Salinomycin Selectively Targets ‘CD133+’ Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Annals of Surgical Oncology

• Publication date

  2011-01-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1245/s10434-011-1561-2PMID 21267784
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
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  2009cited by this paper
• The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

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• Identification of selective inhibitors of cancer stem cells by high-throughput screening.

  2009influential reference
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