Neuroprotection Against Hypoxic-Ischemic Brain Injury by Inhibiting the Apoptotic Protease Activating Factor-1 Pathway

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Stroke

• Publication date

  2010-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/STROKEAHA.109.561852PMID 19910549PMCID PMC2799533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper

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  2018cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2011cites this paper
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