Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis

Zrzavy et al. analyse the phenotype of microglia in evolving lesions from patients with multiple sclerosis. Microglia lose their homeostatic phenotype in active lesions and express activation markers functionally related to tissue injury. Macrophages in the lesions are derived in part from resident microglia and in part from recruited myeloid cells.

• Publication year

  2017

• Venue

  Brain : a journal of neurology

• Publication date

  2017-05-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/brain/awx113PMID 28541408PMCID 6057548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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