Interaction of olfactory ensheathing cells with astrocytes may be the key to repair of tract injuries in the spinal cord: The ‘pathway hypothesis’

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neurocytology

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/S11068-005-8361-1PMID 16841171
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cord

  2005cited by this paper
• Functional Recovery in Traumatic Spinal Cord Injury after Transplantation of Multineurotrophin-Expressing Glial-Restricted Precursor Cells

  2005cited by this paper
• Delayed repair of corticospinal tract lesions as an assay for the effectiveness of transplantation of Schwann cells

  2005cited by this paper
• Recommended guidelines for studies of human subjects with spinal cord injury

  2005cited by this paper
• Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres

  2005cited by this paper
• Myelin inhibitors: does NO mean GO?

  2004cited by this paper
• Regeneration beyond the glial scar

  2004cited by this paper
• Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins

  2004cited by this paper
• Olfactory ensheathing cell grafts have minimal influence on regeneration at the dorsal root entry zone following rhizotomy

  2004cited by this paper
• Ensheathing cell cultures from the olfactory bulb and mucosa

  2004cited by this paper
• Olfactory ensheathing cells and CNS repair: going solo or in need of a friend?

  2004cited by this paper
• Interaction of transplanted olfactory-ensheathing cells and host astrocytic processes provides a bridge for axons to regenerate across the dorsal root entry zone.

  2004cited by this paper
• Ensheathment of the olfactory nerves in the adult rat

  2003cited by this paper
• Transplantation of olfactory ensheathing cells fails to promote significant axonal regeneration from dorsal roots into the rat cervical cord

  2003cited by this paper
• Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS

  2003cited by this paper
• Close axonal injury of rubrospinal neurons induced transient perineuronal astrocytic and microglial reaction that coincided with their massive degeneration.

  2003cited by this paper
• Functional Repair of the Corticospinal Tract by Delayed Transplantation of Olfactory Ensheathing Cells in Adult Rats

  2003cited by this paper
• Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration, Lesion Size, and Functional Recovery after Implantation in the Injured Rat Spinal Cord

  2003cited by this paper
• The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways.

  2003cited by this paper
• Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair.

  2002cited by this paper
• Building a bridge: engineering spinal cord repair.

  2002cited by this paper
• Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS.

  2002cited by this paper
• The oligodendrocyte precursor cell in health and disease.

  2001cited by this paper
• Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats.

  2001cited by this paper
• Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

  2000cited by this paper
• Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.

  2000cited by this paper
• Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord

  2000cited by this paper
• Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes

  2000cited by this paper
• Reinnervation of the rat olfactory bulb after methyl bromide‐induced lesion: Timing and extent of reinnervation

  1999cited by this paper
• Death of oligodendrocytes and microglial phagocytosis of myelin precede immigration of Schwann cells into the spinal cord

  1999cited by this paper
• Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord

  1998cited by this paper
• New techniques for biopsy and culture of human olfactory epithelial neurons.

  1998cited by this paper
• Induction of microglial and astrocytic response in the adult rat lumbar spinal cord following middle cerebral artery occlusion

  1998cited by this paper
• Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells

  1998cited by this paper
• Do olfactory glia have advantages over Schwann cells for CNS repair?

  1997cited by this paper
• Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord

  1997cited by this paper
• Information coding in the vertebrate olfactory system.

  1996cited by this paper
• Motor recovery of patients presenting with motor paralysis and sensory sparing following cervical spinal cord injuries

  1995cited by this paper
• The telencephalic vesicles are innervated by olfactory placode-derived cells: a possible mechanism to induce neocortical development.

  1995cited by this paper
• Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in long-term lesions of the adult rat spinal cord.

  1995cited by this paper
• Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord

  1994cited by this paper
• Regeneration into the spinal cord of transected dorsal root axons is promoted by ensheathing glia transplants.

  1994cited by this paper
• Requirements for schwann cell migration within cns environments: A viewpoint

  1993cited by this paper
• Olfactory ensheathing cells myelinate dorsal root ganglion neurites.

  1992cited by this paper
• Formation of an olfactory glomerulus: morphological aspects of development and organization.

  1992cited by this paper
• The glial framework of central white matter tracts: Segmented rows of contiguous interfascicular oligodendrocytes and solitary astrocytes give rise to a continuous meshwork of transverse and longitudinal processes in the adult rat fimbria

  1992cited by this paper
• Glial cells from adult rat olfactory bulb: immunocytochemical properties of pure cultures of ensheathing cells.

  1992cited by this paper
• Neuroglial arrangements in the olfactory glomeruli of the hedgehog

  1991cited by this paper
• Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro.

  1990cited by this paper
• Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

  1990cited by this paper
• Early neurogenesis of the mouse olfactory nerve: Golgi and electron microscopic studies

  1989cited by this paper
• Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat

  1987cited by this paper
• Specialized neuroglial arrangement may explain the capacity of vomeronasal axons to reinnervate central neurons.

  1985cited by this paper
• Cell migration from the chick olfactory placode: a light and electron microscopic study.

  1982cited by this paper
• Replacement of receptor neurones after section of the vomeronasal nerves in the adult mouse.

  1978cited by this paper
• Neuronal plasticity in the septal nuclei of the adult rat.

  1969cited by this paper
• The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia

  1969cited by this paper
• Degeneration and regeneration of the nervous system

  1960cited by this paper
• Journal of Embryology and Experimental Morphology.

  1953cited by this paper

• Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

  2025cites this paper
• Application and mechanism of cell therapy technology in the repair of spinal cord injury: a narrative review

  2025cites this paper
• Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model

  2025cites this paper
• The Glial Scar: To Penetrate or Not for Motor Pathway Restoration?

  2025cites this paper
• Three-dimensional Collagen Scaffolds in Cultures of Olfactory Ensheathing Cells Used for Severed Spinal Cord Regeneration

  2022cites this paper
• Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration

  2022cites this paper
• Transplantation of Olfactory Ensheathing Cells: Properties and Therapeutic Effects after Transplantation into the Lesioned Nervous System

  2022cites this paper
• Olfactory ensheathing cells: Unique glial cells promising for treatments of spinal cord injury

  2021cites this paper
• Olfactory Ensheathing Cells and the Structure of the Primary Olfactory Projection

  2021cites this paper
• Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease

  2021cites this paper
• Cell Therapies for Spinal Cord Injury: Trends and Challenges of Current Clinical Trials.

  2020cites this paper
• Reconstruction of the Damaged Dorsal Root Entry Zone by Transplantation of Olfactory Ensheathing Cells

  2019cites this paper
• Research progress and prospects of tissue engineering scaffolds for spinal cord injury repair and protection.

  2019cites this paper
• Transplantation or Transference of Cultured Cells as a Treatment for Spinal Cord Injury

  2019cites this paper
• Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity

  2019cites this paper
• Development of strategies for isolation and functional testing of cell lines for neuronal regeneration

  2019cites this paper
• ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM

  2018cites this paper
• Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation

  2018cites this paper
• The serrulatane diterpenoid natural products RAD288 and RAD289 stimulate properties of olfactory ensheathing cells useful for neural repair therapies

  2018cites this paper
• Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives

  2018cites this paper
• Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

  2018cites this paper
• Geoffrey Raisman. 28 June 1939—27 January 2017

  2018cites this paper
• Transplanted olfactory ensheathing cells restore retinal function in a rat model of light-induced retinal damage by inhibiting oxidative stress

  2017cites this paper
• Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Müller Cell Notch Signaling Pathway

  2017cites this paper
• Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

  2017cites this paper
• Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat

  2017cites this paper
• Functional recovery not correlated with axon regeneration through olfactory ensheathing cell-seeded scaffolds in a model of acute spinal cord injury

  2016cites this paper
• Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration

  2016influential citation
• Mouse xenograft model of Corticospinal Tract by Delayed Transplantation of Olfactory Ensheating Cells in Adult Rats

  2016cites this paper
• Axonal regeneration is detected after olfactory ensheathing cell or fibroblast transplantation in Sprague-Dawley rats with completely transected spinal cords

  2016influential citation
• Modulación de las propiedades migratorias de las células de la glia envolvente

  2015cites this paper
• Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures.

  2015cites this paper
• Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord

  2015cites this paper
• Effects of transplantation of olfactory ensheathing cells in chronic spinal cord injury: a systematic review and meta-analysis

  2015cites this paper
• Obtaining the olfactory bulb as a source of olfactory ensheathing cells with the use of minimally invasive neuroendoscopy-assisted supraorbital keyhole approach—cadaveric feasibility study

  2015cites this paper
• Pathway and Effect of Intranasal Orexin

  2015cites this paper
• Transplantation of Olfactory Ensheathing Cells for Neural Repair

  2015cites this paper
• Mechanisms of olfactory ensheathing cell-enhanced neurite outgrowth and axon regeneration after spinal cord injury

  2015influential citation
• Reelin expression and secretion by olfactory ensheathing cells

  2015cites this paper
• Philosophy in Molecular, Cellular, and Integrative Physiology

  2015cites this paper
• Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord

  2015cites this paper
• UNIVERSITY OF CALIFORNIA Los Angeles Reelin expression and secretion by olfactory ensheathing cells A dissertation submitted in partial satisfaction of the requirements for the degree Master of Science in Physiological Science by

  2015cites this paper
• Understanding the neural repair-promoting properties of olfactory ensheathing cells.

  2014cites this paper
• Biological Roles of Olfactory Ensheathing Cells in Facilitating Neural Regeneration: A Systematic Review

  2014cites this paper
• Functional Regeneration of Supraspinal Connections in a Patient with Transected Spinal Cord following Transplantation of Bulbar Olfactory Ensheathing Cells with Peripheral Nerve Bridging

  2014cites this paper
• Immunocytochemical characterisation of olfactory ensheathing cells of zebrafish

  2014cites this paper
• Immunocytochemical characterisation of ensheathing glia in the olfactory and vomeronasal systems of Ambystoma mexicanum (Caudata: Ambystomatidae)

  2014cites this paper
• Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury

  2013cites this paper
• Potential of Olfactory Ensheathing Cells from Different Sources for Spinal Cord Repair

  2013cites this paper
• Motor outcome and allodynia are largely unaffected by novel olfactory ensheathing cell grafts to repair low-thoracic lesion gaps in the adult rat spinal cord.

  2013cites this paper
• A Multilevel Screening Strategy Defines a Molecular Fingerprint of Proregenerative Olfactory Ensheathing Cells and Identifies SCARB2, a Protein That Improves Regenerative Sprouting of Injured Sensory Spinal Axons

  2013cites this paper
• Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion

  2013cites this paper
• A comparative study of glial and non‐neural cell properties for transplant‐mediated repair of the injured spinal cord

  2013cites this paper
• Patogenia de la lesión medular y mecanismos de reparación inducidos por las células de la glía envolvente olfatoria

  2013cites this paper
• [Pathogenesis of spinal cord injuries and mechanisms of repair induced by olfactory ensheathing cells].

  2013cites this paper
• Immunocytochemical characterization of olfactory ensheathing cells in fish

  2012cites this paper
• Carbon nanostructures as nerve scaffolds for repairing large gaps in severed nerves

  2012cites this paper
• Transplanted Olfactory Ensheathing Cells Reduce Retinal Degeneration in Royal College of Surgeons Rats

  2012cites this paper
• Directionality and bipolarity of olfactory ensheathing cells on electrospun nanofibers.

  2012cites this paper
• CHAPTER 2 SCARB 2 , a protein expressed by olfactory ensheathing cells , promotes regeneration of injured sensory spinal axons

  2012cites this paper
• otor outcome and allodynia are largely unaffected by novel olfactory nsheathing cell grafts to repair low-thoracic lesion gaps in the adult at spinal cord

  2012cites this paper
• Repair involves all three surfaces of the glial cell.

  2012cites this paper
• Isolation, characterization, and genetic profiling of subpopulations of olfactory ensheathing cells from the olfactory bulb

  2012cites this paper
• Clinical neural scaffold engineering for olfactory ensheathing cells

  2012influential citation
• Olfactory ensheathing cells: cellular biology and molecular properties: Olfactory ensheathing cells: cellular biology and molecular properties

  2011cites this paper
• Trafficking and secretion of matrix metalloproteinase‐2 in olfactory ensheathing glial cells: A role in cell migration?

  2011cites this paper
• General introduction Understanding the neural repair- promoting properties of olfactory ensheathing cells

  2011cites this paper
• Transplanted olfactory ensheathing cells reduce the gliotic injury response of Müller cells in a rat model of retinitis pigmentosa.

  2011cites this paper
• Olfactory and respiratory lamina propria transplantation after spinal cord transection in rats: effects on functional recovery and axonal regeneration.

  2011cites this paper
• Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem

  2011cites this paper
• Astrocyte-Produced Ephrins Inhibit Schwann Cell Migration via VAV2 Signaling

  2010cites this paper
• Development of a glial network in the olfactory nerve: role of calcium and neuronal activity.

  2010cites this paper
• Olfactory ensheathing cells: biology in neural development and regeneration.

  2010cites this paper
• Intrinsic and Extrinsic Factors for the Regeneration of Brainstem Axons after Spinal Cord Injury

  2010cites this paper
• Intranasal delivery to the central nervous system: mechanisms and experimental considerations.

  2010cites this paper
• Immunhistochemische Charakterisierung von olfaktorischen Rezeptorneuronen und Gliazellen in der Riechschleimhaut des Hundes

  2009cites this paper
• Reactive Astrocytes in Glial Scar Attract Olfactory Ensheathing Cells Migration by Secreted TNF-α in Spinal Cord Lesion of Rat

  2009cites this paper
• Promoting central nervous system regeneration: Lessons from cranial nerve I

  2008cites this paper
• Xenografts of expanded primate olfactory ensheathing glia support transient behavioral recovery that is independent of serotonergic or corticospinal axonal regeneration in nude rats following spinal cord transection.

  2008cites this paper
• Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats

  2008cites this paper
• Olfactory ensheathing glia as a source of neurogeneration-promoting molecules

  2008cites this paper
• Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: a preliminary Phase I clinical study.

  2008cites this paper
• Treatments for spinal cord injury: is there hope in neurosteroids?

  2008cites this paper
• Comparative gene expression profiling of olfactory ensheathing glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheathing glia

  2008influential citation
• Experimental spinal cord injury : Development of protection and repair strategies in rats

  2007cites this paper
• Repair of neural pathways by olfactory ensheathing cells

  2007cites this paper
• Olfactory ensheathing glia: their contribution to primary olfactory nervous system regeneration and their regenerative potential following transplantation into the injured spinal cord.

  2007cites this paper
• AN EXPERIMENTAL MODEL OF VENTRAL ROOT REPAIR SHOWING THE BENEFICIAL EFFECT OF TRANSPLANTING OLFACTORY ENSHEATHING CELLS

  2007cites this paper
• Regeneration and Plasticity in the Brain and Spinal Cord

  2007cites this paper
• Células de glía envolvente olfatoria: potencial para la reparación de lesiones del sistema nervioso central *

  2007cites this paper
• Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site

  2007cites this paper
• B-cell-survival factors in multiple sclerosis and myasthenia gravis

  2007cites this paper
• Olfactory ensheathing cells: ripples of an incoming tide?

  2006cites this paper