Canine Morphology: Hunting for Genes and Tracking Mutations

In this essay, Abigail Shearin and Elaine Ostrander discuss the proposed genomic mechanisms for the extraordinary level of phenotypic variation observed in the domestic dog and the evidence detailing the variants responsible for the many shapes, sizes, textures, and colors of man's best friend.

• Publication year

  2010

• Venue

  PLoS Biology

• Publication date

  2010-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.1000310PMID 20209140PMCID 2830451
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Linkage Disequilibrium and Demographic History of Wild and Domestic Canids

  2009influential reference
• Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

  2009influential reference
• Fine mapping a locus controlling leg morphology in the domestic dog.

  2009cited by this paper
• An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

  2009cited by this paper
• SNP Based Association Mapping of Dog Stereotypes

  2008cited by this paper
• Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

  2008cited by this paper
• The Complete Dog Book

  2008cited by this paper
• A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development

  2008cited by this paper
• Initial sequence and comparative analysis of the cat genome.

  2007cited by this paper
• Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.

  2007cited by this paper
• A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs

  2007cited by this paper
• Efficient mapping of mendelian traits in dogs through genome-wide association

  2007influential reference
• Lessons learned from the dog genome.

  2007cited by this paper
• Genetics and the Shape of Dogs

  2007cited by this paper
• A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs

  2007cited by this paper
• Faculty Opinions recommendation of Maplike representation of celestial E-vector orientations in the brain of an insect.

  2007cited by this paper
• Elevated basal slippage mutation rates among the Canidae.

  2007cited by this paper
• Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

  2007cited by this paper
• Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans.

  2006cited by this paper
• Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome.

  2006cited by this paper
• Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog

  2006cited by this paper
• Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13

  2006cited by this paper
• Documenting Domestication: New Genetic and Archaeological Paradigms

  2006cited by this paper
• Genetic analysis of dog domestication

  2006cited by this paper
• A molecular phylogeny of the Canidae based on six nuclear loci.

  2005cited by this paper
• The canine genome.

  2005cited by this paper
• SINE exonic insertion in the PTPLA gene leads to multiple splicing defects and segregates with the autosomal recessive centronuclear myopathy in dogs.

  2005cited by this paper
• Genome sequence, comparative analysis and haplotype structure of the domestic dog

  2005influential reference
• Extensive and breed-specific linkage disequilibrium in Canis familiaris.

  2004cited by this paper
• Dog star rising: the canine genetic system

  2004cited by this paper
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution

  2004cited by this paper
• Molecular origins of rapid and continuous morphological evolution

  2004influential reference
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution

  2004influential reference
• Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs

  2004cited by this paper
• The Dog Genome: Survey Sequencing and Comparative Analysis

  2003influential reference
• Genetic basis for systems of skeletal quantitative traits: Principal component analysis of the canid skeleton

  2002cited by this paper
• Genetic Evidence for an East Asian Origin of Domestic Dogs

  2002cited by this paper
• Melanocortin 1 receptor variation in the domestic dog

  2000cited by this paper
• Unleashing the canine genome.

  2000cited by this paper
• Identification of a premature stop codon in the melanocyte-stimulating hormone receptor gene (MC1R) in Labrador and Golden retrievers with yellow coat colour.

  2000cited by this paper
• The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

  1999cited by this paper
• The canine genome.

  1997cited by this paper
• A highly repetitive DNA sequence possibly unique to canids.

  1992cited by this paper

• A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons

  2025cites this paper
• Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype

  2025cites this paper
• Integrative Genotyping and Analysis of Canine Structural Variation Using Long-read and Short-read Data

  2025cites this paper
• Canine models of inherited retinal diseases: from neglect to well-recognized translational value

  2024cites this paper
• Pet Wellness and Vitamin A: A Narrative Overview

  2024cites this paper
• Myxomatous mitral valve disease in Labrador Retrievers and Golden Retrievers.

  2024cites this paper
• The iconographic evolution of Patagonian and Fuegian canids

  2024cites this paper
• The Association between the Abundance of Homozygous Deleterious Variants and the Morbidity of Dog Breeds

  2024cites this paper
• The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds

  2023cites this paper
• Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies

  2022cites this paper
• Towards Forensic DNA Phenotyping for Predicting Visible Traits in Dogs

  2021cites this paper
• Did Dog Domestication Contribute to Language Evolution?

  2021cites this paper
• A computed tomography-based method for the assessment of canine retrobulbar cone volume for ophthalmic anaesthesia.

  2021cites this paper
• A Feedback Loop Between Human Self-Domestication and Dog Domestication Contributing to Language Evolution?

  2020cites this paper
• Dog Coat Colour Genetics: A Review

  2020influential citation
• Hypothalamic transcriptome of tame and aggressive silver foxes (Vulpes vulpes) identifies gene expression differences shared across brain regions

  2020cites this paper
• Deciphering the puzzles of dog domestication

  2020cites this paper
• Pawsitive selection : Genetics of dog-human communication

  2020cites this paper
• Animal domestication in the era of ancient genomics

  2020cites this paper
• University of Birmingham Ontogeny vs. phylogeny in primate/canid comparisons

  2019cites this paper
• Ontogeny vs. Phylogeny in Primate/Canid Comparisons: A Meta-analysis of the Object Choice Task.

  2019cites this paper
• Novel contributions in canine craniometry: Anatomic and radiographic measurements in newborn puppies

  2018cites this paper
• Population Genomics of Domestication and Breed Development in Canines in the Context of Cognitive, Social, Behavioral, and Disease Traits

  2018cites this paper
• Demographic history, selection and functional diversity of the canine genome

  2017cites this paper
• The bald and the beautiful: hairlessness in domestic dog breeds

  2017cites this paper
• Domestication Effects on the Stress Response in Chickens : Genetics, Physiology, and Behaviour

  2017cites this paper
• 13. Croissance, développement post-embryonnaire et régénération

  2017cites this paper
• Developmental Anomalies in Domestic Mammals and the One Health Concept

  2017cites this paper
• The Canine Genome: Discoveries, Applications, and Future Potential

  2016influential citation
• Ethology, ecology and epidemiology of canine aggression

  2016cites this paper
• The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine

  2016cites this paper
• Hand/foot splitting and the ‘re-evolution’ of mesopodial skeletal elements during the evolution and radiation of chameleons

  2015cites this paper
• Insights into morphology and disease from the dog genome project.

  2014cites this paper
• The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters

  2014cites this paper
• Detecting Signatures of Selection within the Dog Genome

  2013cites this paper
• Derived variants at six genes explain nearly half of size reduction in dog breeds

  2013cites this paper
• The Genetics of Canine Skull Shape Variation

  2013cites this paper
• Hundegenom: die Auswirkungen der Domestikation

  2012cites this paper
• Allometry of Sexual Size Dimorphism in Domestic Dog

  2012cites this paper
• The canid genome: behavioral geneticists' best friend?

  2012cites this paper
• Domesticated species form a treasure-trove for molecular characterization of Mendelian traits by exploiting the specific genetic structure of these species in across-breed genome wide association studies

  2012cites this paper
• Evolutionary genomics of dog domestication

  2012cites this paper
• Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels.

  2012cites this paper
• Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping

  2011cites this paper
• The domestic dog: man's best friend in the genomic era

  2011cites this paper
• Quaternary small to large canids in Europe: Taxonomic status and biochronological contribution

  2011cites this paper
• Iconography : The species concept in a long-extinct fossil group, the conodonts

  2011cites this paper
• Identification des signatures génétiques de la sélection chez le chien

  2011cites this paper
• EPILEPSY IN HUMANS , LABORATORY RODENTS AND DOGS : COMPARATIVE GENETIC ASPECTS

  2011cites this paper
• Heritable epigenetic responses to environmental challenges : Effects on behaviour, gene expression and DNA-methylation in the chicken

  2011cites this paper
• Are dogs genetically special?

  2011cites this paper
• Fractal analysis in a systems biology approach to cancer.

  2011cites this paper
• Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug development.

  2011cites this paper
• Statistical Methods And Analysis For Genome-Wide Association Studies

  2010cites this paper