Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neuroimmunomodulation

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000156474PMID 19047808PMCID PMC2704383
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Aging Human Brain

  2010cited by this paper
• Intrahippocampal Transplantation of Transgenic Neural Precursor Cells Overexpressing Interleukin-1 Receptor Antagonist Blocks Chronic Isolation-Induced Impairment in Memory and Neurogenesis

  2008cited by this paper
• Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.

  2008cited by this paper
• From inflammation to sickness and depression: when the immune system subjugates the brain

  2008cited by this paper
• Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice.

  2008cited by this paper
• Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

  2008cited by this paper
• The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition.

  2007cited by this paper
• Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide.

  2007cited by this paper
• A dual role for interleukin-1 in hippocampal-dependent memory processes.

  2007cited by this paper
• Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.

  2007cited by this paper
• The blood-brain barrier in psychoneuroimmunology.

  2006cited by this paper
• Peripheral infection and aging interact to impair hippocampal memory consolidation.

  2006cited by this paper
• mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.

  2006cited by this paper
• Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

  2006cited by this paper
• Daily stressors and memory failures in a naturalistic setting: findings from the VA Normative Aging Study.

  2006cited by this paper
• Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

  2005cited by this paper
• Dystrophic microglia in the aging human brain

  2004cited by this paper
• How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

  2004cited by this paper
• Accelerated Prion Disease in the Absence of Interleukin-10

  2004cited by this paper
• Chronic stress and age-related increases in the proinflammatory cytokine IL-6

  2003cited by this paper
• Bi-directional immune–brain communication: Implications for understanding stress, pain, and cognition

  2003cited by this paper
• Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo.

  2003cited by this paper
• The impact of systemic infection on the progression of neurodegenerative disease

  2003cited by this paper
• Systemic infection, interleukin 1β, and cognitive decline in Alzheimer’s disease

  2003cited by this paper
• Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.

  2003cited by this paper
• Prior stressor exposure sensitizes LPS-induced cytokine production.

  2002cited by this paper
• Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging

  2002cited by this paper
• Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior.

  2002cited by this paper
• An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice

  2002cited by this paper
• Inflammatory markers in Alzheimer's disease and multi-infarct dementia.

  2001cited by this paper
• The immune system and memory consolidation: a role for the cytokine IL-1β

  2001cited by this paper
• Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB.

  2001cited by this paper
• Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor κB

  2001cited by this paper
• Intravenous Human Interleukin-1α Impairs Memory Processing in Mice: Dependence on Blood-Brain Barrier Transport into Posterior Division of the Septum

  2001cited by this paper
• The immune system and memory consolidation: a role for the cytokine IL-1beta.

  2001cited by this paper
• Interleukin‐10 modulates neuronal threshold of vulnerability to ischaemic damage

  2000cited by this paper
• Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8.

  2000cited by this paper
• Increased interleukin-6 expression by microglia from brain of aged mice.

  1999cited by this paper
• Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli.

  1999cited by this paper
• Microglial expression of MHC class II increases in normal aging of nonhuman primates.

  1998cited by this paper
• The Role of the Vagus Nerve in Cytokine‐to‐Brain Communication

  1998cited by this paper
• Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice.

  1996cited by this paper
• Peripheral lipopolysaccharide stimulation induces interleukin-1 beta messenger RNA in rat brain microglial cells.

  1995cited by this paper
• The syntax of immune-neuroendocrine communication.

  1994cited by this paper
• Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus

  1993cited by this paper
• Altered antigen expression of microglia in the aged rodent CNS

  1993cited by this paper
• Cognitive impairment, emotional disorder and length of stay of elderly patients in a district general hospital.

  1987cited by this paper

• Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging

  2026cites this paper
• Pathomechanism of postoperative delirium: Systemic inflammatory response and neuroinflammation following anesthesia/surgery.

  2025cites this paper
• Neurological, metabolic and inflammatory phenotypes in a mouse model of ECHS1 deficiency

  2025cites this paper
• Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

  2025cites this paper
• Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer’s disease

  2025cites this paper
• Pre-iTBS alleviates perioperative neurocognitive disorders by inducing long-term neuroprotection against inflammatory injury.

  2025cites this paper
• 1H-MRS study of hippocampus in advanced prostate cancer patients: Relationship between hippocampal secondary damage and cognitive disorder following combined androgen blockade therapy

  2025cites this paper
• Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology

  2025cites this paper
• Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature

  2025cites this paper
• Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration

  2025cites this paper
• Partial microglial depletion through inhibition of colony-stimulating factor 1 receptor improves synaptic plasticity and cognitive performance in aged mice.

  2025cites this paper
• Probiotics as a possible novel therapeutic option to mitigate perioperative neurocognitive disorders: A review exploring the latest research findings.

  2025cites this paper
• Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

  2025cites this paper
• Magnesium and Zinc in Schizophrenia

  2025cites this paper
• Immunological Fluid Biomarkers in Frontotemporal Dementia: A Systematic Review

  2025cites this paper
• Parallel Gene Expression Changes in Ventral Midbrain Dopamine and GABA Neurons during Normal Aging

  2025cites this paper
• Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models

  2024cites this paper
• Long-Term Impact of Diffuse Traumatic Brain Injury on Neuroinflammation and Catecholaminergic Signaling: Potential Relevance for Parkinson’s Disease Risk

  2024cites this paper
• Aging Microglia and Their Impact in the Nervous System.

  2024cites this paper
• The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle.

  2024cites this paper
• Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice

  2024cites this paper
• Immunology of Schizophrenia: A Modern View on Inflammatory Hypotheses of the Disease

  2024cites this paper
• Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review

  2024cites this paper
• Euonymus alatus Leaf Extract Attenuates Effects of Aging on Oxidative Stress, Neuroinflammation, and Cognitive Impairment

  2024cites this paper
• Linking alcohol use to Alzheimer’s disease: Interactions with aging and APOE along immune pathways

  2024cites this paper
• Dynamic Changes in the Activities and Contents of Particular Proteasome Forms in the Cerebral Cortex of C57BL/6 Mice during Aging

  2023cites this paper
• Effects of Thyme (Thymus vulgaris L.) Essential Oil on Aging-Induced Brain Inflammation and Blood Telomere Attrition in Chronologically Aged C57BL/6J Mice

  2023cites this paper
• Dietary inflammatory index and neuropsychiatric disorders

  2023cites this paper
• Neuropsychiatric Outcomes and Sleep Dysfunction in COVID-19 Patients: Risk Factors and Mechanisms

  2023cites this paper
• Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions

  2023cites this paper
• Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation

  2023cites this paper
• Does acupuncture treatment have satisfactory clinical efficacy for late-life depression? A systematic review and meta-analysis.

  2023cites this paper
• Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

  2023cites this paper
• Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease

  2023cites this paper
• Effects of Current Psychotropic Drugs on Inflammation and Immune System.

  2023cites this paper
• Dynamic Changes in the Activity and Content of Particular Proteasome Forms in Cerebral Cortex of C57BL/6 Mice during Aging

  2023cites this paper
• Potential role between inflammatory cytokines and Tie-2 receptor levels and clinical symptoms in patients with first-episode schizophrenia

  2023cites this paper
• Esketamine mitigates cognitive impairment following exposure to LPS by modulating the intestinal flora/subdiaphragmatic vagus nerve/spleen axis.

  2023cites this paper
• The Potential of a Stratified Approach to Drug Repurposing in Alzheimer’s Disease

  2023cites this paper
• Neuroimmune activation and increased brain aging in chronic pain patients after the COVID-19 pandemic onset.

  2023cites this paper
• Inflammation and cognitive performance in first-episode schizophrenia spectrum disorders: The moderating effects of childhood trauma.

  2023cites this paper
• From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders

  2022cites this paper
• Chemobrain: Mysteries and the importance of their revelation

  2022cites this paper
• The role of the complement system in Multiple Sclerosis: A review

  2022cites this paper
• Acute peri‐operative neurocognitive disorders: a narrative review

  2022cites this paper
• Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and ex vivo analysis

  2022cites this paper
• Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders

  2022cites this paper
• TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy.

  2022cites this paper
• Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155

  2022cites this paper
• C-Reactive Protein and Specific Depression Symptoms Among Older Adults: An Exploratory Investigation of Multi-Plane Networks Using Cross-Sectional Data From NHANES (2017–2020)

  2022cites this paper
• The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

  2022cites this paper
• Age-Induced Changes in Mu Opioid Receptor Signaling in the Midbrain Periaqueductal Gray of Male and Female Rats

  2022cites this paper
• Deciphering the Heterogeneity of the Internal Environment of Hippocampal Neurons during Maturation by Raman Spectroscopy

  2022cites this paper
• Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of agedz mice.

  2022cites this paper
• COVID‐19 and neurodegeneration: The mitochondrial connection

  2022cites this paper
• The Effect of Meclofenoxate on the Transcriptome of Aging Brain of Nothobranchius guentheri Annual Killifish

  2022cites this paper
• The dynamic brain N-glycome

  2022cites this paper
• Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

  2022cites this paper
• Effects of Acute and Chronic Trypanosoma cruzi Infection on Pregnancy Outcomes in Mice: Parasite Transmission, Mortality, Delayed Growth, and Organ Damage in Pups.

  2022cites this paper
• Early Adversity and Accelerated Brain Aging: A Mini-Review

  2022cites this paper
• Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice

  2022cites this paper
• Pyridostigmine bromide elicits progressive and chronic impairments in the cholinergic anti-inflammatory pathway in the prefrontal cortex and hippocampus of male rats

  2022cites this paper
• Neuroinflammation and oxidative injury in developmental neurotoxicity

  2022cites this paper
• Cardiovascular therapeutics: A new potential for anxiety treatment?

  2022cites this paper
• Small Extracellular Vesicles from Peripheral Blood of Aged Mice Pass the Blood-Brain Barrier and Induce Glial Cell Activation

  2022cites this paper
• Does the moderator matter? Identification of multiple moderators of the association between peripheral inflammatory markers and depression severity in a large racially diverse community cohort

  2022cites this paper
• Sex-specific remodeling of T-cell compartment with aging: implications for rat susceptibility to central nervous system autoimmune diseases.

  2021cites this paper
• Copper-Binding Peptides Attenuate Microglia Inflammation Through Suppression of NF-kB Pathway.

  2021cites this paper
• Oxidative stress and schizophrenia: A comparative cross‐sectional study of multiple oxidative markers in patients and their first‐degree relatives

  2021cites this paper
• Influences of Dopaminergic System Dysfunction on Late-Life Depression

  2021cites this paper
• d-galactose-induced aging and brain mitochondria

  2021cites this paper
• NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance

  2021cites this paper
• New concepts in the development of schizophrenia, autism spectrum disorders, and degenerative brain diseases based on chronic inflammation: A working hypothesis from continued advances in neuroscience research

  2021cites this paper
• Extra-virgin olive oil, cognition and brain health

  2021cites this paper
• Normal aging, motor neurone disease, and Alzheimer’s disease are characterized by cortical changes in inflammatory cytokines

  2021cites this paper
• Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer’s Disease Model

  2021cites this paper
• Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model

  2021cites this paper
• Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice

  2021cites this paper
• The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

  2021cites this paper
• Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions

  2021cites this paper
• Inflammation and Immunity in Schizophrenia

  2021cites this paper
• Enriched Environment Prevents Surgery-Induced Persistent Neural Inhibition and Cognitive Dysfunction

  2021cites this paper
• Long-term neuropathic pain behaviors correlate with synaptic plasticity and limbic circuit alteration: a comparative observational study in mice

  2021cites this paper
• Opioid-Induced Tolerance and Opioid-Induced Hyperalgesia in Critical Illness

  2021cites this paper
• Orthogonal moment diffusion tensor decomposition reveals age-related degeneration patterns in complex fiber architecture.

  2021cites this paper
• Brain aging and microarray analysis

  2021cites this paper
• Brain-derived neurotrophic factor enhances the therapeutic effect of oleuropein in the lipopolysaccharide-induced models of depression.

  2021cites this paper
• Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.

  2020cites this paper
• Phf15 - a novel transcriptional repressor regulating inflammation in a mouse microglial cell line

  2020cites this paper
• Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

  2020cites this paper
• The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery

  2020cites this paper
• The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery

  2020cites this paper
• Roles of the Choroid Plexus in Aging

  2020cites this paper
• Review: Microglia in motor neuron disease

  2020cites this paper
• Interleukin dynamics during cognitive stress in patients with chronic cerebral ischemia

  2020cites this paper
• Role of the Choroid Plexus in Health and Disease

  2020cites this paper
• Perioperative Neurocognitive Disorder: State of the Preclinical Science.

  2020cites this paper
• Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils

  2020cites this paper
• Impact of Age on Plasma Inflammatory Biomarkers in the 6 Months Following Mild Traumatic Brain Injury

  2020cites this paper
• The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression

  2020cites this paper