A Novel Mechanism for the Control of Translation Initiation by Amino Acids, Mediated by Phosphorylation of Eukaryotic Initiation Factor 2B

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular and Cellular Biology

• Publication date

  2007-12-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01512-07PMID 18160716PMCID PMC2258763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Translational control in biology and medicine

  2007cited by this paper
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• Analysis of mTOR signaling by the small G‐proteins, Rheb and RhebL1

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• Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

  2003influential reference
• Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.

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• Control of protein synthesis by amino acid availability.

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• eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

  1998cited by this paper
• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*

  1998cited by this paper
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  1998cited by this paper
• Amino acid availability regulates p70 S6 kinase and multiple translation factors.

  1998cited by this paper
• Nerve and Epidermal Growth Factor Induce Protein Synthesis and eIF2B Activation in PC12 Cells*

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• Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

  1998influential reference
• Subunit Assembly and Guanine Nucleotide Exchange Activity of Eukaryotic Initiation Factor-2B Expressed in Sf9 Cells*

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• The two forms of the beta-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation.

  1989cited by this paper
• The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.

  1988cited by this paper

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