Demographic history, selection and functional diversity of the canine genome

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature reviews genetics

• Publication date

  2017-09-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrg.2017.67PMID 28944780
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development.

  2017cited by this paper
• Deciphering the Origin of Dogs: From Fossils to Genomes.

  2017cited by this paper
• EPAS1 variants in high altitude Tibetan wolves were selectively introgressed into highland dogs

  2017cited by this paper
• Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs

  2017cited by this paper
• Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2

  2017cited by this paper
• An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity

  2016cited by this paper
• Aristaless-Like Homeobox protein 1 (ALX1) variant associated with craniofacial structure and frontonasal dysplasia in Burmese cats.

  2016cited by this paper
• Ancient DNA and human history

  2016cited by this paper
• Diet adaptation in dog reflects spread of prehistoric agriculture

  2016cited by this paper
• Transmissible Tumors: Breaking the Cancer Paradigm.

  2016cited by this paper
• Evidence of selection signatures that shape the Persian cat breed

  2016cited by this paper
• Dogs as a Model for Cancer.

  2016cited by this paper
• Genomic Analysis Reveals Hypoxia Adaptation in the Tibetan Mastiff by Introgression of the Gray Wolf from the Tibetan Plateau

  2016cited by this paper
• Amy2B copy number variation reveals starch diet adaptations in ancient European dogs

  2016cited by this paper
• Identification of genomic variants putatively targeted by selection during dog domestication

  2016cited by this paper
• Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs

  2016cited by this paper
• Complex disease and phenotype mapping in the domestic dog

  2016cited by this paper
• Genomic and archaeological evidence suggest a dual origin of domestic dogs

  2016cited by this paper
• Worldwide patterns of genomic variation and admixture in gray wolves

  2016cited by this paper
• Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog

  2016cited by this paper
• Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer’s Disease: A Translational Study of Neuropathological and Inflammatory Markers

  2016cited by this paper
• Dietary Variation and Evolution of Gene Copy Number among Dog Breeds

  2016cited by this paper
• CRISPR-mediated multiplexed genetic manipulation

  2016cited by this paper
• A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies

  2016cited by this paper
• Genomic Analysis Reveals Hypoxia Adaptation in the Tibetan Mastiff by Introgression of the Gray Wolf from the Tibetan Plateau.

  2016cited by this paper
• Copper toxicosis in non-COMMD1 Bedlington terriers is associated with metal transport gene ABCA12.

  2016cited by this paper
• Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests

  2016cited by this paper
• Selective sweep on human amylase genes postdates the split with Neanderthals

  2016cited by this paper
• Ancient European dog genomes reveal continuity since the Early Neolithic

  2016cited by this paper
• Genetic mapping of canine fear and aggression

  2016cited by this paper
• Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping

  2016cited by this paper
• Combined Growth Hormone and Thyroid-Stimulating Hormone Deficiency in a Japanese Patient with a Novel Frameshift Mutation in IGSF1

  2015cited by this paper
• Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor

  2015cited by this paper
• Genetic structure in village dogs reveals a Central Asian domestication origin

  2015cited by this paper
• Epidemiological associations between brachycephaly and upper respiratory tract disorders in dogs attending veterinary practices in England

  2015cited by this paper
• The Invaders: How Humans and Their Dogs Drove Neanderthals to Extinction. By Pat Shipman. Belknap Press. Cambridge (Massachusetts): Harvard University Press. $29.95. xv + 266 p.; ill.; index. ISBN: 978-0-674-73676-4. 2015.

  2015cited by this paper
• Out of southern East Asia: the natural history of domestic dogs across the world

  2015cited by this paper
• Copy number variations in the amylase gene (AMY2B) in Japanese native dog breeds.

  2015cited by this paper
• The Invaders

  2015cited by this paper
• Cognitive Function, Progression of Age‐related Behavioral Changes, Biomarkers, and Survival in Dogs More Than 8 Years Old

  2015cited by this paper
• Association study between CDH2 and Gilles de la Tourette syndrome in a Danish cohort.

  2015cited by this paper
• "Lassie," "Toto," and fellow pet dogs: poised to lead the way for advances in cancer prevention.

  2015cited by this paper
• Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

  2015cited by this paper
• Diversity of CRISPR-Cas immune systems and molecular machines

  2015cited by this paper
• Generation of gene-target dogs using CRISPR/Cas9 system.

  2015cited by this paper
• The Italian genome reflects the history of Europe and the Mediterranean basin

  2015cited by this paper
• Homozygosity mapping and sequencing identify two genes that might contribute to pointing behavior in hunting dogs

  2015cited by this paper
• Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer—Evidence for a Relevant Model System and Urine-Based Diagnostic Test

  2015cited by this paper
• Ancient wolf genome reveals an early divergence of domestic dog ancestors and admixture into high-latitude breeds.

  2015cited by this paper
• Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer

  2015cited by this paper
• Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

  2015cited by this paper
• A Simple Repeat Polymorphism in the MITF-M Promoter Is a Key Regulator of White Spotting in Dogs

  2014cited by this paper
• Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage

  2014cited by this paper
• Population variation revealed high-altitude adaptation of Tibetan mastiffs.

  2014cited by this paper
• Domestic dogs and cancer research: a breed-based genomics approach.

  2014cited by this paper
• The changing global distribution and prevalence of canine transmissible venereal tumour

  2014cited by this paper
• Genome Sequencing Highlights the Dynamic Early History of Dogs

  2014cited by this paper
• Frequency of somatic BRAF mutations in melanocytic lesions from patients in a CDK4 melanoma family

  2014cited by this paper
• Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder

  2014cited by this paper
• Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau

  2014cited by this paper
• IGSF1 variants in boys with familial delayed puberty

  2014cited by this paper
• Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia

  2014cited by this paper
• Insights into morphology and disease from the dog genome project.

  2014cited by this paper
• Breed-Predispositions to Cancer in Pedigree Dogs

  2013cited by this paper
• An observational study with long-term follow-up of canine cognitive dysfunction: clinical characteristics, survival, and risk factors.

  2013cited by this paper
• Cas9 as a versatile tool for engineering biology

  2013cited by this paper
• A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit

  2013cited by this paper
• Ageing: it's a dog's life.

  2013cited by this paper
• The Size–Life Span Trade-Off Decomposed: Why Large Dogs Die Young

  2013cited by this paper
• The impact of equilibrium assumptions on tests of selection

  2013cited by this paper
• A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats

  2013cited by this paper
• Multiplex Genome Engineering Using CRISPR/Cas Systems

  2013cited by this paper
• Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010).

  2013cited by this paper
• The genomic signature of dog domestication reveals adaptation to a starch-rich diet

  2013cited by this paper
• Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

  2013cited by this paper
• Fine mapping of fatness QTL on porcine chromosome X and analyses of three positional candidate genes

  2013cited by this paper
• The Genetics of Canine Skull Shape Variation

  2013cited by this paper
• Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs

  2013cited by this paper
• Rapid improvement of canine cognitive dysfunction with immunotherapy designed for Alzheimer's disease.

  2013cited by this paper
• A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies.

  2013cited by this paper
• Derived variants at six genes explain nearly half of size reduction in dog breeds

  2013cited by this paper
• Weak Selection and Protein Evolution

  2012cited by this paper
• The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs

  2012cited by this paper
• Telomere length correlates with life span of dog breeds.

  2012cited by this paper
• Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.

  2012cited by this paper
• Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

  2012cited by this paper
• The MTAP-CDKN2A Locus Confers Susceptibility to a Naturally Occurring Canine Cancer

  2012cited by this paper
• Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

  2012cited by this paper
• A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

  2012cited by this paper
• Variation of BMP3 Contributes to Dog Breed Skull Diversity

  2012cited by this paper
• An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

  2012cited by this paper
• The domestic dog: man's best friend in the genomic era

  2011cited by this paper
• Dog models of naturally occurring cancer.

  2011cited by this paper
• Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

  2011cited by this paper
• Association between body mass index and insulin receptor substrate-4 (IRS-4) gene polymorphisms in patients with schizophrenia.

  2011cited by this paper
• Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry

  2011cited by this paper
• An Assessment of the Individual and Collective Effects of Variants on Height Using Twins and a Developmentally Informative Study Design

  2011cited by this paper
• A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs

  2011cited by this paper
• Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs

  2011cited by this paper
• Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping

  2011cited by this paper

• Genetic structure in a previously extirpated population of gray wolves following reintroduction and natural recolonization

  2026cites this paper
• Applied Dog Genomics

  2025cites this paper
• Diversity in chemosensory receptor genes in dogs and wolves: degeneration of the olfactory receptor gene repertoire in the brachycephalic Pug

  2025cites this paper
• Do ostensive verbal signals have a unique importance when communicating with dogs?

  2025cites this paper
• Cryptic diversity and impacts of domestication in the Black Soldier Fly (Hermetia illucens) genome

  2025cites this paper
• Genetic testing predicts appearance but not behavior in dogs

  2025cites this paper
• GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition

  2025cites this paper
• Origen de las razas del perro doméstico Canis lupus familiaris

  2025cites this paper
• OmniExtract: An automatic data extraction tool based on Large Language Model and Prompt Engineering

  2025cites this paper
• A phylogenetic estimate of canine retrotransposition rates based on genome assembly comparisons

  2025cites this paper
• Genetic assessment and Identification of genes related to characterization of Guangdong local goose breeds based on modern and historical genomes

  2025cites this paper
• Genomic infrastructure for cetacean research and conservation: reference genomes for eight families spanning the cetacean tree of life

  2025cites this paper
• Genome‐wide patterns of local adaptation associated with transposable elements in Tetrastigma hemsleyanum (Vitaceae)

  2025cites this paper
• Genomic evidence for behavioral adaptation of herding dogs

  2025cites this paper
• Copy-cat evolution: Divergence and convergence within and between cat and dog breeds

  2025cites this paper
• Polygenic risk score prediction of complex diseases in companion animals: prospects, opportunities, and challenges.

  2025cites this paper
• Analysis of canine gene constraint identifies new variants for orofacial clefts and stature

  2025cites this paper
• Multiple ancestries and shared gene flow among modern livestock guarding dogs

  2024cites this paper
• Lifetime reproductive characteristics of gray wolves

  2024cites this paper
• Understanding the evolution of domestic dogs

  2024influential citation
• Modulating Vertebrate Physiology by Genomic Fine-Tuning of GPCR Functions.

  2024cites this paper
• The iconographic evolution of Patagonian and Fuegian canids

  2024cites this paper
• Roadmap for maternal behavior research in domestic dogs: lessons from decades of laboratory rodent work

  2024cites this paper
• Dogs and their genes: what ever will they think of next?

  2024cites this paper
• Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022

  2024cites this paper
• Towards a Robust Definition of Sport Sex.

  2024cites this paper
• Ethical Concerns about Fashionable Dog Breeding

  2024cites this paper
• Assessment of Y chromosome copy number alterations in non-neoplastic and neoplastic leukocytes of male dogs.

  2024cites this paper
• A High-Quality Blue Whale Genome, Segmental Duplications, and Historical Demography

  2024influential citation
• How does evolutionary evaluation illuminate body size among canids?

  2024cites this paper
• From wolves to humans: oral microbiome resistance to transfer across mammalian hosts

  2024cites this paper
• Anthropogenic hybridization and its influence on the adaptive potential of the Sardinian wild boar (Sus scrofa meridionalis)

  2023cites this paper
• Going beyond established model systems of Alzheimer’s disease: companion animals provide novel insights into the neurobiology of aging

  2023cites this paper
• Psychological Stress Is Associated with Increased Cancer Risk in Dogs

  2023cites this paper
• Genetic dissection of behavioral traits related to successful training of drug detection dogs

  2023cites this paper
• Crystal Structure of a Classical MHC Class I Molecule in Dogs; Comparison of DLA-88*0 and DLA-88*5 Category Molecules

  2023cites this paper
• Fiber type and metabolic characteristics of skeletal muscle in 16 breeds of domestic dogs

  2023cites this paper
• Classification of Dog Breeds Using Convolutional Neural Network Models and Support Vector Machine

  2023cites this paper
• An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

  2023cites this paper
• Dog Life Spans and the Evolution of Aging

  2023cites this paper
• Machine learning prediction and classification of behavioral selection in a canine olfactory detection program

  2023cites this paper
• The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds

  2023cites this paper
• Age, breed, sex and diet influence serum metabolite profiles of 2000 pet dogs

  2022cites this paper
• Artificial Selection Drives SNPs of Olfactory Receptor Genes into Different Working Traits in Labrador Retrievers

  2022cites this paper
• Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog

  2022cites this paper
• Genetic diversity and mate selection in a reintroduced population of gray wolves

  2022cites this paper
• Selection Signatures in Italian Livestock Guardian and Herding Shepherd Dogs

  2022cites this paper
• Are children and dogs best friends? A scoping review to explore the positive and negative effects of child-dog interactions

  2022cites this paper
• Comparison of behavioural tendencies between “dangerous dogs” and other domestic dog breeds – Evolutionary context and practical implications

  2022cites this paper
• Dog models of human atherosclerotic cardiovascular diseases

  2022cites this paper
• Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice

  2022cites this paper
• Offspring sex ratios are male-biased reflecting sex-biased dispersal in Idaho, USA, wolves

  2022cites this paper
• Genomic Assessment of Cancer Susceptibility in the Threatened Catalina Island Fox (Urocyon littoralis catalinae)

  2022cites this paper
• Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains

  2022cites this paper
• DNA methylation clocks for dogs and humans

  2022cites this paper
• Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America

  2022cites this paper
• Human‐modified canids in human‐modified landscapes: The evolutionary consequences of hybridization for grey wolves and free‐ranging domestic dogs

  2021cites this paper
• Crystal structure of the classical MHC-I molecule: insights into the MHC-I system in antiviral diseases in dogs

  2021cites this paper
• Genetics of canine diabetes mellitus part 1: Phenotypes of disease.

  2021cites this paper
• Epigenetic clock and methylation studies in dogs

  2021cites this paper
• Web resource on available DNA variant tests for hereditary diseases and genetic predispositions in dogs and cats: An Update

  2021cites this paper
• Comparing the behaviour of dogs before and after enucleation due to glaucoma.

  2021cites this paper
• The impact of identity by descent on fitness and disease in dogs

  2021cites this paper
• Best practices for analyzing imputed genotypes from low-pass sequencing in dogs

  2021cites this paper
• Genomic Characterization of the Three Balkan Livestock Guardian Dogs

  2021cites this paper
• Enhancing the Selection and Performance of Working Dogs

  2021cites this paper
• The effects of ionizing radiation on domestic dogs: a review of the atomic bomb testing era

  2021cites this paper
• Dog leukocyte antigen (DLA) class II genotypes associated with chronic enteropathy in French bulldogs and miniature dachshunds.

  2021cites this paper
• Genomic inference of contemporary effective population size in a large island population of collared flycatchers (Ficedula albicollis)

  2021cites this paper
• Towards Forensic DNA Phenotyping for Predicting Visible Traits in Dogs

  2021cites this paper
• Whole Genome Sequencing Reveals Signatures for Artificial Selection for Different Sizes in Japanese Primitive Dog Breeds

  2021cites this paper
• Basal and Luminal Molecular Subtypes in Naturally-Occurring Canine Urothelial Carcinoma are Associated with Tumor Immune Signatures and Dog Breed

  2021cites this paper
• Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials

  2021cites this paper
• Acylcarnitine profile in Alaskan sled dogs during submaximal multiday exercise points out metabolic flexibility and liver role in energy metabolism

  2021cites this paper
• Did Dog Domestication Contribute to Language Evolution?

  2021cites this paper
• Imprinting of canine IGF2 and H19.

  2021cites this paper
• Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications

  2021cites this paper
• The Insidious Disorder Hiding Behind Aging: Canine Cognitive Disorder

  2021cites this paper
• LncRNAs in domesticated animals: from dog to livestock species

  2021cites this paper
• A Brief History of the Human–Animal Bond

  2021cites this paper
• Inherit the kingdom or storm the castle? Breeding strategies in a social carnivore

  2021cites this paper
• OP-ICBJ210072 76..92

  2021cites this paper
• Forensic DNA phenotyping: Canis familiaris breed classification and skeletal phenotype prediction using functionally significant skeletal SNPs and indels.

  2021cites this paper
• Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits

  2020cites this paper
• Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

  2020cites this paper
• Genomic diversity and population structure of the Leonberger dog breed

  2020cites this paper
• Genetic testing of dogs predicts problem behaviors in clinical and nonclinical samples

  2020cites this paper
• Long-read assembly of a Great Dane genome highlights the contribution of GC-rich sequence and mobile elements to canine genomes

  2020cites this paper
• Genome scans of diverse dog behaviors implicate a neurodevelopmental gene network in mammalian adaptation and psychopathology

  2020cites this paper
• Genome scans of dog behavior implicate a gene network underlying psychopathology in mammals, including humans

  2020cites this paper
• Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome.

  2020cites this paper
• 863 genomes reveal the origin and domestication of chicken

  2020cites this paper
• AMY2B Gene Copy-Number Variation Studied by Droplet Digital PCR (ddPCR) in Three Canids: Red Fox, Arctic Fox, and Chinese Raccoon Dog

  2020cites this paper
• Use of Microsatellites in Genetic Diversity Assessment, Parentage Testing and Individual Identification of the Kangal Shepherd Dog

  2020cites this paper
• Ancient hybridization with an unknown population facilitated high altitude adaptation of canids.

  2020cites this paper
• Age influences domestic dog cognitive performance independent of average breed lifespan

  2020cites this paper
• A Feedback Loop Between Human Self-Domestication and Dog Domestication Contributing to Language Evolution?

  2020cites this paper
• A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data of Two Methuselah Dogs

  2020cites this paper
• The Journal of Wildlife Management

  2020cites this paper
• Combining Harvest and Genetics to Estimate Reproduction in Wolves

  2020cites this paper