Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Biophysical Journal

• Publication date

  1999-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-3495(99)77301-7PMID 10049322PMCID PMC1300118
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels

  2005cited by this paper
• Pyruvate metabolism in Helicobacter pylori

  2004cited by this paper
• Double‐stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin

  1998cited by this paper
• Characterisation of a monoclonal antibody and its use to purify the cytotoxin of Helicobacter pylori.

  1998cited by this paper
• Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA

  1998cited by this paper
• The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies.

  1998cited by this paper
• A Pore-forming Toxin Interacts with a GPI-anchored Protein and Causes Vacuolation of the Endoplasmic Reticulum

  1998cited by this paper
• Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.

  1998cited by this paper
• Effect of Helicobacter pylori Vacuolating Toxin on Maturation and Extracellular Release of Procathepsin D and on Epidermal Growth Factor Degradation*

  1997cited by this paper
• Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly

  1997influential reference
• vaccine in The Netherlands . persons vaccinated with inactivated poliovirus Poliovirus-specific immunoglobulin A in

  1997influential reference
• Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol

  1997cited by this paper
• The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin

  1997cited by this paper
• Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers*

  1997cited by this paper
• Helicobacter pylori vacuolating toxin accumulates within the endosomal‐vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia

  1997cited by this paper
• Introduction of unmarked mutations in the Helicobacter pylori vacA gene with a sucrose sensitivity marker

  1997cited by this paper
• Tuberculosis into the next century: Proceedings of a symposium held on 4 February 1995 at the Liverpool School of Tropical Medicine

  1996cited by this paper
• The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori.

  1996cited by this paper
• Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells

  1996cited by this paper
• The vacuolating cytotoxin of Helicobacter pylori

  1996cited by this paper
• Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant (*)

  1995cited by this paper
• Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin.

  1995cited by this paper
• Acetyl-CoA carboxylase activity in Helicobacter pylori and the requirement of increased CO2 for growth.

  1995cited by this paper
• Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies

  1995cited by this paper
• Molecular mechanisms of action of bacterial protein toxins.

  1994cited by this paper
• Helicobacter pylori infection and gastric lymphoma.

  1994cited by this paper
• Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease

  1994cited by this paper
• Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.

  1994cited by this paper
• An international association between Helicobacter pylori infection and gastric cancer

  1993cited by this paper
• Effects of ATPase inhibitors on the response of HeLa cells to Helicobacter pylori vacuolating toxin

  1993cited by this paper
• An international association between Helicobacter pylori infection and gastric cancer. The EUROGAST Study Group.

  1993cited by this paper
• Helicobacter pylori: microbiology of a 'slow' bacterial infection.

  1993cited by this paper
• Bafilomycin A1 inhibits Helicobacter pylori‐induced vacuolization of HeLa cells

  1993cited by this paper
• Purification and characterization of the vacuolating toxin from Helicobacter pylori.

  1992cited by this paper
• Organellar Proton-ATPases

  1992influential reference
• Ion channel and membrane translocation of diphtheria toxin.

  1992cited by this paper
• Sourcebook of bacterial protein toxins

  1991cited by this paper
• Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.

  1988cited by this paper
• Ion Channel Reconstitution

  1986cited by this paper
• Anion inhibition of the proton pump in rat liver multivesicular bodies.

  1986cited by this paper
• Anion inhibition of the proton pump in rat liver multivesicular bodies.

  1986cited by this paper
• How to set up a Bilayer System

  1986cited by this paper
• Kinetics of monensin-induced swelling of Golgi apparatus cisternae of H-2 hepatoma cells.

  1985cited by this paper
• UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC GASTRITIS

  1983cited by this paper
• Unidentified curved bacilli on gastric epithelium in active chronic gastritis.

  1983cited by this paper
• Acidification of macrophage and fibroblast endocytic vesicles in vitro.

  1983influential reference
• Ion‐concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction.

  1979cited by this paper
• The effect of sodium ions on the electrical activity of the giant axon of the squid

  1949cited by this paper

• Mechanisms of Metabolic Reprogramming Regulating Immunosuppression in the Gastric Cancer Tumor Microenvironment

  2026cites this paper
• Bergeyella cardium variant induces a unique cytoplasmic vacuolization cell death floatptosis in macrophage

  2025cites this paper
• Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

  2024cites this paper
• There Are No Insurmountable Barriers: Passage of the Helicobacter pylori VacA Toxin from Bacterial Cytoplasm to Eukaryotic Cell Organelle

  2023influential citation
• Structural analysis of membrane-associated forms of Helicobacter pylori VacA toxin.

  2023cites this paper
• Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells

  2023cites this paper
• Restoration of mitochondrial structure and function within Helicobacter pylori VacA intoxicated cells.

  2023cites this paper
• Restoration of mitochondrial structure and function within Helicobacter pylori VacA intoxicated cells

  2023cites this paper
• Helicobacter pylori vacuolating cytotoxin A exploits human endosomes for intracellular activation

  2022cites this paper
• Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis

  2021cites this paper
• The Vacuolating Autotransporter Toxin (Vat) of Escherichia coli Causes Cell Cytoskeleton Changes and Produces Non-lysosomal Vacuole Formation in Bladder Epithelial Cells

  2020cites this paper
• The Mechanism of CagA and VacA in Gastric Cancer under the Tumor Microenvironment and Vitro Factors

  2020cites this paper
• Role of vacuolating cytotoxin A in Helicobacter pylori infection and its impact on gastric pathogenesis

  2020cites this paper
• Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants

  2020cites this paper
• Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability

  2019cites this paper
• VacA Genotype in Helicobacter pylori

  2019cites this paper
• Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.

  2019cites this paper
• Activity and Functional Importance of Helicobacter pylori Virulence Factors.

  2019cites this paper
• Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA

  2018cites this paper
• Helicobacter pylori Vacuolating Toxin and Gastric Cancer

  2017cites this paper
• Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network.

  2017influential citation
• Structural Analysis of the Helicobacter pylori pore forming toxin, VacA

  2017cites this paper
• Validated species of the genus Helicobacter Species Helicobacter pylori Helicobacter acinonychis Helicobacter aurati Helicobacter bilis Helicobacter bizzozeronii Helicobacter canadensis Helicobacter canis Helicobacter chrolecystus Helicobacter cinaedi Helicobacter felis Helicobacter fennelliae Helic

  2016cites this paper
• Cytoplasmic vacuolization in cell death and survival

  2016cites this paper
• Structural organization of membrane‐inserted hexamers formed by Helicobacter pylori VacA toxin

  2016cites this paper
• An Overview of Helicobacter pylori VacA Toxin Biology

  2016cites this paper
• Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Vacuolating Cytotoxin-Induced Autophagy and Apoptosis During Helicobacter pylori Infection

  2016cites this paper
• New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors

  2016cites this paper
• Interaction of Helicobacter pylori VacA toxin with its target cells.

  2016cites this paper
• Helicobacter pylori Vacuolating Toxin

  2016cites this paper
• Pathobiochemische Funktionen der p33-Untereinheit des vakuolisierenden Zytotoxins VacA von \(\it Helicobacter\) \(\it pylori\)

  2015influential citation
• Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier.

  2015cites this paper
• Molecular Mechanisms of Helicobacter pylori Pathogenesis

  2015cites this paper
• Analysis of Helicobacter pylori VacA-containing vacuoles and VacA intracellular trafficking

  2015cites this paper
• Helicobacter pylori vacuolating toxin

  2015cites this paper
• Complementary DNA display selection of high‐affinity peptides binding the vacuolating toxin (VacA) of Helicobacter pylori

  2015cites this paper
• Effects of Helicobacter pylori Vacuolating Cytotoxin A on intracellular calcium signalling in T-lymphocytes

  2014cites this paper
• Mitochondrial channels: ion fluxes and more.

  2014cites this paper
• Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin.

  2013cites this paper
• Lactic acid bacterial extracts as anti-Helicobacter pylori: a molecular approach

  2013cites this paper
• Mechanisms of Helicobacter pylori-Induced Gastric Inflammation

  2012cites this paper
• Helicobacter pylori VacA: a new perspective on an invasive chloride channel.

  2012cites this paper
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

  2012cites this paper
• Physiology of Host-pathogen Interactions

  2012cites this paper
• Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA)

  2012cites this paper
• Intoxication strategy of Helicobacter pylori VacA toxin.

  2012cites this paper
• Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome

  2012cites this paper
• Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pylori VacA*

  2012cites this paper
• Characteristics of weak base-induced vacuoles formed around individual acidic organelles.

  2011cites this paper
• Helicobacter pylori VacA Reduces the Cellular Expression of STAT3 and Pro-survival Bcl-2 Family Proteins, Bcl-2 and Bcl-XL, Leading to Apoptosis in Gastric Epithelial Cells

  2011cites this paper
• Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity.

  2010cites this paper
• Mechanism of Helicobacter pylori induced gastric cancer : role of the signal transducer and activator of transcription pathway.

  2010cites this paper
• The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk

  2010cites this paper
• Helicobacter pylori in the 21st century

  2010cites this paper
• Surreptitious manipulation of the human host by Helicobacter pylori

  2010cites this paper
• Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA.

  2010influential citation
• Reconstitution of Helicobacter pylori VacA toxin from purified components.

  2010cites this paper
• Helicobacter pylori VacA Toxin/Subunit p34: Targeting of an Anion Channel to the Inner Mitochondrial Membrane

  2010cites this paper
• Endosome–mitochondria juxtaposition during apoptosis induced by H. pylori VacA

  2010cites this paper
• Role of innate immunity in Helicobacter pylori-induced gastric malignancy.

  2010cites this paper
• Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection.

  2009cites this paper
• Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.

  2009cites this paper
• Urease de Canavalia ensiformis : processamento diferencial por ninfas e adultos de Dysdercus peruvianus e formação de canal in vitro

  2009cites this paper
• Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA

  2008cites this paper
• The Helicobacter pylori's protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells

  2008cites this paper
• The concerted action of the Helicobacter pylori cytotoxin VacA and of the v‐ATPase proton pump induces swelling of isolated endosomes

  2007cites this paper
• Helicobacter pylori Vacuolating Cytotoxin Inhibits Activation-Induced Proliferation of Human T and B Lymphocyte Subsets1

  2007cites this paper
• Protein secretion in gram-negative bacteria via the autotransporter pathway.

  2007cites this paper
• 4.23 – Glycoconjugates and Bacterial Infections: Helicobacter pylori

  2007cites this paper
• Human T and B Lymphocyte Subsets Inhibits Activation-Induced Proliferation of Vacuolating Cytotoxin Helicobacter pylori

  2007cites this paper
• External membrane vesicles from Helicobacter pylori induce apoptosis in gastric epithelial cells.

  2006cites this paper
• A Helicobacter pylori Vacuolating Toxin Mutant That Fails To Oligomerize Has a Dominant Negative Phenotype

  2006cites this paper
• Human Polymorphonuclear Leukocytes are Sensitive In Vitro to Helicobacter pylori VacA Toxin

  2006cites this paper
• Clustering of Helicobacter pylori VacA in Lipid Rafts, Mediated by Its Receptor, Receptor-Like Protein Tyrosine Phosphatase β, Is Required for Intoxication in AZ-521 Cells

  2006cites this paper
• Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation*

  2006cites this paper
• Pore Formation of Thermostable Direct Hemolysin Secreted from Vibrio parahaemolyticus in Lipid Bilayers

  2006cites this paper
• Pathogenesis of Helicobacter pylori Infection

  2006cites this paper
• Toxins in the Endosomes

  2006cites this paper
• Toxins as Host Cell Modulators

  2006cites this paper
• CHAPTER 24 – Helicobacter pylori vacuolating toxin

  2006cites this paper
• Diversity of Helicobacter pylori genotypes in Estonian patients with chronic inflammatory gastric diseases

  2006cites this paper
• Random Mutagenesis of Helicobacter pylori vacA To Identify Amino Acids Essential for Vacuolating Cytotoxic Activity

  2006cites this paper
• The Sialic Acid Binding SabA Adhesin of Helicobacter pylori Is Essential for Nonopsonic Activation of Human Neutrophils*

  2005cites this paper
• High resolution structural analysis of Helicobacter pylori VacA toxin oligomers by cryo-negative staining electron microscopy.

  2005cites this paper
• Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes.

  2005cites this paper
• All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion.

  2005cites this paper
• Helicobacter pylori VacA, a paradigm for toxin multifunctionality

  2005cites this paper
• Helicobacter pylori and gastric epithelial cells: from gastritis to cancer.

  2005cites this paper
• Novel activities of the Helicobacter pylori vacuolating cytotoxin: from epithelial cells towards the immune system.

  2004cites this paper
• [Helicobacter pylori: focus on CagA and VacA major virulence factors].

  2004cites this paper
• Helicobacter pylori and gastric diseases: a dangerous association.

  2004cites this paper
• Cloning and Expression of the Heterogenic Vacuolating Cytotoxin From an Iranian Helicobacter pylori Strain

  2004cites this paper
• Infectious agents and cancer: criteria for a causal relation.

  2004cites this paper
• Helicobacter pylori vacuolating cytotoxin, VacA, is responsible for gastric ulceration.

  2004cites this paper
• Glycosylphosphatidylinositol-anchored Proteins and Actin Cytoskeleton Modulate Chloride Transport by Channels Formed by the Helicobacter pylori Vacuolating Cytotoxin VacA in HeLa Cells*

  2004cites this paper
• The multiple cellular activities of the VacA cytotoxin of Helicobacter pylori.

  2004cites this paper
• Membrane channel structure of Helicobacter pylori vacuolating toxin: role of multiple GXXXG motifs in cylindrical channels.

  2004cites this paper
• The Helicobacter pylori Vacuolating Toxin Inhibits T Cell Activation by Two Independent Mechanisms

  2003cites this paper
• Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori

  2003cites this paper
• Recovery from lactacidosis‐induced glial cell swelling with the aid of exogenous anion channels

  2003cites this paper