The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase*

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Biological Chemistry

• Publication date

  2015-09-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M115.688424PMID 26405041PMCID PMC4646389
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

  2015cited by this paper
• The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3.

  2015cited by this paper
• Dpb11 Protein Helps Control Assembly of the Cdc45·Mcm2-7·GINS Replication Fork Helicase*

  2015cited by this paper
• Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

  2015cited by this paper
• Switch on the engine: how the eukaryotic replicative helicase MCM2–7 becomes activated

  2015cited by this paper
• The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-stranded DNA Extrusion and Helicase Assembly*

  2014cited by this paper
• The Replication Initiation Protein Sld2 Regulates Helicase Assembly*

  2013cited by this paper
• Helicase activation and establishment of replication forks at chromosomal origins of replication.

  2013cited by this paper
• Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction

  2013cited by this paper
• Mcm10 plays a role in functioning of the eukaryotic replicative DNA helicase, Cdc45-Mcm-GINS.

  2012cited by this paper
• Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase ε in rolling circle DNA synthesis

  2012cited by this paper
• Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components

  2012cited by this paper
• Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

  2012cited by this paper
• Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

  2011influential reference
• Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2–7 Complex, Allowing the GINS Tetramer to Bind the Mcm2–7 Complex*

  2011cited by this paper
• Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

  2011cited by this paper
• GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding*

  2011cited by this paper
• The structural basis for MCM2–7 helicase activation by GINS and Cdc45

  2011cited by this paper
• Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2–7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA*

  2011cited by this paper
• Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing.

  2011cited by this paper
• Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

  2010cited by this paper
• Sld2 binds to origin single-stranded DNA and stimulates DNA annealing

  2010cited by this paper
• A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

  2010cited by this paper
• Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.

  2010cited by this paper
• Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

  2010cited by this paper
• Homology explains the functional similarities of Treslin/Ticrr and Sld3.

  2010cited by this paper
• Eukaryotic chromosome DNA replication: where, when, and how?

  2010cited by this paper
• CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast.

  2010cited by this paper
• How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

  2010cited by this paper
• Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth*

  2009cited by this paper
• Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

  2009cited by this paper
• The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

  2009cited by this paper
• Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.

  2009cited by this paper
• A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

  2009cited by this paper
• Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

  2009cited by this paper
• Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability

  2008cited by this paper
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  2007cited by this paper
• Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

  2007cited by this paper
• Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.

  2006cited by this paper
• Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

  2006cited by this paper
• GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

  2006cited by this paper
• Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin*♦

  2006cited by this paper
• Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

  2006influential reference
• A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication

  2004cited by this paper
• Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.

  2004cited by this paper
• Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding

  2004cited by this paper
• Reconstitution of the Mcm2-7p Heterohexamer, Subunit Arrangement, and ATP Site Architecture*

  2003cited by this paper
• Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding.

  2003cited by this paper
• S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast

  2002cited by this paper
• Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.

  2002cited by this paper
• SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.

  2002cited by this paper
• Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae

  2001influential reference
• Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.

  2000cited by this paper
• Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase

  2000cited by this paper
• Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication

  1998cited by this paper
• Sld2, Which Interacts with Dpb11 inSaccharomyces cerevisiae, Is Required for Chromosomal DNA Replication

  1998cited by this paper
• Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase.

  1997cited by this paper
• Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.

  1997cited by this paper

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  2021cites this paper
• The Role of Ubiquitination and SUMOylation in DNA Replication.

  2020cites this paper
• Flexibly-oriented double Cdc45-MCM-GINS intermediates during eukaryotic replicative helicase maturation

  2018cites this paper
• Origin DNA Melting—An Essential Process with Divergent Mechanisms

  2017cites this paper
• The replication initiation protein Sld3/Treslin orchestrates the assembly of the replication fork helicase during S phase.

  2017cites this paper
• Mechanisms and regulation of DNA replication initiation in eukaryotes

  2017influential citation
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• Open Peer Review

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