Molecular interactions with mercury in the kidney.

Mercury is unique among the heavy metals in that it can exist in several physical and chemical forms, including elemental mercury, which is a liquid at room temperature. All forms of mercury have toxic effects in a number of organs, especially in the kidneys. Within the kidney, the pars recta of the proximal tubule is the most vulnerable segment of the nephron to the toxic effects of mercury. The biological and toxicological activity of mercurous and mercuric ions in the kidney can be defined largely by the molecular interactions that occur at critical nucleophilic sites in and around target cells. Because of the high bonding affinity between mercury and sulfur, there is particular interest in the interactions that occur between mercuric ions and the thiol group(s) of proteins, peptides and amino acids. Molecular interactions with sulfhydryl groups in molecules of albumin, metallothionein, glutathione, and cysteine have been implicated in mechanisms involved in the proximal tubular uptake, accumulation, transport, and toxicity of mercuric ions. In addition, the susceptibility of target cells in the kidneys to the injurious effects of mercury is modified by a number of intracellular and extracellular factors relating to several thiol-containing molecules. These very factors are the theoretical basis for most of the currently employed therapeutic strategies. This review provides an update on the current body of knowledge regarding the molecular interactions that occur between mercury and various thiol-containing molecules with respect to the mechanisms involved in the renal cellular uptake, accumulation, elimination, and toxicity of mercury.

• Publication year

  2000

• Venue

  Pharmacological Reviews

• Publication date

  2000-03-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/s0031-6997(24)01438-8PMID 10699157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies on the accumulation, metabolism and excretion of inorganic mercury (Hg203) after prolonged subcutaneous administration to rats.

  2009cited by this paper
• Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney

  2004cited by this paper
• Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule.

  2000influential reference
• Luminal and basolateral membrane transport of glutathione in isolated perfused S(1), S(2), and S(3) segments of the rabbit proximal tubule.

  2000cited by this paper
• Toxicological profile for mercury

  1999cited by this paper
• Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats.

  1999cited by this paper
• Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride.

  1999influential reference
• Relationships between alterations in glutathione metabolism and the disposition of inorganic mercury in rats: effects of biliary ligation and chemically induced modulation of glutathione status.

  1999influential reference
• Lessons on renal physiology from transgenic mice lacking aquaporin water channels.

  1999cited by this paper
• Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma.

  1999cited by this paper
• ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

  1998cited by this paper
• Mechanisms of action of 2,3-dimercaptopropane-1-sulfonate and the transport, disposition, and toxicity of inorganic mercury in isolated perfused segments of rabbit proximal tubules.

  1998influential reference
• Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury.

  1998influential reference
• Heterogeneity of glutathione synthesis and secretion in the proximal tubule of the rabbit.

  1998cited by this paper
• Endocrine mechanisms underlying the growth effects of developmental lead exposure in the rat.

  1998cited by this paper
• Basolateral uptake of mercuric conjugates of N-acetylcysteine and cysteine in the kidney involves the organic anion transport system.

  1998influential reference
• Basolateral uptake of inorganic mercury in the kidney.

  1998influential reference
• Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey.

  1998cited by this paper
• Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury.

  1998influential reference
• Intestinal handling of mercury in the rat: implications of intestinal secretion of inorganic mercury following biliary ligation or cannulation.

  1998influential reference
• Role of extracellular thiols in accumulation and distribution of inorganic mercury in rat renal proximal and distal tubular cells.

  1998cited by this paper
• Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

  1997cited by this paper
• Enhanced renal outer medullary uptake of mercury associated with uninephrectomy: implication of a luminal mechanism.

  1997cited by this paper
• Binding of mercury in renal brush-border and basolateral membrane-vesicles.

  1997influential reference
• Effect of non‐toxic mercury, zinc or cadmium pretreatment on the capacity of human monocytes to undergo lipopolysaccharide‐induced activation

  1997cited by this paper
• Mercury-sensitive residues and pore site in AQP3 water channel.

  1997cited by this paper
• Renal Injury and Urinary Excretion

  1997cited by this paper
• Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury.

  1997influential reference
• Comparative Aspects of Renal Organic Anion Transport

  1996cited by this paper
• Nephrotoxicity of inorganic mercury co-administrated with L-cysteine.

  1996influential reference
• Diversion or prevention of biliary outflow from the liver diminishes the renal uptake of injected inorganic mercury.

  1996cited by this paper
• Renal disposition of mercury in rats after intravenous injection of inorganic mercury and cysteine.

  1995influential reference
• Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.

  1995cited by this paper
• Histological and subcellular distribution of 65 and 70 kD heat shock proteins in experimental nephrotoxic injury.

  1995cited by this paper
• Organic anion transport and action of gamma-glutamyl transpeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury.

  1995influential reference
• Enhanced transcription of metallothionein genes in rat kidney: effect of uninephrectomy and compensatory renal growth.

  1995cited by this paper
• Inhibition of gamma-glutamyltranspeptidase decreases renal deposition of mercury after mercury vapor exposure.

  1995cited by this paper
• Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury.

  1995influential reference
• Accumulation and handling of inorganic mercury in the kidney after coadministration with glutathione.

  1995influential reference
• Pretreatment with p-aminohippurate inhibits the renal uptake and accumulation of injected inorganic mercury in the rat.

  1995influential reference
• The kinetics of intravenously administered methyl mercury in man.

  1994cited by this paper
• Activities of enzymes involved in renal cellular glutathione metabolism after uninephrectomy in the rat.

  1994influential reference
• Role of extracellular glutathione and γ‐Glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats

  1994cited by this paper
• Advances in understanding the renal transport and toxicity of mercury.

  1994influential reference
• Influence of 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the renal disposition of mercury in normal and uninephrectomized rats exposed to inorganic mercury.

  1993influential reference
• Redox activities of mercury-thiol complexes: implications for mercury-induced porphyria and toxicity.

  1993cited by this paper
• Markers of early renal changes induced by industrial pollutants. III. Application to workers exposed to cadmium.

  1993cited by this paper
• Tubular secretion and reabsorption of mercury compounds in mouse kidney.

  1993influential reference
• Effect of different renal glutathione levels on renal mercury disposition and excretion in the rat.

  1993cited by this paper
• Molecular and ionic mimicry of toxic metals.

  1993cited by this paper
• Mercury-metallothionein and the renal accumulation and handling of mercury.

  1993influential reference
• In vitro analysis of the accumulation and toxicity of inorganic mercury in segments of the proximal tubule isolated from the rabbit kidney.

  1993influential reference
• Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria.

  1993cited by this paper
• Mechanisms mediating renal secretion of organic anions and cations.

  1993cited by this paper
• Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride.

  1993influential reference
• Loss of calcium homeostasis leads to progressive phase of chlordecone-potentiated carbon tetrachloride hepatotoxicity.

  1993cited by this paper
• Transport and toxicity of methylmercury along the proximal tubule of the rabbit.

  1993influential reference
• Intrarenal distribution of inorganic mercury and albumin after coadministration.

  1993influential reference
• Urinary porphyrin profiles as a biomarker of mercury exposure: studies on dentists with occupational exposure to mercury vapor.

  1993cited by this paper
• Markers of early renal changes induced by industrial pollutants. I. Application to workers exposed to mercury vapour.

  1993cited by this paper
• Water channels in cell membranes.

  1992cited by this paper
• Quantitative determination of porphyrins in rat and human urine and evaluation of urinary porphyrin profiles during mercury and lead exposures.

  1992cited by this paper
• Dose-response studies in murine mercury-induced autoimmunity and immune-complex disease.

  1992cited by this paper
• Mercury blocks Na-K-ATPase by a ligand-dependent and reversible mechanism.

  1992cited by this paper
• Lessons from animal models: the scope of mercury-induced autoimmunity.

  1992cited by this paper
• Renal metallothionein metabolism after a reduction of renal mass. II. Effect of zinc pretreatment on the renal toxicity and intrarenal accumulation of inorganic mercury.

  1992influential reference
• Exogenous metallothionein and renal toxicity of cadmium and mercury in rats.

  1992cited by this paper
• Enhancement of gamma-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury.

  1992cited by this paper
• Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells.

  1992cited by this paper
• Altered intrarenal accumulation of mercury in uninephrectomized rats treated with methylmercury chloride.

  1992influential reference
• Cellular morphology in outer medullary collecting duct: effect of 75% nephrectomy and K+ depletion.

  1992cited by this paper
• Mercury inhibits Na-K-ATPase primarily at the cytoplasmic side.

  1992cited by this paper
• Mercury weakens membrane anchoring of Na-K-ATPase.

  1992cited by this paper
• Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism.

  1992influential reference
• Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity.

  1992cited by this paper
• Routes for renal transport of methylmercury in mice.

  1992cited by this paper
• Methylmercury transport across the blood-brain barrier by an amino acid carrier.

  1992cited by this paper
• Enhancement of γ-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury

  1992cited by this paper
• Primary cultures of rabbit renal proximal tubule cells. III. Comparative cytotoxicity of inorganic and organic mercury.

  1992cited by this paper
• Mercury and monomethylmercury: present and future concerns.

  1991cited by this paper
• Tubular Transport of Amino Acids and Small Peptides

  1991cited by this paper
• Factors affecting inorganic mercury transport and toxicity in the isolated perfused proximal tubule.

  1991influential reference
• Oral glutathione increases tissue glutathione in vivo.

  1991cited by this paper
• Mercury-induced H2O2 production and lipid peroxidation in vitro in rat kidney mitochondria.

  1991cited by this paper
• Renal accumulation and intrarenal distribution of inorganic mercury in the rabbit: effect of unilateral nephrectomy and dose of mercuric chloride.

  1991influential reference
• Determination and metabolism of dithiol chelating agents. XII. Metabolism and pharmacokinetics of sodium 2,3-dimercaptopropane-1-sulfonate in humans.

  1991cited by this paper
• Effectiveness of N-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity.

  1991cited by this paper
• Autometallographic localization of inorganic mercury in the kidneys of rats: effect of unilateral nephrectomy and compensatory renal growth.

  1991influential reference
• Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride.

  1991influential reference
• Renal Excretion and Tubular Transport of Organic Anions and Cations

  1991cited by this paper
• Whole‐body imaging of the distribution of mercury released from dental fillings into monkey tissues

  1990cited by this paper
• Role of γ-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice

  1990influential reference
• Inorganic mercury transport in the proximal tubule of the rabbit.

  1990influential reference
• Accumulation of inorganic mercury along the renal proximal tubule of the rabbit.

  1990cited by this paper
• Role of gamma-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice.

  1990cited by this paper
• Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system.

  1990cited by this paper
• Oxygen consumption and oxidant stress in surviving nephrons.

  1990cited by this paper
• Stimulation of porphyrinogen oxidation by mercuric ion. I. Evidence of free radical formation in the presence of thiols and hydrogen peroxide.

  1990cited by this paper
• Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis.

  1990influential reference
• DMPS as a rescue agent for the nephropathy induced by mercuric chloride.

  1990influential reference

• Environmentally relevant dual-sensing of mercury (II) and hydrazine via reaction-induced fluorescence switching for real-sample and on-site monitoring.

  2026cites this paper
• Quantum chemical studies on chelator combination in Hg2+, Pb2+ and UO22+ poisonings

  2026cites this paper
• High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity

  2026cites this paper
• Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention

  2025cites this paper
• High-sensitivity detection of Hg2+ using surface enhanced Raman scattering of malachite green Isothiocyanate between AuNP aggregates—Plasmon-enhanced chemical reaction site-selectivity in hot spots

  2025cites this paper
• Metal Ion Toxicity in Human Body: Sources, Effects, Mechanisms and Detoxification Methods

  2025cites this paper
• A Comparative Study on the Paradoxical Relationship Between Heavy Metal Exposure and Kidney Function

  2025cites this paper
• Associations of Prenatal Mercury Exposure and PUFA with Telomere Length and mtDNA Copy Number in 7-Year-Old Children in the Seychelles Child Development Nutrition Cohort 2

  2025cites this paper
• Multidrug Resistance-Associated Proteins 3 and 5 Play a Role in the Hepatic Transport of Mercuric Conjugates of Glutathione

  2025cites this paper
• Fast tracking of Hg2+ ions in living cells, food, and environmental samples using a new mitochondria-targeted red emitting probe and its portable applications.

  2025cites this paper
• Pharmacological and toxicological insights into the ayurvedic formulation Rasasindura

  2025cites this paper
• An ultrasensitive benzo[4,5]imidazo[1,2-a]pyrimidine-based fluorescent probe for Hg2+ and potential applications

  2025cites this paper
• Quantification of heavy metal exposure in a British population cohort links total mercury levels in plasma with skin tissue-specific changes in mitochondrial-related gene expression.

  2025cites this paper
• Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

  2025cites this paper
• Reusable fluorescence nanoprobe based on DNA-functionalized metal-organic framework for ratiometric detection of mercury (II) ions

  2024cites this paper
• A Promising Platform for the Rapid and Sensitive sensing of Mercury Ion and its applications in biological and environmental system

  2024cites this paper
• Snow White’s tale in nephrology: the emerging threat of skin-whitening creams on kidney health

  2024cites this paper
• IMPACT OF MERCURY ON SEX HORMONES (LITERATURE REVIEW)

  2024cites this paper
• Exposure to Mercury in the Air and Its Effect on Cardiovascular Diseases (CVD): A Systematic Review

  2024cites this paper
• Revealing mercury species-specific transfer and toxicity mechanisms in placental trophoblasts.

  2024cites this paper
• Flavonoids of Phoenix dactylifera L. Ameliorates Mercury-Toxicity on the Kidney of Wistar Rats. A Biochemical, Morphological and Molecular Approach.

  2024cites this paper
• Analysis of dry and wet season water quality in the municipality of La Gomera, Guatemala

  2024cites this paper
• Increased Adhesiveness of Blood Cells Induced by Mercury Chloride: Protective Effect of Hydroxytyrosol

  2024cites this paper
• What does scientometry tell us about mercury toxicology and its biological impairments?

  2024cites this paper
• Captivating nano sensors for mercury detection: a promising approach for monitoring of toxic mercury in environmental samples

  2024cites this paper
• Monitoring Hg2+ ions in food and environmental matrices using a novel ratiometric NIR fluorescent sensor via carbonothioate-deprotection reaction.

  2024cites this paper
• Understanding and Using Animal Models of Hepatotoxicity.

  2024cites this paper
• Efficacy of Seed Priming Technology in Ameliorating Metals and Metalloids Toxicity in Crops: Prospective and Issues

  2024cites this paper
• Dynamics of mercury stable isotope compounds in Arctic seals: new insights from a controlled feeding trial on hooded seals Cystophora cristata.

  2024cites this paper
• Assessment of the health risks associated with heavy metal contamination in the groundwaters of the Leh district, Ladakh

  2024cites this paper
• The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review

  2024cites this paper
• Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells

  2023cites this paper
• Should ebselen be considered for the treatment of mercury intoxication? A minireview

  2023cites this paper
• More Effective Mobilization of Hg2+ from Human Serum Albumin Compared to Cd2+ by L-Cysteine at Near-Physiological Conditions

  2023cites this paper
• Metalloproteomic Investigation of Hg-Binding Proteins in Renal Tissue of Rats Exposed to Mercury Chloride

  2023cites this paper
• Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review

  2023cites this paper
• N-Acetylcysteine Displaces Glutathionyl-Moieties from Hg2+ and MeHg+ to Form More Hydrophobic Complexes at Near-Physiological Conditions

  2023influential citation
• Anti-ischemic drug trimetazidine blocks mercury nephrotoxicity by suppressing renal redox imbalance, inflammatory stress and caspase-dependent apoptosis in rats

  2023cites this paper
• Assessing Kidney Injury Induced by Mercuric Chloride in Guinea Pigs with In Vivo and In Vitro Experiments

  2023cites this paper
• Recyclable Multifunctional Magnetic Fe3O4@SiO2@Au Core/Shell Nanoparticles for SERS Detection of Hg (II)

  2023cites this paper
• Interaction of mercury species with proteins: towards possible mechanism of mercurial toxicology.

  2023cites this paper
• Quantum Dot-Based Fluorometric Sensor for Hg(II) in Water Customizable for Onsite Visual Detection

  2023cites this paper
• Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension

  2023cites this paper
• Oral and inhalation bioaccessibility of mercury in contaminated soils and potential health risk to the kidneys and neurodevelopment of children in Taiwan

  2023cites this paper
• Disease-associated metabolic pathways affected by heavy metals and metalloid

  2023cites this paper
• Anandamide modulates WNT-5A/BCL-2, IP3/NFATc1, and HMGB1/NF-κB trajectories to protect against mercuric chloride-induced acute kidney injury

  2023cites this paper
• Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset

  2023cites this paper
• A preliminary study on health impacts of Mexican mercury mining workers in a context of precarious employment.

  2022cites this paper
• Hepatic Processing of Mercuric Ions Facilitates Delivery to Renal Proximal Tubules.

  2022cites this paper
• The Association between Mercury and Lead Exposure and Liver and Kidney Function in Pregnant Surinamese Women Enrolled in the Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Environmental Epidemiologic Cohort Study

  2022cites this paper
• Effect of Mercury on Membrane Proteins, Anionic Transport and Cell Morphology in Human Erythrocytes.

  2022cites this paper
• Synthesis and application of a novel polyurethane nanoemulsion bearing coumarin derivative as a "turn-on" fluorescence sensor toward Hg2.

  2022cites this paper
• Carveol ameliorates mercury-induced oxidative stress, neuroinflammation, and neurodegeneration in a mouse brain.

  2022cites this paper
• Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy.

  2022cites this paper
• Greener assembly of Pyrano[3,4-b]pyran derivative as a novel Hg2+ ion chemosensor

  2022cites this paper
• Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4

  2022cites this paper
• Plasma Clearance of Intravenously Infused Adrenomedullin in Rats with Acute Renal Failure

  2022cites this paper
• Curcumin Is an Iconic Ligand for Detecting Environmental Pollutants

  2022cites this paper
• Domestic water and accumulating mercury toxicity in the kidney

  2022cites this paper
• Hydrothermal sulphur bacteria enhance mercury availability for coastal marine organisms

  2022influential citation
• Element Rich Area Associated with Human Health Disorders: A Geomedical Science Approach to Potentially Toxic Elements Contamination

  2021cites this paper
• Antioxidant Potentials of Pentaclethra macrophylla Seed (Ugba) on Mercury Toxicity Induced Hepatic, Renal and Testicular Oxidative Stress in Male Albino Rats

  2021influential citation
• Exploring the potential of curry leaves on mercury‐induced hepatorenal toxicity in an animal model

  2021cites this paper
• C-phycoerythrin from Phormidium persicinum Prevents Acute Kidney Injury by Attenuating Oxidative and Endoplasmic Reticulum Stress

  2021cites this paper
• Synthesis of metal nanoclusters and their application in Hg2+ ions detection: A review.

  2021cites this paper
• Ag–SiO2 nanocomposite for the optical detection of Hg(II) ions and catalytic reduction of methylene blue

  2021cites this paper
• Intrusion of heavy metals/metalloids into rice (Oryza sativa L.) in relation to their status in two different agricultural management systems in Sri Lanka

  2021cites this paper
• Curcumin ameliorated the mercuric chloride induced depression and anxiety in female mice offspring.

  2021cites this paper
• Cinnabar protects serum-nutrient starvation induced apoptosis by improving intracellular oxidative stress and inhibiting the expression of CHOP and PERK

  2021cites this paper
• Arthrospira maxima (Spirulina) prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin

  2021cites this paper
• Deleterious effects of mercuric chloride on blood biochemistry, liver and kidney histology in female albino mice

  2021cites this paper
• Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry.

  2021cites this paper
• Functional interplay of melatonin in the bile duct and gastrointestinal tract to mitigate disease development: An overview

  2021cites this paper
• Dual-channel responsive fluorescent sensor for the logic-controlled detection and bioimaging of Zn2+ and Hg2+

  2021cites this paper
• Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population

  2021cites this paper
• Chromogenic and fluorescent probe for detection of mercury (II) ion based on mono-pyrrolyl substituted BODIPY

  2021cites this paper
• Trimetazidine Protects from Mercury-Induced Kidney Injury

  2021cites this paper
• Evaluation of Punarnavadi Mandura for haematinic activity against mercuric chloride-induced anemia in albino rats

  2021cites this paper
• Environmental metal toxicity assessment by the combined application of metallomics and metabolomics

  2021cites this paper
• Toxic Metal Species and ‘Endogenous’ Metalloproteins at the Blood–Organ Interface: Analytical and Bioinorganic Aspects

  2021cites this paper
• The Prevalence of Inorganic Mercury in Human Kidneys Suggests a Role for Toxic Metals in Essential Hypertension

  2021cites this paper
• Are cysteine residues of human phospholipid scramblase 1 essential for Pb2+ and Hg2+ binding-induced scrambling of phospholipids?

  2021influential citation
• An unusual cause of hypertension: Answers

  2021cites this paper
• Phycocyanobilin is the molecule responsible for the nephroprotective action of phycocyanin in acute kidney injury caused by mercury.

  2021cites this paper
• Preferential Liver Accumulation of Mercury Explains Low Concentrations in Muscle of Caiman yacare (Alligatoridae) in Upper Amazon

  2021cites this paper
• Changes in the renal function after acute mercuric chloride exposure in the rat are associated with renal vascular endothelial dysfunction and proximal tubule NHE3 inhibition.

  2021cites this paper
• Erythrocytes as a Model for Heavy Metal-Related Vascular Dysfunction: The Protective Effect of Dietary Components

  2021cites this paper
• Physiochemical characterization and toxicity assessment of colloidal mercuric formulation-'Sivanar amirtham'.

  2021cites this paper
• Evaluation of transporter expression in HK-2 cells after exposure to free and ester-bound 3-MCPD

  2021cites this paper
• Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells.

  2021cites this paper
• Mercury Kushta Induced Biochemical Changes In Liver and Kidney of Wister Rats

  2021cites this paper
• Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells

  2020cites this paper
• Trace Elements in Chronic Kidney Disease

  2020cites this paper
• Protective effects of curcumin towards anxiety and depression-like behaviors induced mercury chloride

  2020cites this paper
• Preliminary study of the distribution and risk assessment of mercury in different surficial sediments along the coastal area of the province Thai Binh in Vietnam

  2020cites this paper
• Mercury in the Diet, Absorption and Bioaccessibility

  2020cites this paper
• Enhanced Peroxidase Mimetic Activity of Magnetic Porous Carbon (MPC) Utilized in Colorimetric Sensing of Hg (II) Ions in Aqueous Medium

  2020cites this paper
• Current issues of environmental mercury pollution (review)

  2020cites this paper
• Genetic polymorphisms in multispecific transporters mitigates mercury nephrotoxicity in an artisanal and small-scale gold mining community in Colombia.

  2020cites this paper
• Methylmercury biomagnification in aquatic food webs of Poyang Lake, China: Insights from amino acid signatures.

  2020cites this paper