Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Diabetologia

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-011-2323-1PMID 22038515
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention.

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• Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease

  2008cited by this paper
• Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis

  2008influential reference
• The role for endoplasmic reticulum stress in diabetes mellitus.

  2008cited by this paper
• The role of PGP9.5 as a tumor suppressor gene in human cancer

  2008cited by this paper
• Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy

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  2006influential reference
• Essential Role of Ubiquitin-Proteasome System in Normal Regulation of Insulin Secretion*

  2006cited by this paper
• A genomic and functional inventory of deubiquitinating enzymes.

  2005cited by this paper
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  2003cited by this paper
• Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

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  2003cited by this paper
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  2003cited by this paper
• Islet amyloid polypeptide and type 2 diabetes.

  2003cited by this paper
• Expression of PGP9.5 in ductal cells of the rat pancreas during development and regeneration: can it be a marker for pancreatic progenitor cells?

  2002cited by this paper
• Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells

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• The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

  2002cited by this paper
• Interaction and colocalization of PGP9.5 with JAB1 and p27Kip1

  2002cited by this paper
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  2002cited by this paper
• Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?

  2001cited by this paper
• PGP9.5 as a prognostic factor in pancreatic cancer.

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• Basic Medical Research Award. The ubiquitin system.

  2000cited by this paper
• Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome.

  2000cited by this paper
• Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

  1999cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases.

  1998cited by this paper
• Basic Medical Research Award

  1998cited by this paper
• Serial analysis of gene expression in non-small cell lung cancer.

  1998cited by this paper
• Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

  1996cited by this paper
• A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM

  1995cited by this paper
• Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

  1995cited by this paper
• Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

  1994cited by this paper
• A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

  1989cited by this paper
• The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.

  1989cited by this paper
• Gracile Axonal Dystrophy (GAD), a New Neurological Mutant in the Mouse

  1988cited by this paper
• PGP 9.5--a new marker for vertebrate neurons and neuroendocrine cells.

  1983cited by this paper

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  2025cites this paper
• Ubiquitination and Metabolic Disease.

  2024cites this paper
• Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila

  2024cites this paper
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  2023cites this paper
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  2022cites this paper
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