Nitrate Sensing and Metabolism Modulate Motility, Biofilm Formation, and Virulence in Pseudomonas aeruginosa

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Infection and Immunity

• Publication date

  2007-05-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/IAI.00201-07PMID 17526746PMCID PMC1952006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial

  2006cited by this paper
• Microarray analysis of gene regulation by oxygen, nitrate, nitrite, FNR, NarL and NarP during anaerobic growth of Escherichia coli: new insights into microbial physiology.

  2006cited by this paper
• Identification of Pseudomonas aeruginosa Genes Involved in Virulence and Anaerobic Growth

  2006cited by this paper
• N-oxide sensing and denitrification: the DNR transcription factors.

  2006cited by this paper
• Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa

  2006cited by this paper
• A Reassessment of the FNR Regulon and Transcriptomic Analysis of the Effects of Nitrate, Nitrite, NarXL, and NarQP as Escherichia coli K12 Adapts from Aerobic to Anaerobic Growth*

  2006cited by this paper
• Transcriptional Regulation of the Flavohemoglobin Gene for Aerobic Nitric Oxide Detoxification by the Second Nitric Oxide-Responsive Regulator of Pseudomonas aeruginosa

  2005cited by this paper
• Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms

  2005cited by this paper
• Rhamnolipids Modulate Swarming Motility Patterns of Pseudomonas aeruginosa

  2005cited by this paper
• Nitric oxide and nitrosative stress tolerance in bacteria.

  2005cited by this paper
• Production of rhamnolipids by Pseudomonas aeruginosa

  2005cited by this paper
• Mucosal Biofilm Formation on Middle‐Ear Mucosa in a Nonhuman Primate Model of Chronic Suppurative Otitis Media

  2005cited by this paper
• Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms.

  2005cited by this paper
• A Tn7-based broad-range bacterial cloning and expression system

  2005cited by this paper
• Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa.

  2004cited by this paper
• Pseudomonas aeruginosa attachment and biofilm development in dynamic environments

  2004cited by this paper
• Dual Overlapping Promoters Control napF (Periplasmic Nitrate Reductase) Operon Expression in Escherichia coli K-12

  2003cited by this paper
• Synthetic lac Operator Substitutions for Studying the Nitrate- and Nitrite-Responsive NarX-NarL and NarQ-NarP Two-Component Regulatory Systems of Escherichia coli K-12

  2003cited by this paper
• Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants

  2003cited by this paper
• Bacterial motility on a surface: many ways to a common goal.

  2003cited by this paper
• Rhamnolipid Surfactant Production Affects Biofilm Architecture in Pseudomonas aeruginosa PAO1

  2003cited by this paper
• Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host–pathogen model

  2003cited by this paper
• rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids.

  2003cited by this paper
• Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and Environment

  2003cited by this paper
• Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients.

  2002cited by this paper
• The Pseudomonas aeruginosa hemA promoter is regulated by Anr, Dnr, NarL and Integration Host Factor

  2002cited by this paper
• Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms

  2002cited by this paper
• Characterization of NADH dehydrogenases of Pseudomonas fluorescens WCS365 and their role in competitive root colonization.

  2002cited by this paper
• Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.

  2002cited by this paper
• Dependence of Mycobacterium bovis BCG on Anaerobic Nitrate Reductase for Persistence Is Tissue Specific

  2002cited by this paper
• Functional, biochemical and genetic diversity of prokaryotic nitrate reductases

  2001cited by this paper
• Two-component systems in Pseudomonas aeruginosa: why so many?

  2000cited by this paper
• Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa.

  2000cited by this paper
• Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains.

  2000cited by this paper
• Swarming of Pseudomonas aeruginosa Is Dependent on Cell-to-Cell Signaling and Requires Flagella and Pili

  2000cited by this paper
• Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice

  2000cited by this paper
• Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa.

  1999cited by this paper
• Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis.

  1999influential reference
• Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

  1999cited by this paper
• A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.

  1998cited by this paper
• Fnr, NarP, and NarL Regulation of Escherichia coli K-12 napF (Periplasmic Nitrate Reductase) Operon Transcription In Vitro

  1998cited by this paper
• Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis

  1998cited by this paper
• Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development

  1998cited by this paper
• Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes

  1997cited by this paper
• Cell biology and molecular basis of denitrification.

  1997influential reference
• The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N‐butyryl‐homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase

  1997cited by this paper
• Salmonella typhi mutants defective in anaerobic respiration are impaired in their ability to replicate within epithelial cells.

  1997cited by this paper
• Differential regulation by the homologous response regulators NarL and NarP of Escherichia coli K‐12 depends on DNA binding site arrangement

  1997cited by this paper
• Anaerobic activation of the entire denitrification pathway in Pseudomonas aeruginosa requires Anr, an analog of Fnr

  1995cited by this paper
• Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family

  1995cited by this paper
• Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site.

  1995cited by this paper
• Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.

  1995influential reference
• Common virulence factors for bacterial pathogenicity in plants and animals.

  1995cited by this paper
• Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa

  1994cited by this paper
• Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis.

  1994cited by this paper
• Analysis and construction of stable phenotypes in gram-negative bacteria with Tn5- and Tn10-derived minitransposons.

  1994cited by this paper
• Localization of the virulence-associated genes pilA, pilR, rpoN, fliA, fliC, ent, and fbp on the physical map of Pseudomonas aeruginosa PAO1 by pulsed-field electrophoresis

  1993cited by this paper
• Genetics and biochemistry of Pseudomonas aeruginosa rhamnolipid biosurfactant synthesis

  1993cited by this paper
• Hydrocarbon assimilation and biosurfactant production in Pseudomonas aeruginosa mutants

  1991cited by this paper
• Identification and molecular characterization of a transcriptional regulator from Pseudomonas aeruginosa PAO1 exhibiting structural and functional similarity to the FNR protein of Escherichia coli

  1991cited by this paper
• FNR and its role in oxygen-regulated gene expression in Escherichia coli.

  1990cited by this paper
• Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.

  1989cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989influential reference
• Correlation of nitrogen metabolism with biosurfactant production by Pseudomonas aeruginosa

  1989cited by this paper
• The nematode Caenorhabditis elegans.

  1988cited by this paper
• The Nematode Caenorhabditis elegans

  1988cited by this paper
• Pseudomonas aeruginosa biosurfactant production in continuous culture with glucose as carbon source

  1984cited by this paper
• Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

  1982cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper

• The IrlS2-IrlR2 two-component system is a global regulator of biofilm formation, stress adaptation, and virulence in Burkholderia pseudomallei

  2026cites this paper
• Sulfur starvation induces an Fe-replete response and attenuates virulence pathways in Pseudomonas aeruginosa PAO1

  2025cites this paper
• NirA is a Cyanide‐Tolerant Nitrite Reductase Which Protects Pseudomonas aeruginosa From Self‐Poisoning

  2025cites this paper
• Dynamics of Bacterial Communities and Their Relationship with Nutrients in a Full-Scale Shrimp Recirculating Aquaculture System in Brackish Water

  2025cites this paper
• Identifying potential novel widespread determinants of bacterial pathogenicity using phylogenetic-based orthology analysis

  2025cites this paper
• Multi-omics analysis unveils mechanisms underlying ARTP mutagenesis-induced enhancement of rhamnolipid production in Pseudomonas aeruginosa

  2025cites this paper
• Evaluating the Link Between Efflux Pump Expression and Motility Phenotypes in Pseudomonas aeruginosa Treated with Virulence Inhibitors

  2025cites this paper
• The IclR-family transcriptional regulator XyrR controls flotation, motility, antibiotic production and virulence in Serratia sp. ATCC 39006

  2025cites this paper
• [Construction and characterization of a modA gene mutant strain of Klebsiella pneumoniae].

  2024cites this paper
• Novel function of single-target regulator NorR involved in swarming motility and biofilm formation revealed in Vibrio alginolyticus

  2024cites this paper
• Contrasting responses of motile and non-motile Escherichia coli strains in resuscitation against stable ultrafine gold nanosystems

  2024cites this paper
• Molecular mechanisms and environmental adaptations of flagellar loss and biofilm growth of Rhodanobacter under environmental stress.

  2024cites this paper
• Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.

  2024cites this paper
• Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR)

  2023cites this paper
• Isolation and characterization of a newly chrysene-degrading Achromobacter aegrifaciens

  2023cites this paper
• Role of narL gene in the pathogenesis of Salmonella Typhimurium

  2023cites this paper
• Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential

  2023cites this paper
• The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

  2022cites this paper
• The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

  2022cites this paper
• The Alginate and Motility Regulator AmrZ is Essential for the Regulation of the Dispersion Response by Pseudomonas aeruginosa Biofilms

  2022cites this paper
• Two-component systems regulate bacterial virulence in response to the host gastrointestinal environment and metabolic cues

  2022cites this paper
• Respiration-induced biofilm formation as a driver for bacterial niche colonization.

  2022cites this paper
• Is biofilm formation intrinsic to the origin of life?

  2022cites this paper
• A Commensal Streptococcus Dysregulates the Pseudomonas aeruginosa Nitrosative Stress Response

  2022cites this paper
• Pseudomonas aeruginosa post‐translational responses to elevated c‐di‐GMP levels

  2022cites this paper
• Genome-wide analysis reveals a rhamnolipid-dependent modulation of flagellar genes in Pseudomonas aeruginosa PAO1

  2022cites this paper
• Transcriptomics Analysis Uncovers Transient Ceftazidime Tolerance in Burkholderia Biofilms.

  2021cites this paper
• Nitrate- and Nitrite-Sensing Histidine Kinases: Function, Structure, and Natural Diversity

  2021cites this paper
• Sub-Inhibitory Antibiotic Exposure and Virulence in Pseudomonas aeruginosa

  2021cites this paper
• Reduction of alternative electron acceptors drives biofilm formation in Shewanella algae

  2021cites this paper
• The role of uspE in virulence and biofilm formation by Histophilus somni.

  2021cites this paper
• Changes in microbial community diversity, composition, and functions upon nitrate and Cr(VI) contaminated groundwater.

  2021cites this paper
• Physiological Roles of Nitrite and Nitric Oxide in Bacteria: Similar Consequences from Distinct Cell Targets, Protection, and Sensing Systems.

  2021cites this paper
• Identification of a PadR-type regulator essential for intracellular pathogenesis of Burkholderia pseudomallei

  2021cites this paper
• Genome-Wide Analysis Reveals a RhlA-Dependent Modulation of Flagellar Genes in Pseudomonas Aeruginosa PAO1

  2021cites this paper
• Resolving the Multidecade-Long Mystery in MoaA Radical SAM Enzyme Reveals New Opportunities to Tackle Human Health Problems

  2021cites this paper
• Pseudomonas biofilm regulation in the Arabidopsis rhizosphere as a plant-immune evasion strategy

  2020cites this paper
• Pseudomonas aeruginosa biofilm formation on endotracheal tubes requires multiple two-component systems.

  2020cites this paper
• The NarX-NarL two-component system is a global regulator of biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

  2020cites this paper
• NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

  2020cites this paper
• A Shift in Central Metabolism Accompanies Virulence Activation in Pseudomonas aeruginosa

  2020cites this paper
• The role of denitrification genes in anaerobic growth and virulence of Flavobacterium columnare

  2020cites this paper
• Impact of Low pH on Microbial Growth Rate, ATP Production, and NADH to NAD+ ratio

  2020cites this paper
• The mechanism of nitrate-Cr(VI) reduction mediated by microbial under different initial pHs.

  2020cites this paper
• NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target

  2020cites this paper
• Molybdenum Enzymes and How They Support Virulence in Pathogenic Bacteria

  2020cites this paper
• Phenotypic and Transcriptomic Analyses of Seven Clinical Stenotrophomonas maltophilia Isolates Identify a Small Set of Shared and Commonly Regulated Genes Involved in the Biofilm Lifestyle

  2020cites this paper
• Identification of Genes Involved in Antifungal Activity of Burkholderia seminalis Against Rhizoctonia solani Using Tn5 Transposon Mutation Method

  2020cites this paper
• Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles

  2020cites this paper
• Mapping of the Denitrification Pathway in Burkholderia thailandensis by Genome-Wide Mutant Profiling

  2020cites this paper
• VIRULENCE MARKERS ANDMOTILITY PATTERNS EXHIBITED BY PSEUDOMONAS SPP. ISOLATED FROM HIV AND NON-HIV POPULATION WITH LRTI.

  2020influential citation
• Nitrate Metabolism Modulates Biosynthesis of Biofilm Components in Uropathogenic Escherichia coli and Acts as a Fitness Factor During Experimental Urinary Tract Infection

  2020cites this paper
• Insulin treatment enhances pseudomonas aeruginosa biofilm formation by increasing intracellular cyclic di-GMP levels, leading to chronic wound infection and delayed wound healing.

  2019cites this paper
• The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN

  2019cites this paper
• The Role of Two-Component and Small RNA Regulatory Systems in Pseudomonas aeruginosa Biofilms

  2019cites this paper
• Bacterial Hyperswarming as a Protective Response to Intestinal Stress

  2019cites this paper
• The regulation and characterization of surfing motility in Pseudomonas aeruginosa

  2019cites this paper
• Antimicrobial metabolites from Saraca asoca impairs the membrane transport system and quorum-sensing system in Pseudomonas aeruginosa

  2018cites this paper
• C. elegans avoidance of Pseudomonas: thioredoxin shapes the sensory response to bacterially produced nitric oxide

  2018cites this paper
• A microfluidic gradient mixer‐flow chamber as a new tool to study biofilm development under defined solute gradients

  2018cites this paper
• Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms

  2018cites this paper
• Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility

  2018cites this paper
• Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection

  2018cites this paper
• Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide

  2018cites this paper
• Strategies to deliver nitric oxide donors to control biofilms of clinical and industrial interest.

  2017cites this paper
• A single point mutation in class III ribonucleotide reductase promoter renders Pseudomonas aeruginosa PAO1 inefficient for anaerobic growth and infection

  2017cites this paper
• Two-component systems required for virulence in Pseudomonas aeruginosa

  2017cites this paper
• Protein complex formation during denitrification by Pseudomonas aeruginosa

  2017cites this paper
• The Production of Curli Amyloid Fibers Is Deeply Integrated into the Biology of Escherichia coli

  2017cites this paper
• The Atypical Response Regulator AtvR Is a New Player in Pseudomonas aeruginosa Response to Hypoxia and Virulence

  2017cites this paper
• Nitrate Sensing and Metabolism Inhibit Biofilm Formation in the Opportunistic Pathogen Burkholderia pseudomallei by Reducing the Intracellular Concentration of c-di-GMP

  2017cites this paper
• An integrated network analysis reveals that nitric oxide reductase prevents metabolic cycling of nitric oxide by Pseudomonas aeruginosa.

  2017influential citation
• Cloning and expression of rhl AB operon under the control of tac promoter in E. coli

  2017cites this paper
• Uncovering Coxiella burnetii 's Pathogenicity by Elucidating its Metabolism and Host Interactions

  2017cites this paper
• Determining the effect of treatment with an exogenous host defence peptide on Mycobacterium marinum-zebrafish infection

  2017cites this paper
• Bacterial production of biosurfactants under microaerobic and anaerobic conditions

  2017influential citation
• Évolution génotypique et phénotypique d'une souche épidémique de Pseudomonas aeruginosa au cours des 11 ans de sa diffusion hospitalière

  2017cites this paper
• The Role of Burkholderia thailandensis-Encoded MarR Homologs in Response to Host-Derived Signals

  2016cites this paper
• Nitric oxide‐releasing polyacrylonitrile disperses biofilms formed by wound‐relevant pathogenic bacteria

  2016cites this paper
• Pseudomonas aeruginosa Exhibits Deficient Biofilm Formation in the Absence of Class II and III Ribonucleotide Reductases Due to Hindered Anaerobic Growth

  2016cites this paper
• Metabolic flux analyses of Pseudomonas aeruginosa cystic fibrosis isolates.

  2016cites this paper
• Elucidating The Role of MifS-MifR Two-Component System in Regulating Pseudomonas aeruginosa Pathogenicity

  2016cites this paper
• Determinación de la respuesta de IL-6 en células epiteliales infectadas por secuenciales crónicos de Pseudomonas aeruginosa

  2016cites this paper
• A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs

  2016cites this paper
• Multicomponent biosurfactants--A "Green Toolbox" extension.

  2015cites this paper
• Origin and Impact of Nitric Oxide in Pseudomonas aeruginosa Biofilms

  2015cites this paper
• Global transcriptional analysis of Burkholderia pseudomallei high and low biofilm producers reveals insights into biofilm production and virulence

  2015cites this paper
• Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation

  2015cites this paper
• Genome Rearrangements Can Make and Break Small RNA Genes

  2015cites this paper
• Characterisation of the ATP-binding cassette transporters of Pseudomonas aeruginosa

  2015influential citation
• Function of the Pseudomonas aeruginosa NrdR Transcription Factor: Global Transcriptomic Analysis and Its Role on Ribonucleotide Reductase Gene Expression

  2015cites this paper
• Ralstonia solanacearum Uses Inorganic Nitrogen Metabolism for Virulence, ATP Production, and Detoxification in the Oxygen-Limited Host Xylem Environment

  2015cites this paper
• Biofilms of microorganisms and their role for the formation of resistance to anti-bacterial drugs

  2015cites this paper
• Dual RNA-seq transcriptional analysis of wheat roots colonized by Azospirillum brasilense reveals up-regulation of nutrient acquisition and cell cycle genes

  2014cites this paper
• Preliminary investigations into the action of nitric oxide in the control of biodeterioration

  2014influential citation
• Nitrate and periplasmic nitrate reductases.

  2014cites this paper
• The Pseudomonas aeruginosa CreBC Two-Component System Plays a Major Role in the Response to β-Lactams, Fitness, Biofilm Growth, and Global Regulation

  2014cites this paper
• Elucidating the Genetic Basis of Crystalline Biofilm Formation in Proteus mirabilis

  2014cites this paper
• Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis.

  2014influential citation
• Systematic analysis of the ability of Nitric Oxide donors to dislodge biofilms formed by Salmonella enterica and Escherichia coli O157:H7

  2014influential citation