Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis.

Mice homozygous for the nb (normoblastosis) gene have severe hemolytic anemia characterized by increased catabolism were measured in the tissues of homozygous (nb/nb), heterozygous (+/nb), and control (+/+) mice generated on the same genetic background. The functional capacity of the microsomal hemeprotein, cytochrome P-450, was also determined in the livers of these animals. Mice homozygous for the nb gene defect had a marked increase in protoporphyrin content, delta-aminolevulinic acid (ALA)-dehydratase, and uroporphyrinogen I (URO)-synthase activities in erythrocytes. Lesser increases were observed in liver and spleen of nb/nb mice. The homozygous mice also had a marked increase in microsomal heme oxygenase activity in the liver, kidney, and spleen compared to normal controls. The increase in heme oxygenase activity is attributable to a higher specific activity per mg of microsomal protein in the case of the liver and the kidney and to the marked organamegaly in the case of the spleen.

• Publication year

  1979

• Venue

  Journal of Biological Chemistry

• Publication date

  1979-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/s0021-9258(17)37866-3PMID 762094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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