The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular Biology of the Cell

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E07-12-1257PMID 18321988PMCID PMC2366860
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autophagosome formation in mammalian cells

  2010cited by this paper
• Genomewide association study of leprosy.

  2009cited by this paper
• In Vitro Reconstitution of Plant Atg8 and Atg12 Conjugation Systems Essential for Autophagy*

  2008cited by this paper
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy*

  2007influential reference
• Structure of Atg5·Atg16, a Complex Essential for Autophagy*

  2007cited by this paper
• Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae

  2007cited by this paper
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

  2007cited by this paper
• Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

  2007cited by this paper
• A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

  2007cited by this paper
• Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion.

  2007cited by this paper
• Hierarchy of Atg proteins in pre‐autophagosomal structure organization

  2007cited by this paper
• European evidence based consensus on the diagnosis and management of Crohn’s disease: current management

  2006cited by this paper
• Yeast (Saccharomyces cerevisiae).

  2006cited by this paper
• Phosphatidylserine in Addition to Phosphatidylethanolamine Is an in Vitro Target of the Mammalian Atg8 Modifiers, LC3, GABARAP, and GATE-16*

  2006cited by this paper
• The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy

  2005cited by this paper
• Structure-Function Relationship of Atg12, a Ubiquitin-Like Modifier Essential for Autophagy

  2005cited by this paper
• Autophagy: a regulated bulk degradation process inside cells.

  2004cited by this paper
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004cited by this paper
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

  2004cited by this paper
• Autophagy: in sickness and in health.

  2004cited by this paper
• Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

  2004cited by this paper
• In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy*

  2004cited by this paper
• Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

  2003influential reference
• Human Apg3p/Aut1p Homologue Is an Authentic E2 Enzyme for Multiple Substrates, GATE-16, GABARAP, and MAP-LC3, and Facilitates the Conjugation of hApg12p to hApg5p*

  2002cited by this paper
• Yeast autophagosomes: de novo formation of a membrane structure.

  2002cited by this paper
• Autophagosome formation in mammalian cells.

  2002cited by this paper
• The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

  2001cited by this paper
• The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3*

  2001cited by this paper
• Red fluorescent protein

  2001cited by this paper
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

  2001influential reference
• Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems

  2001cited by this paper
• A ubiquitin-like system mediates protein lipidation

  2000cited by this paper
• A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

  2000cited by this paper
• An Essential Role for a Membrane Lipid in Cytokinesis

  2000cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000influential reference
• The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

  2000cited by this paper
• Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

  1999cited by this paper
• Purification and characterization of autophagosomes from rat hepatocytes.

  1998cited by this paper
• A protein conjugation system essential for autophagy

  1998cited by this paper
• A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

  1991cited by this paper

• Role of autophagy in antiviral innate immunity.

  2026cites this paper
• Engineering combination nanomedicines to overcome cancer resistance

  2026cites this paper
• Core principles of autophagy initiation mechanisms.

  2026cites this paper
• The nonsense-mediated mRNA decay factor Upf3 negatively regulates bulk autophagy progression in Saccharomyces cerevisiae

  2026cites this paper
• Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model

  2026cites this paper
• Quantitative and temporal analysis of autophagy: Differential Response to amino acid and glucose starvation.

  2026cites this paper
• The E3 ubiquitin ligase SIAH1 targets a bacterial pore-forming toxin to facilitate xenophagy.

  2025cites this paper
• Autophagy and Bacterial infections

  2025cites this paper
• ATG7 vs. ATG5: Distinct Autophagy Pathways Shaping TGF-β Signaling and Endothelial Function

  2025cites this paper
• Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases

  2025cites this paper
• Autophagy-lysosome pathway in insulin & glucagon homeostasis

  2025cites this paper
• Identification of ATG7 as a protein ATG8ylation substrate.

  2025cites this paper
• Autophagy-Related Proteins in Triple-Negative Breast Cancer: From Molecular Insights to Therapeutic Applications

  2025cites this paper
• Adaptability and stress response mechanisms of abalone Haliotis discus hannai to cadmium in vitro and in vivo

  2025cites this paper
• The Role of Autophagy in the Regulation of Bidirectional Relationships in Diabetic Periodontitis

  2025cites this paper
• The Role of WIPI2, ATG16L1 and ATG12-ATG5 in selective and nonselective autophagy.

  2025cites this paper
• ATG16L1 controls mammalian vacuolar proton ATPase.

  2025cites this paper
• RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages

  2025cites this paper
• Deacetylation of ATG16L1 is required for LC3-associated lysosomal microautophagy

  2025cites this paper
• Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities

  2025cites this paper
• Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy

  2025cites this paper
• Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancer

  2025cites this paper
• Autophagy related genes polymorphisms in Parkinson’s Disease; A systematic review of literature

  2025cites this paper
• ATG-3 limits Orsay virus infection in C. elegans through regulation of collagen pathways

  2025cites this paper
• Mitochondrial Biogenesis in Skeletal Muscle.

  2025cites this paper
• Autophagosome marker, LC3, is released extracellularly via several distinct pathways

  2025cites this paper
• Atg18 facilitates autophagosome formation via its Atg8‐interacting motif in Saccharomyces cerevisiae

  2025cites this paper
• Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins

  2025cites this paper
• Mammalian innate antiviral defenses: beyond interferon

  2025cites this paper
• Detection of Orsay viral replication intermediates reveals spatial and regulatory links to Caenorhabditis elegans innate immune responses

  2025cites this paper
• Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

  2025cites this paper
• B3GNT8-mediated glycosylation maintains intestinal homeostasis and protects against colitis

  2025cites this paper
• C3-CD18-VATPase-ATG16L1 and C3-ATG16L1 axes restrict the escape of microbes through the autophagy-lysosome pathway.

  2025cites this paper
• ATG-3 limits Orsay virus infection in C. elegans and regulates collagen pathways

  2025cites this paper
• Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities

  2025cites this paper
• The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling

  2025cites this paper
• Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms

  2025cites this paper
• Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

  2025cites this paper
• Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis

  2025cites this paper
• The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway

  2025cites this paper
• ATG16L1 membrane recruitment in autophagy

  2025influential citation
• Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing

  2025cites this paper
• S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation

  2025cites this paper
• Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex

  2025cites this paper
• Exploring the interplay between oxidative stress and autophagy in asthma: Pathophysiology and therapeutic potential.

  2025cites this paper
• Programmed mitophagy at the oocyte-to-zygote transition promotes species immortality

  2025cites this paper
• Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy

  2025cites this paper
• How does autophagy impact neurological function?

  2025cites this paper
• The Assessment of Anti-Cancer Effect of Theranekron® on Human Hepatocellular Carcinoma HepG2 Cells

  2025cites this paper
• Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis

  2025cites this paper
• Steroid signaling in autophagy.

  2025cites this paper
• Epigenetich Mechanisms Involved in the Etiology of Lung Cancers: From Noncoding RNAs to Exosomal Noncoding RNAs.

  2025cites this paper
• Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration

  2025cites this paper
• Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis.

  2025cites this paper
• Chaperone-mediated autophagy degrades SERPINA1E342K/α1-antitrypsin Z variant and alleviates cell stress

  2025cites this paper
• Membrane remodeling via ubiquitin-mediated pathways.

  2024cites this paper
• Natural Autophagy Activators to Fight Age-Related Diseases

  2024cites this paper
• Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction

  2024cites this paper
• Mitophagy Responds to the Environmental Temperature and Regulates Mitochondrial Mass in Adipose Tissues.

  2024cites this paper
• Autophagy3D: a comprehensive autophagy structure database

  2024cites this paper
• The role of autophagy dysregulation in low and high-grade nonmuscle invasive bladder cancer: A survival analysis and clinicopathological association.

  2024cites this paper
• Unraveling autophagic imbalances and therapeutic insights in Mecp2-deficient models

  2024cites this paper
• Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication

  2024cites this paper
• Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways

  2024cites this paper
• Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates

  2024cites this paper
• The V-ATPase/ATG16L1 axis is controlled by the V1H subunit.

  2024cites this paper
• Chemotherapeutic Potential of Chlorambucil-Platinum(IV) Prodrugs against Cisplatin-Resistant Colorectal Cancer Cells

  2024cites this paper
• Conjugation of ATG8s to single membranes at a glance

  2024cites this paper
• The Effect of Alpha-Hydroxycholecalciferol and Phytase on the Performance, Carcass Characteristics, Blood Factors, and Expression of Vdr and Cabp-D28k Genes in Broiler Chickens

  2024cites this paper
• The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function

  2024cites this paper
• Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer

  2024cites this paper
• Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential.

  2024cites this paper
• Lens autophagy protein ATG16L1: a potential target for cataract treatment

  2024cites this paper
• From Defense to Dysfunction: Autophagy's Dual Role in Disease Pathophysiology.

  2024cites this paper
• TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways

  2024cites this paper
• Ferritin Hinders Ferroptosis in Non-Tumorous Diseases: Regulatory Mechanisms and Potential Consequences.

  2024cites this paper
• The role of host autophagy in intracellular protozoan parasites diseases.

  2024cites this paper
• Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells

  2024cites this paper
• The interaction of ER stress and autophagy in trophoblasts: navigating pregnancy outcome.

  2024cites this paper
• AMPK regulates phagophore-to-autophagosome maturation

  2024cites this paper
• ATG8ylation of vacuolar membrane protects plants against cell wall damage

  2024cites this paper
• Studying the Changes in Physical Functioning and Oxidative Stress-Related Molecules in People Living with HIV after Switching from Triple to Dual Therapy

  2024cites this paper
• Nanomaterials in crossroad of autophagy control in human cancers: Amplification of cell death mechanisms.

  2024cites this paper
• Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation.

  2024cites this paper
• Unraveling the role of autophagy regulation in Crohn's disease: from genetic mechanisms to potential therapeutics

  2024cites this paper
• Filter-Aided Extracellular Vesicle Enrichment (FAEVEr) for Proteomics

  2024cites this paper
• FIP200 phosphorylation regulates late steps in mitophagy.

  2024cites this paper
• Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway

  2024cites this paper
• Missing WD40 Repeats in ATG16L1 Delays Canonical Autophagy and Inhibits Noncanonical Autophagy

  2024cites this paper
• Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

  2024cites this paper
• Cadmium neurotoxicity and therapeutic strategies

  2024cites this paper
• Illuminating intercellular autophagy: A comprehensive review of cell non-autonomous autophagy.

  2024cites this paper
• Hepatitis C Virus NS5A Activates Mitophagy Through Cargo Receptor and Phagophore Formation

  2024cites this paper
• New insight in treating autoimmune diseases by targeting autophagy

  2024cites this paper
• Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells

  2024cites this paper
• MicroRNA-mediated autophagy and drug resistance in cancer: mechanisms and therapeutic strategies

  2024cites this paper
• Acetylation modification in the regulation of macroautophagy

  2024cites this paper
• Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes

  2024cites this paper
• Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization

  2024cites this paper
• Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

  2024influential citation