Sample Sizes for Clinical Trials

Sample Sizes for Clinical Trials-Steven A. Julious 2009-08-26 Drawing on various real-world applications, Sample Sizes for Clinical Trials takes readers through the process of calculating sample sizes for many types of clinical trials. It provides descriptions of the calculations with a practical emphasis. Focusing on normal, binary, ordinal, and survival data, the book explores a range of trials, including superiority, equivalence, non-inferiority, bioequivalence, and precision for both parallel group and crossover designs. The author discusses how trial objectives impact the study design with respect to the derivation of formulae for sample size calculations. He uses real-life studies throughout to show how the concepts and calculations can be employed. This work underscores the importance of sample size calculation in the design of a clinical trial. With useful calculation tables throughout, it enables readers to quickly find an appropriate formula, formula application, and associated worked example. Watch the author speak about this book at JSM 2012 in San Diego.

• Publication year

  2024

• Venue

  Journal of the Royal Statistical Society: Series A (Statistics in Society)

• Publication date

  2024-10-08

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1093/jrsssa/qnae100
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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