A rush to judgment on Th17

Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role of Th17 cytokines as the central mediators of pathological tissue damage seems to require clarification.

• Publication year

  2008

• Venue

  Journal of Experimental Medicine

• Publication date

  2008-07-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20072066PMID 18591407PMCID 2442627
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells

  2008cited by this paper
• Type 1 interferons cool the inflamed brain.

  2008cited by this paper
• Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

  2008cited by this paper
• Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells.

  2008cited by this paper
• A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

  2008cited by this paper
• IL‐17 receptor signaling influences virus‐induced corneal inflammation

  2008cited by this paper
• Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

  2008cited by this paper
• Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities1

  2008cited by this paper
• Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

  2008cited by this paper
• The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

  2008cited by this paper
• IL-21 and TGF-β are required for differentiation of human TH17 cells

  2008cited by this paper
• IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

  2008cited by this paper
• Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

  2008cited by this paper
• Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

  2008cited by this paper
• Development, cytokine profile and function of human interleukin 17–producing helper T cells

  2007cited by this paper
• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

  2007cited by this paper
• Recombination: an underappreciated factor in the evolution of plant genomes

  2007cited by this paper
• Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

  2007cited by this paper
• TH-17 cells in the circle of immunity and autoimmunity

  2007cited by this paper
• A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

  2007cited by this paper
• Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.

  2007cited by this paper
• T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.

  2007cited by this paper
• Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

  2007cited by this paper
• Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.

  2007cited by this paper
• Systemic lupus erythematosus: all roads lead to type I interferons.

  2006cited by this paper
• Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease

  2006cited by this paper
• Molecular characterization of human adenomyosis.

  2006cited by this paper
• Origins of the T(H)1-T(H)2 model: a personal perspective.

  2006cited by this paper
• Interleukin-17 is a negative regulator of established allergic asthma

  2006cited by this paper
• Interleukin-23 drives innate and T cell–mediated intestinal inflammation

  2006cited by this paper
• IL-23 plays a key role in Helicobacter hepaticus–induced T cell–dependent colitis

  2006cited by this paper
• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  2006cited by this paper
• Origins of the TH1-TH2 model: a personal perspective

  2006cited by this paper
• Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis

  2004cited by this paper
• Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes.

  2004cited by this paper
• Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

  2002cited by this paper
• Cutting Edge: Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice1

  2002cited by this paper
• The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease

  2001cited by this paper
• Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

  2001cited by this paper
• A Role for IL-12 Receptor Expression and Signal Transduction in Host Defense in Leprosy1

  2001cited by this paper
• A novel transcription factor, T-bet, directs Th1 lineage commitment.

  2000cited by this paper
• Immunologic therapy of multiple sclerosis.

  1999cited by this paper
• IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.

  1997cited by this paper
• Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

  1997cited by this paper
• Mouse IL-17: A Cytokine Preferentially Expressed by αβTCR+CD4—CD8— T Cells

  1996cited by this paper
• Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.

  1996cited by this paper
• Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

  1996cited by this paper
• Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

  1996cited by this paper
• Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

  1994cited by this paper
• Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon‐gamma in Lewis rats

  1990cited by this paper
• Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

  1988cited by this paper
• Treatment of multiple sclerosis with gamma interferon

  1987cited by this paper
• EncephalomyelitisDevelopment of Experimental Autoimmune IL-17 Plays an Important Role in the

  year unknowncited by this paper

• The Development of Systemic Inflammatory Diseases in Hidradenitis Suppurativa

  2023cites this paper
• Th17 Cells Contribute to the Pathology of Autoimmune Hypophysitis

  2021cites this paper
• Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review.

  2021cites this paper
• B7-H3: A promising therapeutic target for autoimmune diseases.

  2020cites this paper
• Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis.

  2020cites this paper
• Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.

  2019cites this paper
• Roles of Factor XII in Innate Immunity

  2019cites this paper
• 4 The Role of T Cells in Type 1 Diabetes

  2018cites this paper
• Aberrant IL‐35 levels in patients with primary Sjogren's syndrome

  2018cites this paper
• Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity.

  2018cites this paper
• Regulatory immune cells and functions in autoimmunity and transplantation immunology.

  2017cites this paper
• Molecular Genetic and Epigenetic Basis of Multiple Sclerosis.

  2017cites this paper
• Technology Medicine Open Access book

  2017cites this paper
• Evaluation of Bone Mineral Density in Children with Type I Diabetes Mellitus and Relationship to Serum Levels of Osteopontin

  2017cites this paper
• Increased expression of interleukin-17A in the lesional skin indicates increase of serum antibody anti-phenolic glycolipid-I in leprosy patients

  2017cites this paper
• Primary Immunoprevention of Epithelial Ovarian Carcinoma by Vaccination against the Extracellular Domain of Anti-Müllerian Hormone Receptor II

  2017cites this paper
• Lung Injury and Loss of Regulatory T Cells Primes for Lung-Restricted Autoimmunity.

  2017cites this paper
• Immune Dysregulation in Multiple Sclerosis

  2016cites this paper
• Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

  2016cites this paper
• The Yin and Yang of Innate Lymphoid Cells in Cancer.

  2016cites this paper
• Immunology of Multiple Sclerosis

  2016cites this paper
• Selected Aspects in the Pathogenesis of Autoimmune Diseases

  2015cites this paper
• Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals

  2015cites this paper
• Cytokine Milieu in Undifferentiated Connective Tissue Disease: a Comprehensive Review

  2015cites this paper
• Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis

  2015cites this paper
• The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

  2015cites this paper
• Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors.

  2015cites this paper
• specific for U1-70 in lupus and mixed connective tissue disease

  2015cites this paper
• Tetramers reveal IL-17–secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease

  2015cites this paper
• Kirenol Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Differentiation of Th1 and Th17 Cells and Inducing Apoptosis of Effector T Cells

  2015cites this paper
• Human GI Tract Microbiota in Health and Disease: A Focus on Inflammatory Bowel Diseases

  2015cites this paper
• IL-33 attenuates the development of experimental autoimmune uveitis

  2014cites this paper
• Immunologic Biomarkers for Clinical and Therapeutic Management of Psoriasis

  2014cites this paper
• Development of Central Nervous System Autoimmunity Is Impaired in the Absence of Wiskott-Aldrich Syndrome Protein

  2014cites this paper
• Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells.

  2014cites this paper
• The good and the bad of neuroinflammation in multiple sclerosis.

  2014cites this paper
• Evaluating the Interleukin 17 Serum Level in Psoriatic Patients from the Eastern Egyptian Population

  2014cites this paper
• The risk of herpes zoster during biological therapy for psoriasis and other inflammatory conditions

  2014cites this paper
• Boswellic acids reduce Th17 differentiation via blockade of IL‐1β‐mediated IRAK1 signaling

  2014cites this paper
• Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.

  2014cites this paper
• LPS and IL‐1 differentially activate mouse and human astrocytes: Role of CD14

  2014cites this paper
• Vitamin A is not associated with exacerbations in multiple sclerosis.

  2014cites this paper
• Prostaglandin E Receptor Subtypes EP2 and EP4 Promote TH1 Cell Differentiation and TH17 Cell Expansion Through Different Signaling Modules

  2014cites this paper
• Neuromyelitis Optica Spectrum Disorders

  2014cites this paper
• The Regulatory Roles Of Traf4 Il-17 Receptor Mediated Signaling And Disease Pathology

  2014cites this paper
• Interleukin-10 Superfamily and Cancer

  2014cites this paper
• Developmental endothelial locus-1 (Del-1) is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination

  2014cites this paper
• MYELOID CELLS IN AUTOIMMUNE DISEASES

  2014cites this paper
• The Role of miRNAs in Multiple sclerosis

  2014cites this paper
• Hematopoietic progenitor populations for cell therapy of autoimmune diseases : characterization and comparison of their mechanism of action in Type I Diabetes and Experimental Autoimmune Encephalomyelitis

  2014cites this paper
• The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

  2013cites this paper
• Serum levels of IL-17A in patients with relapsing–remitting multiple sclerosis treated with interferon-β

  2013cites this paper
• Inverse relationship of serum IL-17 with type-II diabetes retinopathy.

  2013cites this paper
• Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis.

  2013cites this paper
• Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

  2013cites this paper
• Epigenetic changes in patients with multiple sclerosis

  2013cites this paper
• AntiIL12/IL23 treatment for a psoriatic patient with heart failure

  2013cites this paper
• β remitting multiple sclerosis treated with interferon-− Serum levels of IL-17 A in patients with relapsing

  2013cites this paper
• Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders.

  2013cites this paper
• Effect of narrow-band ultraviolet B on the level of interleukin-17 in psoriasis patients

  2013cites this paper
• Additive effect of prostaglandin E2 and adenosine in mouse experimental autoimmune encephalomyelitis.

  2013cites this paper
• MicroRNA Regulation in Multiple Sclerosis

  2013cites this paper
• Investigating the role of Th17 cells in the initiation and chronification of autoimmune CNS demyelination

  2013cites this paper
• Elevated CD8 + IL-17 + Tc17 Levels and Their Correlation with Disease Activity in Patients with Rheumatoid Arthritis

  2013cites this paper
• Mechanisms of allergic diseases

  2013cites this paper
• Anti­IL­12/IL­23 treatment for a psoriatic patient with heart failure

  2013cites this paper
• Nitric Oxide–Induced Regulatory T Cells Inhibit Th17 but Not Th1 Cell Differentiation and Function

  2013cites this paper
• Immune aspects of the pathogenesis of inflammatory bowel disease.

  2013cites this paper
• Investigation of osteopontin levels and genomic variation of osteopontin and its receptors in Type 1 diabetes mellitus

  2013cites this paper
• Molecular mechanisms of apoptosis induced by dexamethasone in chronic lymphocytic leukemia

  2012cites this paper
• Lithium Controls Central Nervous System Autoimmunity through Modulation of IFN-γ Signaling

  2012cites this paper
• Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis.

  2012cites this paper
• Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

  2012cites this paper
• MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis

  2012cites this paper
• Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells

  2012influential citation
• IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils

  2012cites this paper
• Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation

  2012cites this paper
• Prostaglandins and chronic inflammation.

  2012cites this paper
• RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation

  2012cites this paper
• IL-17/IFN-γ Interactions Regulate Intestinal Inflammation in TNBS-Induced Acute Colitis

  2012cites this paper
• The roles of Galectin-3 in autoimmunity and tumor progression

  2012cites this paper
• [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis].

  2012cites this paper
• IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway.

  2012cites this paper
• Immunovirological parameters and cytokines in HIV infection.

  2012cites this paper
• Involvement of IL-1R/TLR signalling in experimental autoimmune encephalomyelitis and multiple sclerosis.

  2012cites this paper
• Immunological Abnormalities in the Pathogenesis of Inflammatory Bowel Disease

  2012cites this paper
• The Role of Genetics and Immune Mechanisms in the Pathogenesis of Diabetic Retinopathy

  2012influential citation
• Mechanisms underlying immunomodulation of HIV-1-specific T-cell responses

  2012cites this paper
• Caractérisation des propriétés anti-inflammatoires de souches commensales de Streptococcus salivarius

  2012cites this paper
• Activation des cellules rétiniennes lors d'uvéites autoimmunes expérimentales: rôle des cytokines pro-inflammatoires et effet du transfert du gène SOCS1

  2012cites this paper
• IL‐33 attenuates EAE by suppressing IL‐17 and IFN‐γ production and inducing alternatively activated macrophages

  2012cites this paper
• IL-17 receptor signaling and Th17-mediated autoimmune demyelinating disease

  2012cites this paper
• The roles of Galectin-3 in autoimmunity and tumor progression

  2012cites this paper
• The Role of T Cells in Type 1 Diabetes

  2012cites this paper
• This information is current as Suppression The Resurrection of T Cell-Mediated

  2011cites this paper
• Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism

  2011cites this paper
• Ustekinumab: differential use in psoriasis

  2011cites this paper
• Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice.

  2011cites this paper
• Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice

  2011cites this paper
• Role of NK cells in DC-based immunotherapy of melanoma

  2011cites this paper