Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Molecular Biology of the Cell

• Publication date

  1998-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.9.12.3547PMID 9843587PMCID PMC25675
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure and function in the nucleus.

  1998influential reference
• Phosphoinositide 3-kinase in rat liver nuclei.

  1998influential reference
• A Novel Phosphatidylinositol-5-phosphate 4-Kinase (Phosphatidylinositol-phosphate Kinase IIγ) Is Phosphorylated in the Endoplasmic Reticulum in Response to Mitogenic Signals*

  1998cited by this paper
• Type I Phosphatidylinositol-4-phosphate 5-Kinases

  1998cited by this paper
• Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate*

  1998cited by this paper
• Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1.

  1998cited by this paper
• Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic

  1998cited by this paper
• Interphase Nuclei of Many Mammalian Cell Types Contain Deep, Dynamic, Tubular Membrane-bound Invaginations of the Nuclear Envelope

  1997influential reference
• The dynamics of a pre-mRNA splicing factor in living cells

  1997cited by this paper
• Protein Kinase C-mediated Interphase Lamin B Phosphorylation and Solubilization*

  1997cited by this paper
• Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

  1997cited by this paper
• Nuclear diacylglycerol, the cell cycle, the enzymes and a red herring (or how we came to love phosphatidylcholine).

  1997cited by this paper
• Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription.

  1997influential reference
• Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.

  1997influential reference
• Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ*

  1997cited by this paper
• Phosphatidylinositol-4-phosphate 5-Kinase Isozymes Catalyze the Synthesis of 3-Phosphate-containing Phosphatidylinositol Signaling Molecules*

  1997cited by this paper
• Compartmentalization of eukaryotic gene expression: causes and effects.

  1997cited by this paper
• A Role for Nuclear Phosphatidylinositol-specific Phospholipase C in the G2/M Phase Transition*

  1997cited by this paper
• A Novel Interaction between the Juxtamembrane Region of the p55 Tumor Necrosis Factor Receptor and Phosphatidylinositol-4-phosphate 5-Kinase*

  1997cited by this paper
• A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

  1997cited by this paper
• Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

  1997cited by this paper
• Fluorescently labeled phosphatidylinositol transfer protein isoforms (alpha and beta), microinjected into fetal bovine heart endothelial cells, are targeted to distinct intracellular sites.

  1996cited by this paper
• The phosphatidylinositol 4-phosphate 5-kinase family.

  1996cited by this paper
• Type I Phosphatidylinositol-4-phosphate 5-Kinases Are Distinct Members of This Novel Lipid Kinase Family*

  1996cited by this paper
• SRPK1 and Clk/Sty Protein Kinases Show Distinct Substrate Specificities for Serine/Arginine-rich Splicing Factors*

  1996cited by this paper
• Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors.

  1996cited by this paper
• A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.

  1996cited by this paper
• Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription

  1996cited by this paper
• Interleukin-1 alpha induces variations of the intranuclear amount of phosphatidylinositol 4,5-bisphosphate and phospholipase C beta 1 in human osteosarcoma Saos-2 cells.

  1996cited by this paper
• A New Phospholipase C 4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus (*)

  1996cited by this paper
• Nuclear organization and gene expression.

  1996influential reference
• Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells

  1996cited by this paper
• The localization of sites containing nascent RNA and splicing factors.

  1996cited by this paper
• The cloning and sequence of the C isoform of PtdIns4P 5-kinase.

  1995cited by this paper
• The Sequence of Phosphatidylinositol-4-phosphate 5-Kinase Defines a Novel Family of Lipid Kinases (*)

  1995influential reference
• A Phospholipase D-mediated Pathway for Generating Diacylglycerol in Nuclei from Madin-Darby Canine Kidney Cells (*)

  1995cited by this paper
• Nuclear Phospholipase D in Madin-Darby Canine Kidney Cells

  1995cited by this paper
• The architectural organization of nuclear metabolism.

  1995cited by this paper
• Immunocytochemical detection of the intranuclear variations of phosphatidylinositol 4,5‐bisphosphate amount associated with changes of activity and amount of phospholipase C β1 in cells exposed to mitogenic or differentiating agonists

  1995cited by this paper
• Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.

  1994cited by this paper
• A serine kinase regulates intracellular localization of splicing factors in the cell cycle

  1994cited by this paper
• Lipid-dependent nuclear signalling: morphological and functional features.

  1994influential reference
• Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

  1994cited by this paper
• Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid.

  1994cited by this paper
• Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.

  1994cited by this paper
• The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.

  1994cited by this paper
• Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly.

  1994cited by this paper
• Purification and characterization of nuclear phospholipase C specific for phosphoinositides.

  1994cited by this paper
• Stimulation of nuclear protein kinase C leads to phosphorylation of nuclear inositol 1,4,5-trisphosphate receptor and accelerated calcium release by inositol 1,4,5-trisphosphate from isolated rat liver nuclei.

  1993influential reference
• Phosphoinositidase C isoforms are specifically localized in the nuclear matrix and cytoskeleton of Swiss 3T3 cells.

  1993cited by this paper
• Visualization of focal sites of transcription within human nuclei.

  1993cited by this paper
• Inositides and the nucleus and inositides in the nucleus.

  1993influential reference
• Reversible disassembly of transcription domains in lymphocyte nuclei during inhibition of RNA synthesis by DRB

  1993cited by this paper
• gCap39 is phosphorylated. Stimulation by okadaic acid and preferential association with nuclei.

  1993cited by this paper
• Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

  1992influential reference
• Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

  1992cited by this paper
• A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.

  1992influential reference
• Existence of phosphoinositide-specific phospholipase C in rat liver nuclei and its change during liver regeneration.

  1992cited by this paper
• The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin.

  1992cited by this paper
• Associations between distinct pre‐mRNA splicing components and the cell nucleus.

  1991cited by this paper
• Casein kinase I is regulated by phosphatidylinositol 4,5-bisphosphate in native membranes.

  1991cited by this paper
• A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle

  1990cited by this paper
• The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes.

  1990cited by this paper
• Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

  1990cited by this paper
• Quantitative changes in polyphosphoinositides 1,2-diacylglycerol and inositol 1,4,5-trisphosphate by platelet-derived growth factor and prostaglandin F2 alpha.

  1989cited by this paper
• Production and characterization of monoclonal antibodies that bind to phosphatidylinositol 4,5-bisphosphate.

  1988influential reference
• Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis.

  1988cited by this paper
• Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2.

  1988cited by this paper
• Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation.

  1987influential reference
• Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections

  1984cited by this paper
• Immunoelectron microscopic localization of snRNPs

  1983influential reference
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983influential reference
• Phosphorylation of rat liver nuclear envelopes. I. Characterization of in vitro protein phosphorylation.

  1983cited by this paper
• Phosphorylation of rat liver nuclear envelopes. II. Characterization of in vitro lipid phosphorylation.

  1983cited by this paper
• New directions in antinuclear antibody research: the Sm, RNP, Ro, and La antigens are found on small-RNA protein particles.

  1982influential reference
• Burns

  1828cited by this paper

• Nuclear phosphoinositide signaling in cell biology and disease.

  2026cites this paper
• Nuclear phosphoinositides: An exploration into their regulation, roles and physico-chemical environment.

  2026cites this paper
• The cell biologist's guide to detecting and modulating membrane phospholipids.

  2026cites this paper
• The oily nucleus– role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm

  2025cites this paper
• The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers

  2025cites this paper
• Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complex

  2025cites this paper
• Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex

  2025cites this paper
• Potential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1

  2025cites this paper
• Agonist- and stress-driven compartmentalized phosphoinositide signaling in cells.

  2025cites this paper
• The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

  2025influential citation
• The Role of Nuclear Phosphoinositides in the p53-MDM2 Nexus

  2025cites this paper
• Lipid Transfer Proteins and PI4KIIα Generate a Phosphoinositide-Linked Proteome

  2025cites this paper
• Non-canonical functions of PIP4K2A and its role in cancer biology: A review.

  2025cites this paper
• Non-cell autonomous regulation of cell–cell signaling and differentiation by mitochondrial ROS

  2024cites this paper
• Splicing regulation through biomolecular condensates and membraneless organelles

  2024cites this paper
• Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer

  2024cites this paper
• Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation

  2024cites this paper
• Behind the stoNE wall: a fervent activity for nuclear lipids.

  2024cites this paper
• Nuclear patterns of phosphatidylinositol 4,5‐ and 3,4‐bisphosphate revealed by super‐resolution microscopy differ between the consecutive stages of RNA polymerase II transcription

  2024cites this paper
• Nuclear Phospholipids and Signaling: An Update of the Story

  2024cites this paper
• Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling.

  2024cites this paper
• Linking Phosphoinositides to Proteins: A Novel Signaling PIPeline.

  2024cites this paper
• PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer

  2023cites this paper
• Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

  2023cites this paper
• Viruses and phospholipids: Friends and foes during infection

  2023cites this paper
• Nuclear Phosphoinositides as Key Determinants of Nuclear Functions

  2023cites this paper
• SF-1 Induces Nuclear PIP2

  2023cites this paper
• Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts

  2023cites this paper
• Characterizing the metabolomes of phase-separated condensates

  2023cites this paper
• Steroidogenic Factor-1 form and function: From phospholipids to physiology.

  2023cites this paper
• Biomolecular condensates create phospholipid-enriched microenvironments

  2023cites this paper
• When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response

  2022cites this paper
• PIP kinases: A versatile family that demands further therapeutic attention.

  2022cites this paper
• A p53–phosphoinositide signalosome regulates nuclear AKT activation

  2022cites this paper
• Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells

  2021cites this paper
• Nanoscale mapping of nuclear phosphatidylinositol phosphate landscape by dual-color dSTORM.

  2021cites this paper
• The basis of nuclear phospholipase C in cell proliferation.

  2021cites this paper
• A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

  2021cites this paper
• Phosphoinositide 3-kinase signalling in the nucleolus

  2021cites this paper
• Lipid Signaling in Human Diseases

  2020cites this paper
• Cętki jądrowe jako modelowe ciałka jądrowe. Cętki jądrowe w układzie nerwowym

  2020cites this paper
• The nuclear phosphoinositide response to stress

  2020influential citation
• Splicing at the phase-separated nuclear speckle interface: a model

  2020cites this paper
• Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes

  2020cites this paper
• The Role of Phosphatidylinositol Phosphate Kinases during Viral Infection

  2020cites this paper
• Hot topic: Thermosensing in plants

  2020cites this paper
• Protein Kinase C Theta Modulates PCMT1 through hnRNPL to Regulate FOXP3 Stability in Regulatory T Cells.

  2020cites this paper
• Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane

  2020cites this paper
• Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome

  2020cites this paper
• Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins

  2020cites this paper
• Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks

  2019cites this paper
• Nuclear Phosphoinositides—Versatile Regulators of Genome Functions

  2019cites this paper
• T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

  2019cites this paper
• Nuclear Phosphoinositides: Their Regulation and Roles in Nuclear Functions

  2019cites this paper
• Phospholipase D2 in prostate cancer: protein expression changes with Gleason score

  2019cites this paper
• Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction.

  2019cites this paper
• Functions of Nuclear Polyphosphoinositides.

  2019cites this paper
• A nuclear phosphoinositide kinase complex regulates p53

  2019cites this paper
• Nuclear phosphoinositides and phase separation: Important players in nuclear compartmentalization.

  2019cites this paper
• PIP2 epigenetically represses rRNA genes transcription interacting with PHF8.

  2018cites this paper
• New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

  2018cites this paper
• Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

  2018cites this paper
• Phospholipidation of nuclear proteins by the human papillomavirus E6 oncoprotein: implication in carcinogenesis

  2018cites this paper
• Myosin‐1C uses a novel phosphoinositide‐dependent pathway for nuclear localization

  2018cites this paper
• Defining and Manipulating the Function of Protein Kinase C-theta in Graft versus Host Responses

  2018cites this paper
• Multiple Aspects of PIP2 Involvement in C. elegans Gametogenesis

  2018cites this paper
• Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease

  2018cites this paper
• Role of the class I PI3K p110ß and PtdIns(3,4,5)P3 in rRNA transcription in the nucleolus

  2018cites this paper
• Phospholipids and inositol phosphates linked to the epigenome

  2018cites this paper
• Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells

  2018cites this paper
• Nuclear phosphoinositide regulation of chromatin

  2018cites this paper
• Nuclear Inositide Signaling Via Phospholipase C

  2017cites this paper
• Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion

  2017cites this paper
• DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

  2017cites this paper
• Nuclear speckles: molecular organization, biological function and role in disease

  2017cites this paper
• Arabidopsis phosphatidylinositol 4‐phosphate 5‐kinase 2 contains a functional nuclear localization sequence and interacts with alpha‐importins

  2017cites this paper
• SURVEY AND SUMMARY Nuclear speckles: molecular organization, biological function and role in disease

  2017cites this paper
• 2-Arakidonilglizerol endokannabinoidearen sintesi- eta degradazio-makineria neuronaren nukleoan: Diazilglizerol Lipasa alfa-ren konpartimentazioa eta aktibitate entzimatikoa

  2017cites this paper
• Participation of prostaglandin D2 in the mobilization of the nuclear-localized CTP:phosphocholine cytidylyltransferase alpha in renal epithelial cells.

  2016cites this paper
• Ubiquitin Localization Changes as C. elegans Undergo Stress

  2016cites this paper
• Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts[S]

  2016cites this paper
• Tools for visualization of phosphoinositides in the cell nucleus

  2016influential citation
• Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts

  2016cites this paper
• A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction

  2016cites this paper
• Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress.

  2016cites this paper
• IQGAP1 is a phosphoinositide effector and kinase scaffold.

  2016cites this paper
• Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C

  2016cites this paper
• Understanding PI3K signalling in colorectal cancer: from function to therapy

  2016influential citation
• PIP kinases define PI4,5P₂signaling specificity by association with effectors.

  2015cites this paper
• PIP kinases de fi ne PI 4 , 5 P 2 signaling speci fi city by association with effectors ☆

  2015influential citation
• The Basal Transcription Complex Component TAF3 Transduces Changes in Nuclear Phosphoinositides into Transcriptional Output

  2015cites this paper
• Mecanismo molecular de la activación de la síntesis de fosfolípidos por la proto-oncoproteína c-Fos

  2015cites this paper
• Nuclear PI3K signaling in cell growth and tumorigenesis

  2015influential citation
• Endomembrane PtdIns(3,4,5)P3 activates the PI3K–Akt pathway

  2015cites this paper
• PIP4K and the role of nuclear phosphoinositides in tumour suppression.

  2015cites this paper
• Nuclear diacylglycerol lipase‐α in rat brain cortical neurons: evidence of 2‐arachidonoylglycerol production in concert with phospholipase C‐β activity

  2015cites this paper
• Exploring phosphatidylinositol 5-phosphate 4-kinase function

  2015influential citation
• Control of mammalian gene expression by selective mRNA export

  2015cites this paper
• Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions.

  2015cites this paper
• PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation

  2015cites this paper