The absence of sterol synthesis in insects.

A. J. Clark,Konrad Bloch

Published 1959 in Journal of Biological Chemistry

ABSTRACT

The indispensability of sterols for the growth of insects has been amply established by nutritional studies. This requirement has been shown to exist in every insect studied and it is satisfied in all cases by cholesterol (1). In many species how-ever cholesterol can be replaced by sterols of plant or fungal origin such as /I-sitosterol, stigmasterol, or ergosterol. This nutritional requirement has been reasonably regarded as a manifestation of a partial or complete inability of insects to synthesize sterols. The present investigation was undertaken to test this assumption and also to determine whether sterol synthesis in insects is singly or multiply blocked. The hide beetle Dermestes vulpinus Fabr. (Coleoptera) has been used because of its carnivorous feeding habits. In a forthcoming study these results will be compared with those obtained with an omnivorous insect. and Their Rearing-The in this study

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