Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Science

• Publication date

  2015-07-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/science.aaa8064PMID 26185250PMCID PMC4854322
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2

  2015cited by this paper
• Neutrophils sense microbial size and selectively release neutrophil extracellular traps in response to large pathogens

  2014cited by this paper
• Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

  2014cited by this paper
• A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

  2014cited by this paper
• Mechanisms and functions of inflammasomes.

  2014cited by this paper
• Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

  2014cited by this paper
• Molecular mechanisms regulating NETosis in infection and disease

  2013cited by this paper
• Aldara activates TLR7-independent immune defence

  2013cited by this paper
• Cholesterol Crystals and Inflammation

  2013cited by this paper
• CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation

  2013cited by this paper
• NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

  2013cited by this paper
• Activation and regulation of the inflammasomes

  2013cited by this paper
• Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

  2012cited by this paper
• TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

  2012cited by this paper
• Role for peptidylarginine deiminase enzymes in disease and female reproduction.

  2012cited by this paper
• Presence of luminal neutrophil extracellular traps in atherosclerosis

  2012cited by this paper
• Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

  2012cited by this paper
• Sensing necrotic cells.

  2012cited by this paper
• Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

  2011cited by this paper
• Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.

  2011cited by this paper
• Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

  2010cited by this paper
• NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease

  2010cited by this paper
• Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

  2010cited by this paper
• Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions.

  2010cited by this paper
• Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

  2010cited by this paper
• The inflammasomes.

  2010cited by this paper
• Intracellular DNA recognition

  2010cited by this paper
• Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

  2009cited by this paper
• CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

  2009cited by this paper
• Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.

  2008cited by this paper
• Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

  2007cited by this paper
• Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

  2006cited by this paper
• MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus.

  2006cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Neutrophil Extracellular Traps Kill Bacteria

  2004cited by this paper
• Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model.

  2002cited by this paper
• Inhibition of the Spontaneous Apoptosis of Neutrophil Granulocytes by the Intracellular Parasite Leishmania major1

  2002cited by this paper
• Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes

  2002cited by this paper
• Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

  1992cited by this paper
• Vascular Biology, Atherosclerosis and Endothelium Biology Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE (cid:1) / (cid:1) Mice

  year unknowncited by this paper

• PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury.

  2026cites this paper
• A dual pH/ROS-sensitive nanoplatform blocking NETs formation and co-delivering paclitaxel for potent therapeutic efficacy against triple-negative breast cancer and lung metastasis.

  2026cites this paper
• Exercise and the hallmarks of cardiovascular aging.

  2026cites this paper
• The Dual Role of 25-Hydroxycholesterol in Atherosclerosis: From Homeostatic Regulation to Plaque Instability.

  2026cites this paper
• Structural characterization of Taiwanofungus camphoratus polysaccharide and its ameliorative effects on myelosuppression and immunosuppression by regulating macrophage activation.

  2026cites this paper
• Immuno‐Neuroprotectants Facilitate Neurological Recovery via Sequestration of Neutrophil Extracellular Traps (NETs) and Promotion of Neuroregeneration

  2026cites this paper
• Subclinical atherosclerosis in rheumatoid arthritis is driven by MicroRNA polymorphisms and NETosis

  2026cites this paper
• Unraveling the role of IL-17 signaling pathway in breast cancer-related depression: insights from in vivo/in vitro models and transcriptomic analysis

  2026cites this paper
• Neutrophils as critical orchestrators of chronic inflammation

  2026cites this paper
• Analytical review of atherosclerosis risk factors

  2026cites this paper
• Self‐Assembled Nanocomplexes of Oligomerized Catechins and Deoxyribonuclease‐I for Synergistically Enhancing Diabetic Wound Healing

  2026cites this paper
• Targeting gut-derived NETosis: A paradigm shift in understanding metformin's therapeutic action.

  2026cites this paper
• Emerging therapeutic pipelines on kidney fibrosis: challenges in translational research.

  2026cites this paper
• A Two Birds with One Stone Strategy: Sialic Acid-Modified Pitavastatin Liposomes for Combating Atherosclerosis and Tumors.

  2026cites this paper
• Neutrophil Extracellular Traps: Potential Therapeutic Targets of Traditional Chinese Medicine and Natural Products for Cardiovascular Diseases

  2026cites this paper
• Recent Advances in Nanodelivery Systems Based on Extracellular and Intracellular Reprogramming Strategies for Enhanced Therapy of Atherosclerosis

  2026cites this paper
• Immunomodulatory strategies and targeted delivery systems in atherosclerosis therapy.

  2026cites this paper
• Evaluating the Link Between High‐Density Lipoprotein‐Related Inflammatory Indices and Gallstone Disease in U.S. Adults

  2026cites this paper
• Fuzheng Jiedu formula attenuates acute pneumonia by coordinated regulation of macrophage NLRP3 inflammasome and neutrophil NETs

  2026cites this paper
• Inflammation in atherosclerosis: Lessons and therapeutic implications.

  2025cites this paper
• Circulating cfdna: A novel biomarker for preventing early recurrence in ischemic stroke.

  2025cites this paper
• Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction

  2025cites this paper
• Formation of neutrophil extracellular traps in the early stages exacerbate the healing process by regulating macrophage polarization in Achilles tendon-bone injury

  2025cites this paper
• Correlation between neutrophil extracellular traps and macrophages in thrombi of patients with acute ischemic stroke

  2025cites this paper
• Heart of the matter: Neutrophils, cancer, and cardiovascular disease.

  2025cites this paper
• Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA

  2025cites this paper
• Colchicine as a Potential Anti-Inflammatory Strategy for Aortic Aneurysm.

  2025cites this paper
• Cholesterol crystal embolization syndrome: Systemic and end-organ injury

  2025cites this paper
• Unveiling the inflammatory messengers after intracerebral hemorrhage: the crosstalk between peripheral NETs and microglia

  2025cites this paper
• Analysis of GSDMD-N abnormality promoting neutrophil NETs mediated RA disease through NLRP3-dependent pathway

  2025cites this paper
• Cholesterol Crystals as Triggers of NLRP3 Inflammasome Activation in Atherosclerosis

  2025cites this paper
• Dual Nature of Neutrophil Extracellular Traps (NETs)—From Cancer’s Ally to Therapeutic Target

  2025cites this paper
• A Bibliometric Analysis of Strategies for Atherosclerosis Treatment with Organic Nanoparticles

  2025cites this paper
• Targeting Inflammation After Acute Myocardial Infarction.

  2025cites this paper
• Targeting Programmed Cell Death as an Innovative Strategy Against Atherosclerosis: Potential of Natural Compound Supplements

  2025cites this paper
• Neutrophil extracellular traps-related markers in chronic limb threatening ischemia - a relation with progression and prognosis.

  2025cites this paper
• The Inflammasome-NETosis Axis: A Critical Pathway in Atherosclerosis Pathogenesis and Therapeutic Targeting

  2025influential citation
• Higher Neutrophil-Percentage-to-Albumin Ratio Was Associated with Poor Outcome in Endovascular Thrombectomy Patients

  2025cites this paper
• NETosis in myocardial ischemia-reperfusion injury: From mechanisms to therapies (Review)

  2025cites this paper
• Mechanisms and immune crosstalk of neutrophil extracellular traps in response to infection

  2025cites this paper
• Exploring the Roles of Liver X Receptors in Lipid Metabolism and Immunity in Atherosclerosis

  2025cites this paper
• Association between neutrophil count and the risk of cardiovascular disease: A community-based cohort study in Taiwan

  2025cites this paper
• Pathological roles of NETs-platelet synergy in thrombotic diseases: From molecular mechanisms to therapeutic targeting.

  2025cites this paper
• Chronic ozone exposure induces hippocampal microglia activation by microbial dysbiosis in rat lungs.

  2025cites this paper
• Neutrophil Extracellular Traps (NETs) in Sterile Inflammatory Diseases

  2025cites this paper
• The flavonoids of Rosa roxburghii Tratt alleviate endotoxemia progression by inhibiting the proinflammatory effects of neutrophil and macrophage via ROS/NLRP3 signaling pathway.

  2025cites this paper
• Neutrophil Extracellular Traps Induce Pyroptosis of Gingival Fibroblasts in Peri-Implantitis.

  2025cites this paper
• Coronary Atherosclerosis and Subclinical Cerebral Small Vessel Disease: A Robust Association Beyond Intracranial Atherosclerosis and Cardiac Systolic Function

  2025cites this paper
• Identification and validation of hub genes related to neutrophil extracellular traps-mediated cell damage and immune recruitment during abdominal aortic aneurysm

  2025cites this paper
• Application of Traditional Chinese Medicine in the different pathological stages of ischemic stroke: Target Immune Cells.

  2025cites this paper
• Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth

  2025cites this paper
• Neutrophil extracellular traps in cardiovascular disease: a bibliometric analysis (2005–2024)

  2025cites this paper
• Association between alopecia areata and cardiovascular disease: a systematic review and meta-analysis

  2025cites this paper
• Neutrophil Extracellular Traps (NETs) as drivers of atherosclerosis: Pathogenic mechanisms and therapeutic opportunities.

  2025cites this paper
• Neutrophil Extracellular Traps in Cardiovascular Diseases: Pathological Roles and Therapeutic Implications

  2025cites this paper
• A comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases

  2025cites this paper
• Biomechanic regulation of neutrophil extracellular traps in the cardiovascular system.

  2025cites this paper
• Decoding neutrophil extracellular traps and key gene drivers in unexplained pregnancy loss

  2025cites this paper
• Anti-inflammatory strategies for patients with atherosclerotic coronary disease

  2025cites this paper
• The Dynamic Expression Changes of Neutrophil Extracellular Traps in Mouse Apical Periodontitis: A Potential Correlation With IL‐17

  2025cites this paper
• Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis

  2025cites this paper
• Harnessing multiomics technologies and machine learning for advancing personalized theranostic approaches in atherosclerosis.

  2025cites this paper
• Exosomes and MicroRNAs: key modulators of macrophage polarization in sepsis pathophysiology

  2025cites this paper
• Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury

  2025cites this paper
• Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment

  2025cites this paper
• Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology

  2025cites this paper
• MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

  2025cites this paper
• Neutrophil Extracellular Traps: Emerging Biomarker and Prototype of Functional Materials

  2025cites this paper
• Neutrophil Hitchhiking‐Mediated Delivery of ROS‐Scavenging Biomimetic Nanoparticles for Enhanced Treatment of Atherosclerosis

  2025cites this paper
• Inflammation-Driven Plaque Erosion in Atherosclerosis: A Focus on Complement System Pathways

  2025cites this paper
• Neutrophil Extracellular Traps in Atherosclerosis: Research Progress

  2025influential citation
• Advancements in the study of short-chain fatty acids and their therapeutic effects on atherosclerosis.

  2025cites this paper
• Comparing the therapeutic influence of bone marrow Mesenchymal stem cells versus its derived exosomes against diabetic hepatopathy in rats.

  2025cites this paper
• The roles of neutrophils in cardiovascular diseases

  2025cites this paper
• A patent review of peptidylarginine deiminase 4 (PAD4) inhibitors (2014–present)

  2025cites this paper
• The Role of Neutrophil Extracellular Traps in Atherosclerosis: From the Molecular to the Clinical Level

  2025influential citation
• Is L‐Arginine an Appropriate Alternative for Conventional Anti‐Atherosclerotic Therapy?: A Comprehensive Review

  2025cites this paper
• Saturated fatty acid-induced neutrophil extracellular traps contribute to exacerbation and biologic therapy resistance in obesity-related psoriasis

  2025cites this paper
• Polymeric Nanomaterials for Atherosclerosis Diagnosis and Treatment

  2025cites this paper
• NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance

  2025cites this paper
• Deep insight into cytokine storm: from pathogenesis to treatment

  2025cites this paper
• Anti-β2glycoprotein I-induced neutrophil extracellular traps cause endothelial activation

  2025cites this paper
• Unraveling the significance of innate inflammation in vascular disease

  2025cites this paper
• Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets

  2025cites this paper
• Role of Hemoglobin-Stimulated Macrophages and Intraplaque Hemorrhage in the Development of Vascular Diseases.

  2025cites this paper
• Metabolic reprograming of immune cells in MASH.

  2025cites this paper
• Neutrophil extracellular traps (NETs): Relevance to thrombosis and hemostasis. A narrative review

  2025cites this paper
• Activated Immune and Complement C3 Are Potential Contributors in MASH via Stimulating Neutrophil Extracellular Traps

  2025cites this paper
• Targeting Neutrophil Extracellular Traps: A New Strategy for the Treatment of Acute Ischemic Stroke Based on Thrombolysis Resistance

  2025cites this paper
• Targeted nanosystems reshape the inflammatory immune microenvironment by integrated cholesterol crystal dissolution with lymphatic drainage restoration for atherosclerosis treatment

  2025cites this paper
• Integration analysis of transcriptomics revealed NETosis heterogeneity and Ncf1 as a prognostic biomarker in neutrophil asthma.

  2025cites this paper
• Interleukin-17 family in health and immune diseases: From origin to clinical implications

  2025cites this paper
• A new insight: crosstalk between neutrophil extracellular traps and the gut-liver axis for nonalcoholic fatty liver disease

  2025cites this paper
• Impact of resveratrol on neutrophil extracellular traps.

  2025cites this paper
• Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications

  2025cites this paper
• Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

  2025cites this paper
• Wearable, self-cleaning, ultrathin and flexible biosensor with automatic sweat processing capability for non-invasive cytokine monitoring

  2025cites this paper
• Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation

  2025cites this paper
• Sex-dependent effects of peptidylarginine deiminases on neutrophil function and long-term outcomes after spinal cord injury.

  2025cites this paper
• Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease

  2025cites this paper