Triangulating a Cognitive Control Network Using Diffusion-Weighted Magnetic Resonance Imaging (MRI) and Functional MRI

The ability to stop motor responses depends critically on the right inferior frontal cortex (IFC) and also engages a midbrain region consistent with the subthalamic nucleus (STN). Here we used diffusion-weighted imaging (DWI) tractography to show that the IFC and the STN region are connected via a white matter tract, which could underlie a “hyperdirect” pathway for basal ganglia control. Using a novel method of “triangulation” analysis of tractography data, we also found that both the IFC and the STN region are connected with the presupplementary motor area (preSMA). We hypothesized that the preSMA could play a conflict detection/resolution role within a network between the preSMA, the IFC, and the STN region. A second experiment tested this idea with functional magnetic resonance imaging (fMRI) using a conditional stop-signal paradigm, enabling examination of behavioral and neural signatures of conflict-induced slowing. The preSMA, IFC, and STN region were significantly activated the greater the conflict-induced slowing. Activation corresponded strongly with spatial foci predicted by the DWI tract analysis, as well as with foci activated by complete response inhibition. The results illustrate how tractography can reveal connections that are verifiable with fMRI. The results also demonstrate a three-way functional–anatomical network in the right hemisphere that could either brake or completely stop responses.

• Publication year

  2007

• Venue

  Journal of Neuroscience

• Publication date

  2007-04-04

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.0519-07.2007PMID 17409238PMCID PMC6672420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The Neural Basis of Inhibition in Cognitive Control

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• Switching from automatic to controlled action by monkey medial frontal cortex

  2007influential reference
• Dissociation of response inhibition and performance monitoring in the stop signal task using event‐related fMRI

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  2006influential reference
• Individual differences in the functional neuroanatomy of inhibitory control.

  2006cited by this paper
• Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making

  2006influential reference
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  2005cited by this paper
• Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent.

  2004cited by this paper
• The neural basis of error detection: conflict monitoring and the error-related negativity.

  2004influential reference
• Inhibition and the right inferior frontal cortex.

  2004cited by this paper
• Conflict monitoring and anterior cingulate cortex: an update.

  2004influential reference
• The Role of the Medial Frontal Cortex in Cognitive Control

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• Is the subthalamic nucleus hypointense on T2-weighted images? A correlation study using MR imaging and stereotactic atlas data.

  2004cited by this paper
• Action sets and decisions in the medial frontal cortex.

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• Stimulation of STN impairs aspects of cognitive control in PD

  2004cited by this paper
• Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance.

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• Detection power, estimation efficiency, and predictability in event-related fMRI.

  2001cited by this paper
• Cognitive and emotional influences in anterior cingulate cortex.

  2000influential reference
• Prefrontal–cingulate interactions in action monitoring

  2000influential reference
• Corticostriatal and corticosubthalamic input zones from the presupplementary motor area in the macaque monkey: comparison with the input zones from the supplementary motor area.

  1999cited by this paper
• Prefrontal cortex regulates inhibition and excitation in distributed neural networks.

  1999cited by this paper
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  1997influential reference
• The basal ganglia: focused selection and inhibition of competing motor programs.

  1996influential reference
• Strategies and mechanisms in nonselective and selective inhibitory motor control.

  1995cited by this paper
• Functional organization of human supplementary motor cortex studied by electrical stimulation

  1991cited by this paper
• Localization of Cortical Function: New Information from Extraoperative Monitoring of Patients with Epilepsy

  1988cited by this paper
• On the ability to inhibit thought and action

  1984cited by this paper
• The Prefrontal Cortex: Anatomy, Physiology and Neuropsychology of the Frontal Lobe

  1982cited by this paper
• The supplementary motor area of the cerebral cortex; a clinical and experimental study.

  1951cited by this paper
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  year unknowncited by this paper

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