The neuroprotective role of TERT via an antiapoptotic mechanism in neonatal rats after hypoxia-ischemia brain injury.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neuroscience Letters

• Publication date

  2012-04-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neulet.2012.03.014PMID 22446191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.

  2011cited by this paper
• Telomerase Reverse Transcriptase Upregulation Attenuates Astrocyte Proliferation and Promotes Neuronal Survival in the Hypoxic–Ischemic Rat Brain

  2011cited by this paper
• Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

  2011cited by this paper
• Neuroprotection Against Hypoxic-Ischemic Brain Injury by Inhibiting the Apoptotic Protease Activating Factor-1 Pathway

  2010cited by this paper
• [Telomerase reverse transcriptase expression and cell apoptosis during hypoxia ischemia brain damage in neonatal rats].

  2010cited by this paper
• Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia

  2010cited by this paper
• [Protective effect of conditioned medium from astrocytes transfected with telomerase reverse transcriptase on hypoxia-ischemia neurons].

  2010cited by this paper
• Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

  2009cited by this paper
• Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

  2008cited by this paper
• [The role of HIF-1alpha in neuronal apoptosis after hypoxia/hypoxia ischemia brain damage in neonatal rats].

  2008cited by this paper
• The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

  2005cited by this paper
• Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

  2004cited by this paper
• Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity

  2004cited by this paper
• Mitochondrial hTERT exacerbates free‐radical‐mediated mtDNA damage

  2004cited by this paper
• hTERT associates with human telomeres and enhances genomic stability and DNA repair

  2003cited by this paper
• Telomerase as a Growth-Promoting Factor

  2003cited by this paper
• Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

  2003cited by this paper
• Telomerase protects developing neurons against DNA damage-induced cell death.

  2001cited by this paper
• Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

  2001cited by this paper
• The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis.

  2000cited by this paper
• The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function

  2000cited by this paper
• The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

  2000cited by this paper
• Apoptosis Has a Prolonged Role in the Neurodegeneration after Hypoxic Ischemia in the Newborn Rat

  2000cited by this paper
• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia.

  1998cited by this paper
• Telomerase activity, cell proliferation, and cancer.

  1998cited by this paper
• Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats.

  1997cited by this paper
• The influence of immaturity on hypoxic‐ischemic brain damage in the rat

  1981cited by this paper

• Neuroprotection and safety profile of Astragalus membranaceus extract TA-65 in neonatal hypoxic-ischemic brain damage by activating mitochondrial telomerase reverse transcriptase: Evidence from in vitro and in vivo studies.

  2025cites this paper
• Potential roles of telomeres and telomerase in neurodegenerative diseases

  2024cites this paper
• The neuro-protective role of telomerase via TERT/TERF-2 in the acute phase of spinal cord injury

  2023cites this paper
• Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage

  2022cites this paper
• Potential roles of telomeres and telomerase in neurodegenerative diseases.

  2020cites this paper
• [Expression and role of Pim1 in cultured cortical neurons with oxygen-glucose deprivation/reoxygen injury].

  2020cites this paper
• Effect of carbamylated erythropoietin on neuronal apoptosis in fetal rats during intrauterine hypoxic-ischemic encephalopathy

  2019cites this paper
• TERT inhibition leads to reduction of IL‐6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model

  2019cites this paper
• Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage

  2019cites this paper
• RETRACTED: Cerebellar fastigial nucleus electrical stimulatin protects against cerebral ischemic damage by upregulating telomerase activity

  2019cites this paper
• Down-regulation of telomerase reverse transcriptase-related anti-apoptotic function in a rat model of acrylamide induced neurobehavioral deficits

  2018cites this paper
• Effects of hUCB-MSCs on recovery of neurological function and TERT expression in brain tissue of rats with cerebral ischemia-reperfusion injury

  2017cites this paper
• [Effect of telomerase activation on biological behaviors of neural stem cells in rats with hypoxic-ischemic insults].

  2017cites this paper
• miR-30d-5p Plays an Important Role in Autophagy and Apoptosis in Developing Rat Brains After Hypoxic–Ischemic Injury

  2017cites this paper
• The Role of Telomere Maintenance in Adult Mammalian Acute Central Nervous System Injury and Retinal Ganglion Cell Apoptosis

  2016cites this paper
• [The neuroprotective role of exogenous TERT gene in neonatal rats with hypoxic-ischemic brain damage].

  2016cites this paper
• Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system.

  2016cites this paper
• Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons

  2016cites this paper
• PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression.

  2015influential citation
• Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage

  2015cites this paper
• Umbilical cord blood mesenchymal stem cells co‐modified by TERT and BDNF: A novel neuroprotective therapy for neonatal hypoxic‐ischemic brain damage

  2014cites this paper
• Autophagy in the brain of neonates following hypoxia-ischemia shows sex- and region-specific effects.

  2014cites this paper
• Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damage

  2014cites this paper
• The neuroprotective role and mechanisms of TERT in neurons with oxygen-glucose deprivation.

  2013cites this paper