HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy

No abstract is available for this paper.

• Publication year

  2012

• Venue

  AIDS (London)

• Publication date

  2012-04-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/QAD.0b013e328351f756PMID 22313961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma levels of soluble CD14 independently predict mortality in HIV infection.

  2011cited by this paper
• IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults.

  2011cited by this paper
• Differential Expression of CD163 on Monocyte Subsets in Healthy and HIV-1 Infected Individuals

  2011cited by this paper
• Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients.

  2011cited by this paper
• Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy.

  2011cited by this paper
• Telomere diseases.

  2010cited by this paper
• Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

  2010cited by this paper
• Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation.

  2010cited by this paper
• Increased Monocyte Turnover from Bone Marrow Correlates with Severity of SIV Encephalitis and CD163 Levels in Plasma

  2010cited by this paper
• Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy.

  2009cited by this paper
• Biomarkers of human immunosenescence: impact of Cytomegalovirus infection.

  2009cited by this paper
• Premature Aging of T cells Is Associated With Faster HIV-1 Disease Progression

  2009cited by this paper
• Association of C-Reactive Protein and HIV Infection With Acute Myocardial Infarction

  2009cited by this paper
• Telomere diseases.

  2009cited by this paper
• Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.

  2009cited by this paper
• Cytomegalovirus and human immunosenescence

  2009cited by this paper
• Macrophage Polarization in Bacterial Infections

  2008cited by this paper
• Increased expression of CD16, CD69, and very late antigen-1 on blood monocytes in active sarcoidosis.

  2008cited by this paper
• Immune activation and inflammation in HIV‐1 infection: causes and consequences

  2008cited by this paper
• Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

  2008cited by this paper
• Immunosenescence and Immunogenetics of Human Longevity

  2008cited by this paper
• Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study.

  2007cited by this paper
• Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.

  2007cited by this paper
• HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.

  2007cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Inflammation markers predicting frailty and mortality in the elderly.

  2006cited by this paper
• Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients.

  2006cited by this paper
• Chemokine CXCL10 Promotes Atherogenesis by Modulating the Local Balance of Effector and Regulatory T Cells

  2006cited by this paper
• Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac‐1 integrin

  2006cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Cerebrospinal fluid interferon-gamma-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection.

  2005cited by this paper
• Molecular mechanisms of HIV-1 associated neurodegeneration

  2005cited by this paper
• Cerebrospinal fluid interferon-γ-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection

  2005cited by this paper
• Assessment of Telomere Length, Phenotype, and DNA Content

  2004cited by this paper
• Local Monocyte Chemoattractant Protein-1 Therapy Increases Collateral Artery Formation in Apolipoprotein E–Deficient Mice but Induces Systemic Monocytic CD11b Expression, Neointimal Formation, and Plaque Progression

  2003cited by this paper
• Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1

  2002cited by this paper
• In the Elderly, Interleukin-6 Plasma Levels and the −174G>C Polymorphism Are Associated With the Development of Cardiovascular Disease

  2002cited by this paper
• Neopterin as a marker for immune system activation.

  2002cited by this paper
• The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF1

  2002cited by this paper
• Serum Interleukin‐6 and Hemoglobin as Physiological Correlates in the Geriatric Syndrome of Frailty: A Pilot Study

  2002cited by this paper
• Interferons and interferon (IFN)‐inducible protein 10 during highly active anti‐retroviral therapy (HAART)—possible immunosuppressive role of IFN‐α in HIV infection

  2000cited by this paper
• Granulocyte-macrophage colony-stimulating factor augments phagocytosis of Mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo.

  2000cited by this paper
• Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10.

  1999cited by this paper
• Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

  1999cited by this paper
• Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly.

  1999cited by this paper
• Impaired telomerase activity in uninfected haematopoietic progenitors in HIV‐1‐infected patients

  1998cited by this paper
• Expanded CD14+ CD16+Monocyte Subpopulation in Patients with Acute and Chronic Infections Undergoing Hemodialysis

  1998cited by this paper
• Disease progression and survival following specific AIDS-defining conditions: a retrospective cohort study of 2048 HIV-infected persons in London

  1998cited by this paper
• Disease progression and survival following specific AIDS‐defining conditions: a retrospective cohort study of 2048 HIV‐infected persons in London

  1998cited by this paper
• Unique monocyte subset in patients with AIDS dementia.

  1997cited by this paper
• Loss of CD28 expression on T lymphocytes: a marker of replicative senescence.

  1997cited by this paper
• Immunosenescence in HIV pathogenesis.

  1997cited by this paper
• Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

  1997cited by this paper
• Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

  1996cited by this paper
• T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover

  1996cited by this paper
• Altered expression of CD11b/CD18 and CD62L on human monocytes after cell preparation procedures.

  1995cited by this paper
• Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, t

  1995cited by this paper
• CD14lowCD16high: A cytokine‐producing monocyte subset which expands during human immunodeficiency virus infection

  1995cited by this paper
• HIV Infection of monocyte‐derived macrophages in vitro reduces phagocytosis of Candida albicans

  1994cited by this paper
• Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.

  1994cited by this paper
• The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients.

  1993cited by this paper
• The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients

  1993cited by this paper
• Downregulation of M-CSF receptors by lipopolysaccharide in murine peritoneal exudate macrophages is mediated through a phospholipase C dependent pathway.

  1993cited by this paper
• Role of dimerization and modification of the CSF‐1 receptor in its activation and internalization during the CSF‐1 response.

  1991cited by this paper
• Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.

  1990cited by this paper
• Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors.

  1990cited by this paper
• HIV-1-stimulated expression of CD11/CD18 integrins and ICAM-1: a possible mechanism for extravascular dissemination of HIV-1-infected cells.

  1989cited by this paper
• SERUM NEOPTERIN AND β2-MICROGLOBULIN IN ANTI-HIV POSITIVE BLOOD DONORS

  1986cited by this paper
• Serum neopterin and beta 2-microglobulin in anti-HIV positive blood donors.

  1986cited by this paper
• γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

  1985cited by this paper
• Ultrastructural identification of monocyte-derived foam cells in fatty streak lesions.

  1980cited by this paper
• Ultrastructural identification of monocyte-derived foam cells in fatty streak lesions.

  1980cited by this paper
• A human neoplastic hematopoietic cell line producing a fibroblast type of interferon.

  1979cited by this paper
• AGE-DEPENDENT SENSITIVITY TO SALICYLATE

  1975cited by this paper

• Long-Term Elite Controllers of HIV-1 Infection Exhibit a Deep Perturbation of Monocyte Homeostasis

  2025cites this paper
• Clinical and experimental treatment of residual immune activation in people living with HIV.

  2025cites this paper
• Longitudinal T-Cell Phenotypic Dynamics During Sustained Antiretroviral Therapy in People With HIV.

  2025cites this paper
• HIV infection and immunosenescence: challenges and intervention strategies

  2025cites this paper
• Increased IFN responses drive myeloid cell activation in people living with HIV-1

  2025cites this paper
• Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.

  2024cites this paper
• IL-10 induces activated phenotypes of monocytes observed in virally-suppressed HIV-1-infected individuals.

  2024cites this paper
• Characterization of proinflammatory cytokines profile during acute SARS-CoV-2 infection in people with human immunodeficiency virus.

  2024cites this paper
• Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease

  2024cites this paper
• Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection

  2024cites this paper
• Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy.

  2024cites this paper
• Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection

  2024cites this paper
• HIV and Inflamm-Aging: How Do We Reach the Summit of Healthy Aging?

  2024cites this paper
• Melanoma in people living with HIV: Immune landscape dynamics and the role of immuno- and antiviral therapies

  2024cites this paper
• Concrete‐Inspired Bionic Bone Glue Repairs Osteoporotic Bone Defects by Gluing and Remodeling Aging Macrophages

  2024cites this paper
• Multiplex Analysis of Cytokines and Chemokines in Persons Aging With or Without HIV

  2023influential citation
• Multiplex analysis of cytokines and chemokines in persons aging with or without HIV

  2023cites this paper
• Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

  2023cites this paper
• A Systematic Review and Meta-Analysis on the Impact of Statin Treatment in HIV Patients on Antiretroviral Therapy

  2023cites this paper
• Increased transmigration of intermediate monocytes associated with atherosclerotic burden in people with HIV on antiretroviral therapy.

  2023cites this paper
• Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach

  2022cites this paper
• Methadone use is associated with increased levels of sCD14, immune activation, and inflammation during suppressed HIV infection

  2022cites this paper
• NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses

  2022influential citation
• Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.

  2022cites this paper
• Persistent Inflammation and Non-AIDS Comorbidities During ART: Coming of the Age of Monocytes

  2022cites this paper
• Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4+ T Cells From HIV-1 Patients

  2022cites this paper
• Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging

  2022influential citation
• Residual immune dysfunction under antiretroviral therapy.

  2021cites this paper
• Adjunct Therapy for CD4+ T-Cell Recovery, Inflammation and Immune Activation in People Living With HIV: A Systematic Review and Meta-Analysis

  2021cites this paper
• Monocyte/Macrophage-Mediated Innate Immunity in HIV-1 Infection: From Early Response to Late Dysregulation and Links to Cardiovascular Diseases Onset

  2021cites this paper
• SARS-CoV-2 and HIV-1: Should HIV-1-Infected Individuals in Sub-Saharan Africa Be Considered a Priority Group for the COVID-19 Vaccines?

  2021cites this paper
• IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection

  2021cites this paper
• Increased Mitochondrial Mass Related To Heightened Pyroptosis of CD4+T Cells In HIV-1 Infection

  2021cites this paper
• Development of a Novel In Vitro Primary Human Monocyte-Derived Macrophage Model To Study Reactivation of HIV-1 Transcription

  2021cites this paper
• Mechanisms of Musculoskeletal Frailty in People Living with HIV

  2021cites this paper
• Heterogeneous photocatalysis of triclocarban and triclosan in greywater: a systematic and bibliometric review analysis

  2021cites this paper
• Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages

  2021cites this paper
• Increased risk for cerebral small vessel disease is associated with quantitative susceptibility mapping in HIV infected and uninfected individuals

  2021cites this paper
• Effect of Opioid Use on Immune Activation and HIV Persistence on ART

  2020cites this paper
• Modulation of Monocyte Activation and Function during Direct Antiviral Agent Treatment in Patients Coinfected with HIV and Hepatitis C Virus

  2020cites this paper
• Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells

  2020cites this paper
• Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases

  2020cites this paper
• Pathomechanisms of HIV-Associated Cerebral Small Vessel Disease: A Comprehensive Clinical and Neuroimaging Protocol and Analysis Pipeline

  2020cites this paper
• Impact of HIV infection on aging and immune status

  2020cites this paper
• Managing HIV‐associated inflammation and ageing in the era of modern ART

  2020cites this paper
• Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors

  2020cites this paper
• Combined protein and transcript single cell RNA sequencing reveals cardiovascular disease and HIV signatures

  2020cites this paper
• How Monocytes Contribute to Increased Risk of Atherosclerosis in Virologically-Suppressed HIV-Positive Individuals Receiving Combination Antiretroviral Therapy

  2019cites this paper
• Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework

  2019cites this paper
• Immunosuppression and HIV Viremia Associated with More Atherogenic Lipid Profile in Older People with HIV

  2019influential citation
• Myeloid and lymphoid activation markers in AIDS and non-AIDS presenters.

  2019cites this paper
• Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study

  2019cites this paper
• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery

  2019cites this paper
• The HIV Reservoir in Monocytes and Macrophages

  2019cites this paper
• The Role of Macrophages in HIV-1 Persistence and Pathogenesis

  2019cites this paper
• Isolation, Transfection, and Culture of Primary Human Monocytes.

  2019cites this paper
• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4 R recovery monocytes, regulatory T cells

  2019cites this paper
• Zidovudine-Based Treatments Inhibit the Glycosylation of ADAM17 and Reduce CD163 Shedding From Monocytes

  2018cites this paper
• Understanding mechanisms to promote successful aging in persons living with HIV.

  2018cites this paper
• Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression.

  2018cites this paper
• In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells

  2018cites this paper
• Circulating inflammatory monocytes contribute to impaired influenza vaccine responses in HIV-infected participants

  2018cites this paper
• Sex Differences in the Kinetics of Immune Reconstitution under Antiretroviral Therapy

  2018cites this paper
• Dyslipidemia in the Setting of HIV Infection and Its Management with Statin Therapy Among a Cohort of HIV-Infected Patients in Washington, DC

  2018cites this paper
• Beneficial and Detrimental Effects of Antiretroviral Therapy on HIV-Associated Immunosenescence

  2018cites this paper
• The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis

  2018influential citation
• CD16-expressing monocytes correlate with arterial stiffness in HIV-infected ART-naïve men

  2018cites this paper
• Fatores associados aos níveis de marcadores inflamatórios em indivíduos com infecção pelo HIV em seguimento ambulatorial

  2018cites this paper
• Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men

  2017cites this paper
• Inflammatory Markers and Plasma Lipids in HIV Patients: A Correlation Analysis Study

  2017cites this paper
• Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era.

  2017cites this paper
• Assessing immune aging in HIV-infected patients

  2017cites this paper
• Aging and comorbidity among HIV-infected individuals

  2017cites this paper
• Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy

  2017cites this paper
• High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid

  2017cites this paper
• Persistence of Activated and Adaptive-Like NK Cells in HIV+ Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy

  2017cites this paper
• Immune activation in prolonged cART-suppressed HIV patients is comparable to that of healthy controls.

  2017cites this paper
• Plasma Interferon-Gamma–Inducible Protein 10 Level Associates With Abnormal Memory B Cells Phenotypes in Perinatal HIV Infection

  2017cites this paper
• Mucosal and Systemic Immune Phenotype is Altered During HIV-1 Infection and is Partially Restored and Further Disrupted in the Absence of Detectable Viral Replication

  2017cites this paper
• Immunosenescence and hurdles in the clinical management of older HIV-patients

  2017cites this paper
• Monocyte and macrophage apoptosis and activation during HIV-1 infection and antiretroviral therapy

  2016influential citation
• Aging attenuates the association between coronary artery calcification and bone loss among HIV-infected persons

  2016cites this paper
• Growing old with HIV: narratives of women in Manicaland Zimbabwe

  2016cites this paper
• High-risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART-suppressed HIV-1-infected women

  2016cites this paper
• Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts

  2016cites this paper
• Effects of Well-Controlled HIV Infection on Complement Activation and Function

  2016cites this paper
• Immune activation and cardiovascular disease in chronic HIV infection

  2016cites this paper
• Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons

  2016cites this paper
• Phenotype and Polyfunctional Deregulation Involving Interleukin 6 (IL-6)- and IL-10-Producing Monocytes in HIV-Infected Patients Receiving Combination Antiretroviral Therapy Differ From Those in Healthy Older Individuals.

  2016cites this paper
• Immune activation and immune aging in HIV infection

  2016cites this paper
• Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms.

  2016influential citation
• Development of an Evaluation Device for Phagocytic Activity of New Phagocytes Using Simple and pH-sensitive Particles that Do Not Require Pre-treatment.

  2016cites this paper
• Antiretroviral therapy in HIV‐1‐infected individuals with CD4 count below 100 cells/mm3 results in differential recovery of monocyte activation

  2016cites this paper
• HIV and Aging: Parallels and Synergistic Mechanisms Leading to Premature Disease and Functional Decline

  2016cites this paper
• Filling the gaps: Towards improved surveillance and monitoring of immunological status relevant to long term co-morbidities in HIV infection

  2016cites this paper
• An NK Cell Population Lacking FcRγ Is Expanded in Chronically Infected HIV Patients

  2015cites this paper
• Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration

  2015cites this paper
• National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2.

  2015cites this paper
• Inflammation‐induced foam cell formation in chronic inflammatory disease

  2015cites this paper
• Cardiovascular disease in human immunodeficiency virus infected patients: A true or perceived risk?

  2015cites this paper