Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Epilepsy Research

• Publication date

  1995-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0920-1211(95)00077-1PMID 8991787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes.

  1995cited by this paper
• Newer Antiepileptic Drugs

  1994cited by this paper
• Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats.

  1993cited by this paper
• Genetic absence epilepsy in rats from Strasbourg--a review.

  1992cited by this paper
• ucb L059, a novel anti-convulsant drug: pharmacological profile in animals.

  1992cited by this paper
• Protective effect of ucb L059 against postural stimulation-induced seizures in EL mice

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• Kindling of audiogenic seizures in the rat.

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• The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs.

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• A Model of Chronic Spontaneous Petit Mal‐like Seizures in the Rat: Comparison with Pentylenetetrazol‐Induced Seizures

  1984cited by this paper
• Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures.

  1984cited by this paper
• Genetic animal models of epilepsy as a unique resource for the evaluation of anticonvulsant drugs. A review.

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• Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy.

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• Challenging the preclinical paradigm: Adverse effects of antiseizure medicines in male rats with drug‐resistant epilepsy

  2025cites this paper
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  2025cites this paper
• Evaluating the Efficacy of Levetiracetam on Non-Cognitive Symptoms and Pathology in a Tau Mouse Model

  2024cites this paper
• Potential neuroprotective and autophagy-enhancing effects of alogliptin on lithium/pilocarpine-induced seizures in rats: Targeting the AMPK/SIRT1/Nrf2 axis.

  2024cites this paper
• Innovative drug discovery strategies in epilepsy: integrating next-generation syndrome-specific mouse models to address pharmacoresistance and epileptogenesis

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  2023cites this paper
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  2023cites this paper
• Impact of Valproate and Levetiracetam Exposure on GAERS Behavior During Pregnancy

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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• Effect of antiepileptic drug levetiracetam on cochlear function.

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  2020cites this paper
• Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

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• СУЧАСНІ ПРИНЦИПИ ТА ТЕХНІЧНЕ ЗАБЕЗПЕЧЕННЯ ДОСЛІДЖЕНЬ НА МОДЕЛІ ГЕНЕТИЧНОЇ ФОРМИ АБСАНСНОЇ ЕПІЛЕПСІЇ

  2020cites this paper
• Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls

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  2019cites this paper
• Levetiracetam combined with ACEA, highly selective cannabinoid CB1 receptor agonist changes neurogenesis in mouse brain.

  2019cites this paper
• Chirality as an Important Factor for the Development of New Antiepileptic Drugs

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.

  2018cites this paper
• Pronounced antiepileptic activity of the subtype‐selective GABAA‐positive allosteric modulator PF‐06372865 in the GAERS absence epilepsy model

  2018cites this paper
• Genetic Models of Absence Epilepsy in Rats and Mice

  2017cites this paper
• Experimental Treatment Options in Absence Epilepsy.

  2017cites this paper
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  2017cites this paper
• Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

  2016cites this paper
• Comparison of Cardioprotective Therapy with Atenolol and Diltiazem in Seizure-Induced Cardiomyopathy

  2015cites this paper
• Effects of Anti-seizure Drugs on Motor Maps and Neurovascular Function

  2015cites this paper
• Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and vigabatrin in the mouse 6Hz psychomotor seizure model - a type II isobolographic analysis.

  2014cites this paper
• Firing dynamics of thalamic neurones during genetically determined experimental absence seizures

  2014cites this paper
• Models in research of pharmacoresistant epilepsy: present and future in development of antiepileptic drugs.

  2014cites this paper
• Mechanisms of Levetiracetam in the Control of Status Epilepticus and Epilepsy

  2014cites this paper
• Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER).

  2013cites this paper
• Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal).

  2013cites this paper
• Additional Antiepileptic Mechanisms of Levetiracetam in Lithium-Pilocarpine Treated Rats

  2013cites this paper
• ONO‐2506 inhibits spike–wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation

  2013cites this paper
• Isobolographic characterization of interaction of levetiracetam with clobazam in the mouse 6 Hz psychomotor seizure model

  2012cites this paper
• Drug Treatment of Epilepsy in the 1990 s Achievements and New Developments

  2012cites this paper
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  2011cites this paper
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• Levetiracetam: a review of its use in epilepsy.

  2011cites this paper
• [Pharmacology and clinical results of levetiracetam (E Keppra(®) Tablets), a new antiepileptic drug].

  2011cites this paper
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  2011cites this paper
• [Physiologic foundations and some perspectives of the further development of antiepileptic drugs].

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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• [The investigation of cataleptic muscle tonus changes in rats after audiogenic seizures].

  2008cites this paper
• SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper