Biosynthesis of hyperforin in Hypericum perforatum.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2002-09-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM0209782PMID 12361406
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

  2002cited by this paper
• Analysis of plant complex matrices by use of nuclear magnetic resonance spectroscopy: St. John's wort extract.

  2001cited by this paper
• A Worrisome Side Effect of an Antianxiety Remedy

  2001cited by this paper
• St John's wort: Prozac from the plant kingdom.

  2001cited by this paper
• Biosynthesis of thiophenes in Tagetes patula.

  2001cited by this paper
• Deoxyxylulose phosphate pathway to terpenoids.

  2001cited by this paper
• How the Body's 'Garbage Disposal' May Inactivate Drugs

  2001cited by this paper
• Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

  2001cited by this paper
• Managing depression in medical outpatients.

  2000cited by this paper
• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

  2000cited by this paper
• Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

  2000cited by this paper
• Auxin biosynthesis in maize kernels.

  2000cited by this paper
• Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus.

  1999cited by this paper
• Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone.

  1999cited by this paper
• Isolation, Purity Analysis and Stability of Hyperforin as a Standard Material from Hypericum perforatum L.

  1999cited by this paper
• Hyperforin as a possible antidepressant component of hypericum extracts.

  1998cited by this paper
• Hyperforin, Possibly the Major Non-Nitrogenous Secondary Metabolite of Hypericum perforatum L.

  1998cited by this paper
• Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.

  1998cited by this paper
• Retrobiosynthetic NMR Studies with 13C-Labeled Glucose

  1997cited by this paper
• Stereochemistry of valine biosynthesis. Configuration of the product of rearrangement of alpha-acetolactate.

  1980cited by this paper
• [Antibiotic hyperforin from Hypericum perforatum L].

  1971cited by this paper

• Inspired by taxol: biosynthesis and engineering of hypericin and other phytochemicals in Hypericum

  2026influential citation
• Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis.

  2025cites this paper
• A synthetic investigation into the biosynthesis of hypsampsone A.

  2025cites this paper
• Tocotrienols in Eleven Species of Hypericum Genus Leaves

  2025cites this paper
• Synthetic Biology in Natural Product Biosynthesis.

  2025cites this paper
• Exploring specialized metabolic pathways in medicinal plants with single-cell and spatial omics

  2025cites this paper
• Catalytic prenyl conjugate additions for synthesis of enantiomerically enriched PPAPs

  2024cites this paper
• Specialized metabolism in St John's wort.

  2024cites this paper
• Single cell RNA sequencing facilitates the elucidation of the complete biosynthesis of the antidepressant hyperforin in St. John's wort.

  2024cites this paper
• Chitosan/Hyaluronate Complex-Coated Electrospun Poly(3-hydroxybutyrate) Materials Containing Extracts from Melissa officinalis and/or Hypericum perforatum with Various Biological Activities: Antioxidant, Antibacterial and In Vitro Anticancer Effects

  2024cites this paper
• Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism

  2024cites this paper
• Bioinspired Total Synthesis of Hyperireflexolides A and B.

  2023cites this paper
• A review of nemorosone: Chemistry and biological properties.

  2023cites this paper
• Convergent gene clusters underpin hyperforin biosynthesis in St John's wort.

  2022cites this paper
• Targeting the biological activity and biosynthesis of hyperforin: a mini-review.

  2022cites this paper
• Evolutionary Aspects of Hypericin Productivity and Endogenous Phytohormone Pools Evidenced in Hypericum Species In Vitro Culture Model

  2022cites this paper
• Evolution of a Synthetic Strategy for Garsubellin A.

  2022cites this paper
• Colupulone, colupone and novel deoxycohumulone geranyl analogues as larvicidal agents against Culex pipiens.

  2022cites this paper
• Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin.

  2022cites this paper
• Pd-Catalyzed Enantioselective Dearomative Allylic Annulation to Access PPAPs Analogues.

  2021cites this paper
• Enantioselective Total Synthesis of (+)‐Garsubellin A

  2021cites this paper
• Cultivation of Hypericum Perforatum (St. John’s Wort) and Biotechnological Approaches for Improvement of Plant Raw Material Quality

  2021cites this paper
• The Phytochemistry and Pharmacology of Hypericum.

  2020cites this paper
• The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

  2020influential citation
• Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action.

  2020cites this paper
• Progress in the Chemistry of Organic Natural Products 112

  2020cites this paper
• Secondary metabolites of medicinal use in Hypericum spp.: a rich history and a promising future

  2020cites this paper
• Biosynthesis of Indole Diterpenes

  2020cites this paper
• Programmable meroterpene synthesis

  2020cites this paper
• Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum

  2020cites this paper
• Hyphenone A, the first 3,3-diisoprenylated bicyclic polyprenylated acylphloroglucinols as Cav3.1 T-type calcium channel inhibitor from Hypericum henryi

  2019cites this paper
• Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A.

  2019cites this paper
• Extraction and chromatographic determination of phenolic compounds from medicinal herbs in the Lamiaceae and Hypericaceae families: A review

  2019cites this paper
• St. John’s Wort (Hypericum perforatum)

  2019cites this paper
• Sequential regiospecific gem-diprenylation of tetrahydroxyxanthone by prenyltransferases from Hypericum sp.

  2019cites this paper
• Sneak peek of Hypericum perforatum L.: phytochemistry, phytochemical efficacy and biotechnological interventions

  2019cites this paper
• Functional characterization of prenyltransferases involved in the biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols in the genus Hypericum

  2018influential citation
• Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron.

  2018cites this paper
• Hypatulone A, a Homoadamantane-Type Acylphloroglucinol with an Intricately Caged Core from Hypericum patulum.

  2018cites this paper
• Research Progress of Polycyclic Polyprenylated Acylphloroglucinols.

  2018cites this paper
• Super Antibiotics, Part VI: Hyperforin, Revision of Stereochemistry. Short Communications

  2018cites this paper
• Biosynthetic and Total Synthetic Approaches for (+)-Hyperforin

  2018cites this paper
• Super Antibiotics, Part IV. Hyperforin, Relative and Absolute Stereochemistry Elucidated by Gas-Chromatography Mass-Spectrometry with Supersonic Molecular Beams

  2017cites this paper
• Callistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis

  2017cites this paper
• A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum

  2017cites this paper
• Skeleton Reassignment of Type C Polycyclic Polyprenylated Acylphloroglucinols.

  2017cites this paper
• Biotechnological production of hyperforin for pharmaceutical formulation

  2017cites this paper
• Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.

  2017cites this paper
• Computed Regioselectivity and Conjectured Biological Activity of Ene Reactions of Singlet Oxygen with the Natural Product Hyperforin

  2017cites this paper
• Biosynthesis of phlorisovalerophenone and 4-hydroxy-6-isobutyl-2-pyrone in Escherichia coli from glucose

  2016cites this paper
• Domino Michael-aldol annulations for the stereocontrolled synthesis of bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane derivatives

  2016cites this paper
• Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi

  2016cites this paper
• Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories

  2016cites this paper
• Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms.

  2016cites this paper
• Tricyclic Acylphloroglucinols from Hypericum lanceolatum and Regioselective Synthesis of Selancins A and B.

  2016cites this paper
• Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.

  2016cites this paper
• Strategien für die Synthese von Naturstoffen mit benachbarten stereogenen quartären Kohlenstoffatomen

  2016cites this paper
• Hypersubones A and B, new polycyclic acylphloroglucinols with intriguing adamantane type cores from Hypericum subsessile.

  2015cites this paper
• Reconstitution of biosynthetic machinery for the synthesis of the highly elaborated indole diterpene penitrem.

  2015cites this paper
• Symphonia globulifera, a Widespread Source of Complex Metabolites with Potent Biological Activities

  2015cites this paper
• Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts

  2015cites this paper
• Total Synthesis of Hyperforin.

  2015cites this paper
• Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.

  2015cites this paper
• Isolation and Structure Elucidation of Hyperibine J [Revised Structure of Adhyperfirin (7‐Deprenyl‐13‐methylhyperforin)]: Synthesis of Hyperibone J

  2015cites this paper
• Hypercohin K, a polycyclic polyprenylated acylphloroglucinol with an unusual spiro-fused cyclopropane ring from Hypericum cohaerens

  2015cites this paper
• Friedel-crafts alkylation of acylphloroglucinols catalyzed by a fungal indole prenyltransferase.

  2015cites this paper
• Hyperuralones A and B, new acylphloroglucinol derivatives with intricately caged cores from Hypericum uralum.

  2014cites this paper
• In vitro Growth Inhibition by Hypericum Extracts and Isolated Pure Compounds of Paenibacillus larvae, a Lethal Disease Affecting Honeybees Worldwide

  2014cites this paper
• Metabolite profiling and fingerprinting of Hypericum species: a comparison of MS and NMR metabolomics

  2014cites this paper
• Hyperforin and deoxycohumulone as a larvicidal agent against Culex pipiens (Diptera: Culicidae).

  2014cites this paper
• New acylphloroglucinol derivatives with diverse architectures from Hypericum henryi.

  2014cites this paper
• Investigation of the elemental profiles of Hypericum perforatum as used in herbal remedies

  2014cites this paper
• Metabolism and localization of polyketides in the genus Hypericum

  2014cites this paper
• Chemistry and Biology of the Polycyclic Polyprenylated Acylphloroglucinol Hyperforin

  2014cites this paper
• Nuclear Magnetic Resonance of Small Molecules in Natural Products

  2014cites this paper
• Neurotrophe Naturstoffe – ihre Chemie und Biologie

  2014cites this paper
• Neurotrophic natural products: chemistry and biology.

  2014cites this paper
• Use of Metabolomics and Transcriptomics to Gain Insights into the Regulation and Biosynthesis of Medicinal Compounds: Hypericum as a Model

  2013cites this paper
• An approach toward the synthesis of PPAP natural product garsubellin A: construction of the tricyclic core

  2013cites this paper
• The bidirectional total synthesis of sampsonione P and hyperibone I.

  2013cites this paper
• Traditional Phytomedicinal Systems, Scientific Validations and Current Popularity as Nutraceuticals

  2013cites this paper
• Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai

  2013cites this paper
• Identification and biosynthesis of acylphloroglucinols in Hypericum gentianoides.

  2013cites this paper
• Possible ways of fagopyrin biosynthesis and production in buckwheat plants.

  2013cites this paper
• The potential health benefit of polyisoprenylated benzophenones from Garcinia and related genera: ethnobotanical and therapeutic importance.

  2013cites this paper
• Die bidirektionale Totalsynthese von Sampsonion P und Hyperibon I

  2013cites this paper
• Enantioselective total synthesis of hyperforin.

  2013cites this paper
• A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

  2012cites this paper
• Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures

  2012cites this paper
• The chemistry of the polycyclic polyprenylated acylphloroglucinols.

  2012cites this paper
• Mechanistic insights into the antileukemic activity of hyperforin.

  2012cites this paper
• De Novo Sequencing of Hypericum perforatum Transcriptome to Identify Potential Genes Involved in the Biosynthesis of Active Metabolites

  2012cites this paper
• Fast differentiation of Apocynum venetum with related species by UPLC/MS and UPLC/SPE/NMR

  2012cites this paper
• Polyphenol composition and antioxidant activity of selected medicinal herbs

  2011cites this paper
• Lathrophytoic acids A and B: two novel polyprenylated phloroglucinol derivatives from Kielmeyera lathrophyton

  2011cites this paper
• Morphological and Phytochemical Diversity among Hypericum Species of the Mediterranean Basin.

  2011cites this paper
• Taxonomy and Chemotaxonomy of the Genus Hypericum.

  2011cites this paper
• Polyprenylated Phloroglucinols and Xanthones

  2011cites this paper
• Essential Oil and Volatile Components of the Genus Hypericum (Hypericaceae)

  2010cites this paper
• Biosynthesis of hypericins and hyperforins in Hypericum perforatum L. (St. John’s wort) – precursors and genes involved

  2010influential citation