A new challenge for successful immunotherapy by tumors that are resistant to apoptosis: two complementary signals to overcome cross-resistance.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Advances in Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0065-230X(02)85005-9PMID 12374285
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hierarchy of in vitro sensitivity and resistance of tumor cells to cytotoxic effector cells, cytokines, drugs and toxins

  2005cited by this paper
• Multidrug resistance in cancer chemotherapy

  2004cited by this paper
• Immunosensitization of Melanoma Tumor Cells to Non-MHC Fas-Mediated Killing by MART-1-Specific CTL Cultures1

  2001cited by this paper
• Apoptosis-resistant Mitochondria in T Cells Selected for Resistance to Fas Signaling*

  2001cited by this paper
• Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis.

  2001cited by this paper
• Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins.

  2001cited by this paper
• Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand.

  2001cited by this paper
• Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

  2001cited by this paper
• Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway.

  2001cited by this paper
• Livin, a Novel Inhibitor of Apoptosis Protein Family Member*

  2001cited by this paper
• Phosphatidylinositol 3-Kinase/Akt Activity Regulates c-FLIP Expression in Tumor Cells*

  2001cited by this paper
• Enhanced sensitivity of bladder cancer cells to tumor necrosis factor related apoptosis inducing ligand mediated apoptosis by cisplatin and carboplatin.

  2001cited by this paper
• Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

  2001cited by this paper
• Actinomycin D and Gemcitabine Synergistically Sensitize Androgen-Independent Prostate Cancer Cells to Apo2L/TRAIL-Mediated Apoptosis

  2001cited by this paper
• Modulation of apoptotic pathways triggered by cytotoxic agents.

  2001cited by this paper
• Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

  2000cited by this paper
• Apoptosis in development

  2000cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

  2000cited by this paper
• Molecular determinants of response to TRAIL in killing of normal and cancer cells.

  2000cited by this paper
• Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling

  2000cited by this paper
• Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.

  2000cited by this paper
• Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line

  2000cited by this paper
• tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c.

  2000cited by this paper
• Failure of Bcl‐2 to block cytochrome c redistribution during TRAIL‐induced apoptosis

  2000cited by this paper
• KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death.

  2000cited by this paper
• Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

  2000cited by this paper
• Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype

  2000cited by this paper
• Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells.

  2000cited by this paper
• Cytotoxic T Cells Specifically Induce Fas on Target Cells, Thereby Facilitating Exocytosis-Independent Induction of Apoptosis1

  2000cited by this paper
• Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression

  2000cited by this paper
• Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug-resistant cells.

  2000cited by this paper
• Role of BAX in the apoptotic response to anticancer agents.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

  2000cited by this paper
• Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells.

  2000cited by this paper
• p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines.

  2000cited by this paper
• ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.

  2000cited by this paper
• Cellular mechanisms of multidrug resistance of tumor cells.

  2000cited by this paper
• Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

  2000cited by this paper
• Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

  2000cited by this paper
• Apoptosis signaling.

  2000cited by this paper
• Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

  2000cited by this paper
• Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

  2000cited by this paper
• The IAP family: endogenous caspase inhibitors with multiple biological activities

  2000cited by this paper
• Coordinated regulation of two TRAIL-R2/KILLER/DR5 mRNA isoforms by DNA damaging agents, serum and 17β-estradiol in human breast cancer cells

  2000cited by this paper
• Multidrug resistance transporters and modulation

  2000cited by this paper
• Transduction of Apaf-1 or caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediated apoptosis.

  2000cited by this paper
• Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies

  2000cited by this paper
• Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

  2000cited by this paper
• Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95‐mediated apoptosis by down‐regulating FLIP‐L expression

  2000cited by this paper
• 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells.

  2000cited by this paper
• Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling Implications for Cancer Therapy

  2000cited by this paper
• Synergistic cytotoxicity and apoptosis by Apo-2 ligand and adriamycin against bladder cancer cells.

  1999cited by this paper
• Immunotherapy with CTLs restricted by nonself MHC.

  1999cited by this paper
• High-dose chemotherapy: is it standard management for any common solid tumor?

  1999cited by this paper
• Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation.

  1999cited by this paper
• STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.

  1999cited by this paper
• Safety and antitumor activity of recombinant soluble Apo2 ligand.

  1999cited by this paper
• Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.

  1999cited by this paper
• The role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis.

  1999cited by this paper
• A human IAP-family gene, apollon, expressed in human brain cancer cells.

  1999cited by this paper
• Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells

  1999cited by this paper
• Functional absence of FADD in PLC/PRF/5 hepatoma cells: possible involvement in the transformation to hepatoma in HBV-infected hepatocytes.

  1999cited by this paper
• BCL-2 family members and the mitochondria in apoptosis.

  1999cited by this paper
• Sensitization of AIDS-Kaposi's sarcoma cells to Apo-2 ligand-induced apoptosis by actinomycin D.

  1999cited by this paper
• Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).

  1999cited by this paper
• An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*

  1999cited by this paper
• Mechanisms of apoptosis avoidance in cancer.

  1999cited by this paper
• Chemoimmunosensitization of the T24 human bladder cancer line to Fas-mediated cytotoxicity and apoptosis by cisplatin and 5-fluorouracil.

  1999cited by this paper
• Fas Ligand-independent, FADD-mediated Activation of the Fas Death Pathway by Anticancer Drugs*

  1999cited by this paper
• Differential requirement for caspase 9 in apoptotic pathways in vivo.

  1998cited by this paper
• Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

  1998cited by this paper
• Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

  1998cited by this paper
• Modulation of apoptosis by endogenous Bcl-xL expression in MKN-45 human gastric cancer cells

  1998cited by this paper
• Death receptors: signaling and modulation.

  1998cited by this paper
• Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.

  1998cited by this paper
• Inhibition of Fas-induced apoptosis by Bcl-2

  1998cited by this paper
• Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction.

  1998cited by this paper
• Tumor immunology: the glass is half full.

  1998cited by this paper
• Downregulation of Fas ligand by shedding

  1998cited by this paper
• Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

  1998cited by this paper
• Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

  1998cited by this paper
• IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases

  1998cited by this paper
• A matter of life and cell death.

  1998cited by this paper
• Resistance to apoptosis correlates with a highly proliferative phenotype and loss of Fas and CPP32 (caspase‐3) expression in human leukemia cells

  1998cited by this paper
• FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.

  1998cited by this paper
• Adoptive immunotherapy following allogeneic bone marrow transplantation.

  1998cited by this paper
• CD4 T cells kill melanoma cells by mechanisms that are independent of Fas (CD95)

  1998cited by this paper
• How do cytotoxic lymphocytes kill their targets?

  1998cited by this paper
• Two CD95 (APO‐1/Fas) signaling pathways

  1998cited by this paper
• Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Apoptosis: Death cycle and Swiss army knives

  1998cited by this paper
• Selection for drug resistance results in resistance to Fas-mediated apoptosis.

  1997cited by this paper
• Chemosensitization of human prostate carcinoma cell lines to anti-fas-mediated cytotoxicity and apoptosis.

  1997cited by this paper
• Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

  1997cited by this paper
• Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases).

  1997cited by this paper

• Advancing the understanding of the role of apoptosis in lung cancer immunotherapy: Global research trends, key themes, and emerging frontiers

  2025cites this paper
• Tumor targeted combination therapeutic system for the effective treatment of drug resistant triple negative breast cancer.

  2023cites this paper
• Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics

  2022cites this paper
• Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

  2022cites this paper
• Case Report: Intra-Tumoral Vaccinations of Quadrivalent HPV-L1 Peptide Vaccine With Topical TLR-7 Agonist Following Recurrence: Complete Resolution of HPV-HR-Associated Gynecologic Squamous Cell Carcinomas in Two Patients

  2021cites this paper
• Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.

  2020cites this paper
• Garcinone-E exhibits anticancer effects in HeLa human cervical carcinoma cells mediated via programmed cell death, cell cycle arrest and suppression of cell migration and invasion

  2020cites this paper
• Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

  2020cites this paper
• Targeting Protein Kinases to Enhance the Response to anti-PD-1/PD-L1 Immunotherapy

  2019cites this paper
• Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer

  2017cites this paper
• Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo

  2017cites this paper
• Romidepsin alone or in combination with anti-CD20 chimeric antigen receptor expanded natural killer cells targeting Burkitt lymphoma in vitro and in immunodeficient mice

  2017cites this paper
• Plant-based natural compounds and herbal extracts as promising apoptotic agents : their implications for cancer prevention and treatment

  2016cites this paper
• Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma

  2016cites this paper
• Indoleamine 2,3-dioxygenase confers resistance to chemotherapy and γ radiation to cancer cells, independent of direct immune involvement

  2014cites this paper
• Downregulation of endogenous STAT3 augments tumoricidal activity of interleukin 15 activated dendritic cell against lymphoma and leukemia via TRAIL.

  2014cites this paper
• Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer.

  2013cites this paper
• Tumor Resistance to Antibody-Mediated Immunotherapy and Reversal of Resistance: Rituximab as Prototype

  2013cites this paper
• Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis

  2012cites this paper
• Inhibition of nuclear factor-&kgr;B by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells

  2012cites this paper
• Targeting the L-arginine-nitric oxide pathway for cancer treatment.

  2010cites this paper
• Pem renders tumor cells resistant to apoptotic cell death induced by a CD8+ T cell-mediated immune response or anticancer drug treatment.

  2010cites this paper
• Nitric Oxide Donors Are a New Class of Anti-cancer Therapeutics for the Reversal of Resistance and Inhibition of Metastasis

  2010cites this paper
• Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ.

  2009cites this paper
• Resveratrol: a natural polyphenol with multiple chemopreventive properties.

  2009cites this paper
• Coumarin A/AA induces apoptosis‐like cell death in HeLa cells mediated by the release of apoptosis‐inducing factor

  2009cites this paper
• Delivery of apoptotic signal to rolling cancer cells: A novel biomimetic technique using immobilized TRAIL and E‐selectin

  2009cites this paper
• Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells.

  2008cites this paper
• CD73 Participates in Cellular Multiresistance Program and Protects against TRAIL-Induced Apoptosis1

  2008cites this paper
• Influence of SiRNA Targeting Survivin on Chemosensitivity of H460/cDDP Lung Cancer Cells

  2008cites this paper
• TRAIL-Induced Apoptosis Program and Protects against CD 73 Participates in Cellular Multiresistance

  2008cites this paper
• Tumor Cell Resistance to Apoptosis by Infi ltrating Cytotoxic Lymphocytes

  2008cites this paper
• Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer.

  2008cites this paper
• NK Cells and Cancer1

  2007cites this paper
• The NO TRAIL to YES TRAIL in cancer therapy (review).

  2007influential citation
• Reversal of resistance to cytotoxic cancer therapies: DHMEQ as a chemo-sensitizing and immuno-sensitizing agent.

  2007cites this paper
• Involvement of the TNF-alpha autocrine-paracrine loop, via NF-kappaB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis.

  2006cites this paper
• Chemotherapy pretreatment sensitizes solid tumor‐derived cell lines to Vα24+ NKT cell‐mediated cytotoxicity

  2006cites this paper
• Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination

  2006cites this paper
• Immunosensitization of Tumor Cells to Dendritic Cell-Activated Immune Responses with the Proteasome Inhibitor Bortezomib (PS-341, Velcade)1

  2006cites this paper
• Construction of three-dimensional In Vitro culture model of ovarian carcinoma and the study of its multicellular drug resistance

  2006cites this paper
• Overcoming tumor resistance to immunotherapy

  2006cites this paper
• Velcade ) with the Proteasome Inhibitor Bortezomib Dendritic Cell-Activated Immune Responses Immunosensitization of Tumor Cells to

  2006cites this paper
• CHAPTER 16 – Principles of Tumor Immunology

  2006cites this paper
• Involvement of the TNF-α autocrine–paracrine loop, via NF-κB and YY1, in the regulation of tumor cell resistance to Fas-induced apoptosis

  2006cites this paper
• Construction of three-dimensional In Vitro culture model of ovarian carcinoma and the study of its multicellular drug resistance

  2006cites this paper
• Expression of transcription factor Yin Yang 1 in prostate cancer.

  2005cites this paper
• Rituximab-mediated chemosensitization of AIDS and non-AIDS non-Hodgkin's lymphoma.

  2005cites this paper
• Pretreatment of Acetylsalicylic Acid Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Down-regulating BCL-2 Gene Expression*

  2005cites this paper
• Resveratrol as a Sensitizer to Apoptosis-Inducing Stimuli

  2005cites this paper
• Novel platinum(IV) complexes induce rapid tumor cell death in vitro

  2005cites this paper
• Can we develop biomarkers that predict response of cancer patients to immunotherapy?

  2005cites this paper
• Strategies of Antigen-Specific T-Cell–Based Immunotherapy for Cancer

  2005cites this paper
• Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis.

  2004cites this paper
• Flavonoids Induce Apoptosis in Human Leukemia U937 Cells Through Caspase- and Caspase-Calpain-Dependent Pathways

  2004cites this paper
• Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κB and inhibition of Bcl-xL expression

  2004cites this paper
• Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis.

  2004cites this paper
• Experimental study on therapeutic effect of in vivo expression of Cell I-Hep II recombinant polypeptide of fibronectin on murine H22 hepatocellular carcinoma.

  2003cites this paper
• Synergy is achieved by complementation with Apo2L/TRAIL and actinomycin D in Apo2L/TRAIL‐mediated apoptosis of prostate cancer cells: Role of XIAP in resistance

  2002cites this paper
• X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-bi

  2002cites this paper