If Current and Spontaneous Activity in Mouse Embryonic Ventricular Myocytes

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Circulation Research

• Publication date

  2001-03-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.88.5.536PMID 11249878
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence of postnatal-development on I(f) occurrence and properties in neonatal rat ventricular myocytes.

  1999cited by this paper
• Decreased inward rectifier current in adult rabbit ventricular myocytes maintained in primary culture: a single-channel study.

  1999cited by this paper
• β-Adrenergic modulation of L-type Ca2+-channel currents in early-stage embryonic mouse heart.

  1999cited by this paper
• Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues.

  1999cited by this paper
• Inaugural editorial: a new era for Circulation Research.

  1999cited by this paper
• The membrane current (I(f)) in human atrial cells: implications for atrial arrhythmias.

  1998cited by this paper
• Characterization of the hyperpolarization-activated inward current in isolated human atrial myocytes.

  1998cited by this paper
• Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

  1998cited by this paper
• Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts.

  1998cited by this paper
• Characterization of a hyperpolarization‐activated current in dedifferentiated adult rat ventricular cells in primary culture

  1998cited by this paper
• Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells

  1997cited by this paper
• Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart.

  1997cited by this paper
• Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis.

  1997cited by this paper
• Occurrence and properties of the hyperpolarization-activated current If in ventricular myocytes from normotensive and hypertensive rats during aging.

  1996cited by this paper
• Developmental changes in ionic channel activity in the embryonic murine heart.

  1996cited by this paper
• The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current.

  1995cited by this paper
• Pacemaker current i(f) in adult canine cardiac ventricular myocytes.

  1995cited by this paper
• Hyperpolarization-activated inward current in embryonic chick cardiac myocytes: developmental changes and modulation by isoproterenol and carbachol.

  1993cited by this paper
• Pacemaker current exists in ventricular myocytes.

  1993cited by this paper
• Cardiac pacemaking in the sinoatrial node.

  1993cited by this paper
• The Atlas of Mouse Development

  1992cited by this paper
• Developmental increases in the inwardly rectifying potassium current of rat ventricular myocytes.

  1992cited by this paper
• Persisting zones of slow impulse conduction in developing chicken hearts.

  1992cited by this paper
• Identification of the hyperpolarization-activated inward current in young embryonic chick heart myocytes.

  1991cited by this paper
• Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

  1986cited by this paper
• The cardiac hyperpolarizing-activated current, if. Origins and developments.

  1985cited by this paper
• Pacemaker currents in chick embryonic heart cells change with development

  1980cited by this paper
• Location of pacemaker in chick embryo heart at the time of initiation of heartbeat

  1967cited by this paper
• The initiation of contraction in the embryonic chick heart

  1933cited by this paper

• A model for the human fetal ventricular myocyte electrophysiology

  2026cites this paper
• Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2025.4

  2025cites this paper
• VOLTAGE-GATED ION CHANNEL'S GENE EXPRESSION IN THE MYOCARDIUM OF EMBRYO AND ADULT CHICKENS.

  2024cites this paper
• Cardiac maturation.

  2023cites this paper
• Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2023.1

  2023cites this paper
• HCN2 channel‐induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling

  2022cites this paper
• NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond

  2022cites this paper
• Dual role of miR-1 in the development and function of sinoatrial cells.

  2021cites this paper
• Effect of Ivabradine on Cardiac Ventricular Arrhythmias: Friend or Foe?

  2021cites this paper
• The rationale for repurposing funny current inhibition for management of ventricular arrhythmia.

  2020cites this paper
• Ivabradine prevents deleterious effects of dopamine therapy in heart failure: No role for HCN4 overexpression.

  2020cites this paper
• Differentiable PKC Activation on Pacemaking Activity of Cardiomyocytes Derived from Mouse Embryonic Stem Cells Par

  2020cites this paper
• HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair

  2020cites this paper
• Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling

  2019cites this paper
• Biophysical modelling of rat cardiac electrophysiology and calcium handling

  2019cites this paper
• Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

  2019cites this paper
• Cyclic nucleotide-regulated channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• 25 – Stem Cell–Derived Sinoatrial-Like Cardiomyocytes as a Novel Pharmacological Tool

  2018cites this paper
• HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns

  2018cites this paper
• Long‐term treatment with ivabradine in transgenic atrial fibrillation mice counteracts hyperpolarization‐activated cyclic nucleotide gated channel overexpression

  2018cites this paper
• Transcription factor Tbx18 induces the differentiation of c-kit+ canine mesenchymal stem cells (cMSCs) into SAN-like pacemaker cells in a co-culture model in vitro.

  2018cites this paper
• Sinus Node Disease and Cardiac Conduction Disease

  2018cites this paper
• Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis

  2017cites this paper
• Prevalence of EBV, HPV and MMTV in Pakistani breast cancer patients: A possible etiological role of viruses in breast cancer.

  2017cites this paper
• HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner

  2017cites this paper
• The Inhibitory Effects of Ketamine on Human Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and Action Potential in Rabbit Sinoatrial Node

  2017cites this paper
• Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

  2016cites this paper
• Age-associated expression of HCN channel isoforms in rat sinoatrial node

  2016cites this paper
• Dysfunctional Hyperpolarization-Activated Cyclic Nucleotide-gated Ion Channels in Cardiac Diseases

  2016cites this paper
• Control of the heart rate of rat embryos during the organogenic period

  2016cites this paper
• Biopacemaking : new targets and new mechanisms

  2016cites this paper
• The electrophysiological development of cardiomyocytes.

  2016cites this paper
• Role of Inositol 1, 4, 5-Triphosphate on Heart Rate in Isolated Heart Models of Wistar Rats

  2015cites this paper
• New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development.

  2015cites this paper
• Stem Cell–Derived Nodal-Like Cardiomyocytes as a Novel Pharmacologic Tool: Insights from Sinoatrial Node Development and Function

  2015cites this paper
• RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.

  2015cites this paper
• The IgCAM CAR regulates calcium homeostasis in the developing heart

  2015influential citation
• Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2.

  2015cites this paper
• Distinct expression patterns of HCN channels in HL-1 cardiomyocytes

  2015cites this paper
• Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.

  2015cites this paper
• Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study

  2014cites this paper
• Functional Expression and Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels (HCN) in Mouse iPS Cell-derived Cardiomyocytes after UTF1-Neo Selection

  2014cites this paper
• Role of sodium channels in the spontaneous excitability of early embryonic cardiomyocytes.

  2014cites this paper
• Sélection de gènes de référence pour la normalisation des expériences de PCR quantitative dans un modèle de dysfonction diastolique de lapin

  2014cites this paper
• Dual effects of amiodarone on pacemaker currents in hypertrophied ventricular myocytes isolated from spontaneously hypertensive rats

  2014cites this paper
• miRNA in the regulation of ion channel/transporter expression.

  2013cites this paper
• Role of Non-myocytes in Engineering of Highly Functional Pluripotent Stem Cell-derived Cardiac Tissues

  2013cites this paper
• Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development

  2013cites this paper
• Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts

  2013cites this paper
• Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy.

  2013cites this paper
• Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study

  2013influential citation
• Effect of hyperpolarization-activated current I(f) on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na(+) concentration.

  2013cites this paper
• Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes

  2013cites this paper
• Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

  2012cites this paper
• Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine

  2012cites this paper
• Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

  2012influential citation
• Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

  2012cites this paper
• Chapter 25 – Developmental Changes in Ion Channels

  2012cites this paper
• Prediction of potentially unstable electrical activity during embryonic development of rodent ventricular myocytes

  2012cites this paper
• In Vitro Epigenetic Reprogramming of Human Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular Precursors

  2012cites this paper
• HCN channels in the heart: lessons from mouse mutants

  2012cites this paper
• Electrophysiological-metabolic modeling of microbes: applications in fuel cells and environment analysis.

  2012cites this paper
• Functional cardiac tissue engineering.

  2012cites this paper
• Functional expression of potassium channels in cardiomyocytes derived from embryonic stem cells

  2012influential citation
• Long‐term treatment with ivabradine in post‐myocardial infarcted rats counteracts f‐channel overexpression

  2012cites this paper
• Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle.

  2012cites this paper
• Molecular and functional changes in voltage-gated Na⁺ channels in cardiomyocytes during mouse embryogenesis.

  2011cites this paper
• Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.

  2011cites this paper
• Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes

  2011influential citation
• processcardiac properties through a cell fusion

  2011cites this paper
• The Funny Current in Cardiac Non-Pacemaker Cells: Functional Role and Pharmacological Modulation

  2011cites this paper
• Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function.

  2011cites this paper
• Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.

  2011cites this paper
• Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self‐organization

  2011cites this paper
• Specific inhibition of HCN channels slows rhythm differently in atria, ventricle and outflow tract and stabilizes conduction in the anoxic-reoxygenated embryonic heart model.

  2010cites this paper
• Cycling in the Mechanism of Pacemaking Cardiac Pacemaking : Historical Overview and Future Directions

  2010cites this paper
• Expression of key ion channels in the rat cardiac conduction system by laser capture microdissection and quantitative real‐time PCR

  2010influential citation
• Non-Cardiomyocytes Influence the Electrophysiological Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes During Differentiation

  2010cites this paper
• Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts.

  2010cites this paper
• Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.

  2010cites this paper
• Characterization of the Rapidly Activating Delayed Rectifier Potassium Current, IKr, in HL-1 Mouse Atrial Myocytes

  2010cites this paper
• unny channel-based pacemaking

  2010cites this paper
• Identification, Isolation and Characterization of HCN4‐Positive Pacemaking Cells Derived from Murine Embryonic Stem Cells during Cardiac Differentiation

  2010cites this paper
• Prenatal exposure to carbon monoxide delays postnatal cardiac maturation

  2010cites this paper
• The Role of MicroRNA in Cardiac Excitability

  2010cites this paper
• Funny channel-based pacemaking.

  2010cites this paper
• 6.02 – Cardiovascular Development*

  2010cites this paper
• Regulation of functional cell surface expression by oligomerization and N-linked glycosylation of membrane proteins

  2010cites this paper
• The cardiac pacemaker current.

  2010influential citation
• UvA-DARE ( Digital Academic Repository ) Embryonic stem cell-derived cardiomyocytes

  2009cites this paper
• Outline General Introduction Figure 1. Schematic Overview of the Major Staging Systems of Embryonic Structural Cardiogenesis and Transitions in Electrical Wiring of the Developing Heart 1.1. Structural Heart Development Figure 2. Schematic Representation of the Spatiotemporal Relation of the Figure

  2009cites this paper
• The “Funny” Pacemaker Current

  2009cites this paper
• F ibroblasts from human post-myocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene Chapter

  2009cites this paper
• Assessment of potassium current in Royan B1 stem cell derived cardiomyocytes by patch-clamp technique

  2009cites this paper
• Hyperpolarization-activated cation channels: from genes to function.

  2009cites this paper
• Cardiomyocyte enrichment from human embryonic stem cell cultures by selection of ALCAM surface expression.

  2009cites this paper
• Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

  2009cites this paper
• What keeps us ticking: a funny current, a calcium clock, or both?

  2009cites this paper
• Role of the T-type calcium channel CaV3.2 in the chronotropic action of corticosteroids in isolated rat ventricular myocytes.

  2009cites this paper
• Transcriptional Control of Pacemaker Channel Genes HCN2 and HCN4 by Sp1 and Implications in Re-expression of These Genes in Hypertrophied Myocytes

  2009cites this paper