Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Neurochemistry

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2006.04368.xPMID 17448147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain insulin.

  2008influential reference
• Insulin and insulin-like growth factor receptors in the nervous system

  2008cited by this paper
• Molecular basis of insulin action.

  2007cited by this paper
• Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats.

  2006cited by this paper
• Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease

  2006influential reference
• Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat

  2006cited by this paper
• Alzheimer‐like changes in protein kinase B and glycogen synthase kinase‐3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway

  2006influential reference
• An electron microscopic study

  2005cited by this paper
• Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

  2005cited by this paper
• Learning abilities depend on NMDA-receptor density in hippocampus in adult rats

  2005cited by this paper
• Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat

  2005cited by this paper
• The source of cerebral insulin.

  2004cited by this paper
• Role for neuronal insulin resistance in neurodegenerative diseases.

  2004cited by this paper
• Gene expression profile in streptozotocin rat model for sporadic Alzheimer’s disease

  2004cited by this paper
• Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study.

  2004cited by this paper
• Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity

  2004cited by this paper
• Insulin and the insulin receptor in experimental models of learning and memory.

  2004cited by this paper
• Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes

  2004cited by this paper
• Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain--an immunohistochemical study.

  2004cited by this paper
• Glucose metabolism and insulin receptor signal transduction in Alzheimer disease.

  2004cited by this paper
• Distribution of glucokinase, glucose transporter GLUT2, sulfonylurea receptor-1, glucagon-like peptide-1 receptor and neuropeptide Y messenger RNAs in rat brain by quantitative real time RT-PCR.

  2003cited by this paper
• Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats.

  2003cited by this paper
• Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes

  2003cited by this paper
• Fluorescent multicolor multiplex homogeneous assay for the simultaneous analysis of the two most common hemochromatosis mutations.

  2002cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

  2002cited by this paper
• Differential Sensitivity of GLUT1- and GLUT2-Expressing β Cells to Streptozotocin

  2001cited by this paper
• Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus.

  2001cited by this paper
• The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.

  2001influential reference
• Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures.

  2001cited by this paper
• Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin.

  2001cited by this paper
• EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis*

  2000cited by this paper
• Early-life programming of susceptibility to dysregulation of glucose metabolism and the development of Type 2 diabetes mellitus.

  2000cited by this paper
• Intracerebroventricular insulin enhances memory in a passive-avoidance task.

  2000cited by this paper
• Insulin-like growth factor 1 regulates developing brain glucose metabolism.

  2000cited by this paper
• The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses

  1999cited by this paper
• Brain Insulin Receptors and Spatial Memory

  1999cited by this paper
• Molecular basis of insulin action.

  1998cited by this paper
• Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis

  1998influential reference
• Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats.

  1998influential reference
• Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

  1998cited by this paper
• Insulin signal transduction through protein kinase cascades

  1998cited by this paper
• Persistence of tyrosine-phosphorylated FcepsilonRI in deactivated cells.

  1996cited by this paper
• Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system.

  1996cited by this paper
• Persistence of Tyrosine-phosphorylated FcεRI in Deactivated Cells*

  1996cited by this paper
• Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage.

  1995cited by this paper
• Insulin receptor substrate-1 (IRS-1) expression in rat brain.

  1994cited by this paper
• Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats

  1994influential reference
• The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

  1994cited by this paper
• Insulin gene expression and insulin synthesis in mammalian neuronal cells.

  1994cited by this paper
• Glucose transporter 2 (GLUT 2): expression in specific brain nuclei.

  1994cited by this paper
• The Insulin-Like Growth Factor-I Receptor

  1994cited by this paper
• Prevention of High- and Low-Dose STZ-Induced Diabetes With D-Glucose and 5-Thio-D-Glucose

  1993cited by this paper
• Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors I and II.

  1993cited by this paper
• Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.

  1993cited by this paper
• Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: correlation with insulin-like growth factors

  1993cited by this paper
• Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus

  1993cited by this paper
• Long‐Term Diabetogenic Effect of Streptozotocin in Rats

  1993cited by this paper
• Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation.

  1993cited by this paper
• Spatial learning deficit and reduced hippocampal ChAT activity in rats after an ICV injection of streptozotocin.

  1993cited by this paper
• The inheritance pattern of dysplastic naevi in families of dysplastic naevus patients.

  1993cited by this paper
• Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system.

  1993cited by this paper
• Regulation of insulin receptor signaling by protein-tyrosine dephosphorylation.

  1993cited by this paper
• Nerve growth factor and choline acetyltransferase activity levels in the rat brain following experimental impairment of cerebral glucose and energy metabolism

  1992cited by this paper
• Insulin in the brain: a hormonal regulator of energy balance.

  1992cited by this paper
• Developmental regulation of insulin in the mammalian central nervous system.

  1992cited by this paper
• Modulation of rat brain insulin receptor kinase activity in diabetes.

  1992cited by this paper
• Changes in tyrosine phosphorylation of insulin receptors and a 170,000 molecular weight nonreceptor protein in vivo in skeletal muscle of streptozotocin-induced diabetic rats: effects of insulin and glucose.

  1992cited by this paper
• Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases

  1991influential reference
• Differential Effects of Diabetes on Adipocyte and Liver Phosphotyrosine and Phosphoserine Phosphatase Activities

  1991cited by this paper
• The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance

  1991cited by this paper
• Animal test systems to study behavioral dysfunctions of neurodegenerative disorders.

  1991cited by this paper
• Localization of type I insulin-like growth factor receptor messenger RNA in the adult rat brain by in situ hybridization.

  1991cited by this paper
• Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex.

  1991cited by this paper
• Localization of insulin and type 1 IGF receptors in rat brain by in vitro autoradiography and in situ hybridization.

  1991cited by this paper
• Insulin in the cerebrospinal fluid.

  1991cited by this paper
• Luminography – a new, highly sensitive visualization method for electrophoresis

  1991cited by this paper
• Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats.

  1990cited by this paper
• Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.

  1990cited by this paper
• Islet transplantation to the renal subcapsular space in streptozotocin-diabetic rats: short-term effects on glucose-stimulated insulin secretion.

  1989cited by this paper
• Early appearance of in vivo insulin resistance in adult streptozotocin-injected rats.

  1989cited by this paper
• Distribution of insulin receptor-like immunoreactivity in the rat forebrain.

  1989cited by this paper
• Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.

  1989cited by this paper
• Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization

  1989cited by this paper
• Insulin receptors in the brain: Structural and physiological characterization

  1988cited by this paper
• Differential expression of insulin-like growth factor genes in rat central nervous system.

  1988cited by this paper
• Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1.

  1985cited by this paper
• The effect of age on glucose and energy metabolism in brain cortex of rats.

  1985cited by this paper
• Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

  1984cited by this paper
• Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets

  1981cited by this paper
• Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus.

  1980cited by this paper
• Insulin-binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography.

  1979cited by this paper
• Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

  1976cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Studies on Streptozotocin Diabetes

  1976cited by this paper
• A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.

  1967cited by this paper
• Insulin in the Cerebrospinal Fluid

  1967cited by this paper

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• Insulin signaling disruption exacerbates memory impairment and seizure susceptibility in an epilepsy model with Alzheimer’s disease-like pathology

  2025cites this paper
• Loss of brain insulin production impairs learning and memory in female mice

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• Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease

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