In Vitro Theranostics Platform for Cancer Research.

  2019cites this paper
• Integrated cancer tissue engineering models for precision medicine

  2019cites this paper
• Application of 3D cultured multicellular spheroid tumor models in tumor‐targeted drug delivery system research

  2018cites this paper
• Prefabricated flaps and neoangiogenesis initiated via venous grafts in arteriovenous loops

  2018cites this paper
• Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

  2018cites this paper
• Vascularized microfluidic platforms to mimic the tumor microenvironment

  2018cites this paper
• Innovation for hepatotoxicity in vitro research models: A review

  2018cites this paper
• The Arteriovenous Loop: Engineering of Axially Vascularized Tissue

  2018cites this paper
• Cellulose-based scaffolds for fluorescence lifetime imaging-assisted tissue engineering.

  2018cites this paper
• Three Dimensional In Vitro Tumor Platforms for Cancer Discovery

  2018cites this paper
• Tissue-Engineered Models for Studies of Bone Metastasis

  2018cites this paper
• Experimental models of bone metastasis: Opportunities for the study of cancer dormancy

  2018cites this paper
• Dissociation of mono- and co-culture spheroids into single cells for subsequent flow cytometric analysis.

  2018cites this paper
• Tumor Organoids

  2018influential citation
• A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo”

  2018cites this paper
• Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death

  2018cites this paper
• The Chemotherapeutic Effect of Docetaxel, Cisplatin and Fluorouracil Regimen on Gastric Cancer Stem Cells.

  2017cites this paper
• A 3D Biomimetic Scaffold using Electrospinning for Tissue Engineering Applications

  2017cites this paper
• Ex vivo construction of human primary 3D-networked osteocytes.

  2017cites this paper
• First Place : Development of Three-Dimensional Lung Multicellular Spheroids in Air and Liquid Interface Culture for the Evaluation of Anti-Cancer Therapeutics

  2017cites this paper
• The status and development of tumor microenvironment simulation platforms

  2017cites this paper
• Polyurethane foam scaffold as in vitro model for breast cancer bone metastasis.

  2017cites this paper
• A 3 D Biomimetic Scaffold using Electrospinning for Tissue Engineering Applications

  2017cites this paper
• Integration and automation of a micro-tissue and microsphere based tissue engineering system and its application in cartilage regeneration and cancer models

  2017cites this paper
• Entwicklung eines neuen Zellisolationsverfahrens zur Erforschung der Mammakarzinompathogenese und -angiogenese für experimentelle in vitro und in vivo Assays

  2017cites this paper
• The fourth annual BRDS on genome editing and silencing for precision medicines

  2017cites this paper
• Growth of MCF-7 breast cancer cells and efficacy of anti-angiogenic agents in a hydroxyethyl chitosan/glycidyl methacrylate hydrogel

  2017cites this paper
• Hypoxic Three-Dimensional Cellular Network Construction Replicates Ex Vivo the Phenotype of Primary Human Osteocytes

  2017cites this paper
• 5.19 In Vivo Bioreactors

  2017cites this paper
• Modeling Cancer Using CRISPR-Cas9 Technology

  2017cites this paper
• Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

  2017cites this paper
• Alcohol and Cancer: Mechanisms and Therapies

  2017cites this paper
• CXCL12-Abundant Reticular (CAR) Cells: A Review of the Literature with Relevance to Cancer Stem Cell Survival

  2016cites this paper
• Three‐dimensional spatial configuration of tumour cells confers resistance to chemotherapy independent of drug delivery

  2016cites this paper
• Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

  2016cites this paper
• Cancer Stem Cells: Issues with In Vitro Expansion and Model Systems

  2016cites this paper
• Bioreactor-Based Tumor Tissue Engineering

  2016cites this paper
• In vitro three-dimensional cancer metastasis modeling: Past, present, and future

  2016cites this paper
• Collagen Extracted from Persian Gulf Squid Exhibits Anti-Cytotoxic Properties on Apple Pectic Treated Cells: Assessment in an In Vitro Bioassay Model

  2016cites this paper
• Fabrication of collagen-based microfluidic devices for in vitro study of tumor microenvironment

  2016cites this paper
• Three-Dimensional Tissue-Engineered Cancer Models for Tumorigenic Studies and Drug-Testing Applications

  2016cites this paper
• Supplementary Issue: Targeted Therapies in Breast Cancer Treatment

  2016cites this paper
• A review on three dimensional scaffolds for tumor engineering

  2016cites this paper
• Development of a High-Throughput 3D Tumor Model for Bone Sarcomas

  2016cites this paper
• A Novel Suspended Hydrogel Membrane Platform for Cell Culture

  2015cites this paper
• Life in 3D is never flat: 3D models to optimise drug delivery.

  2015cites this paper
• Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three‐dimensional multilayered patty‐like spheroids in feeder‐free culture and maintain their pluripotency

  2015cites this paper
• Biomaterials in Regenerative Medicine and the Immune System

  2015cites this paper
• A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers

  2015cites this paper
• The role of matrix compliance on cell responses to drugs and toxins: towards predictive drug screening platforms.

  2015cites this paper
• Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo".

  2015cites this paper
• Acellular organ scaffolds for tumor tissue engineering

  2015cites this paper
• Tissue engineering of a morphologically and functionally intact humanized bone organ for bone metastasis research

  2015cites this paper
• Biomaterial-Based Modulation of Cancer

  2015cites this paper
• Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis

  2015cites this paper
• CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling

  2015cites this paper
• Three‐Dimensional in Vitro Model to Study Osteobiology and Osteopathology

  2015cites this paper
• Experimental models of bone metastasis: Opportunities for the study of cancer dormancy.

  2015cites this paper
• Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape.

  2014cites this paper
• Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models

  2014cites this paper
• A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

  2014cites this paper
• 3D tissue-engineered model of Ewing's sarcoma.

  2014cites this paper
• In vitro ovarian cancer model based on three-dimensional agarose hydrogel

  2014cites this paper
• The Dominant Role of IL-8 as an Angiogenic Driver in a Three-Dimensional Physiological Tumor Construct for Drug Testing

  2014cites this paper
• Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses.

  2014cites this paper
• Nanoparticle enhanced optical imaging and phototherapy of cancer.

  2014cites this paper
• In vitro modeling of the prostate cancer microenvironment.

  2014cites this paper
• Lessons from patient-derived xenografts for better in vitro modeling of human cancer.

  2014cites this paper
• Bioengineering 3D environments for cancer models.

  2014cites this paper
• Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis.

  2014cites this paper
• "In vitro" 3D models of tumor-immune system interaction.

  2014cites this paper
• 3D tumor models: history, advances and future perspectives.

  2014cites this paper
• Three-dimensional in vitro cancer models: a short review

  2014cites this paper
• Tissue Engineering Concept in the Research of the Tumor Biology

  2014cites this paper
• Oswald Biological Sciences First Place: Development of Thr ee-Dimensional Lung Multicellular Spheroids in Air and Liquid Interface Culture for the Evaluation of Anti-Cancer The rapeutics

  2014cites this paper
• Tissue-Engineered Prostate Cancer Xenografts: A Biomaterials-Based Approach to Study Tumorigenesis and Dormancy Escape

  2014cites this paper
• In vitro microenvironments to study breast cancer bone colonisation.

  2014cites this paper
• Maligne Knochentumoren der Hand

  2014cites this paper
• Maligne Knochentumoren der Hand

  2013cites this paper
• Tissue Engineering of a Human 3D in vitro Tumor Test System

  2013cites this paper
• A tissue-engineered subcutaneous pancreatic cancer model for antitumor drug evaluation

  2013cites this paper
• [Malignant bone tumors of the hand].

  2013cites this paper
• A tissue-engineered gastric cancer model for mechanistic study of anti-tumor drugs

  2013cites this paper
• Spatially Controlled Delivery of siRNAs to Stem Cells in Implants Generated by Multi‐Component Additive Manufacturing

  2013cites this paper