Gq‐coupled receptors as mechanosensors mediating myogenic vasoconstriction

No abstract is available for this paper.

• Publication year

  2008

• Venue

  EMBO Journal

• Publication date

  2008-12-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/emboj.2008.233PMID 18987636PMCID PMC2599876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conformational switch of angiotensin II type 1 receptor underlying mechanical stress‐induced activation

  2008cited by this paper
• Revisiting TRPC1 and TRPC6 mechanosensitivity

  2007cited by this paper
• Adiponectin is a novel humoral vasodilator.

  2007cited by this paper
• TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.

  2007cited by this paper
• How regulators of G protein signaling achieve selective regulation.

  2007cited by this paper
• Regulator of G protein signalling 2 ameliorates angiotensin II‐induced hypertension in mice

  2007cited by this paper
• Transient Receptor Potential Channels in Cardiovascular Function and Disease

  2006cited by this paper
• Twenty odd years of stretch-sensitive channels

  2006cited by this paper
• Movement of ‘gating charge’ is coupled to ligand binding in a G-protein-coupled receptor

  2006cited by this paper
• G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils.

  2006cited by this paper
• Cellular mechanotransduction: putting all the pieces together again

  2006cited by this paper
• Mechanisms of mechanotransduction.

  2006cited by this paper
• Do orphan G‐protein‐coupled receptors have ligand‐independent functions?

  2006influential reference
• A common mechanism underlies stretch activation and receptor activation of TRPC6 channels

  2006cited by this paper
• A possible unifying principle for mechanosensation

  2005influential reference
• Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice

  2005cited by this paper
• Ion channels in smooth muscle: regulators of intracellular calcium and contractility.

  2005influential reference
• TRPC1 forms the stretch-activated cation channel in vertebrate cells

  2005cited by this paper
• Mechanosensitive ion channels: molecules of mechanotransduction

  2004cited by this paper
• Critical Role for Transient Receptor Potential Channel TRPM4 in Myogenic Constriction of Cerebral Arteries

  2004cited by this paper
• Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

  2004cited by this paper
• Non‐selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP

  2004cited by this paper
• TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

  2003cited by this paper
• Dominant role of smooth muscle L‐type calcium channel Cav1.2 for blood pressure regulation

  2003cited by this paper
• Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation*

  2003cited by this paper
• TRP channels as cellular sensors

  2003influential reference
• Subunit composition of mammalian transient receptor potential channels in living cells

  2002cited by this paper
• Australian Physiological and Pharmacological Society Symposium : Cellular and Mechanical Coupling in the Arteriolar Wall CELLULAR SIGNALLING IN ARTERIOLAR MYOGENIC CONSTRICTION : INVOLVEMENT OF TYROSINE PHOSPHORYLATION PATHWAYS

  2002cited by this paper
• Signalling: Seven-transmembrane receptors

  2002cited by this paper
• TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells.

  2002cited by this paper
• Periadventitial fat releases a vascular relaxing factor

  2002cited by this paper
• Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries

  2002cited by this paper
• Regulation of phosphoinositide-specific phospholipase C.

  2001cited by this paper
• The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular &agr;1-Adrenoceptor–Activated Ca2+-Permeable Cation Channel

  2001cited by this paper
• The functional ratio of chymase and angiotensin converting enzyme in angiotensin I-induced vascular contraction in monkeys, dogs and rats.

  2000cited by this paper
• Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

  1999influential reference
• Signaling mechanisms underlying the vascular myogenic response.

  1999influential reference
• Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

  1999cited by this paper
• Salt induces vascular AT1 receptor overexpression in vitro and in vivo.

  1998cited by this paper
• Ontogeny of local sarcoplasmic reticulum Ca2+ signals in cerebral arteries: Ca2+ sparks as elementary physiological events.

  1998cited by this paper
• Stretch‐Activated Whole‐Cell Currents in Smooth Muscle Cells from Mesenteric Resistance Artery of Guinea‐Pig

  1997cited by this paper
• Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet.

  1997cited by this paper
• Regulation of membrane potential and diameter by voltage-dependent K+ channels in rabbit myogenic cerebral arteries.

  1995cited by this paper
• Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol.

  1994influential reference
• Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries.

  1993cited by this paper

• All-Atom GPCR-Ligand Simulation via Residual Isometric Latent Flow

  2026cites this paper
• TRPC3 and TRPC6: Multimodal Cation-Conducting Channels Regulating Cardiovascular Contractility and Remodeling

  2026cites this paper
• Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

  2025cites this paper
• The machinery of healthy vasodilatation: an overview

  2025cites this paper
• Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways

  2025cites this paper
• Arteries are finely tuned thermosensors regulating myogenic tone and blood flow

  2025cites this paper
• Smooth Signals: Computational Insights into Autonomic Vascular Control.

  2025cites this paper
• Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate

  2025cites this paper
• A mechano-resistance mechanism in skin adapts to terrestrial locomotion.

  2025cites this paper
• Endogenous muscarinic acetylcholine receptor signaling blunts α1-adrenergic vasoconstriction during higher-intensity handgrip exercise in humans.

  2025cites this paper
• Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Progressive Aortic Dilatation in Marfan Syndrome.

  2025cites this paper
• The machinery of healthy vasoconstriction: an overview

  2025cites this paper
• Mechanosensing of Shear Stress and Uterine Spiral Artery Remodeling by Invasive Trophoblasts in Early Pregnancy

  2025cites this paper
• Increases in Plasma Viscosity Disrupt Microvascular Flow Dynamics

  2025cites this paper
• Physiological functions and pharmacological targeting of transient receptor potential channels

  2025cites this paper
• Non-Ser36 phosphorylated p66Shc inhibits TRPC-dependent and TRPC-independent calcium influx in vascular smooth muscle cells.

  2025cites this paper
• Integration of Mechanics and Immunology: Perspective for Understanding Fibrotic Disease Mechanisms and Innovating Therapeutic Strategies.

  2025cites this paper
• Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

  2025cites this paper
• Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes.

  2025cites this paper
• GABA-independent activation of GABAB receptor by mechanical forces

  2025cites this paper
• Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells

  2025cites this paper
• Insights into new mechanosensitive behaviors of G protein-coupled receptors.

  2025cites this paper
• Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

  2025cites this paper
• Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli

  2025cites this paper
• Vesicle fusion and release in neurons under dynamic mechanical equilibrium

  2024cites this paper
• Force versus Response: Methods for Activating and Characterizing Mechanosensitive Ion Channels and GPCRs

  2024cites this paper
• Mechanosensory entities and functionality of endothelial cells

  2024cites this paper
• Role of transient receptor potential channels in the regulation of vascular tone.

  2024cites this paper
• Hypertension, Neurodegeneration, and Cognitive Decline

  2024cites this paper
• Pacemaking in the lymphatic system.

  2024cites this paper
• Phosphodiesterases Mediate the Augmentation of Myogenic Constriction by Inhibitory G Protein Signaling and is Negatively Modulated by the Dual Action of RGS2 and 5

  2024cites this paper
• Transient Receptor Potential Channels in Vascular Mechanotransduction.

  2024cites this paper
• The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging

  2024cites this paper
• GPCR-mediated regulation of beige adipocyte formation: implications for obesity and metabolic health.

  2024cites this paper
• Protocol for assessing myogenic tone and perfusion pressure in isolated mouse kidneys

  2024cites this paper
• Post-injury Inhibition of Endothelin-1 Dependent Renal Vasoregulation Mitigates Rhabdomyolysis-Induced Acute Kidney Injury

  2023cites this paper
• Arteries are finely tuned thermosensors regulating myogenic tone and blood flow

  2023cites this paper
• Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization

  2023cites this paper
• Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels

  2023cites this paper
• Vascular Mechanotransduction.

  2023cites this paper
• A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

  2023cites this paper
• ANTXR1 as a Potential Sensor of Extracellular Mechanical Cues.

  2023cites this paper
• Apelin/ELABELA-APJ system in cardiac hypertrophy: Regulatory mechanisms and therapeutic potential.

  2023cites this paper
• Mechanosensitive GPCRs and ion channels in shear stress sensing.

  2023cites this paper
• Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor

  2023cites this paper
• Mechanosensitive channels in the mechanical component of the exercise pressor reflex.

  2023cites this paper
• Handbook of Ion Channels

  2023cites this paper
• Membrane force reception: mechanosensation in GPCRs and tools to address it

  2023cites this paper
• A new model for evaluating pressure-induced vascular tone in small cerebral arteries

  2023cites this paper
• Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells

  2023cites this paper
• Death‐associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries

  2023cites this paper
• Defining a role of NADPH oxidase in myogenic tone development

  2022cites this paper
• The normalized slope conductance as a tool for quantitative analysis of current-voltage relations

  2022cites this paper
• Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries

  2022cites this paper
• Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

  2022cites this paper
• Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1 Receptor

  2022cites this paper
• Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells.

  2022cites this paper
• Mechanical regulation of bone remodeling

  2022cites this paper
• Gut feelings: mechanosensing in the gastrointestinal tract

  2022cites this paper
• TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes

  2022cites this paper
• Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

  2022cites this paper
• The Effects of TRPC6 Knockout in Animal Models of Kidney Disease

  2022cites this paper
• Arterial Myogenic Response and Aging.

  2022cites this paper
• Angiotensin receptor blockade is associated with increased risk of giant cell arteritis.

  2022cites this paper
• Endothelial Cells and the Cerebral Circulation.

  2022cites this paper
• Neural crest mechanosensors: Seeing old proteins in a new light.

  2022cites this paper
• A dual-clock-driven model emulating the effects of either Ano1 or IP3R knock-out on lymphatic muscle cell pace-making

  2022cites this paper
• Death-associated protein kinase 3 (DAPK3) regulates the myogenic reactivity of cerebral arterioles

  2022cites this paper
• Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

  2022cites this paper
• Gq Signaling in Autophagy Control: Between Chemical and Mechanical Cues

  2022cites this paper
• Central regulation of body fluid homeostasis

  2022cites this paper
• The Biomechanics of Venous Remodeling

  2021cites this paper
• Mechanosensitive Regulation of Fibrosis

  2021cites this paper
• Transient receptor potential channel-dependent myogenic responsiveness in small-sized resistance arteries

  2021cites this paper
• REGULATION OF CEREBRAL BLOOD FLOW IN HUMANS: PHYSIOLOGY AND CLINICAL IMPLICATIONS OF AUTOREGULATION.

  2021cites this paper
• GPCRs Under Flow and Pressure

  2021cites this paper
• Contributions of Wall Stretch and Shear Stress to Vascular Regulation: Molecular Mechanisms of Homeostasis and Expansion

  2021cites this paper
• Flow-mediated vasodilation through mechanosensitive G protein-coupled receptors in endothelial cells.

  2021cites this paper
• Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies

  2021cites this paper
• TRPV1 in arteries enables a rapid myogenic tone

  2021cites this paper
• Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation

  2021cites this paper
• What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells.

  2021cites this paper
• Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke

  2021cites this paper
• Cardiovascular mechanosensitive ion channels-Translating physical forces into physiological responses.

  2021cites this paper
• Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation

  2021cites this paper
• Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

  2021cites this paper
• Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes

  2021cites this paper
• The Endothelial Glycocalyx as a Double-Edged Sword in Microvascular Homeostasis and Pathogenesis

  2021cites this paper
• Myogenic Tone in Peripheral Resistance Arteries and Arterioles: The Pressure Is On!

  2021cites this paper
• Vascular Smooth Muscle Cells Mechanosensitive Regulators and Vascular Remodeling

  2021cites this paper
• Angiotensin II type 1 receptor is involved in flow-induced vasomotor responses of isolated middle cerebral arteries. Role of oxidative stress.

  2021cites this paper
• Ion channels and arteriolar tone: Ion channels and the regulation ofmyogenic tone in peripheral arterioles

  2021cites this paper
• Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model

  2021cites this paper
• Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone

  2021cites this paper
• Mechanical and chemical activation of GPR68 (OGR1) probed with a genetically-encoded fluorescent reporter.

  2021cites this paper
• Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice

  2020cites this paper
• Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca2+ entry after pressure-overload induced cardiac remodelling.

  2020cites this paper
• TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease

  2020cites this paper
• Regulation of blood flow in small arteries: mechanosensory events underlying myogenic vasoconstriction

  2020influential citation
• Myogenic Vasoconstriction Requires Canonical Gq/11 Signaling of the Angiotensin II Type 1a Receptor in the Murine Vasculature

  2020cites this paper