Targeting Human Papillomavirus Type 16 E7 to the Endosomal/Lysosomal Compartment Enhances the Antitumor Immunity of DNA Vaccines against Murine Human Papillomavirus Type 16 E7-Expressing Tumors

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Human Gene Therapy

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/10430349950016474PMID 10584920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
• Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

  1997influential reference
• Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

  1996cited by this paper
• Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

  1996cited by this paper
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  1996cited by this paper
• DNA–based immunization by in vivo transfection of dendritic cells

  1996cited by this paper
• Exposing the immunology of naked DNA vaccines.

  1995cited by this paper
• Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells.

  1995cited by this paper
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  1995cited by this paper
• The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif.

  1995cited by this paper
• Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.

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• Potential DNA Vaccine Integration into Host Cell Genome

  1995cited by this paper
• Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens.

  1994cited by this paper
• Immunology of the human papilloma virus in relation to cancer.

  1994influential reference
• Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

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• Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

  1993cited by this paper
• DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

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  1993cited by this paper
• Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

  1993influential reference
• Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

  1992cited by this paper
• Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.

  1991cited by this paper
• A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes.

  1991cited by this paper
• Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail

  1990cited by this paper
• Identification of two lysosomal membrane glycoproteins

  1985cited by this paper
• Glycoproteins of the lysosomal membrane

  1985cited by this paper

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