Immunoelectronmicroscopic localization of IgA in skin of patients with dermatitis herpetiformis.

Ultrastructural localization of in vivo-bound IgA in the skin of patients with dermatitis herpetiformis was determined by using a modified peroxidase-antiperoxidase multistep method. Three types of reaction product deposition are seen. The most common type of reaction product deposition, that which is identified by direct immunofluorescence as the speckled type of IgA deposit, shows up as clumps and yarnlike fibrils. The second type of IgA deposition, which is a linear band by direct immunofluorescence, appears to be associated with anchoring fibrils. The third of IgA deposition, which is also linear by immunofluorescence, is confined to the lamina lucida.

• Publication year

  1976

• Venue

  Journal of Investigative Dermatology

• Publication date

  1976-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/1523-1747.EP12664534PMID 972257
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Andrew Moynihan Claye.

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