Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Psychological Medicine

• Publication date

  2015-08-12

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1017/S0033291715001506PMID 26266877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ketamine safety and tolerability in clinical trials for treatment-resistant depression.

  2015influential reference
• From the Centers for Disease Control and Prevention

  2015cited by this paper
• Existing and novel biological therapeutics in suicide prevention.

  2014cited by this paper
• EFFECTS OF KETAMINE ON EXPLICIT AND IMPLICIT SUICIDAL COGNITION: A RANDOMIZED CONTROLLED TRIAL IN TREATMENT‐RESISTANT DEPRESSION

  2014influential reference
• Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety.

  2014influential reference
• A randomized controlled trial of intranasal ketamine in major depressive disorder.

  2014cited by this paper
• Mental health: A road map for suicide research and prevention

  2014cited by this paper
• Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment.

  2013cited by this paper
• BDNF promoter methylation and suicidal behavior in depressive patients.

  2013cited by this paper
• Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis

  2013influential reference
• Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depression.

  2013cited by this paper
• Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression.

  2013influential reference
• Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims.

  2013cited by this paper
• Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.

  2013influential reference
• Neurobiology of suicidal behaviour.

  2012cited by this paper
• Connecting inflammation with glutamate agonism in suicidality

  2012cited by this paper
• Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.

  2012cited by this paper
• Ketamine for Treatment-Resistant Unipolar Depression

  2012influential reference
• Synaptic Dysfunction in Depression: Potential Therapeutic Targets

  2012cited by this paper
• Ketamine as a Novel Antidepressant: From Synapse to Behavior

  2012influential reference
• Leading causes of unintentional and intentional injury mortality: United States, 2000-2009.

  2012influential reference
• Suicidal thoughts and behaviors among adults aged ≥18 years--United States, 2008-2009.

  2011cited by this paper
• Concise Associated Symptoms Tracking scale: a brief self-report and clinician rating of symptoms associated with suicidality.

  2011cited by this paper
• A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department.

  2011cited by this paper
• Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk.

  2011influential reference
• A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

  2010cited by this paper
• mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

  2010cited by this paper
• Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.

  2010cited by this paper
• Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression.

  2009cited by this paper
• Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.

  2009cited by this paper
• Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies

  2009cited by this paper
• Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression.

  2009cited by this paper
• Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

  2009cited by this paper
• Familial transmission of suicidal behavior.

  2008cited by this paper
• Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants.

  2007cited by this paper
• Medical management of depression.

  2006cited by this paper
• Lithium versus antidepressants in the long-term treatment of unipolar affective disorder.

  2006cited by this paper
• A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

  2006cited by this paper
• Suicide brain is associated with decreased expression of neurotrophins.

  2005cited by this paper
• The medical management of depression.

  2005cited by this paper
• Suicide prevention strategies: a systematic review.

  2005cited by this paper
• Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

  2005cited by this paper
• Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design.

  2004cited by this paper
• The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression.

  2003cited by this paper
• Psychological autopsy studies of suicide: a systematic review

  2003cited by this paper
• Neurobiology of suicidal behaviour

  2003cited by this paper
• Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

  2003cited by this paper
• Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS)

  1998influential reference
• The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.

  1998cited by this paper
• Scale for Suicide Ideation: psychometric properties of a self-report version.

  1988cited by this paper
• A New Depression Scale Designed to be Sensitive to Change

  1979cited by this paper
• A Rating Scale for Mania: Reliability, Validity and Sensitivity

  1978cited by this paper
• Basic dimensions of change in the symptomatology of chronic schizophrenics.

  1961cited by this paper

• Ketamine treatment alleviates suicide ideation in high-risk populations: a systematic review and meta-analysis

  2026cites this paper
• Ketamine as a Mental Health Treatment.

  2026cites this paper
• Novel perspectives for glutamatergic strategies, psychedelics and antipsychotic augmentation in Treatment Resistant Depression: A narrative review

  2025influential citation
• Triple-network model–based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials

  2025cites this paper
• Making Progress in Clinical Trials for Suicide Prevention: A Review.

  2025cites this paper
• Ketamine to enhance methadone treatment retention in patients with opioid use disorder and co-morbid depression

  2025cites this paper
• Effects of ketamine and esketamine on death, suicidal behaviour, and suicidal ideation in psychiatric disorders: A systematic review and meta-analysis

  2025cites this paper
• Oral esketamine for patients with severe treatment-resistant depression: Effectiveness, safety, and tolerability of a six-week open-label treatment program

  2025cites this paper
• Intranasal (R)-ketamine modulates depression symptom and neurotransmitters-associated human brain connectivity.

  2025cites this paper
• Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression

  2025cites this paper
• The Ketamine Trial for Acute Suicidality (KETA): Study Protocol of a Double‐Blind Randomized Placebo‐Controlled Superiority Trial on Intranasal Racemic Ketamine Compared to the Active Placebo Intranasal Midazolam as Treatment for Acute Suicidality

  2025cites this paper
• Ketamine/esketamine in the treatment of depression with comorbid borderline personality disorder or traits: A systematic review of effectiveness

  2025cites this paper
• Association of life stressors and suicidal ideation with long-term outcomes in patients with acute coronary syndrome and stroke.

  2025cites this paper
• Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severity and craving intensity

  2025cites this paper
• The Effects of Psychotherapy on Single and Repeated Ketamine Infusion(s) Therapy for Treatment-Resistant Depression: The Convergence of Molecular and Psychological Treatment

  2025cites this paper
• The Analgesic and Dissociative Properties of Ketamine are Separate and Correspond to Distinct Neural Mechanisms

  2025cites this paper
• Review: Suicide and its relationship to aggression and impulsivity

  2025cites this paper
• Symptom modulation and tolerability of intravenous ketamine in treatment-resistant bipolar depression: A retrospective study.

  2025cites this paper
• Ketamine in clinical practice: transitioning from anesthetic agent to psychiatric therapeutic

  2025cites this paper
• Improvement of Mental Health Symptoms in Response to Ketamine Therapy in Medicaid-Eligible Patients

  2024cites this paper
• Treatment resistant patients with baseline suicidal ideation required more treatments to achieve therapeutic response with ketamine/esketamine.

  2024cites this paper
• New and emerging treatments for major depressive disorder

  2024cites this paper
• Social exclusion and suicide intention in Chinese college students: a moderated mediation model

  2024cites this paper
• Assessing suicide risk in chronic pain management: a narrative review across drug classes

  2024cites this paper
• Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.

  2024cites this paper
• Effects of Ketamine vs. Midazolam in Adolescent Treatment Resistant Depression

  2024cites this paper
• Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis

  2024cites this paper
• EFFICACY AND SAFETY OF ESKETAMINE NASAL SPRAY IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER AND ACTIVE SUICIDAL IDEATION: RESULTS FROM A RANDOMIZED DOUBLE-BLIND STUDY

  2024cites this paper
• Oral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality

  2024cites this paper
• Ketamine and electroconvulsive therapy for severe depression: A network meta-analysis of efficacy and safety.

  2024cites this paper
• Predicting suicidal ideation using multiple serum biomarkers in patients with acute coronary syndrome.

  2024cites this paper
• Rapid and long-lasting effects of subcutaneous esketamine on suicidality: An open-label study in patients with treatment-resistant depression.

  2024cites this paper
• Entactogen Effects of Ketamine: A Reverse-Translational Study.

  2024cites this paper
• Psychedelic Therapy: A Primer for Primary Care Clinicians—Ketamine

  2024cites this paper
• Efficacy of single and repeated ketamine administration for suicidal ideation in adults with psychiatric disorders: A meta-analysis.

  2024cites this paper
• Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

  2023cites this paper
• Comparison of ketamine with buprenorphine as adjunctive therapy in the treatment of comorbid major depressive disorder and opium use disorders: A randomized controlled trial

  2023cites this paper
• Ketamine for Major Depressive Disorder.

  2023cites this paper
• Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice.

  2023cites this paper
• Short-term ketamine use in bipolar depression: a review of the evidence for short-term treatment management

  2023cites this paper
• A systematic review of the incidence of medical serious adverse events in sub-anesthetic ketamine treatment of psychiatric disorders.

  2023cites this paper
• Oral ketamine may offer a solution to the ketamine conundrum

  2023cites this paper
• Brain Derived Neurotrophic Factor Methylation and Long-term Outcomes after Stroke Interacting with Suicidal Ideation

  2023cites this paper
• Bipolar II Disorder: Understudied and Underdiagnosed.

  2023cites this paper
• Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol.

  2023cites this paper
• Ghrelin Modifies the Impact of Life Stress on Suicidality in Patients With Acute Coronary Syndrome

  2023cites this paper
• Antidepressant and anti-suicidal effects of ketamine in treatment-resistant depression associated with psychiatric and personality comorbidities: A double-blind randomized trial.

  2023cites this paper
• A Randomized, Double-Blind, Midazolam-Controlled Trial of Low-Dose Ketamine Infusion in Patients With Treatment-Resistant Depression and Prominent Suicidal Ideation

  2023influential citation
• Acute Effects of Intravenous Sub-Anesthetic Doses of Ketamine and Intranasal Inhaled Esketamine on Suicidal Ideation: A Systematic Review and Meta-Analysis

  2023cites this paper
• Cortical inhibition function is associated with baseline suicidal symptoms and post-ketamine suicidal symptom reduction among patients with treatment-resistant depression and strong suicidal ideation.

  2023cites this paper
• Effect Modification of Cortisol on the Associations Between Obsessive-Compulsive Symptoms on Suicidality in Patients With Acute Coronary Syndrome

  2023cites this paper
• Rethinking the medication management of major depression

  2023cites this paper
• Oral ketamine for depression: An updated systematic review

  2023cites this paper
• Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review

  2023cites this paper
• Ketamine as a Treatment Option for Severe Borderline Personality Disorder: A Case Report.

  2023cites this paper
• Low-dose ketamine infusions for chronic pain management: Does this qualify as evidence-based practice?

  2023cites this paper
• Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome

  2023cites this paper
• The Role of Psychotherapy in the Management of Treatment-Resistant Depression.

  2023cites this paper
• Combinations of dextromethorphan for the treatment of mood disorders - a review of the evidence

  2023cites this paper
• The effects of ketamine on symptoms of depression and anxiety in real-world care settings: A retrospective controlled analysis.

  2023cites this paper
• Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome

  2023cites this paper
• Role of klotho on antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression and suicidal ideation.

  2023cites this paper
• Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions.

  2023cites this paper
• Pharmacotherapy: Ketamine and Esketamine.

  2023cites this paper
• Arketamine, a new rapid-acting antidepressant: A historical review and future directions.

  2022cites this paper
• A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Non-Suicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine.

  2022cites this paper
• An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose ketamine in children with ADNP syndrome

  2022cites this paper
• Early psychiatric referral after attempted suicide helps prevent suicide reattempts: A longitudinal national cohort study in South Korea

  2022cites this paper
• A Pilot Study of Ketamine Infusion after Suicide Attempt: New Frontiers in Treating Acute Suicidality in a Real-World Medical Setting

  2022cites this paper
• Ketamine as a prophylactic resilience-enhancing agent

  2022cites this paper
• International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators

  2022cites this paper
• Past-year hallucinogen use in relation to psychological distress, depression, and suicidality among US adults.

  2022cites this paper
• Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation

  2022cites this paper
• Anhedonia and Suicide.

  2022cites this paper
• SYSTEMATIC REVIEW AND META-ANALYSIS Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis

  2022cites this paper
• Magnetoencephalography biomarkers of suicide attempt history and antidepressant response to ketamine in treatment-resistant major depression.

  2022cites this paper
• Suizidpräventive Effekte von Ketamin und Esketamin

  2022cites this paper
• Time for united action on depression: a Lancet-World Psychiatric Association Commission.

  2022cites this paper
• Ketamine and esketamine for crisis management in patients with depression: Why, whom, and how?

  2022cites this paper
• Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation

  2022cites this paper
• Clinical use of ketamine in psychiatric disorders

  2022cites this paper
• A transdiagnostic systematic review and meta-analysis of ketamine’s anxiolytic effects

  2022cites this paper
• Interaction effects of diabetes and brain-derived neurotrophic factor on suicidal ideation in patients with acute coronary syndrome

  2022cites this paper
• Case report: Medical student types journals during ketamine infusions for suicidal ideation, treatment-resistant depression, post-traumatic stress disorder, and generalized anxiety disorder

  2022cites this paper
• Neural Correlates of the DEEPP (Anti-suicidal Response to Ketamine in Treatment-Resistant Bipolar Depression) Study: Protocol for a Pilot, Open-Label Clinical Trial

  2022cites this paper
• mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression.

  2022cites this paper
• Inpatient suicide in psychiatric settings: Evaluation of current prevention measures

  2022cites this paper
• (Es)Ketamine for Suicidal Ideation and Behavior: Clinical Efficacy

  2022cites this paper
• Serotonin modifies the impact of sleep disturbance on suicidality in patients with acute coronary syndrome

  2022cites this paper
• The effect of ketamine on cognition, anxiety, and social functioning in adults with psychiatric disorders: A systematic review and meta-analysis

  2022influential citation
• A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice

  2022cites this paper
• Trends in Presentations for Suicidal Ideation in an Emergency Department During COVID-19

  2022cites this paper
• Associations of systemic inflammation and social support with suicidal ideation in patients with acute coronary syndrome and stroke.

  2022cites this paper
• Ketamine for suicidality: An umbrella review

  2022cites this paper
• Depression and antidepressant effects of ketamine and its metabolites: The pivotal role of gut microbiota.

  2022cites this paper
• S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway.

  2021cites this paper
• Ketamine in depression and electroconvulsive therapy

  2021cites this paper
• Blinding and expectancy confounds in psychedelic randomized controlled trials

  2021cites this paper
• Evaluating the Role of Ketamine/Esketamine in the Management of Major Depressive Disorder with Suicide Risk

  2021cites this paper
• Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression.

  2021cites this paper