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Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Sevim Uzun,R. Djamin,H. Hoogsteden,J. Aerts,M. Eerden

Published 2013 in Unknown venue

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a disease which is characterized by airway inflammation and progressive airflow limitation with poor reversibility. Patients with COPD can experience periods of acute deterioration, which are called exacerbations. There are different definitions for an acute exacerbation of COPD (AECOPD). A symptom reported AECOPD is defined solely based on a patient’s symptoms [1]. This is regardless of whether the patient seeks medical attention or receives treatment for the exacerbation. An event defined AECOPD requires a therapeutic intervention such as a change in COPD medications or a change in healthcare utilization [1]. Generally accepted is the definition as in the guidelines of the World Health Organization, US National Heart Lung and Blood Institute and Global Initiative for Chronic Obstructive Lung Disease (GOLD), which define an exacerbation as “an event in the natural course of the disease characterized by a change in the patient’s baseline dyspnoea, cough, and/or sputum that is beyond normal day-to-day variations, is acute in onset and may warrant a change in regular medication in a patient with COPD” [2]. Frequent exacerbations can result in a decreased health related quality of life [3], a decline in lung function [4], an increased risk of hospitalization [5] and an increase in mortality [6].

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