Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.90538.2008PMID 18812463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

  2008cited by this paper
• The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

  2008cited by this paper
• Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

  2008cited by this paper
• The role for endoplasmic reticulum stress in diabetes mellitus.

  2008cited by this paper
• The Ubi brothers reunited

  2008cited by this paper
• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  2008cited by this paper
• Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

  2008cited by this paper
• Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

  2008cited by this paper
• Advances in male contraception.

  2008cited by this paper
• Ubiquitination system and autoimmunity: the bridge towards the modulation of the immune response.

  2008cited by this paper
• The role of gut hormones in glucose homeostasis.

  2007cited by this paper
• The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?

  2007cited by this paper
• Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy

  2007cited by this paper
• Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.

  2007cited by this paper
• Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein

  2007cited by this paper
• ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

  2007cited by this paper
• Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

  2007cited by this paper
• Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation

  2007cited by this paper
• Macroautophagy: Protector in the Diabetes Drama?

  2007cited by this paper
• ERADicate ER Stress or Die Trying

  2007cited by this paper
• Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

  2007cited by this paper
• Autophagy: from phenomenology to molecular understanding in less than a decade

  2007cited by this paper
• Endoplasmic reticulum stress signaling in pancreatic beta-cells.

  2007cited by this paper
• Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

  2007cited by this paper
• Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.

  2007cited by this paper
• A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.

  2007cited by this paper
• Mapping of possible prion protein self-interaction domains using peptide arrays

  2007cited by this paper
• ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum

  2007cited by this paper
• A ubiquitin-like protein involved in membrane fusion.

  2007cited by this paper
• Signal integration in the endoplasmic reticulum unfolded protein response

  2007cited by this paper
• The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy*

  2007cited by this paper
• Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

  2007cited by this paper
• Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

  2007cited by this paper
• Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

  2007cited by this paper
• Endoplasmic Reticulum Stress Signaling in Pancreatic β-Cells

  2007cited by this paper
• Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

  2007cited by this paper
• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.

  2007cited by this paper
• Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

  2007cited by this paper
• Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

  2007cited by this paper
• HECT E3s and human disease

  2007cited by this paper
• Endoplasmic Reticulum Stress Triggers Autophagy*

  2006cited by this paper
• Essential Role of Ubiquitin-Proteasome System in Normal Regulation of Insulin Secretion*

  2006cited by this paper
• GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

  2006cited by this paper
• Critical nodes in signalling pathways: insights into insulin action

  2006cited by this paper
• Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

  2006cited by this paper
• Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)

  2006cited by this paper
• Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

  2006cited by this paper
• Inflammation and metabolic disorders

  2006cited by this paper
• The Role of Autophagy in Alpha-1-Antitrypsin Deficiency: A Specific Cellular Response in Genetic Diseases Associated with Aggregation-Prone Proteins

  2006cited by this paper
• GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.

  2006cited by this paper
• Loss of autophagy in the central nervous system causes neurodegeneration in mice

  2006cited by this paper
• Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

  2006cited by this paper
• Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

  2006cited by this paper
• Fatty acid signaling in the beta-cell and insulin secretion.

  2006cited by this paper
• Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets

  2006cited by this paper
• Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

  2006cited by this paper
• Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death1

  2006cited by this paper
• p62/SQSTM1: A Missing Link between Protein Aggregates and the Autophagy Machinery

  2006cited by this paper
• Ubiquitin ligases: cell-cycle control and cancer

  2006cited by this paper
• Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell.

  2006cited by this paper
• ALIS are Stress-Induced Protein Storage Compartments for Substrates of the Proteasome and Autophagy

  2006cited by this paper
• Membrane Origin for Autophagy

  2006cited by this paper
• Fatty Acid Signaling in the β-Cell and Insulin Secretion

  2006cited by this paper
• Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis*

  2006cited by this paper
• Glucoreceptor mechanisms and the control of insulin release and biosynthesis

  2005cited by this paper
• Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels.

  2005cited by this paper
• Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

  2005cited by this paper
• ERAD: the long road to destruction

  2005cited by this paper
• Ubiquitin and ubiquitin-like proteins as multifunctional signals

  2005cited by this paper
• Protein quality control: chaperones culling corrupt conformations

  2005cited by this paper
• Autophagy and signaling: their role in cell survival and cell death

  2005cited by this paper
• Aggresome formation.

  2005cited by this paper
• ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity

  2005cited by this paper
• Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

  2005cited by this paper
• Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

  2005cited by this paper
• ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity.

  2005cited by this paper
• p62 protein is expressed in pancreatic beta cells.

  2005cited by this paper
• Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene

  2005cited by this paper
• A new pharmacology--drugging stressed folding pathways.

  2005cited by this paper
• Type 2 diabetes mellitus as a conformational disease.

  2005cited by this paper
• Proteasome Inhibition Alters Glucose-stimulated (Pro)insulin Secretion and Turnover in Pancreatic β-Cells*

  2005cited by this paper
• Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

  2005cited by this paper
• Accumulation of Mutant α1-Antitrypsin Z in the Endoplasmic Reticulum Activates Caspases-4 and -12, NFκB, and BAP31 but Not the Unfolded Protein Response*

  2005cited by this paper
• p62 protein is expressed in pancreatic β cells

  2005cited by this paper
• High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin.

  2004cited by this paper
• Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

  2004cited by this paper
• Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

  2004cited by this paper
• Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.

  2004cited by this paper
• Stress, Protein (Mis)folding, and Signaling: The Redox Connection

  2004cited by this paper
• Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

  2004cited by this paper
• Diabetes mellitus : a fundamental and clinical text

  2004cited by this paper
• Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress

  2004cited by this paper
• Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

  2004cited by this paper
• Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes*

  2004cited by this paper
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004cited by this paper
• Ald6p Is a Preferred Target for Autophagy in Yeast, Saccharomyces cerevisiae*

  2004cited by this paper
• All roads lead to ATF4.

  2003cited by this paper
• Insulin granule dynamics in pancreatic beta cells

  2003cited by this paper
• U-box proteins as a new family of ubiquitin ligases.

  2003cited by this paper
• Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells

  2003cited by this paper

• Inhibition of proteasome activity facilitates definitive endodermal specification of pluripotent stem cells by influencing YAP signalling.

  2024cites this paper
• Serotonin Influences Insulin Secretion in Rat Insulinoma INS-1E Cells

  2024cites this paper
• Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

  2022cites this paper
• Dynamics of ubiquitination in differentiation and dedifferentiation of pancreatic β-cells: Putative Target for Diabetes.

  2022cites this paper
• Effect of pioglitazone on the expression of ubiquitin proteasome system and autophagic proteins in rat pancreas with metabolic syndrome

  2021cites this paper
• HRD1, an Important Player in Pancreatic β-Cell Failure and Therapeutic Target for Type 2 Diabetic Mice

  2020cites this paper
• Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

  2020cites this paper
• Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings.

  2019cites this paper
• Key genes and co‐expression network analysis in the livers of type 2 diabetes patients

  2019cites this paper
• Ubiquitin‐proteasome system and ER stress in the brain of diabetic rats

  2018cites this paper
• An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis

  2018cites this paper
• Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

  2018cites this paper
• Les produits de glycation avancée des protéines

  2018cites this paper
• Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

  2018cites this paper
• The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.

  2017cites this paper
• Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view.

  2016cites this paper
• The Role of PJA2-CDK5R1 in β-cell Function

  2015cites this paper
• Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis

  2015cites this paper
• Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells*

  2015cites this paper
• Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.

  2015cites this paper
• Liraglutide protects pancreatic β-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E−/− mice by activating autophagy

  2015cites this paper
• Study of the reproductive factors associated with development of type II diabetes among perimenopausal females in El Minia district, Egypt

  2015cites this paper
• CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion

  2015cites this paper
• Genetic Determinants of Type 2 Diabetes in Asians.

  2015cites this paper
• Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion

  2015cites this paper
• development, neurological processes, and glucose homeostasis

  2015cites this paper
• Ubiquitin carboxyl hydrolase L1 significance for human diseases.

  2014cites this paper
• Lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population.

  2014cites this paper
• Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets

  2014cites this paper
• Therapeutic potential of pterostilbene against pancreatic beta‐cell apoptosis mediated through Nrf2

  2014cites this paper
• Impaired proteostasis: role in the pathogenesis of diabetes mellitus

  2014cites this paper
• Novel approaches to drug discovery for the treatment of type 2 diabetes

  2014cites this paper
• Autophagy in the endocrine glands.

  2014cites this paper
• Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes, and glucose homeostasis

  2014cites this paper
• Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.

  2014cites this paper
• The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.

  2013cites this paper
• Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner*

  2013cites this paper
• In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated β-cell dysfunction during the progression of type-2 diabetes.

  2013cites this paper
• Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus

  2013cites this paper
• Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62.

  2013cites this paper
• Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets

  2012cites this paper
• Dual functions of autophagy in the response of breast tumor cells to radiation

  2012cites this paper
• Autophagy: cellular defense to excessive inflammation.

  2012cites this paper
• The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells

  2012cites this paper
• Genetics of Type 2 Diabetes in East Asian Populations

  2012cites this paper
• Investigation of the Effect of Herbicide Amiprophos Methyl on Spindle Formation and Proteome Change in Maize by Immunofluorescence and Proteomic Technique

  2011cites this paper
• Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

  2011cites this paper
• Two‐dimensional gel proteome reference map of INS‐1E cells

  2011cites this paper
• Genetic Predisposition for Type 1 Diabetes Mellitus - The Role of Endoplasmic Reticulum Stress in Human Disease Etiopathogenesis

  2010cites this paper
• AUTOPHAGY IN HEALTH AND DISEASE: IV.The role of pancreatic beta-cell

  2010cites this paper
• Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes.

  2010cites this paper
• Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines.

  2010cites this paper
• Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.

  2010cites this paper
• Autophagy protects against human islet amyloid polypeptide‐associated apoptosis

  2010cites this paper
• A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

  2010cites this paper
• A role for autophagy in b-cell life and death

  2009cites this paper
• A role for autophagy in β-cell life and death

  2009cites this paper
• Autophagy in disease: a double-edged sword with therapeutic potential.

  2009cites this paper