Association between wild type and mutant APC gene products.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Cancer Research

• Publication date

  1993-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8389242
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutational analysis of patients with adenomatous polyposis: identical inactivating mutations in unrelated individuals.

  1993cited by this paper
• The APC gene product in normal and tumor cells.

  1993influential reference
• Identification of APC gene mutations in Italian adenomatous polyposis coli patients by PCR-SSCP analysis.

  1993cited by this paper
• Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

  1993cited by this paper
• Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis.

  1992cited by this paper
• APC mutations occur early during colorectal tumorigenesis

  1992cited by this paper
• Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

  1992cited by this paper
• Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.

  1992cited by this paper
• Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

  1992cited by this paper
• Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.

  1992cited by this paper
• Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

  1992cited by this paper
• Amplification of a gene encoding a p53-associated protein in human sarcomas

  1992cited by this paper
• Identification of deletion mutations and three new genes at the familial polyposis locus.

  1991cited by this paper
• High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors.

  1991cited by this paper
• Identification of FAP locus genes from chromosome 5q21.

  1991cited by this paper
• Identification and characterization of the familial adenomatous polyposis coli gene

  1991cited by this paper
• Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

  1991cited by this paper
• A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

  1990cited by this paper
• Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.

  1990cited by this paper
• Initiation and characterization of cultures of human colonic carcinoma with different biological characteristics utilizing feeder layers of confluent fibroblasts.

  1981cited by this paper
• Characteristics of a human cell line transformed by DNA from human adenovirus type 5.

  1977cited by this paper
• Classification of human colorectal adenocarcinoma cell lines.

  1976cited by this paper

• Predicting colorectal cancer risk in FAP patients using patient-specific organoids

  2025cites this paper
• APC Binds to the Novel Protein EB11

  2021cites this paper
• Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

  2021cites this paper
• APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival

  2020cites this paper
• Computational modeling of the role of adenomatous polyposis coli (apc) gene in the initiation of colorectal cancer

  2019cites this paper
• Automatisation de la différenciation des cellules souches pluripotentes humaines en cellules de l’épithélium pigmentaire rétinien et modélisation des symptômes rétiniens associés à la mutation d’APC

  2018cites this paper
• Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

  2017influential citation
• Microtubule plus-end tracking of end-binding protein 1 (EB1) is regulated by CDK5 regulatory subunit-associated protein 2

  2017cites this paper
• The non-Wnt functions of APC : unravelling the link between APC and apoptosis

  2016cites this paper
• Two Novel Somatic Mutations in Exon 15 of the Adenomatous Polyposis Coli Gene in Iranian Familial Adenomatousis Polyposis Coli Patients

  2016cites this paper
• Two Novel Somatic Mutations in Exon 15 of the Adenomatous Polyposis Coli Gene in Iranian Familial Adenomatousis Polyposis Coli Patients

  2016cites this paper
• The role of APC in Wnt/ β-Catenin Pathway In gastric Cancer

  2016cites this paper
• The WNT signalling pathway in colorectal cancer

  2015cites this paper
• Proktokolektomia odtwórcza z zespoleniem ileoanalnym w przebiegu wrzodziejącego zapalenia jelita grubego lub rodzinnej polipowatości gruczolakowatej a nietolerancje pokarmowe

  2015cites this paper
• Proktokolektomia odtwórcza z zespoleniem ileoanalnym w przebiegu wrzodziejącego zapalenia jelita grubego lub rodzinnej polipowatości gruczolakowatej a nietolerancje pokarmowe

  2015cites this paper
• A novel role for Adenomatous Polyposis Coli protein in the transport of mitochondria

  2015influential citation
• The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

  2014cites this paper
• More than two decades of Apc modeling in rodents.

  2013cites this paper
• Wnt signaling in bone formation and its therapeutic potential for bone diseases

  2013cites this paper
• Destruction Complex Function in the Wnt Signaling Pathway of Drosophila Requires Multiple Interactions Between Adenomatous Polyposis Coli 2 and Armadillo

  2012cites this paper
• The ApcMin/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy

  2012cites this paper
• The Roles of Intrinsic Disorder in Orchestrating the Wnt-Pathway

  2012cites this paper
• Kinesin-2 and +TIP dependent directed growth maintains the uniformly polarized microtubule array in Drosophila dendrites

  2011influential citation
• Generation and analysis of mouse models of aberrant β-catenin function

  2011influential citation
• Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between APC2 and Armadillo

  2011cites this paper
• Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila

  2011cites this paper
• The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis.

  2010cites this paper
• Geração de vacinas antitumorais de células dendríticas humanas sensibilizadas com RNA de células tumorais pré-tratadas com agentes antineoplásicos

  2010cites this paper
• NUCLEAR FUNCTIONS OF ADENOMATOUS POLYPOSIS COLI: REGULATION OF THE G2-M CELL CYCLE TRANSITION & INTERMEDIATE FILAMENT INTERACTION

  2009influential citation
• Right pelvic mass in a patient with a radically resected carcinoid of the appendix

  2009cites this paper
• Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2.

  2009cites this paper
• APC in cell migration.

  2009cites this paper
• Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2

  2009cites this paper
• Molecular genetic and phenotypic characteristics of patients with adenomatous colorectal polyposis

  2008cites this paper
• The Role of Apc in Medulloblastoma

  2008cites this paper
• Novel self-association of the APC molecule affects APC clusters and cell migration

  2008cites this paper
• The interaction of adenomatous polyposis coli (APC) and base excision repair proteins: Its implications in colorectal carcinogenesis

  2008cites this paper
• Recessive oncogenes: Current status

  2008cites this paper
• Estudo de mutações somáticas no gene APC em doentes com cancro do cólon e recto em idade jovem

  2008cites this paper
• Alterations of the Wnt /-catenin Signaling Pathway in Cancer of the Ampulla of Vater Corresponding

  2007cites this paper
• Genetic and Epigenetic Alterations of the Wnt/ -catenin Signaling Pathway in Cancer of the Ampulla of Vater

  2007cites this paper
• Sphingosine-1-Phosphate Metabolism and Intestinal Tumorigenesis: Lipid Signaling Strikes Again

  2007cites this paper
• Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia

  2007cites this paper
• BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment

  2007cites this paper
• BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment

  2007cites this paper
• Molecular Pathogenesis of Human Cancer

  2006cites this paper
• Examination of actin and microtubule dependent APC localisations in living mammalian cells

  2006cites this paper
• LOSS OF APC PROTEIN EXPRESSED BY HUMAN COLONIC EPITHELIAL CELLS AND THE APPEARANCE OF A SPECIFIC WITH APOPTOSIS IN VITRO LOW-MOLECULAR-WEIGHT FORM IS ASSOCIATED

  2006cites this paper
• Advances in Brief Alternatively Spliced Adenomatous Polyposis Coli ( APC ) Gene Transcripts That Delete Exons Mutated in Attenuated APC 1

  2006cites this paper
• The role of the APC tumor suppressor in chromosomal instability.

  2006cites this paper
• Ape Gene Mutation Is Associated with a Dominant-Negative Effect upon Intestinal Cell Migration1

  2006cites this paper
• Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein.

  2005cites this paper
• The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro11 NIH CA 63517 (J. Groden) and CA 53683 (M.C. Barton) and Albert J. Ryan Foundation (K. Steigerwald).

  2005cites this paper
• Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.

  2005cites this paper
• Identification and characterisation of the Cdx1 and Apc1 cis-regulatory elements in mouse and "Fugu rubripes".

  2005cites this paper
• Inherited Colorectal Cancer Syndromes

  2005cites this paper
• Involvement of adenomatous polyposis coli in colorectal tumorigenesis.

  2005cites this paper
• Aberrations of theAPC gene in primary breast carcinoma

  2005cites this paper
• APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.

  2005cites this paper
• Suppression of β-Catenin by Antisense Oligomers Augments Tumor Response to Isolated Limb Perfusion in a Rodent Model of Adenomatous Polyposis Coli–Mutant Colon Cancer

  2005cites this paper
• Tumor suppressors APC and VHL: gatekeepers of the intestine and kidney.

  2005cites this paper
• Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity

  2005cites this paper
• Ocular Manifestations of Familial Adenomatous Polyposis

  2005cites this paper
• Ocular manifestations of familial adenomatous polyposis (Gardner syndrome).

  2005cites this paper
• Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells.

  2004cites this paper
• Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin*

  2004cites this paper
• Establishment and evaluation of a new clinical service for women with a family history of breast cancer

  2004cites this paper
• Attenuated familial adenomatous polyposis (AFAP): a review of the literature

  2004cites this paper
• Tumor suppressor genes and their roles in breast cancer

  2004cites this paper
• Enhanced stem cell survival in familial adenomatous polyposis.

  2004cites this paper
• Identification and characterization of a novel Dvl‐binding protein that suppresses Wnt signalling pathway

  2003cites this paper
• Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients.

  2003cites this paper
• The APC tumor suppressor pathway.

  2003cites this paper
• Analysing Apc function in the mammary gland

  2003cites this paper
• Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC

  2003cites this paper
• Caught up in a Wnt storm: Wnt signaling in cancer.

  2003cites this paper
• Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers

  2003cites this paper
• Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization.

  2003cites this paper
• UNIVERSIDAD DE MURCIA

  2003cites this paper
• Genetic alterations of the APC gene in familial adenomatous polyposis patients of the hellenic group for the study of colorectal cancer.

  2003cites this paper
• Predisposing and modifying genes in hereditary colorectal cancer syndromes

  2002cites this paper
• Attenuated APC alleles produce functional protein from internal translation initiation

  2002cites this paper
• APC and CTNNB1 Mutations in a Large Series of Sporadic Colorectal Carcinomas Stratified by the Microsatellite Instability Status

  2002cites this paper
• Differential occurrence of mutations causative of eye diseases in the Chinese population

  2002cites this paper
• The molecular and genetic basis of colon cancer.

  2002cites this paper
• The Molecular Biology of Colorectal Carcinoma

  2002cites this paper
• Jcb: Article Introduction

  2002cites this paper
• Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.

  2001cites this paper
• Mutations at the APC exon 15 in the colorectal neoplastic tissues of serial array

  2001cites this paper
• A distinct splice form ofAPC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours

  2001cites this paper
• Human APC 2 Localization and Allelic Imbalance 1

  2001cites this paper
• Famlliäre adenomatöse Polyposis

  2001cites this paper
• The ABC of APC.

  2001cites this paper
• Human APC2 localization and allelic imbalance.

  2001cites this paper
• Congenital Hypertrophy of the Retinal Pigment Epithelium and APC Mutations in Chinese with Familial Adenomatous Polyposis

  2001cites this paper
• ARM Domain-dependent Nuclear Import of Adenomatous Polyposis Coli Protein Is Stimulated by the B56α Subunit of Protein Phosphatase 2A*

  2001cites this paper
• The many faces of the tumor suppressor gene APC.

  2001cites this paper
• Autosomal dominant polycystic kidney disease unlinked to thePKD1 and PKD2loci presenting as familial cerebral aneurysm

  2001cites this paper
• APC mutations in sporadic medulloblastomas.

  2000cites this paper
• Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522.

  2000cites this paper