Genetic and environmental factors in the cause of Parkinson's disease

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Annals of Neurology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/ana.10487PMID 12666095
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic association between cytochrome P450IA1 gene and susceptibility to Parkinson's disease

  2005cited by this paper
• Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan

  2005cited by this paper
• Mutations in NR4A2 associated with familial Parkinson disease

  2003cited by this paper
• Mutations in NR4A2 associated with familial Parkinson disease

  2003cited by this paper
• Two large British kindreds with familial Parkinson's disease: a clinico-pathological and genetic study.

  2002cited by this paper
• Park6‐linked parkinsonism occurs in several european families

  2002cited by this paper
• Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

  2002cited by this paper
• Recent advances in the genetics and pathogenesis of Parkinson disease

  2002cited by this paper
• Recent advances in the genetics and pathogenesis of Parkinson's disease.

  2002cited by this paper
• A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1

  2002cited by this paper
• Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson’s disease

  2002cited by this paper
• Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

  2002cited by this paper
• Putative Transmembrane Polypeptide , which Can Lead to Endoplasmic Reticulum Stress , Is a Substrate of Parkin

  2001cited by this paper
• Complete genomic screen in Parkinson Disease

  2001cited by this paper
• An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2.

  2001cited by this paper
• Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease.

  2001cited by this paper
• Genetics of Parkinson's disease

  2001cited by this paper
• Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36.

  2001cited by this paper
• Complete genomic screen in Parkinson disease: evidence for multiple genes.

  2001cited by this paper
• alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

  2001cited by this paper
• Genome-wide scan for Parkinson's disease: the GenePD Study.

  2001cited by this paper
• An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

  2001cited by this paper
• α-synuclein gene haplotypes are associated with Parkinson’s disease

  2001cited by this paper
• Chronic systemic pesticide exposure reproduces features of Parkinson's disease

  2000cited by this paper
• Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.

  2000cited by this paper
• A Drosophila model of Parkinson's disease

  2000cited by this paper
• Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

  2000cited by this paper
• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  2000cited by this paper
• Familial aggregation of Parkinson's disease in Iceland.

  2000cited by this paper
• Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.

  2000cited by this paper
• Variability and validity of polymorphism association studies in Parkinson’s disease

  2000cited by this paper
• Association between early-onset Parkinson's disease and mutations in the parkin gene.

  2000cited by this paper
• Mice Lacking a-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine

  2000cited by this paper
• Parkinson disease in twins: an etiologic study.

  1999cited by this paper
• N-acetyltransferase-2 polymorphism in Parkinson’s disease: the Rotterdam study

  1999cited by this paper
• The septin CDCrel-1 binds syntaxin and inhibits exocytosis

  1999cited by this paper
• Nutritional and occupational factors influencing the risk of Parkinson's disease: A case‐control study in southeastern Sweden

  1999cited by this paper
• A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.

  1999cited by this paper
• Increased susceptibility to sporadic Parkinson's disease by a certain combined α‐synuclein/apolipoprotein E genotype

  1999cited by this paper
• The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease.

  1999cited by this paper
• Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson’s disease

  1999cited by this paper
• A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.

  1999cited by this paper
• The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins

  1999cited by this paper
• Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.

  1999cited by this paper
• Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.

  1998cited by this paper
• Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

  1998cited by this paper
• Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

  1998cited by this paper
• The ubiquitin pathway in Parkinson's disease

  1998cited by this paper
• Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease.

  1998cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• Sequencing of the alpha-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. The European Consortium on Genetic Susceptibility in Parkinson's Disease (GSPD).

  1998cited by this paper
• AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

  1998cited by this paper
• Failure to find the a‐synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease

  1998cited by this paper
• The role of the α-synuclein gene mutation in patients with sporadic Parkinson’s disease in the United Kingdom

  1998cited by this paper
• Sequencing of the α-Synuclein Gene in a Large Series of Cases of Familial Parkinson's Disease Fails to Reveal any Further Mutations

  1998cited by this paper
• Failure to find the alpha-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease.

  1998cited by this paper
• Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease

  1998cited by this paper
• Mutation, sequence analysis, and association studies of α-synuclein in Parkinson's disease

  1998cited by this paper
• A susceptibility locus for Parkinson's disease maps to chromosome 2p13

  1998cited by this paper
• The dopamine transporter gene and Parkinson's disease in a Chinese population

  1997cited by this paper
• Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease.

  1997cited by this paper
• Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

  1997cited by this paper
• Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

  1997cited by this paper
• Maternal inheritance in Parkinson's disease

  1997cited by this paper
• Association of a polymorphism in the dopamine‐transporter gene with parkinson's disease

  1997cited by this paper
• Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

  1997cited by this paper
• Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

  1997cited by this paper
• Alpha-synuclein in Lewy bodies.

  1997cited by this paper
• Dopaminergic function in familial Parkinson's disease: A clinical and 18F‐dopa positron emission tomography study

  1997cited by this paper
• G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease

  1997cited by this paper
• Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease

  1997cited by this paper
• The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease.

  1996cited by this paper
• Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

  1996cited by this paper
• Origin and functional consequences of the complex I defect in Parkinson's disease

  1996cited by this paper
• Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease

  1996cited by this paper
• Clinical genetic analysis of Parkinson's disease in the contursi kindred

  1996cited by this paper
• The role of the environment in Parkinson's disease.

  1996cited by this paper
• Frequency of the apolipoprotein E epsilon 4 allele in a case-control study of early onset Parkinson's disease.

  1996cited by this paper
• Possible environmental, occupational, and other etiologic factors for Parkinson's disease

  1996cited by this paper
• Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism

  1996cited by this paper
• Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

  1995cited by this paper
• Advances in the understanding of the cause of Parkinson's disease.

  1995cited by this paper
• An allelic association study of monoamine oxidase B in parkinson's disease

  1995cited by this paper
• A Greek‐American kindred with autosomal dominant, levodopa‐responsive parkinsonism and anticipation

  1995cited by this paper
• Advances in the Understanding of the Cause of Parkinson's Disease

  1994cited by this paper
• No allelic association between Parkinson's disease and dopamine D2, D3, and D4 receptor gene polymorphisms.

  1994cited by this paper
• Familial juvenile parkinsonism

  1994cited by this paper
• Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

  1994cited by this paper
• A clinical genetic study of Parkinson's disease

  1994cited by this paper
• Positron emission tomographic evidence for progression of human MPTP‐induced dopaminergic lesions

  1994cited by this paper
• Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

  1993cited by this paper
• Familial juvenile parkinsonism: clinical and pathologic study in afamily

  1993cited by this paper
• Mutant debrisoquine hydroxylation genes in Parkinson's disease.

  1992cited by this paper
• Parkinson's disease and exposure to agricultural work and pesticide chemicals

  1992cited by this paper
• Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.

  1992cited by this paper
• Parkinson's Disease and Exposure to Rural Environmental Factors: A Population Based Case-Control Study

  1991cited by this paper
• A large kindred with autosomal dominant Parkinson's disease

  1990cited by this paper
• Twin studies and the genetics of Parkinson's disease—a reappraisal

  1990cited by this paper
• A parkinsonian kindred

  1989cited by this paper
• THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE

  1989cited by this paper

• Intestinal macrophages modulate synucleinopathy along the gut–brain axis

  2026cites this paper
• Chromatin accessibility and transcriptome in human neuronal model exposed to Parkinson's environmental toxins.

  2026cites this paper
• Exploring Indole-Based Molecules as Novel Therapeutics for Parkinson's Disease: A Comprehensive Review.

  2025cites this paper
• Chromosome 12 and Environmental Factors in Parkinson’s Disease: An All of Us Data Analysis

  2025cites this paper
• Effects of Smoking on Motor and Non-Motor Symptoms in Parkinson's Disease: A Statistical Approach

  2025cites this paper
• Progranulin is increased during prodromal pathology in LRRK2 G2019S mice.

  2025cites this paper
• The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

  2025cites this paper
• Oxidative stress in neurodegeneration: in vitro models for investigating cellular damage and neuroprotective strategies

  2025cites this paper
• Association of LRRK2 R1628P variant with Parkinson’s disease in Kinh Vietnamese: a cross-sectional study

  2025cites this paper
• The role of cytochrome P450 and gut microbiome in drug metabolism: Insights into Parkinson disease treatment.

  2025cites this paper
• Update on mGlu4 modulator patents: 2017 to present

  2025cites this paper
• Zinc-Dependent Modulation of Dopamine Release and Uptake Is Altered in Parkinson's Disease Model Zebrafish.

  2025cites this paper
• Assessment of Sexual Dysfunction in Male Patients with Young-Onset Parkinson’s Disease: A Case-Control Study

  2024cites this paper
• Mitochondrial Dysfunction as a Potential Mechanism Mediating Cardiac Comorbidities in Parkinson’s Disease

  2024cites this paper
• Multidisciplinary rehabilitation for Parkinson’s disease

  2024cites this paper
• Phytochemical screening, antioxidant and anti-Parkinson activities of Berula erecta: A novel medicinal plant

  2024cites this paper
• Colonoscopy and Subsequent Risk of Parkinson’s Disease

  2024cites this paper
• Novel Gene Therapy Approaches for Targeting Neurodegenerative Disorders: Focusing on Delivering Neurotrophic Genes

  2024cites this paper
• Compositional Features and Codon Usage Pattern of Genes Associated with Parkinson’s Disease

  2024cites this paper
• Implications for the role of natural products in Parkinson disease therapy

  2024cites this paper
• TIN-X version 3: update with expanded dataset and modernized architecture for enhanced illumination of understudied targets

  2024cites this paper
• Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

  2024cites this paper
• The Relationship Between Pesticide Exposure and Neurodegenerative Diseases: A Mini-Review

  2024cites this paper
• Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction

  2024cites this paper
• Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model

  2024cites this paper
• Role of Artificial Intelligence Techniques and Neuroimaging Modalities in Detection of Parkinson’s Disease: A Systematic Review

  2023cites this paper
• Neurological Insights into Sleep Disorders in Parkinson’s Disease

  2023cites this paper
• Repositioning the existing drugs for neuroinflammation: a fusion of computational approach and biological validation to counter the Parkinson’s disease progression

  2023cites this paper
• Caffeic acid recarbonization: A green chemistry, sustainable carbon nano material platform to intervene in neurodegeneration induced by emerging contaminants.

  2023cites this paper
• Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.

  2023cites this paper
• Investigation of the mechanism of action of deep brain stimulation for the treatment of Parkinson’s disease

  2023cites this paper
• Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust

  2023cites this paper
• Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT

  2023cites this paper
• Silkworm Bombyx mori as a model organism: A review

  2023cites this paper
• Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project

  2023cites this paper
• 2-AMINOETHOXYDIPHENYL BORATE AMELIORATES MITOCHONDRIAL DYSFUNCTIONS IN MPTP/MPP+ MODEL OF PARKINSON'S DISEASE.

  2023cites this paper
• Transcriptomics and Proteomics Approach for the Identification of Altered Blood microRNAs and Plasma Proteins in Parkinson’s Disease

  2023cites this paper
• Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

  2023cites this paper
• Neuroprotective potential of Afzelin: A novel approach for alleviating catalepsy and modulating Bcl-2 expression in Parkinson's disease therapy

  2023cites this paper
• Liquid-liquid phase separation of α-Synuclein: A new mechanistic insight for α-Synuclein aggregation associated with Parkinson's disease pathogenesis.

  2022cites this paper
• Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

  2022cites this paper
• Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

  2022cites this paper
• Use of common spatial patterns for early detection of Parkinson’s disease

  2022cites this paper
• Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo Hypothesis

  2022cites this paper
• From lysosomal storage disorders to Parkinson's Disease - Challenges and opportunities.

  2022cites this paper
• The Effect of Aggregated Alpha Synuclein on Synaptic and Axonal Proteins in Parkinson’s Disease—A Systematic Review

  2022cites this paper
• Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration

  2022cites this paper
• Psychotropic medication use and Parkinson's disease risk amongst older women

  2022cites this paper
• The role of NURR1 in metabolic abnormalities of Parkinson’s disease

  2022cites this paper
• Açai Berry Mitigates Parkinson’s Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways

  2022cites this paper
• Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases

  2022cites this paper
• Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats’ Striatum

  2022cites this paper
• Role of CD36 rs1761667 AA genotype in the expression of inflammatory cytokines and Parkinson's disease progression: A case-control study in a northern Han Chinese population.

  2022cites this paper
• Investigation of Factors Affecting the Side of the Disease Onset in Parkinson's Disease.

  2022cites this paper
• Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis.

  2021cites this paper
• Parkinson’s disease hospitalization rates and pesticide use in urban and non-urban regions of Brazil

  2021cites this paper
• Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions.

  2021cites this paper
• A REVIEW ON PARKINSON’S DISEASE: AN OVERVIEW

  2021cites this paper
• Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease

  2021cites this paper
• The role of amyloids in Alzheimer's and Parkinson's diseases.

  2021cites this paper
• Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study

  2021cites this paper
• The impact of clinical scales in Parkinson’s disease: a systematic review

  2021cites this paper
• Application of serum SNCA gene in the diagnosis of Parkinson’s disease

  2021cites this paper
• Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids

  2021cites this paper
• LRRK2 at the Crossroad of Aging and Parkinson’s Disease

  2021cites this paper
• Environmental Aspects of Alzheimer's and Parkinson's Diseases Neuropathologies

  2021cites this paper
• Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities

  2021cites this paper
• MicroPET imaging of vesicular monoamine transporter 2 revealed the potentiation of (+)-dihydrotetrabenazine on MPTP-induced degeneration of dopaminergic neurons.

  2021cites this paper
• Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

  2021cites this paper
• GLP-1 and GIP receptor agonists in the treatment of Parkinson’s disease: Translational systematic review and meta-analysis protocol of clinical and preclinical studies

  2021cites this paper
• Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

  2021cites this paper
• Curcumin and neurological diseases

  2020cites this paper
• Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity

  2020cites this paper
• Next generation sequencing exome data analysis aids in the discovery of SNP and INDEL patterns in Parkinson's disease.

  2020cites this paper
• The Impacts of Prominent Gene Polymorphisms in DNA Repair Enzymes on Parkinson's Disease.

  2020cites this paper
• Parkinsonism and Potential of Mucuna Beans

  2020cites this paper
• Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions.

  2020cites this paper
• Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders

  2020cites this paper
• Targeting the Wnt/β-catenin pathway in neurodegenerative diseases: recent approaches and current challenges

  2020cites this paper
• Neuroprotective effect ofAster yomena(Kitam.) Honda against hydrogen peroxide-induced oxidative stress in SH-SY5Y cells

  2020cites this paper
• Anxiety: An ignored aspect of Parkinson's disease lacking attention.

  2020cites this paper
• Parkinson’s disease determinants, prediction and gene–environment interactions in the UK Biobank

  2020cites this paper
• Association of slow acetylator genotype of N-acetyltransferase 2 with Parkinson's disease from south Indian population.

  2020cites this paper
• Investigation of the Effect of the SIRT1 Gene Polymorphisms in Parkinson's Disease

  2020cites this paper
• Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson’s disease

  2020cites this paper
• The role of sex and sex Hormones in Neurodegenerative Diseases.

  2020cites this paper
• A Role for SERCA Pumps in the Neurobiology of Neuropsychiatric and Neurodegenerative Disorders.

  2020cites this paper
• Neuroprotective effect of Aster yomena (Kitam.) Honda against hydrogen peroxide-induced oxidative stress in SH-SY5Y cells

  2020cites this paper
• Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain

  2020cites this paper
• Association between epidermal growth factor receptor gene polymorphisms and susceptibility to Parkinson's disease.

  2020cites this paper
• Cell-Permeable Calpain Inhibitor SJA6017 Provides Functional Protection to Spinal Motoneurons Exposed to MPP+

  2020cites this paper
• Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease

  2020cites this paper
• Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease

  2020cites this paper
• Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson’s Disease?

  2019cites this paper
• Association of LAG3 genetic variation with an increased risk of PD in Chinese female population

  2019cites this paper
• Pharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects

  2019cites this paper
• Anti‐ageing and anti‐Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans

  2019cites this paper
• Genetics of Alzheimer's disease: where we are, and where we are going.

  2019cites this paper
• Identification of potential blood biomarkers for Parkinson’s disease by gene expression and DNA methylation data integration analysis

  2019cites this paper
• Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences

  2019cites this paper