Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  JCI Insight

• Publication date

  2017-05-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/jci.insight.92872PMID 28469084PMCID PMC5414559
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance

  2016cited by this paper
• Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.

  2016cited by this paper
• A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal Antibodies

  2016cited by this paper
• Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification

  2015cited by this paper
• Global control of hepatitis C virus

  2015cited by this paper
• Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance.

  2015cited by this paper
• Mechanism of human antibody-mediated neutralization of Marburg virus.

  2015cited by this paper
• Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

  2015cited by this paper
• Community Outbreak of HIV Infection Linked to Injection Drug Use of Oxymorphone — Indiana, 2015

  2015cited by this paper
• Increases in Hepatitis C Virus Infection Related to Injection Drug Use Among Persons Aged ≤30 Years — Kentucky, Tennessee, Virginia, and West Virginia, 2006–2012

  2015cited by this paper
• Antibody responses to envelope glycoproteins in HIV-1 infection

  2015cited by this paper
• Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity

  2014cited by this paper
• Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

  2014cited by this paper
• B-cell repertoire responses to varicella-zoster vaccination in human identical twins

  2014cited by this paper
• Broadly neutralizing antibodies abrogate established hepatitis C virus infection

  2014cited by this paper
• A high‐throughput shotgun mutagenesis approach to mapping B‐cell antibody epitopes

  2014cited by this paper
• Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006-2012.

  2014cited by this paper
• Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

  2013cited by this paper
• Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

  2013cited by this paper
• Global epidemiology of hepatitis C virus infection: New estimates of age‐specific antibody to HCV seroprevalence

  2013cited by this paper
• Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

  2013cited by this paper
• Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

  2012cited by this paper
• Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

  2012cited by this paper
• Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

  2012cited by this paper
• Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

  2012cited by this paper
• Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

  2012cited by this paper
• Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1

  2012cited by this paper
• IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences.

  2011cited by this paper
• Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations

  2011cited by this paper
• Atomic-level mapping of antibody epitopes on a GPCR.

  2009cited by this paper
• Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

  2009cited by this paper
• Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

  2009cited by this paper
• Development and characterization of hepatitis C virus genotype 1‐7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

  2009cited by this paper
• Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus.

  2009cited by this paper
• Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

  2008cited by this paper
• An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies.

  2008cited by this paper
• IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

  2008cited by this paper
• Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

  2008cited by this paper
• A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope

  2008cited by this paper
• Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

  2008cited by this paper
• Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus

  2007cited by this paper
• Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

  2007cited by this paper
• Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding

  2006cited by this paper
• Pvclust: an R package for assessing the uncertainty in hierarchical clustering

  2006cited by this paper
• Prospective evaluation of community-acquired acute-phase hepatitis C virus infection.

  2005cited by this paper
• Neutralizing antibody response during acute and chronic hepatitis C virus infection.

  2004cited by this paper
• Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

  2003cited by this paper
• Evolutionary distance estimation under heterogeneous substitution pattern among lineages.

  2002cited by this paper
• Corrgrams

  2002cited by this paper
• V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen.

  2001cited by this paper
• The Epidemic Behavior of the Hepatitis C Virus

  2001cited by this paper
• Human Monoclonal Antibodies That Inhibit Binding of Hepatitis C Virus E2 Protein to CD81 and Recognize Conserved Conformational Epitopes

  2000cited by this paper
• Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.

  1993cited by this paper
• Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

  1992cited by this paper

• Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent

  2026cites this paper
• mAbClust with AlphaFold 3 avoids hallucinations to define a quaternary broadly neutralizing HCV epitope

  2026cites this paper
• Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.

  2026cites this paper
• Structural repertoire of HCV broadly neutralizing antibodies targeting the E2 front layer supersite.

  2026cites this paper
• Structural Repertoire of HCV Broadly Neutralizing Antibodies Targeting the E2 Front Layer Supersite

  2025cites this paper
• Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity

  2025cites this paper
• Broadly Neutralizing Antibody Characteristics in Hepatitis C Virus Infection and Implications for Vaccine Design

  2025influential citation
• Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers

  2025cites this paper
• Structural basis for hepatitis E virus neutralization by potent human antibodies

  2025cites this paper
• Public antibodies: convergent signatures in human humoral immunity against pathogens

  2025cites this paper
• Anti-HCV antibodies: A battle for breadth and potency.

  2025cites this paper
• Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity

  2025cites this paper
• Norway rat hepacivirus resembles hepatitis C virus in terms of intra-host evolution and escape from neutralizing antibodies.

  2025cites this paper
• Towards an HCV vaccine: an overview of the immunization strategies for eliciting an effective B-cell response

  2025cites this paper
• Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques

  2025cites this paper
• The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages

  2025cites this paper
• Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein

  2025cites this paper
• Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.

  2025cites this paper
• Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein

  2024cites this paper
• Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

  2024cites this paper
• Sustained Long-Term Decline in Anti-HCV Neutralizing Antibodies in HIV/HCV-Coinfected Patients Five Years after HCV Therapy: A Retrospective Study

  2024cites this paper
• Exploring T-Cell Immunity to Hepatitis C Virus: Insights from Different Vaccine and Antigen Presentation Strategies

  2024cites this paper
• Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection

  2024cites this paper
• Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine Development

  2024cites this paper
• Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance.

  2024cites this paper
• Characterization of antibody‐dependent cellular phagocytosis in patients infected with hepatitis C virus with different clinical outcomes

  2024cites this paper
• The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus

  2023cites this paper
• Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

  2023cites this paper
• Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

  2023cites this paper
• Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

  2023cites this paper
• Microorganisms-derived antigens for preventive anti-cancer vaccines.

  2023cites this paper
• Current Hepatitis C Vaccine Candidates Based on the Induction of Neutralizing Antibodies

  2023cites this paper
• Application of germline antibody features to vaccine development, antibody discovery, antibody optimization and disease diagnosis.

  2023cites this paper
• Convergent antibody responses are associated with broad neutralization of hepatitis C virus

  2023cites this paper
• Hepatitis C virus hypervariable region 1 antibodies interrupt E2-SR-B1 interaction to suppress viral infection.

  2023cites this paper
• Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor

  2023cites this paper
• Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection.

  2023cites this paper
• Functional antibodies exhibit light chain coherence

  2022cites this paper
• Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

  2022cites this paper
• Human Antibodies for Viral Infections.

  2022cites this paper
• Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

  2022cites this paper
• Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants

  2022cites this paper
• Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen specificity

  2022cites this paper
• Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

  2022cites this paper
• The Neutralizing Antibody Responses of Individuals That Spontaneously Resolve Hepatitis C Virus Infection

  2022influential citation
• Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

  2022cites this paper
• B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection

  2022cites this paper
• Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening.

  2022cites this paper
• Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potency

  2022cites this paper
• Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis.

  2022cites this paper
• Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity

  2021cites this paper
• Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion.

  2021cites this paper
• Vaccines against hepatitis C: a travel into neutralisation space

  2021cites this paper
• Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

  2021cites this paper
• Evolutionary modelling of HCV subtypes provides rationale for their different disease outcomes

  2021cites this paper
• Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins.

  2021cites this paper
• To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity

  2021cites this paper
• Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

  2021cites this paper
• From Structural Studies to HCV Vaccine Design

  2021cites this paper
• Structural and Biophysical Characterization of the HCV E1E2 Heterodimer for Vaccine Development

  2021cites this paper
• Potent germline-like monoclonal antibodies: rapid identification of promising candidates for antibody-based antiviral therapy

  2021cites this paper
• Where to Next? Research Directions after the First Hepatitis C Vaccine Efficacy Trial

  2021cites this paper
• Mechanisms of HCV resistance to broadly neutralizing antibodies.

  2021cites this paper
• Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

  2021cites this paper
• A Tale of Two Viruses: Immunological Insights Into HCV/HIV Coinfection

  2021cites this paper
• Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback

  2021cites this paper
• Hepatitis C Virus Vaccine Research: Time to Put Up or Shut Up

  2021cites this paper
• Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

  2021cites this paper
• An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development

  2021cites this paper
• In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet?

  2021cites this paper
• B cell clonal expansion is correlated with antigen-specificity in young but not old mice

  2021cites this paper
• Evolutionary modeling reveals enhanced mutational flexibility of HCV subtype 1b compared with 1a

  2021influential citation
• Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.

  2021cites this paper
• Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with hepatitis C virus envelope glycoproteins

  2021influential citation
• Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization

  2020cites this paper
• Hepatitis C virus vaccine design: focus on the humoral immune response

  2020cites this paper
• SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in ‘lasso’ for the multi-faced virus

  2020cites this paper
• Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

  2020cites this paper
• HCV Glycoprotein Structure and Implications for B-Cell Vaccine Development

  2020cites this paper
• Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71

  2020cites this paper
• An entropic safety catch controls hepatitis C virus entry and antibody resistance

  2020cites this paper
• Camel milk is a neglected source of brucellosis among rural Arab communities

  2020cites this paper
• Antibody Responses in Hepatitis C Infection.

  2020influential citation
• Anti‐envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection

  2020cites this paper
• Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody

  2020cites this paper
• Hepatitis C Virus Vaccine: Challenges and Prospects

  2020cites this paper
• Broadly neutralizing antibodies against hepatitis C virus: location, location, location.

  2020cites this paper
• Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

  2020cites this paper
• Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development

  2020cites this paper
• Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection

  2020cites this paper
• Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

  2020cites this paper
• Defective circulating and intrahepatic B cells in chronic HBV

  2019cites this paper
• Current Progress and Challenges in the Development of a Hepatitis C Virus Vaccine

  2019cites this paper
• Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development.

  2019cites this paper
• Hepatitis C Virus Protocols

  2019influential citation
• B cell immunodominance in primary hepatitis C virus infection.

  2019cites this paper
• Challenges and Promise of a Hepatitis C Virus Vaccine.

  2019cites this paper
• Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies

  2019cites this paper
• Rational design of hepatitis C virus E2 core nanoparticle vaccines

  2019cites this paper
• Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR

  2019cites this paper