MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Clinical Oncology

• Publication date

  2001-11-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1200/JCO.2001.19.22.4259PMID 11709570
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1998cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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