SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng.106PMID 18327257
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prevalence of the metabolic syndrome in individuals with hyperuricemia.

  2007cited by this paper
• Human renal organic anion transporter 4 operates as an asymmetric urate transporter.

  2007cited by this paper
• The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts

  2007cited by this paper
• A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity

  2007cited by this paper
• Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents

  2007cited by this paper
• Genomewide Rapid Association Using Mixed Model and Regression: A Fast and Simple Method For Genomewide Pedigree-Based Quantitative Trait Loci Association Analysis

  2007cited by this paper
• Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms.

  2007cited by this paper
• TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

  2007cited by this paper
• Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits.

  2007cited by this paper
• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  2007cited by this paper
• Renal urate transport.

  2006cited by this paper
• Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population.

  2006cited by this paper
• Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes.

  2006cited by this paper
• Effects of inbreeding, endogamy, genetic admixture, and outbreeding on human health: a (1001 Dalmatians) study.

  2006cited by this paper
• Hyperuricemia and associated diseases.

  2006cited by this paper
• Role of uric acid in hypertension, renal disease, and metabolic syndrome.

  2005cited by this paper
• Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease

  2005cited by this paper
• Uric acid, evolution and primitive cultures.

  2005cited by this paper
• The SLC2 family of facilitated hexose and polyol transporters

  2004cited by this paper
• Identification and Characterization of Human Glucose Transporter-like Protein-9 (GLUT9)

  2004cited by this paper
• The SLC2 family of facilitated hexose and polyol transporters

  2004cited by this paper
• Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

  2004cited by this paper
• Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

  2004cited by this paper
• Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.

  2003cited by this paper
• The Structure of Haplotype Blocks in the Human Genome

  2002cited by this paper
• Multiple portions of poly(A)‐binding protein stimulate translation in vivo

  2000cited by this paper
• Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).

  2000cited by this paper
• QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site.

  1998cited by this paper
• Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. The DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland. Medicines Monitoring Unit.

  1997cited by this paper
• Preliminary criteria for the classification of the acute arthritis of primary gout.

  1977cited by this paper
• Effect of oral fructose on urate production.

  1974cited by this paper
• Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

  year unknowncited by this paper

• Complex interactions of gut-derived short-chain fatty acids in hyperuricemia and gout pathophysiology

  2026cites this paper
• Single-Nucleus Transcriptional Profiling Revealed Cell Diversity and Albino Mutation Mechanism in the Skin of Channa argus

  2026cites this paper
• Urinary phytoestrogen metabolites are associated with a reduced risk of hyperuricemia

  2026cites this paper
• Genome-wide association studies and traditional Chinese medicine in hyperuricemia: current evidence and mechanistic insights

  2026cites this paper
• The biomedical landscape of genomic structural variation in the qatari population

  2026influential citation
• Kidney Urate Underexcretion Mediates the Relationship between Per- and Polyfluoroalkyl Substances and their Alternatives and Uric Acid Levels: Evidence from a Case-Control Study and an Animal Study.

  2026cites this paper
• Single Nucleotide Variants of the SLC2A9 Gene are Associated With Hyperuricemia in Mexican Patients With Type 2 Diabetes.

  2025cites this paper
• A genome-wide study on gene–nutrient interactions for hyperuricemia in a large Korean cohort (KoGES)

  2025cites this paper
• Human and bacterial genetic variation shape oral microbiomes and health

  2025cites this paper
• Automatic Molecular Dynamics Simulation with Binding Affinity Prediction Using Deep Learning

  2025cites this paper
• The Central Role of Gut Microbes in Host Purine Homeostasis.

  2025cites this paper
• GLUT2/SLC2A2 is a bi-directional urate transporter

  2025influential citation
• Comparative analysis of hyperuricemia induction methods and probiotic interventions in mice

  2025cites this paper
• Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

  2025cites this paper
• Impact of Nutrition on the Gut Microbiota: Implications for Parkinson's Disease.

  2025cites this paper
• Structural Basis for Inhibition of Urate Reabsorption in URAT1

  2025cites this paper
• Hyperuricaemia and metabolic syndrome

  2025cites this paper
• Adaptive Responses of Large Yellow Croaker Larimichthys crocea to Ocean Acidification: Integrative Analysis of Gill and Kidney Transcriptomics and Antioxidant Enzyme Activities

  2025cites this paper
• Back to the Physiology: Renal Tubular Handling of Uric Acid and Emerging Strategies for Managing Hyperuricemia.

  2025cites this paper
• Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment

  2025cites this paper
• Cu-MOF@TMB Integrated Test Strips for Naked Eye Colorimetric Detection of a Critical Biomarker for Metabolic and Renal Disorders.

  2025cites this paper
• Acute Kidney Injury and Chronic Kidney Disease Associated with a Genetic Defect: A Report of Two Cases

  2025influential citation
• Advances in Traditional Chinese Medicine for the treatment of hyperuricemia and associated diseases: pathogenesis, mechanisms, and future directions

  2025cites this paper
• Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542)

  2025cites this paper
• Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

  2025cites this paper
• Structural basis of urate transport by glucose transporter 9.

  2025cites this paper
• A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels

  2025cites this paper
• The Long-Term Effects of the Selective Inhibitor of Urate Transporter 1, Dotinurad, on Metabolic Parameters and Renal Function in Japanese Patients With Asymptomatic Hyperuricemia

  2025cites this paper
• Solute carriers: The gatekeepers of metabolism.

  2025cites this paper
• Comprehensive Treatment of Gout with Traditional Chinese Medicine: A Modern Pathophysiological Perspective

  2025cites this paper
• Litiasis úrica

  2025cites this paper
• Functional transposition of renal functions to the posterior intestine during maturation in male three-spined stickleback

  2025cites this paper
• Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman

  2025cites this paper
• Synteny – a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function

  2025cites this paper
• Phytotherapeutic insights into hyperuricemia: a mechanistic and clinical perspective

  2025cites this paper
• The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout

  2025cites this paper
• Comparison between compositional data analysis and principal component analysis for identifying dietary patterns associated with hyperuricemia

  2025cites this paper
• Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter

  2025cites this paper
• Buffering and non-monotonic behavior of gene dosage response curves for human complex traits

  2024cites this paper
• Recent Progress and Future Perspectives on Anti-Hyperuricemic Agents.

  2024cites this paper
• Lithiase urique

  2024cites this paper
• Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout

  2024cites this paper
• Pharmacogenetic study of antipsychotic–induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study

  2024cites this paper
• Large-scale cross-ancestry genome-wide meta-analysis of serum urate

  2024cites this paper
• A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults

  2024cites this paper
• SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids

  2024cites this paper
• Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance

  2024cites this paper
• A System for Discovering Novel Uricosurics Targeting Urate Transporter 1 Based on In Vitro and In Vivo Modeling

  2024cites this paper
• Distribution of the SLC2A9 genotype and its association with the uric acid level in patients with arterial hypertension and atrial fibrillation

  2024cites this paper
• Design, synthesis and bioactivity evaluation of isobavachin derivatives as hURAT1 inhibitors for hyperuricemia agents.

  2024cites this paper
• Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4/MyD88 signaling and uric acid reabsorption.

  2024cites this paper
• Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation

  2024cites this paper
• A Possible Therapeutic Application of the Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease

  2024cites this paper
• Hyperuricemia and its related diseases: mechanisms and advances in therapy

  2024cites this paper
• The Impact of Chrysanthemi Indici Flos-Enriched Flavonoid part on the Model of Hyperuricemia Based on Inhibiting Synthesis and Promoting Excretion of Uric Acid.

  2024cites this paper
• The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program.

  2024cites this paper
• Caffeine Inhibits Both Basal and Insulin‐Activated Urate Transport

  2024cites this paper
• Gout: global epidemiology, risk factors, comorbidities and complications: a narrative review

  2024influential citation
• No causal relationship between serum urate and neurodegenerative diseases: A Mendelian randomization study.

  2024cites this paper
• Structural basis for urate recognition and apigenin inhibition of human GLUT9

  2024cites this paper
• D-glucaro-1,4-lactone improves Diethylnitrosamine induced hepatocellular carcinoma in rats via the uric acid-ROS pathway.

  2024cites this paper
• Regulation of Urate Homeostasis by Membrane Transporters

  2024cites this paper
• ADVANCEMENTS IN UNDERSTANDING THE MOLECULAR MECHANISMS REGULATING URIC ACID METABOLISM IN THE INTESTINE

  2024cites this paper
• [Uric Acid Metabolism, Uric Acid Transporters and Dysuricemia].

  2024cites this paper
• Network Pharmacology Combined with Experimental Validation to Investigate the Mechanism of the Anti-Hyperuricemia Action of Portulaca oleracea Extract

  2024cites this paper
• Biochemical and Histological Effects of Moringa oleifera Extract against Valproate-Induced Kidney Damage

  2024cites this paper
• Association of Functional Genetic Variations in Uric Acid Transporters with the Risk of Idiopathic Male Infertility: A Genetic Association Study and Bioinformatic Analysis

  2024cites this paper
• Harnessing Protein Hydrolysates and Peptides for Hyperuricemia Management: Insights into Sources, Mechanisms, Techniques, and Future Directions.

  2024cites this paper
• Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo.

  2023cites this paper
• Evaluation of ABCG2-mediated extra-renal urate excretion in hemodialysis patients

  2023cites this paper
• Identification of a dysfunctional exon-skipping splice variant in GLUT9/SLC2A9 causal for renal hypouricemia type 2

  2023cites this paper
• Raised CK and acute kidney injury following intense exercise in three patients with a history of exercise intolerance due to homozygous mutations in SLC2A9.

  2023cites this paper
• The Evolving Landscape of Gout in the Female: A Narrative Review

  2023cites this paper
• Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment

  2023cites this paper
• Asymptomatic hyperuricaemia in chronic kidney disease: mechanisms and clinical implications

  2023cites this paper
• Differential Gene Expression in the Penile Cavernosum of Streptozotocin-Induced Diabetic Rats

  2023cites this paper
• Molecular mechanisms regulating uric acid metabolism in the human intestine, systematic literature review

  2023cites this paper
• Agents for the Treatment of Gout: Current Advances and Future Perspectives.

  2023cites this paper
• Inhibiting Hepatocyte Uric Acid Synthesis and Reabsorption Ameliorates Acetaminophen-Induced Acute Liver Injury in Mice

  2023cites this paper
• Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors

  2023cites this paper
• Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives

  2023cites this paper
• Red Grape Skins Red uce Hyperuricemia Induced by High Fructose Intake in Rats قشر العنب الأحمر يقلل ارتفاع حمض يوريك الدم في الفئران المصابة بواسطة المأخوذ العالي من الفركتوز

  2023cites this paper
• Prevalence and Risk Factors of Hyperuricemia in the Urban Health Checkup Population in Xinjiang, China: A Cross-Sectional Study

  2023cites this paper
• Gout therapeutics and drug delivery.

  2023cites this paper
• GLUT9 as a potential drug target for chronic kidney disease: Drug target validation by a Mendelian randomization study

  2023influential citation
• Population pharmacokinetics, pharmacodynamics and pharmacogenetics modelling of oxypurinol in Hmong adults with gout and/or hyperuricemia

  2023cites this paper
• Characterization and Immunogenicity of Recombinant A. flavus Uox Modified by Co/EDTA Carbon Dots.

  2023cites this paper
• Development of a tumor microenvironment‐related prognostic signature in glioma to predict immune landscape and potential therapeutic drugs

  2023cites this paper
• Epigenetic and Metabolic Regulation of Macrophages during Gout

  2023cites this paper
• Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics

  2023cites this paper
• Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M)

  2023cites this paper
• Sex differences in the association between urate metabolism and kidney outcomes in patients with chronic kidney disease

  2023cites this paper
• Changes of serum uric acid level during acute gout flare and related factors

  2023cites this paper
• Autosomal Recessive Renal Hypouricemia Type 2 Presenting with Childhood Stroke in a Sri Lankan Child.

  2023cites this paper
• A review on gout: Looking back and looking ahead.

  2023cites this paper
• Urate Transporter 1 Can Be a Therapeutic Target Molecule for Chronic Kidney Disease and Diabetic Kidney Disease: A Retrospective Longitudinal Study

  2023cites this paper
• Intestine‐Targeted Explosive Hydrogel Microsphere Promotes Uric Acid Excretion for Gout Therapy

  2023cites this paper
• Recurrent exercise-induced acute kidney injury associated with hypouricemia: a case report and literature review

  2023cites this paper
• The in-silico evaluation of important GLUT9 residue for uric acid transport based on renal hypouricemia type 2.

  2023cites this paper
• Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations

  2023cites this paper