Fetal alcohol exposure impairs hedgehog cholesterol modification and signaling

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Laboratory Investigation

• Publication date

  2007-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/labinvest.3700516PMID 17237799
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ALKOHOLEMBRYOPATHIE IM ERWACHSENENALTER : EINE LANGZEITUNTERSUCHUNG

  2008cited by this paper
• Teratogenic effects of ethanol exposure on zebrafish visual system development.

  2006cited by this paper
• Effects of prenatal alcohol exposure on fine motor coordination and balance: A study of two adult samples.

  2006cited by this paper
• Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.

  2006cited by this paper
• Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis

  2005cited by this paper
• Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels.

  2005cited by this paper
• Conserved patterns of cell movements during vertebrate gastrulation.

  2005cited by this paper
• Role for Hedgehog signaling in hepatic stellate cell activation and viability

  2005cited by this paper
• Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull

  2005cited by this paper
• FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination

  2005cited by this paper
• Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish.

  2004cited by this paper
• Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome.

  2004cited by this paper
• Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids

  2004cited by this paper
• Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis.

  2004cited by this paper
• Two Zebrafish Alcohol Dehydrogenases Share Common Ancestry with Mammalian Class I, II, IV, and V Alcohol Dehydrogenase Genes but Have Distinct Functional Characteristics*

  2004cited by this paper
• Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.

  2004cited by this paper
• ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway

  2004cited by this paper
• Novel lipid modifications of secreted protein signals.

  2004cited by this paper
• A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

  2003cited by this paper
• Touching base

  2003cited by this paper
• Effect of ethanol on cell growth and cholesterol metabolism in cultured Hep G2 cells.

  2003cited by this paper
• Effects of embryonic exposure to ethanol on zebrafish visual function.

  2002cited by this paper
• Ethanol-induced caspase-3 activation in the in vivo developing mouse brain.

  2002cited by this paper
• Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila.

  2002cited by this paper
• Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure

  2002cited by this paper
• Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

  2001cited by this paper
• Developmental expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio).

  2001cited by this paper
• Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein.

  2001cited by this paper
• A freely diffusible form of Sonic hedgehog mediates long-range signalling

  2001cited by this paper
• N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.

  2001cited by this paper
• Mutations in holoprosencephaly

  2000cited by this paper
• The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity.

  2000cited by this paper
• Cholesterol modification of proteins.

  2000cited by this paper
• Risk factors for cytogenetically normal holoprosencephaly in California: a population-based case-control study.

  2000cited by this paper
• Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.

  2000cited by this paper
• [Fetal alcohol syndrome in adulthood. A long-term study].

  1999cited by this paper
• Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3*

  1999cited by this paper
• Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.

  1999cited by this paper
• Teratogen-mediated inhibition of target tissue response to Shh signaling.

  1998cited by this paper
• Incorporation of exogenous precursors into neutral lipids and phospholipids in rat hepatocytes: effect of ethanol in vitro.

  1998cited by this paper
• Effect of S -Adenosyl-L-Methionine and Dilinoleoylphosphatidylcholine on Liver Lipid Composition and Ethanol Hepatotoxicity in Isolated Perfused Rat Liver

  1998cited by this paper
• Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog*

  1998cited by this paper
• Ethanol impairs migration of the prechordal plate in the zebrafish embryo.

  1998cited by this paper
• Neuromuscular responses to disturbance of balance in children with prenatal exposure to alcohol.

  1998cited by this paper
• The world according to hedgehog.

  1997cited by this paper
• Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome.

  1997cited by this paper
• A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.

  1997cited by this paper
• The world according to bedgebog

  1997cited by this paper
• The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

  1996cited by this paper
• Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome

  1996cited by this paper
• Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

  1996cited by this paper
• Holoprosencephaly in RSH/Smith-Lemli-Opitz syndrome: does abnormal cholesterol metabolism affect the function of Sonic Hedgehog?

  1996cited by this paper
• Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

  1996cited by this paper
• Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning.

  1996cited by this paper
• Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity.

  1996cited by this paper
• Ethanol-induced teratogenesis: free radical damage as a possible mechanism.

  1995cited by this paper
• Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain.

  1995cited by this paper
• Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord.

  1994cited by this paper
• Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites.

  1994cited by this paper
• Ethanol inhibits neural cell-cell adhesion.

  1994cited by this paper
• Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

  1993cited by this paper
• Sonic hedgehog mediates the polarizing activity of the ZPA.

  1993cited by this paper
• Midline cerebral dysgenesis, dysfunction of the hypothalamic-pituitary axis, and fetal alcohol effects.

  1993cited by this paper
• Ethanol has an acute effect on bile acid biosynthesis in man

  1991cited by this paper
• Holoprosencephaly in a fetal macaque (Macaca nemestrina) following weekly exposure to ethanol.

  1991cited by this paper
• Holoprosencephaly as a possible embryonic alcohol effect.

  1991cited by this paper
• Lack of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase in fibroblasts from a child with urinary excretion of 3 beta-hydroxy-delta 5-bile acids. A new inborn error of metabolism.

  1990cited by this paper
• Arrest of epidermal growth factor-dependent growth in fetal hepatocytes after ethanol exposure.

  1989cited by this paper
• Children of alcoholic mothers.

  1987cited by this paper
• Myosin expression and specialization among the earliest muscle fibers of the developing avian limb.

  1986cited by this paper
• Children of Alcoholic Mothers: Growth and Motor Performance Compared to Matched Controls

  1985cited by this paper
• Fetal alcohol syndrome: embryogenesis in a mouse model.

  1981cited by this paper
• [Alcohol--currently the most significant agent causing malformations. Severe multiple abnormalities in children of alcoholics are increasing at an alarming rate. A warning from DOFONOS].

  1978influential reference
• Recognition of the fetal alcohol syndrome in early infancy.

  1973cited by this paper
• SALMONELLAS IN MEAT.

  1964cited by this paper

• The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.

  2026cites this paper
• Physiologic and molecular effects of alcohol in the esophagus: a narrative review

  2025cites this paper
• Effect of functional groups of polystyrene nanoplastics on the neurodevelopmental toxicity of acrylamide in the early life stage of zebrafish.

  2024cites this paper
• Efcab7 Deletion Sensitizes Mice to the Teratogenic Effects of Gastrulation-Stage Alcohol Exposure.

  2024cites this paper
• Sonic hedgehog signaling in craniofacial development.

  2023cites this paper
• Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction

  2023cites this paper
• Gene-alcohol interactions in birth defects.

  2023cites this paper
• Embryonic ethanol exposure disrupts craniofacial neuromuscular integration in zebrafish larvae

  2023cites this paper
• Holoprosencephaly: Review of Embryology, Clinical Phenotypes, Etiology and Management

  2023cites this paper
• Fetal alcohol spectrum disorders

  2023cites this paper
• Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol‐induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder

  2022cites this paper
• Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish

  2022cites this paper
• Effect of Embryonic Alcohol Exposure on Craniofacial and Skin Melanocyte Development: Insights from Zebrafish (Danio rerio)

  2022cites this paper
• Application of zebrafish in the study of craniomaxillofacial developmental anomalies

  2022cites this paper
• Ethanol Exposure Perturbs Sea Urchin Development and Disrupts Developmental Timing

  2022cites this paper
• High‐throughput detection of craniofacial defects in fluorescent zebrafish

  2022cites this paper
• Zebrafish models of fetal alcohol spectrum disorders

  2021influential citation
• Extracellular Vesicles in Premature Aging and Diseases in Adulthood Due to Developmental Exposures

  2021influential citation
• Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube.

  2021cites this paper
• Avobenzone and nanoplastics affect the development of zebrafish nervous system and retinal system and inhibit their locomotor behavior.

  2021cites this paper
• Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation

  2021cites this paper
• Neural crest metabolism: At the crossroads of development and disease.

  2021cites this paper
• Behavioral genetics of embryonic ethanol exposure in zebrafish: a model for FASD

  2020cites this paper
• Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human.

  2020cites this paper
• Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol‐Induced Craniofacial Defects

  2020cites this paper
• Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors

  2020cites this paper
• Identifying environmental risk factors and gene–environment interactions in holoprosencephaly

  2020cites this paper
• Ethanol and cannabinoids regulate zebrafish GABAergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor dependent mechanism.

  2020cites this paper
• Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children’s Study

  2020cites this paper
• Prenatal alcohol exposure disrupts Shh pathway and primary cilia genes in the mouse neural tube 5 6

  2019cites this paper
• Animal models of gene–alcohol interactions

  2019cites this paper
• Primary cilia dysfunction as a novel pathogenic mechanism of prenatal alcohol-induced birth defects

  2019cites this paper
• Differentially sensitive neuronal subpopulations in the central nervous system and the formation of hindbrain heterotopias in ethanol‐exposed zebrafish

  2019cites this paper
• Ethanol and cannabinoids interact to alter behavior in a zebrafish fetal alcohol spectrum disorder model

  2019cites this paper
• Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders

  2019cites this paper
• Prenatal alcohol exposure disrupts Shh pathway and primary cilia genes in the mouse neural tube

  2019cites this paper
• Hedgehog Signaling and Embryonic Craniofacial Disorders

  2019influential citation
• Colorectal Cancer and Alcohol Consumption—Populations to Molecules

  2018cites this paper
• Diving into the world of alcohol teratogenesis: a review of zebrafish models of fetal alcohol spectrum disorder.

  2018cites this paper
• Developmental processes regulate craniofacial variation in disease and evolution

  2018influential citation
• Identifying and Preventing Cardiac Risk Factors from Fetal Life

  2018cites this paper
• Metabolomics and fetal alcohol spectrum disorder.

  2018cites this paper
• Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia

  2017cites this paper
• Chapter 57 – Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity

  2017cites this paper
• Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog‐Stimulated Stem Cell Antigen‐1 Positive Progenitor Stem Cell Expansion

  2017cites this paper
• Long-term behavioral change as a result of acute ethanol exposure in zebrafish: Evidence for a role for sonic hedgehog but not retinoic acid signaling.

  2017cites this paper
• The alcohol‐sensitive period during early octavolateral organ development in zebrafish (Danio rerio)

  2017cites this paper
• Genetic vulnerabilities to prenatal alcohol exposure: Limb defects in sonic hedgehog and GLI2 heterozygous mice.

  2017cites this paper
• Comparison of molecular marker expression in early zebrafish brain development following chronic ethanol or morpholino treatment

  2017cites this paper
• Gene–environment interactions in development and disease

  2017cites this paper
• Gene‐environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies

  2017cites this paper
• Local injection of granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model

  2016cites this paper
• Hedgehog receptor function during craniofacial development Developmental Biology

  2016cites this paper
• Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

  2016cites this paper
• Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

  2016cites this paper
• Hedgehog receptor function during craniofacial development.

  2016cites this paper
• Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function

  2016cites this paper
• Dhcr7 Regulates Palatal Shelf Fusion through Regulation of Shh and Bmp2 Expression

  2016cites this paper
• Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine.

  2016cites this paper
• Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice.

  2016cites this paper
• Prevalence of Heavy Prenatal Alcohol Exposure in Uganda via Analysis of Fatty Acid Ethyl Esters in Meconium

  2016cites this paper
• The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development.

  2016cites this paper
• The Genetics of Fetal Alcohol Spectrum Disorders.

  2016cites this paper
• Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity

  2016cites this paper
• Computational modeling and simulation of genital tubercle development.

  2016cites this paper
• Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma.

  2015cites this paper
• Ethanol exposure during gastrulation alters neuronal morphology and behavior in zebrafish.

  2015cites this paper
• Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure

  2015cites this paper
• [Influence of 7-dehydrocholesterol reductase gene silencing on the fusion of mouse palatal shelves].

  2015cites this paper
• Teratogenic effects of embryonic alcohol exposure on the limb buds of chicks (Gallus gallus)

  2015cites this paper
• Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form.

  2015cites this paper
• Microfluidic and optogenetic technologies to model spinal cord development and neuromuscular junction formation and function

  2015cites this paper
• Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish.

  2015cites this paper
• The effect of chronic preconception paternal alcohol intake on sperm methylation signatures and subsequent gene expression in mouse offspring

  2015cites this paper
• Effects of Global DNA Methylation Changes on Neurobehavior in Zebrafish

  2015cites this paper
• Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1.

  2014cites this paper
• Fetal alcohol spectrum disorders and cognitive functions of young children

  2014cites this paper
• Maternal periconceptional alcohol consumption and congenital limb deficiencies.

  2014cites this paper
• The Teratogenic Effects of Prenatal Ethanol Exposure Are Exacerbated by Sonic Hedgehog or Gli2 Haploinsufficiency in the Mouse

  2014cites this paper
• A screen of zebrafish mutants identifies ethanol-sensitive genetic loci.

  2014cites this paper
• Ocular involvement in fetal alcohol spectrum disorder: a review.

  2014cites this paper
• Canonical and non-canonical Hedgehog signalling and the control of metabolism.

  2014cites this paper
• Gene–ethanol interactions underlying fetal alcohol spectrum disorders

  2014cites this paper
• Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD

  2014influential citation
• 5-mehtyltetrahydrofolate rescues alcohol-induced neural crest cell migration abnormalities

  2014cites this paper
• Melanin-concentrating hormone expression in the rat hypothalamus is not affected in an experiment of prenatal alcohol exposure.

  2014cites this paper
• Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages.

  2014cites this paper
• Neural crest development in fetal alcohol syndrome.

  2014cites this paper
• Developmental age strengthens barriers to ethanol accumulation in zebrafish.

  2014influential citation
• An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders.

  2014influential citation
• Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: highlights from animal studies.

  2014cites this paper
• Investigating mechanisms of neuronal migration in the zebrafish embryo

  2014cites this paper
• The role of kynurenine metabolism in the development of the central nervous system

  2014cites this paper
• Commentary: catching a conserved mechanism of ethanol teratogenicity.

  2014cites this paper
• Alcohol-Induced Morphological Deficits in the Development of Octavolateral Organs of the Zebrafish (Danio rerio)

  2013cites this paper
• Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway.

  2013cites this paper
• Perspectives On Ethanol Toxicity In Medaka Embryogenesis And Possible Protection By Asian Ginseng (Panax Ginseng): Histological And Biochemical Analysis

  2013cites this paper
• Forebrain and hindbrain development in zebrafish is sensitive to ethanol exposure involving agrin, Fgf, and sonic hedgehog function.

  2013cites this paper
• Sonic hedgehog expression is disrupted following in ovo ethanol exposure during early chick eye development.

  2013cites this paper
• Holoprosencephaly–polydactyly/pseudotrisomy 13: a presentation of two new cases and a review of the literature

  2012cites this paper