Mutations in the Stalk of the Measles Virus Hemagglutinin Protein Decrease Fusion but Do Not Interfere with Virus-Specific Interaction with the Homologous Fusion Protein

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Virology

• Publication date

  2007-07-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.00909-07PMID 17626104PMCID PMC2045382
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Measles virus receptors and tropism.

  2006cited by this paper
• Addition of N-Glycans in the Stalk of the Newcastle Disease Virus HN Protein Blocks Its Interaction with the F Protein and Prevents Fusion

  2006cited by this paper
• Amino Acid Substitutions in the F-Specific Domain in the Stalk of the Newcastle Disease Virus HN Protein Modulate Fusion and Interfere with Its Interaction with the F Protein

  2004influential reference
• Triggering of Human Parainfluenza Virus 3 Fusion Protein (F) by the Hemagglutinin-Neuraminidase (HN) Protein: an HN Mutation Diminishes the Rate of F Activation and Fusion

  2003cited by this paper
• Mutations in the Putative HR-C Region of the Measles Virus F2 Glycoprotein Modulate Syncytium Formation

  2003cited by this paper
• Structural features of paramyxovirus F protein required for fusion initiation.

  2003influential reference
• Strength of Envelope Protein Interaction Modulates Cytopathicity of Measles Virus

  2002cited by this paper
• Membrane Fusion Tropism and Heterotypic Functional Activities of the Nipah Virus and Hendra Virus Envelope Glycoproteins

  2002cited by this paper
• Measles Virus Envelope Glycoproteins Hetero-oligomerize in the Endoplasmic Reticulum*

  2001cited by this paper
• Measles Viruses on Throat Swabs from Measles Patients Use Signaling Lymphocytic Activation Molecule (CDw150) but Not CD46 as a Cellular Receptor

  2001cited by this paper
• CD150 (SLAM) Is a Receptor for Measles Virus but Is Not Involved in Viral Contact-Mediated Proliferation Inhibition

  2001cited by this paper
• The Hemagglutinin of Canine Distemper Virus Determines Tropism and Cytopathogenicity

  2001cited by this paper
• Cell surface expression of immature H glycoprotein in measles virus-infected cells.

  2000cited by this paper
• Recombinant measles virus requiring an exogenous protease for activation of infectivity.

  2000cited by this paper
• Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with the homologous F protein in the promotion of fusion.

  1999cited by this paper
• Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain.

  1999cited by this paper
• Mutational Analysis of Heptad Repeats in the Membrane-Proximal Region of Newcastle Disease Virus HN Protein

  1999cited by this paper
• Measles Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence

  1998cited by this paper
• Enhanced antigenicity of a four-contact-residue epitope of the measles virus hemagglutinin protein by phage display libraries: evidence of a helical structure in the putative active site.

  1998cited by this paper
• The molecular basis of virus crossreactivity and neutralisation after immunisation with optimised chimeric peptides mimicking a putative helical epitope of the measles virus hemagglutinin protein.

  1998cited by this paper
• Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding

  1997cited by this paper
• Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin

  1997cited by this paper
• Antibodies to a new linear site at the topographical or functional interface between the haemagglutinin and fusion proteins protect against measles encephalitis.

  1997influential reference
• Functional chimeric HN glycoproteins derived from Newcastle disease virus and human parainfluenza virus-3.

  1997cited by this paper
• Association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces

  1997cited by this paper
• Orthomyxoviridae: The Viruses and Their Replication.

  1996cited by this paper
• Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion

  1996cited by this paper
• Paramyxoviridae : The virus and their replication

  1996cited by this paper
• Localization of a domain on the paramyxovirus attachment protein required for the promotion of cellular fusion by its homologous fusion protein spike.

  1995cited by this paper
• Quantitative measurement of paramyxovirus fusion: differences in requirements of glycoproteins between simian virus 5 and human parainfluenza virus 3 or Newcastle disease virus

  1995cited by this paper
• Localization of monoclonal antibody epitopes and functional domains in the hemagglutinin protein of measles virus

  1995influential reference
• Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion.

  1995cited by this paper
• The hemagglutinin envelope protein of canine distemper virus (CDV) confers cell tropism as illustrated by CDV and measles virus complementation analysis

  1995cited by this paper
• Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation

  1994cited by this paper
• Measles virus fusion: role of the cysteine-rich region of the fusion glycoprotein

  1994cited by this paper
• Site-directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin-neuraminidase glycoprotein: effects on antigenic structure and function

  1994cited by this paper
• Paramyxovirus fusion: a hypothesis for changes.

  1993cited by this paper
• Molecular characterization of epitopes on the measles virus hemagglutinin protein.

  1993cited by this paper
• Cell fusion by the envelope glycoproteins of persistent measles viruses which caused lethal human brain disease

  1993cited by this paper
• The human CD46 molecule is a receptor for measles virus (Edmonston strain).

  1993cited by this paper
• Glycosylation of measles virus haemagglutinin protein in infected cells.

  1991cited by this paper
• The nucleotide and predicted amino acid sequence of the attachment protein of canine distemper virus.

  1991influential reference
• Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion.

  1991cited by this paper
• Kinetics of pH-dependent fusion between 3T3 fibroblasts expressing influenza hemagglutinin and red blood cells. Measurement by dequenching of fluorescence.

  1989cited by this paper
• Sequence determination of the mumps virus HN gene.

  1988cited by this paper
• Nucleotide sequence of the gene encoding the Newcastle disease virus hemagglutinin-neuraminidase protein and comparisons of paramyxovirus hemagglutinin-neuraminidase protein sequences.

  1987influential reference
• Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

  1986cited by this paper
• Human parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein: nucleotide sequence of mRNA and limited amino acid sequence of the purified protein

  1986cited by this paper
• The predicted primary structure of the measles virus hemagglutinin.

  1986cited by this paper
• Characterization of epitopes on the measles virus hemagglutinin.

  1986cited by this paper
• The measles virus

  1980cited by this paper

• Understanding the structure of measles virus and its implications for novel drug discovery

  2025cites this paper
• Molecular detection and whole genome characterization of Canine Parainfluenza type 5 in Thailand

  2021cites this paper
• Quantitative imaging and dynamics of tumor therapy with viruses

  2021cites this paper
• Roles of conserved residues in the receptor binding sites of human parainfluenza virus type 3 HN protein.

  2021cites this paper
• Screening and mechanistic study of key sites of the hemagglutinin-neuraminidase protein related to the virulence of Newcastle disease virus

  2020cites this paper
• Probing Morbillivirus Antisera Neutralization Using Functional Chimerism between Measles Virus and Canine Distemper Virus Envelope Glycoproteins

  2019cites this paper
• Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro

  2018cites this paper
• Quantitative investigation of the direct interaction between Hemagglutinin and fusion proteins of Peste des petits ruminant virus using surface Plasmon resonance

  2018cites this paper
• Development and validation of an epitope-blocking ELISA using an anti-haemagglutinin monoclonal antibody for specific detection of antibodies in sheep and goat sera directed against peste des petits ruminants virus

  2018cites this paper
• Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein

  2017cites this paper
• Viral Fusion Protein TM-TM Interactions: Modulators of Protein Function and Potential Antiviral Targets

  2017cites this paper
• Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

  2017cites this paper
• Structural Insights into Viral Membrane Fusion Machinery via Cryo-Electron Tomography: Influenza Virus and Human Parainfluenza Virus

  2016cites this paper
• Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins

  2016cites this paper
• Paramyxovirus Glycoproteins and the Membrane Fusion Process

  2016cites this paper
• Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

  2015cites this paper
• The Molecular Biology of Peste des Petits Ruminants Virus

  2015cites this paper
• Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process.

  2015cites this paper
• Peste des Petits Ruminants Virus

  2015cites this paper
• Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry

  2015influential citation
• Sequential Conformational Changes in the Morbillivirus Attachment Protein Initiate the Membrane Fusion Process

  2015cites this paper
• Unity in diversity: shared mechanism of entry among paramyxoviruses.

  2015cites this paper
• Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera

  2014cites this paper
• Activation of paramyxovirus membrane fusion and virus entry.

  2014cites this paper
• Allowing Efficient HN-F Complex despite Prevents Triggering of the F Protein Hemagglutinin-Neuraminidase (HN) Protein Disease Virus A Mutation in the Stalk of the Newcastle

  2014cites this paper
• Efficient Reovirus- and Measles Virus-Mediated Pore Expansion during Syncytium Formation Is Dependent on Annexin A1 and Intracellular Calcium

  2014cites this paper
• Biochemical mapping of the measles virus H and F envelope glycoprotein protein-protein interface

  2014cites this paper
• Fusion Activation through Attachment Protein Stalk Domains Indicates a Conserved Core Mechanism of Paramyxovirus Entry into Cells

  2014cites this paper
• The Role of the Hendra Virus and Nipah Virus Attachment Glycoproteins in Receptor Binding and Antibody Neutralization

  2014cites this paper
• Deletions in the highly polymorphic region (HPR) of infectious salmon anaemia virus HPR0 haemagglutinin-esterase enhance viral fusion and influence the interaction with the fusion protein.

  2014cites this paper
• Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain

  2013cites this paper
• A Mutation in the Stalk of the Newcastle Disease Virus Hemagglutinin-Neuraminidase (HN) Protein Prevents Triggering of the F Protein despite Allowing Efficient HN-F Complex Formation

  2013cites this paper
• A Stabilized Headless Measles Virus Attachment Protein Stalk Efficiently Triggers Membrane Fusion

  2013cites this paper
• Hydrophobic and Charged Residues in the Central Segment of the Measles Virus Hemagglutinin Stalk Mediate Transmission of the Fusion-Triggering Signal

  2013cites this paper
• Viral Entry into Host Cells

  2013cites this paper
• Envelope Protein Dynamics in Paramyxovirus Entry

  2013cites this paper
• Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein.

  2013cites this paper
• Mutations in the Parainfluenza Virus 5 Fusion Protein Reveal Domains Important for Fusion Triggering and Metastability

  2013cites this paper
• Identification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation

  2013cites this paper
• Measles Virus Fusion Machinery Activated by Sialic Acid Binding Globular Domain

  2013cites this paper
• Paramyxoviruses crossing the host membrane: mechanisms for entry

  2013cites this paper
• Mutations in the parainfluenza virus 5 fusion (F) protein reveal

  2013cites this paper
• Paramyxovirus entry.

  2013cites this paper
• Development of Instantaneous Protection against SARS-CoV with Implications for Multiple RNA Viruses

  2012cites this paper
• EARLY EVENTS OF HUMAN METAPNEUMOVIRUS INFECTION

  2012cites this paper
• Triggering the measles virus membrane fusion machinery

  2012influential citation
• Molecular virology of the henipaviruses.

  2012cites this paper
• Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics

  2012cites this paper
• Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering

  2012cites this paper
• Regulation of Paramyxovirus Fusion Activation: the Hemagglutinin-Neuraminidase Protein Stabilizes the Fusion Protein in a Pretriggered State

  2012cites this paper
• Henipavirus membrane fusion and viral entry.

  2012cites this paper
• The Second Receptor Binding Site of the Globular Head of the Newcastle Disease Virus Hemagglutinin-Neuraminidase Activates the Stalk of Multiple Paramyxovirus Receptor Binding Proteins To Trigger Fusion

  2012cites this paper
• Mechanism for Active Membrane Fusion Triggering by Morbillivirus Attachment Protein

  2012cites this paper
• Structural and Mechanistic Studies of Measles Virus Illuminate Paramyxovirus Entry

  2011cites this paper
• Spring-Loaded Model Revisited: Paramyxovirus Fusion Requires Engagement of a Receptor Binding Protein beyond Initial Triggering of the Fusion Protein

  2011cites this paper
• Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions

  2011cites this paper
• Structure and Working of Viral Fusion Machinery

  2011cites this paper
• Structure and Mutagenesis of the Parainfluenza Virus 5 Hemagglutinin-Neuraminidase Stalk Domain Reveals a Four-Helix Bundle and the Role of the Stalk in Fusion Promotion

  2011cites this paper
• the Role of the Stalk in Fusion Promotion Domain Reveals a Four-Helix Bundle and Hemagglutinin-Neuraminidase Stalk Parainfluenza Virus 5 Structure and Mutagenesis of the

  2011cites this paper
• 1 2 Structure and mutagenesis of the parainfluenza virus 5 3 hemagglutinin-neuraminidase stalk domain reveals a four-helix 4 bundle and the role of the stalk in fusion promotion 5 6

  2011cites this paper
• Mechanism of Fusion Triggering by Human Parainfluenza Virus Type III

  2011cites this paper
• Modes of paramyxovirus fusion: a Henipavirus perspective.

  2011cites this paper
• Canine Distemper Virus Infects Canine Keratinocytes and Immune Cells by Using Overlapping and Distinct Regions Located on One Side of the Attachment Protein

  2011cites this paper
• Mutations in the Stalk Region of the Measles Virus Hemagglutinin Inhibit Syncytium Formation but Not Virus Entry

  2010influential citation
• The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.

  2010cites this paper
• Blue Native PAGE and Biomolecular Complementation Reveal a Tetrameric or Higher-Order Oligomer Organization of the Physiological Measles Virus Attachment Protein H

  2010cites this paper
• Measles virus‐induced suppression of immune responses

  2010cites this paper
• Récepteurs cellulaires du virus de la rougeole et dissémination in vivo

  2010cites this paper
• New insights into measles virus propagation: from entry to shedding

  2010cites this paper
• A Quantitative and Kinetic Fusion Protein-Triggering Assay Can Discern Distinct Steps in the Nipah Virus Membrane Fusion Cascade

  2010cites this paper
• Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein.

  2009cites this paper
• Measles Virus Glycoprotein Complex Assembly, Receptor Attachment, and Cell Entry

  2009cites this paper
• The mechanism of henipavirus fusion: Examining the relationships between the attachment and fusion glycoproteins

  2009cites this paper
• Glycoprotein interactions in paramyxovirus fusion.

  2009cites this paper
• Bimolecular Complementation of Paramyxovirus Fusion and Hemagglutinin-Neuraminidase Proteins Enhances Fusion: Implications for the Mechanism of Fusion Triggering

  2009influential citation
• Probing the Spatial Organization of Measles Virus Fusion Complexes

  2009influential citation
• A Novel Receptor-induced Activation Site in the Nipah Virus Attachment Glycoprotein (G) Involved in Triggering the Fusion Glycoprotein (F)*

  2009cites this paper
• Viral entry mechanisms: the increasing diversity of paramyxovirus entry

  2009cites this paper
• A Histidine Switch in Hemagglutinin-Neuraminidase Triggers Paramyxovirus-Cell Membrane Fusion

  2008cites this paper
• Evil versus 'eph-ective' use of ephrin-B2

  2008cites this paper
• Paramyxoviruses: different receptors - different mechanisms of fusion.

  2008cites this paper
• Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

  2008cites this paper
• The Measles Virus Fusion Protein Transmembrane Region Modulates Availability of an Active Glycoprotein Complex and Fusion Efficiency

  2008cites this paper
• Engineered Intermonomeric Disulfide Bonds in the Globular Domain of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein: Implications for the Mechanism of Fusion Promotion

  2008cites this paper
• Functional Interaction between Paramyxovirus Fusion and Attachment Proteins*

  2008cites this paper
• Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.

  2008cites this paper
• Residues in the Stalk Domain of the Hendra Virus G Glycoprotein Modulate Conformational Changes Associated with Receptor Binding

  2008cites this paper
• Repository Citation

  year unknowncites this paper