Notch3 marks clonogenic mammary luminal progenitor cells in vivo

Notch3 expression characterizes a highly clonogenic and transiently quiescent luminal progenitor population in the mammary gland, the expansion of which is restricted by Notch3 receptor activity.

• Publication year

  2013

• Venue

  Journal of Cell Biology

• Publication date

  2013-10-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201307046PMID 24100291PMCID 3798243
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium

  2013cited by this paper
• The functional role of Notch signaling in triple-negative breast cancer.

  2013cited by this paper
• Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages

  2013cited by this paper
• c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer

  2012cited by this paper
• Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.

  2012cited by this paper
• A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

  2012cited by this paper
• Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland

  2012cited by this paper
• Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland

  2011cited by this paper
• Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice

  2011cited by this paper
• ΔNp63α promotes cellular quiescence via induction and activation of Notch3

  2011cited by this paper
• Distinct stem cells contribute to mammary gland development and maintenance

  2011cited by this paper
• Notch3 Null Mutation in Mice Causes Muscle Hyperplasia by Repetitive Muscle Regeneration

  2010cited by this paper
• BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

  2010cited by this paper
• Notch: the past, the present, and the future.

  2010cited by this paper
• Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

  2009cited by this paper
• Mammary development meets cancer genomics

  2009cited by this paper
• Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates

  2009cited by this paper
• Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

  2009cited by this paper
• Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

  2008cited by this paper
• NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.

  2008cited by this paper
• NOTCH 3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB 2-Negative Human Breast Cancer Cells

  2008cited by this paper
• Transcriptome analysis of the normal human mammary cell commitment and differentiation process.

  2008cited by this paper
• Asymmetric self-renewal and commitment of satellite stem cells in muscle.

  2007cited by this paper
• A global double‐fluorescent Cre reporter mouse

  2007cited by this paper
• Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

  2007cited by this paper
• Purification and unique properties of mammary epithelial stem cells

  2006cited by this paper
• Key stages in mammary gland development - Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ

  2006cited by this paper
• Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium

  2006cited by this paper
• Generation of a functional mammary gland from a single stem cell

  2006cited by this paper
• Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.

  2004cited by this paper
• Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

  2003cited by this paper
• Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

  2003cited by this paper
• Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

  2003cited by this paper
• Mammary epithelial stem cells

  2001cited by this paper
• Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis.

  1983cited by this paper

• Classification of Breast Cancer Through the Perspective of Cell Identity Models.

  2025cites this paper
• Notch signaling in cancer: metabolic reprogramming and therapeutic implications

  2025cites this paper
• Defining breast epithelial cell types in the single-cell era.

  2025cites this paper
• Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal mouse mutants

  2025cites this paper
• Role of Notch signaling in corticalization.

  2025cites this paper
• Mammary stem cells: molecular cues, orchestrated regulatory mechanisms and its implications in breast cancer.

  2025cites this paper
• Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis.

  2024cites this paper
• Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research

  2023cites this paper
• Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer

  2023influential citation
• NOTCH and AKT Signalling Interact to Drive Mammary Tumour Heterogeneity

  2023cites this paper
• A tumor-suppressive function for Notch3 in the parous mammary gland.

  2022cites this paper
• Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells

  2022cites this paper
• Temporal regulation of notch activation improves arteriovenous fistula maturation

  2022cites this paper
• Expansion of mouse castration-resistant intermediate prostate stem cells in vitro

  2022cites this paper
• Lineage Tracing Methods to Study Mammary Epithelial Hierarchies In Vivo.

  2022cites this paper
• Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland

  2022cites this paper
• Polarity-driven laminar pattern formation by lateral-inhibition in 2D and 3D bilayer geometries

  2022cites this paper
• Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

  2022cites this paper
• Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN

  2021influential citation
• Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk

  2021cites this paper
• In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation

  2021cites this paper
• Notch Signalling in Breast Development and Cancer

  2021cites this paper
• Mammary Development and Breast Cancer: a Notch Perspective

  2021cites this paper
• Alveolar progenitor differentiation and lactation depends on paracrine inhibition of notch via ROBO1/CTNNB1/JAG1

  2021cites this paper
• Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1

  2021cites this paper
• Proteomics of Mammary Gland and Mammary Stem Cells

  2021cites this paper
• The Skeleton of Lateral Meningocele Syndrome

  2021cites this paper
• Glandular stem cells in the skin during development, homeostasis, wound repair and regeneration

  2021cites this paper
• Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in BRCA1 Mutation Carriers

  2021cites this paper
• Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling

  2021influential citation
• Algebraic framework for determining laminar pattern bifurcations by lateral-inhibition in 2D and 3D bilayer geometries

  2021cites this paper
• Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma

  2021cites this paper
• Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis

  2020cites this paper
• The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance

  2020cites this paper
• Stem Cells and the Differentiation Hierarchy in Mammary Gland Development.

  2020cites this paper
• Notch3 in Development, Health and Disease

  2020cites this paper
• PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis

  2020cites this paper
• Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution

  2019cites this paper
• Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity

  2019cites this paper
• Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.

  2019cites this paper
• Hormones induce the formation of luminal-derived basal cells in the mammary gland

  2019cites this paper
• Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance

  2019cites this paper
• Isolation and characterization of a new basal-like luminal progenitor in human breast tissue

  2019cites this paper
• Heterogeneity of Mammary Stem Cells.

  2019cites this paper
• Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells

  2018cites this paper
• MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines

  2018cites this paper
• Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

  2018cites this paper
• Dissecting the mammary gland one cell at a time

  2018cites this paper
• The Role of Notch in Breast Cancer

  2018cites this paper
• Out on the Fringe: Modulation of Notch Signaling by Glycosylation

  2018cites this paper
• Notch3 orchestrates epithelial and inflammatory responses to promote acute kidney injury.

  2018cites this paper
• Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer

  2018cites this paper
• Cellular Plasticity of Mammary Epithelial Cells Underlies Heterogeneity of Breast Cancer

  2018cites this paper
• Early lineage segregation of multipotent embryonic mammary gland progenitors

  2018cites this paper
• Moving Breast Cancer Therapy up a Notch

  2018cites this paper
• Mammary Stem Cells: Premise, Properties, and Perspectives.

  2017cites this paper
• Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

  2017cites this paper
• Cancer cell redirection biomarker discovery using a mutual information approach

  2017cites this paper
• Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer

  2017cites this paper
• Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life

  2017cites this paper
• Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage

  2017influential citation
• Análisis de los perfiles de expresión de microRNAs en cáncer de mama y de la implicación de la familia miR-200 en metástasis

  2017cites this paper
• Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-α

  2017cites this paper
• Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

  2017cites this paper
• Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing

  2017cites this paper
• Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.

  2017cites this paper
• Regulation of Mammary Luminal Cell Fate and Tumorigenesis by p38α

  2017cites this paper
• Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration

  2017cites this paper
• The identification of novel strategies for the prevention and treatment of breast cancer in BRCA1-mutation carriers

  2016cites this paper
• Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

  2016cites this paper
• Mammary gland stem cells and their application in breast cancer

  2016cites this paper
• The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling

  2016cites this paper
• Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer

  2016cites this paper
• Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells

  2016influential citation
• The transcriptional repressor Blimp 1 is expressed in rare luminal progenitors and is essential for mammary gland development

  2016cites this paper
• The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development

  2016cites this paper
• Uncovering the stem cell hierarchy by genetic lineage tracing in the mammary gland

  2016cites this paper
• Tissue-specific designs of stem cell hierarchies

  2016cites this paper
• The Notch-Mediated Proliferation Circuitry.

  2016cites this paper
• Luminal Progenitors Restrict Their Lineage Potential during Mammary Gland Development

  2015influential citation
• Comprehensive genomic profiles of small cell lung cancer

  2015cites this paper
• Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

  2015cites this paper
• Regulators of genetic risk of breast cancer identified by integrative network analysis

  2015cites this paper
• Mammary lineage tracing: the coming of age

  2015cites this paper
• Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

  2015cites this paper
• ERrrr…Where are the Progenitors? Hormone Receptors and Mammary Cell Heterogeneity

  2015cites this paper
• Ecole Doctorale COMPLEXITE DU VIVANT – Fiche Projet CONCOURS

  2015cites this paper
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

  2014cites this paper
• Lineage Tracing of Mammary Epithelial Cells Using Cell-Type-Specific Cre-Expressing Adenoviruses

  2014cites this paper
• Au-delà du cerveau : une importance majeure de la huntingtine et de sa phosphorylation à la sérine 421 dans les cancers du sein

  2014cites this paper
• Plasticity of epithelial stem cells in tissue regeneration

  2014cites this paper
• Bringing androgens up a NOTCH in breast cancer.

  2014influential citation
• Mammary stem cells and the differentiation hierarchy: current status and perspectives

  2014cites this paper
• Notching up neural stem cell homogeneity in homeostasis and disease

  2014cites this paper
• Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination

  2013cites this paper