Glycolytic enzymes localize to synapses under energy stress to support synaptic function

No abstract is available for this paper.

• Publication year

  2016

• Venue

  bioRxiv

• Publication date

  2016-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1101/042002PMID 27068791PMCID PMC4840048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites.

  2016cited by this paper
• Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria

  2015cited by this paper
• Regulation of mitochondrial transport in neurons.

  2015cited by this paper
• Disturbed mitochondrial dynamics and neurodegenerative disorders

  2015cited by this paper
• Axons degenerate in the absence of mitochondria in C. elegans.

  2014cited by this paper
• The Structural and Functional Coordination of Glycolytic Enzymes in Muscle: Evidence of a Metabolon?

  2014cited by this paper
• Activity-driven local ATP synthesis is required for synaptic function.

  2014influential reference
• Mitochondrial trafficking in neurons.

  2013influential reference
• Brain energy metabolism

  2013cited by this paper
• Serotonergic Neurosecretory Synapse Targeting Is Controlled by Netrin-Releasing Guidepost Neurons in Caenorhabditis elegans

  2013cited by this paper
• Synapse location during growth depends on glia location.

  2013cited by this paper
• Vesicular glycolysis provides on-board energy for fast axonal transport.

  2013cited by this paper
• Identification of the Components of a Glycolytic Enzyme Metabolon on the Human Red Blood Cell Membrane*

  2012cited by this paper
• Synaptic energy use and supply.

  2012cited by this paper
• Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

  2011cited by this paper
• KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells

  2011cited by this paper
• Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.

  2010cited by this paper
• Regional aerobic glycolysis in the human brain

  2010cited by this paper
• Graded synaptic transmission at the Caenorhabditis elegans neuromuscular junction

  2009influential reference
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans

  2009cited by this paper
• Synaptic Vesicle-bound Pyruvate Kinase can Support Vesicular Glutamate Uptake

  2009cited by this paper
• Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice.

  2008cited by this paper
• Episodic swimming behavior in the nematode C. elegans

  2008cited by this paper
• Bmc Developmental Biology Developmental Genetics of the C. Elegans Pharyngeal Neurons Nsml and Nsmr

  2008cited by this paper
• The synaptic vesicle proteome

  2007influential reference
• Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans

  2007cited by this paper
• Metabolic functions of glycosomes in trypanosomatids.

  2006cited by this paper
• Overexpression of caveolin‐1 results in increased plasma membrane targeting of glycolytic enzymes: The structural basis for a membrane associated metabolic compartment

  2006cited by this paper
• Factors regulating the abundance and localization of synaptobrevin in the plasma membrane.

  2006cited by this paper
• Identification of Genes Involved in Synaptogenesis Using a Fluorescent Active Zone Marker in Caenorhabditis elegans

  2005cited by this paper
• Systematic analysis of genes required for synapse structure and function

  2005cited by this paper
• BMC Genomics BioMed Central Methodology article Rapid single nucleotide polymorphism mapping in C. elegans

  2005cited by this paper
• Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia.

  2005cited by this paper
• The Caenorhabditis elegans lev‐8 gene encodes a novel type of nicotinic acetylcholine receptor α subunit

  2005influential reference
• Addiction research in a simple animal model: the nematode Caenorhabditis elegans.

  2004cited by this paper
• Coverslip hypoxia: a novel method for studying cardiac myocyte hypoxia and ischemia in vitro.

  2004influential reference
• The GABA nervous system in C. elegans.

  2004cited by this paper
• Glyceraldehyde-3-Phosphate Dehydrogenase Is a GABAA Receptor Kinase Linking Glycolysis to Neuronal Inhibition

  2004cited by this paper
• A Drosophila Temperature-Sensitive Seizure Mutant in Phosphoglycerate Kinase Disrupts ATP Generation and Alters Synaptic Function

  2004influential reference
• The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans.

  2003cited by this paper
• Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.

  2003cited by this paper
• Enzymes of Glycolysis Are Functionally Associated with the Mitochondrion in Arabidopsis Cells Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.012500.

  2003cited by this paper
• Mitochondria and release at hippocampal synapses

  2003cited by this paper
• Analysis of glycolytic enzyme co-localization in Drosophila flight muscle

  2003cited by this paper
• Glycolysis and Glutamate Accumulation into Synaptic Vesicles ROLE OF GLYCERALDEHYDE PHOSPHATE DEHYDROGENASE AND 3-PHOSPHOGLYCERATE KINASE*

  2003cited by this paper
• Glycolysis and Glutamate Accumulation into Synaptic Vesicles

  2003cited by this paper
• SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans

  2002cited by this paper
• Cooperation and Competition in the Evolution of ATP-Producing Pathways

  2001cited by this paper
• Glycolysis in Neurons, Not Astrocytes, Delays Oxidative Metabolism of Human Visual Cortex during Sustained Checkerboard Stimulation in vivo

  2001cited by this paper
• Three-Dimensional Comparison of Ultrastructural Characteristics at Depressing and Facilitating Synapses onto Cerebellar Purkinje Cells

  2001cited by this paper
• rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.

  2000cited by this paper
• Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

  2000cited by this paper
• Subcellular localization of aldolase B

  2000cited by this paper
• C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.

  1999cited by this paper
• UNC-13 is required for synaptic vesicle fusion in C. elegans

  1999influential reference
• The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans

  1999influential reference
• One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction

  1999cited by this paper
• elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer

  1999cited by this paper
• Macromolecular design of permselective membranes

  1999influential reference
• The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide.

  1997cited by this paper
• [Brain energy metabolism].

  1997cited by this paper
• Flight muscle function in Drosophila requires colocalization of glycolytic enzymes.

  1997influential reference
• Mobility of Synaptic Vesicles in Nerve Endings Monitored by Recovery from Photobleaching of Synaptic Vesicle-Associated Fluorescence

  1996cited by this paper
• The effects of temperature, pH, and magnesium on the diffusion coefficient of ATP in solutions of physiological ionic strength.

  1996cited by this paper
• Cognitive function during insulin-induced hypoglycemia in humans: short-term cerebral adaptation does not occur

  1995cited by this paper
• Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur

  1995cited by this paper
• Where is the glycolytic complex? A critical evaluation of present data from muscle tissue

  1991cited by this paper
• Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.

  1991cited by this paper
• Cellular differentiation and the microcompartmentation of glycolysis.

  1991cited by this paper
• Biological sciences

  1990cited by this paper
• Anoxia produces smaller changes in synaptic transmission, membrane potential, and input resistance in immature rat hippocampus.

  1989cited by this paper
• DNA transformation.

  1988cited by this paper
• The structure of the nervous system of the nematode Caenorhabditis elegans.

  1986cited by this paper
• Supramolecular organization of glycolytic enzymes.

  1985influential reference
• Glycolytic enzyme levels in synaptosomes.

  1985influential reference
• [The organization of metabolism : subcellular localization of glycolytic enzymes].

  1985influential reference
• Interactions between glycolytic enzymes and components of the cytomatrix

  1984cited by this paper
• Interaction of muscle glycolytic enzymes with thin filament proteins.

  1981cited by this paper
• Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis.

  1981cited by this paper
• Design of glycolysis.

  1981cited by this paper
• The journal of neuroscience : the official journal of the Society for Neuroscience.

  1981cited by this paper
• Interaction of Selected Brain Glycolytic Enzymes with an F‐Actin‐Tropomyosin Complex

  1980cited by this paper
• Compartmentation of glycolytic enzymes in nerve endings as determined by glutaraldehyde fixation.

  1980cited by this paper
• Association of glycolytic enzymes with particulate fractions from nerve endings.

  1978cited by this paper
• The tentative identification in Escherichia coli of a multienzyme complex with glycolytic activity.

  1976cited by this paper
• On the association of glycolytic enzymes with structural proteins of skeletal muscle.

  1975influential reference
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• The metabolic function of oxygen and biochemical lesions of hypoxia.

  1972cited by this paper
• Effect of sodium azide on oxidation and phosphorylation processes in rat-liver mitochondria

  1966cited by this paper
• Effects of Oligomycin on Respiration and Swelling of Isolated Liver Mitochondria

  1961cited by this paper
• The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues.

  1954cited by this paper
• THE METABOLISM OF TUMORS

  1931cited by this paper
• THE METABOLISM OF TUMORS IN THE BODY

  1927cited by this paper

• Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition.

  2026cites this paper
• Mitochondrial Ca2+ Signaling at the Tripartite Synapse: A Unifying Framework for Glutamate Homeostasis, Metabolic Coupling, and Network Vulnerability

  2026cites this paper
• Advances in sleep research based on the Caenorhabditis elegans: an intestinal microbiota perspective and cutting-edge technology applications.

  2026cites this paper
• Mitochondrial specialization and signaling shape neuronal function.

  2026cites this paper
• Phosphofructokinase in Glycolysis: Bridging Enzymology and Cell Biology.

  2026cites this paper
• Asymmetric distribution of mitochondrial Ca2+ regulators specifies compartment-specific mitochondrial function and neuronal development

  2025cites this paper
• HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients

  2025cites this paper
• Functional requirements of the liver isoform of phosphofructokinase-1 in breast cancer cell migration

  2025cites this paper
• Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity

  2025cites this paper
• Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

  2025cites this paper
• Cellular view of metabolism: metabolic biomolecular condensates

  2025cites this paper
• Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression

  2025cites this paper
• Phase-Separated Dual-Enzyme protein condensates promote biodegradation of polyethylene terephthalate and phthalate Plasticizers.

  2025cites this paper
• Spatial Partitioning of Core Glycolysis Enables Tissue-Specific Metabolic Programs In Vivo

  2025cites this paper
• The influence of peripheral glucose on sleep brain oscillations

  2025cites this paper
• The role of glycolytic condensates in the cellular stress response during cancer progression.

  2025cites this paper
• Mitochondrial membrane junction-mediated ATP channeling drives activity-dependent glucose metabolism

  2025cites this paper
• Glycogen supports glycolytic plasticity in neurons

  2025cites this paper
• Activity-dependent citrate dynamics in neurons.

  2025cites this paper
• Phase Separation Regulates Metabolism, Mitochondria, and Diseases

  2025cites this paper
• Designer Glycolysomes: Colocalisation of Glycolytic Enzymes on a Cellulosome‐Based Synthetic Protein Scaffold

  2025cites this paper
• Drosophila HS dendrites are resilient to adult-onset deficits in mitochondrial dynamics

  2025cites this paper
• Two-metal ion mechanism of DNA cleavage by activated, filamentous SgrAI

  2024cites this paper
• Synaptic sabotage: How Tau and α-Synuclein undermine synaptic health.

  2024cites this paper
• Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?

  2024cites this paper
• TPM4 condensates glycolytic enzymes and facilitates actin reorganization under hyperosmotic stress

  2024cites this paper
• Organization of a functional glycolytic metabolon on mitochondria for metabolic efficiency

  2024cites this paper
• Artificial Compartments Encapsulating Enzymatic Reactions: Towards the Construction of Artificial Organelles.

  2024cites this paper
• Brain energy metabolism: A roadmap for future research

  2024cites this paper
• Glycolysis: A multifaceted metabolic pathway and signaling hub

  2024cites this paper
• Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors

  2024cites this paper
• Ribosome External Electric Field Regulates Metabolic Enzyme Activity: The RAMBO Effect

  2024cites this paper
• TPM4 condensates glycolytic enzymes to fuel actin reorganization under hyperosmotic stress

  2024cites this paper
• Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions

  2024cites this paper
• O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production

  2024cites this paper
• Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species

  2024cites this paper
• Glycolytic enzymes form membrane-less condensates in the malaria parasite Plasmodium falciparum by sensing glucose levels

  2024cites this paper
• Neuronal glycolysis: focus on developmental morphogenesis and localized subcellular functions

  2024cites this paper
• Enhancing tumor-infiltrating T cells with an exclusive fuel source

  2024cites this paper
• Protein aggregation and biomolecular condensation in hypoxic environments (Review)

  2024cites this paper
• Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophrenia

  2024cites this paper
• Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP

  2024cites this paper
• Local and dynamic regulation of neuronal glycolysis in vivo

  2024cites this paper
• Self-organizing glycolytic waves fuel cell migration and cancer progression

  2024cites this paper
• Structural basis for allosteric regulation of human phosphofructokinase-1

  2024cites this paper
• Structural basis for allosteric regulation of human phosphofructokinase-1

  2024cites this paper
• Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner

  2024cites this paper
• VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity

  2024cites this paper
• Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage

  2023cites this paper
• A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport

  2023cites this paper
• Optogenetic control of neural activity: The biophysics of microbial rhodopsins in neuroscience

  2023cites this paper
• Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

  2023cites this paper
• Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation

  2023cites this paper
• Functional Organization of Glycolytic Metabolon on Mitochondria

  2023influential citation
• Glycolytic Metabolon Assembly on Mitochondria via Hexokinase O-GlcNAcylation Promotes Metabolic Efficiency

  2023cites this paper
• Site-Specific Crosslinking Reveals Phosphofructokinase-L Inhibition Drives Self-Assembly and Attenuation of Protein Interactions

  2023cites this paper
• Anti-seizure effect of 2-deoxyglucose (2-DG) is not dependent on the presynaptic vacuole ATP pump (V-ATPase) or the somatic ATP-sensitive K+ channel (KATP).

  2023cites this paper
• Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

  2023cites this paper
• Foci-forming regions of pyruvate kinase and enolase at the molecular surface incorporate proteins into yeast cytoplasmic metabolic enzymes transiently assembling (META) bodies

  2023cites this paper
• Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons: Potential Involvement of Inflammation

  2023cites this paper
• Hypoxia induces a glycolytic complex in intestinal epithelial cells independent of HIF-1-driven glycolytic gene expression

  2023cites this paper
• The metabolic state of the heart regulates mitochondrial supercomplex abundance in mice

  2023cites this paper
• Energy metabolic pathways in neuronal development and function

  2023cites this paper
• Oligodendrocyte-derived transcellular signaling regulates axonal energy metabolism.

  2023cites this paper
• VAP spatially stabilizes dendritic mitochondria to locally fuel synaptic plasticity

  2023cites this paper
• Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation

  2023cites this paper
• O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans

  2023cites this paper
• Local and dynamic regulation of neuronal glycolysis in vivo

  2023cites this paper
• Synaptic modifications transform neural networks to function without oxygen

  2023cites this paper
• Protein condensation diseases: therapeutic opportunities

  2022cites this paper
• Evaluation of nanoplastics toxicity in the soil nematode Caenorhabditis elegans by iTRAQ-based quantitative proteomics.

  2022cites this paper
• Glycolysis regulates neuronal excitability via lactate receptor, HCA1R.

  2022cites this paper
• TGF-β-Upregulated Lnc-Nr6a1 Acts as a Reservoir of miR-181 and Mediates Assembly of a Glycolytic Complex

  2022cites this paper
• Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport

  2022cites this paper
• Biomolecular Condensation: A New Phase in Cancer Research

  2022cites this paper
• Mitochondrial heterogeneity and homeostasis through the lens of a neuron

  2022cites this paper
• Isoflurane inhibition of endocytosis is an anesthetic mechanism of action.

  2022cites this paper
• BrainPhys Neuronal Media Support Physiological Function of Mitochondria in Mouse Primary Neuronal Cultures

  2022cites this paper
• Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells

  2022cites this paper
• Enzyme Trafficking and Co-Clustering Precede and Accurately Predict Human Breast Cancer Recurrences: An Interdisciplinary Review.

  2022cites this paper
• Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate

  2022cites this paper
• Mitochondrial form and function in hair cells

  2022cites this paper
• Emerging evidence for compromised axonal bioenergetics and axoglial metabolic coupling as drivers of neurodegeneration.

  2022cites this paper
• A Ribosomal Perspective on Neuronal Local Protein Synthesis

  2022cites this paper
• Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

  2022cites this paper
• Neuron‐glia (mis)interactions in brain energy metabolism during aging

  2022cites this paper
• Schizophrenia: a disorder of broken brain bioenergetics

  2022cites this paper
• Research Progress on the Function of Chk2 Protein

  2022cites this paper
• Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion.

  2022influential citation
• Condensate Formation by Metabolic Enzymes in Saccharomyces cerevisiae

  2022cites this paper
• Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

  2022cites this paper
• A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents

  2022cites this paper
• Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease

  2022cites this paper
• Synapses: The Brain’s Energy-Demanding Sites

  2022cites this paper
• Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease.

  2021cites this paper
• The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics

  2021cites this paper
• Regulation | Metabolite Channeling in Energy Metabolism

  2021cites this paper
• Neurons undergo pathogenic metabolic reprograming in models of familial ALS

  2021cites this paper
• Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand

  2021cites this paper
• Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

  2021cites this paper