Tools for Semantic Analysis Based on Semantic Similarity

Marianna Milano

Published 2019 in Encyclopedia of Bioinformatics and Computational Biology

ABSTRACT

Experimental data about gene products have been integrated with information related to their function, localization, and role. Biological knowledge is encoded by using special terms, or annotation terms, describing function or localization of genes and proteins. Biological ontologies systematize the corpus of such terms and offer a formal framework to represent biological knowledge. For instance, Gene Ontology provides a set of descriptions of biological aspects, namely GO Term. In order to evaluate the similarity among terms belonging to the same ontology, researchers developed a set of formal instruments called Semantic Similarity Measures (SSM). Computing semantic similarity between two genes or proteins is a key point to discover relationships between different genes or proteins.

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