Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development

O-2A progenitor cells give rise to both oligodendrocytes and type-2 astrocytes in vitro. Whereas oligodendrocyte differentiation occurs constitutively, type-2 astrocyte differentiation requires extracellular signals, one of which is thought to be ciliary neurotrophic factor (CNTF). CNTF, however, is insufficient by itself to induce the development of stable type-2 astrocytes. In this report we show the following: (a) that molecules associated with the extracellular matrix (ECM) cooperate with CNTF to induce stable type-2 astrocyte differentiation in serum-free cultures. The combination of CNTF and the ECM-associated molecules thus mimics the effect of FCS, which has been shown previously to induce stable type-2 astrocyte differentiation in vitro. (b) Both the ECM-associated molecules and CNTF act directly on O- 2A progenitor cells and can induce them to differentiate prematurely into type-2 astrocytes. (c) ECM-associated molecules also inhibit oligodendrocyte differentiation, even in the absence of CNTF, but this inhibition is not sufficient on its own to induce type-2 astrocyte differentiation. (d) Whereas the effect of ECM on oligodendrocyte differentiation is mimicked by basic fibroblast growth factor (bFGF), the effect of ECM on type-2 astrocyte differentiation is not. (e) The ECM-associated molecules that are responsible for inhibiting oligodendrocyte differentiation and for cooperating with CNTF to induce type-2 astrocyte differentiation are made by non-glial cells in vitro. (f) Molecules that have these activities and bind to ECM are present in the optic nerve at the time type-2 astrocytes are thought to be developing.

• Publication year

  1990

• Venue

  Journal of Cell Biology

• Publication date

  1990-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.111.2.635PMID 2199462PMCID 2116219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of the cell-cell interactions that control type-2 astrocyte development in vitro.

  1990cited by this paper
• Domains of laminin with growth-factor activity.

  1989cited by this paper
• Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

  1989cited by this paper
• PDGF and intracellular signaling in the timing of oligodendrocyte differentiation

  1989cited by this paper
• Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins

  1989cited by this paper
• Fibronectin inhibits the terminal differentiation of human keratinocytes

  1989cited by this paper
• Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells

  1989cited by this paper
• Glial cell diversification in the rat optic nerve.

  1989cited by this paper
• A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.

  1988cited by this paper
• Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell.

  1988cited by this paper
• Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

  1988cited by this paper
• Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

  1988cited by this paper
• Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: a sequence of events in sympathetic development.

  1988cited by this paper
• Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation

  1988cited by this paper
• Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astrocytes.

  1988cited by this paper
• Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

  1987influential reference
• In vivo effect of brain‐derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

  1987cited by this paper
• An inducer protein may control the timing of fate switching in a bipotential glial progenitor cell in rat optic nerve.

  1987cited by this paper
• Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

  1987cited by this paper
• Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells in vitro: implications for a role of heparinase-like enzymes in the neovascular response.

  1987cited by this paper
• Metabolically inactive 3T3 cells can substitute for marrow stromal cells to promote the proliferation and development of multipotent haemopoietic stem cells

  1987cited by this paper
• Purification of adult rat sciatic nerve ciliary neuronotrophic factor.

  1986cited by this paper
• Heparin protects basic and acidic FGF from inactivation

  1986cited by this paper
• Differentiation of a bipotential glial progenitor cell in single cell microculture

  1985cited by this paper
• A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: in vivo evidence for two distinct astrocyte lineages.

  1985cited by this paper
• Macroglial cell development in embryonic rat brain: studies using monoclonal antibodies, fluorescence activated cell sorting, and cell culture.

  1985cited by this paper
• A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

  1983cited by this paper
• Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

  1982cited by this paper
• Astrocytes, ependymal cells, and oligodendrocytes develop on schedule in dissociated cell cultures of embryonic rat brain.

  1981cited by this paper
• Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture.

  1979cited by this paper
• Monoclonal antibody to a plasma membrane antigen of neurons.

  1979cited by this paper
• Laminin--a glycoprotein from basement membranes.

  1979cited by this paper
• Thy-1 antigen on astrocytes in long-term cultures of rat central nervous system

  1979cited by this paper
• Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

  1979cited by this paper
• Glycosaminoglycans and their binding to biological macromolecules.

  1978cited by this paper
• Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence.

  1972cited by this paper

• Research progress of ciliary neurotrophic factors

  2024cites this paper
• Astrocyte-like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells and is capable of forming neuron-like cells after ischemic injury

  2023cites this paper
• Astrocyte‐like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells

  2023cites this paper
• Effect of NK-5962 on Gene Expression Profiling of Retina in a Rat Model of Retinitis Pigmentosa

  2021cites this paper
• Molecular signature of extracellular matrix pathology in schizophrenia

  2020cites this paper
• Glial Differentiation Of Human Umbilical Stem Cells In 2 d And 3 d Environments 2011

  2018cites this paper
• Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-line3 Retinitis Pigmentosa Model

  2016cites this paper
• Studies of integrins' lateral dynamics at a single particle level

  2014cites this paper
• Role of insulin receptor and insulin signaling on αPS2CβPS integrins’ lateral diffusion

  2014cites this paper
• Design of cell culture substrates for large-scale preparation of neural cells

  2013cites this paper
• A perspective on the role of the extracellular matrix in progressive retinal degenerative disorders.

  2013cites this paper
• Zac1 Regulates Astroglial Differentiation of Neural Stem Cells Through Socs3

  2013cites this paper
• Enhancing remyelination in disease--can we wrap it up?

  2011cites this paper
• Oligodendrocyte Progenitors Reversibly Exit the Cell Cycle and Give Rise to Astrocytes in Response to Interferon-γ

  2011influential citation
• Array-based functional screening of growth factors toward optimizing neural stem cell microenvironments.

  2011cites this paper
• The effects of CNTF and BMP on neural stem cell differentiation

  2011cites this paper
• Glial Differentiation Of Human Umbilical Stem Cells In 2d And 3d Environments

  2011cites this paper
• Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes

  2009cites this paper
• Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

  2008cites this paper
• Zellkulturtechniken, Zellmodelle und Tissue Engineering

  2008cites this paper
• Ocular extracellular matrices in development.

  2007cites this paper
• Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein.

  2006cites this paper
• Inflammatory Complexities in the CNS: New Insights into the Effects of Intracellular Redox State and Viral Infection in Modulating the Biology of Oligodendrocytes and Their Precursor Cells

  2005cites this paper
• Effects of Ciliary Neurotrophic Factor on Differentiation of Late Retinal Progenitor Cells

  2005cites this paper
• Effects of Glial Transplantation on Functional Recovery following Acute Spinal Cord Injury

  2005cites this paper
• A role for Noggin in the development of oligodendrocyte precursor cells.

  2004cites this paper
• Chapter 11 – Oligodendroglial Lineage

  2004cites this paper
• Enhancement of Oligodendrocyte Differentiation from Murine Embryonic Stem Cells by an Activator of gp130 Signaling

  2004cites this paper
• Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS.

  2003cites this paper
• Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment.

  2003influential citation
• STATs in the Central Nervous System

  2003cites this paper
• Regulation of oligodendrocyte development in the vertebrate CNS.

  2002cites this paper
• Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells.

  2002cites this paper
• Cells and Signaling in Oligodendrocyte Development

  2002cites this paper
• Influence of cell density and thyroid hormone on glial cell development in primary cultures of embryonic rat cerebral hemisphere

  2002influential citation
• Mitogen‐activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG‐4

  2001cites this paper
• In vitro expression and regulation of ciliary neurotrophic factor and its alpha receptor subunit in neonatal rat olfactory ensheathing cells.

  2001cites this paper
• Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis.

  2001cites this paper
• Modulation of Human Leukocyte Antigen and Intracellular Adhesion Molecule—1 Surface Expression in Malignant and Nonmalignant Human Thyroid Cells by Cytokines in the Context of Extracellular Matrix

  2000cites this paper
• Human polyomavirus JCV and expression of myelin genes.

  2000cites this paper
• Activity of growth factors in the IL-6 group in the differentiation of human lung adenocarcinoma

  2000cites this paper
• Developmental changes in neural progenitor cell lineage commitment do not depend on epidermal growth factor receptor signaling

  2000cites this paper
• Cytokines that Signal Through the Leukemia Inhibitory Factor Receptor‐β Complex in the Nervous System

  2000cites this paper
• Purification and Characterization of Astrocyte Precursor Cells in the Developing Rat Optic Nerve

  1999cites this paper
• Neurogenesis in the developing neural tube

  1999cites this paper
• Astrocytes induce oligodendrocyte processes to align with and adhere to axons.

  1999cites this paper
• Regenerative potential of adult O1+ oligodendrocytes

  1999cites this paper
• Neuregulin is a mitogen and survival factor for olfactory bulb ensheathing cells and an isoform is produced by astrocytes

  1999cites this paper
• Genetic Regulatory Elements Introduced Into Neural Stem and Progenitor Cell Populations

  1999influential citation
• Gene Transfer Approaches to the Lysosomal Storage Disorders

  1999cites this paper
• Ciliary neurotrophic factor protects hippocampal neurons from excitotoxic damage.

  1999cites this paper
• Trophic and tropic factors in the development of the central nervous system.

  1998cites this paper
• The human polyomavirus, JCV, and neurological diseases (review).

  1998cites this paper
• Axonal Versus Dendritic Outgrowth Is Differentially Affected by Radial Glia in Discrete Layers of the Retina

  1998cites this paper
• Multiple Routes to Astrocytic Differentiation in the CNS

  1998cites this paper
• Regulation of oligodendrocyte development

  1998cites this paper
• Cytokines which signal through the LIF receptor and their actions in the nervous system.

  1997cites this paper
• Neural precursor cells: applications for the study and repair of the central nervous system.

  1997cites this paper
• Zellkulturtechniken und Zellmodelle

  1997cites this paper
• Bone Morphogenetic Proteins Induce Astroglial Differentiation of Oligodendroglial–Astroglial Progenitor Cells

  1997cites this paper
• Glial lineages and myelination in the central nervous system.

  1997cites this paper
• Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells.

  1997cites this paper
• Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

  1997cites this paper
• Isolation, cloning and characterization of a putative type-1 astrocyte cell line.

  1997cites this paper
• Review: Glial lineages and myelination in the central nervous system

  1997cites this paper
• CNTF induces GFAP in a S-100α brain cell population: the pattern of CNTF-αR suggests an indirect mode of action

  1997cites this paper
• Growth factors and myelin regeneration in multiple sclerosis

  1997cites this paper
• CNTF induces GFAP in a S-100 alpha brain cell population: the pattern of CNTF-alpha R suggests an indirect mode of action.

  1997cites this paper
• Regulation of Oligodendrocyte Development by the LIF Cytokine Subfamily: Studies of the Neonatal Lineage Cultured from Rat Cerebrum

  1997cites this paper
• Fate determination and migration of progenitors in the postnatal mammalian CNS.

  1997cites this paper
• Ciliary Neurotrophic Factor Activates JAK/Stat Signal Transduction Cascade and Induces Transcriptional Expression of Glial Fibrillary Acidic Protein in Glial Cells

  1997cites this paper
• Characterization of focal adhesion assembly in XR1 glial cells

  1997cites this paper
• Glial ontogeny and glial neoplasia: The search for closure

  1997cites this paper
• Microglial ramification requires nondiffusible factors derived from astrocytes.

  1996cites this paper
• Characteristic Localization of gpl30 (the Signal‐transducing Receptor Component Used in Common for IL‐6/IL‐11/CNTF/LIF/OSM) in the Rat Brain

  1996cites this paper
• Leukaemia Inhibitory Factor or Related Factors Promote the Differentiation of Neuronal and Astrocytic Precursors within the Developing Murine Spinal Cord

  1996cites this paper
• Effects of ciliary neurotrophic factor on retrograde cell reaction after facial nerve crush in young adult rats.

  1996cites this paper
• Chapter 15 – Astroglial neurotrophic and neurite-promoting factors

  1996cites this paper
• Complementary distribution of collagen type IV and the epidermal growth factor receptor in the rat embryonic telencephalon.

  1996cites this paper
• Regulation of oligodendrocyte cell survival and differentiation by ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, and interleukin-6.

  1996cites this paper
• Microencapsulated ciliary neurotrophic factor: physical properties and biological activities.

  1996cites this paper
• STAT proteins are activated by ciliary neurotrophic factor in cells of central nervous system origin

  1996cites this paper
• Physiological effects of CNTF-induced wasting.

  1996cites this paper
• A study of the requirement for LIF receptor in mouse development and embryonic stem cell self-renewal

  1996cites this paper
• N-cadherin expression and function in cultured oligodendrocytes.

  1996cites this paper
• The 9E3/CEF4 cytokine: kinetics of secretion, processing by plasmin, and interaction with extracellular matrix.

  1996cites this paper
• Oligodendroblasts distinguished from O-2A glial progenitors by surface phenotype (O4+GalC-) and response to cytokines using signal transducer LIFR beta.

  1995cites this paper
• Preparation and a structure-function analysis of human ciliary neurotrophic factor.

  1995cites this paper
• CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system.

  1995cites this paper
• Glial differentiation: a review with implications for new directions in neuro-oncology.

  1995cites this paper
• Mechanisms of damage and repair in multiple sclerosis — a review

  1995cites this paper
• Astroglial control of oligodendrocyte survival mediated by PDGF and leukemia inhibitory factor-like protein.

  1995influential citation
• Astroglial neurotrophic and neurite-promoting factors.

  1995cites this paper
• Asynchronous differentiation of clonally related spinal cord oligodendrocytes.

  1995cites this paper
• The regulation of neural precursor cells within the mammalian brain.

  1995cites this paper
• Growth factors in the CNS and their effects on oligodendroglia.

  1995cites this paper
• The CNS-specific hyaluronan-binding protein BEHAB is expressed in ventricular zones coincident with gliogenesis

  1995cites this paper
• Cellular aging and the importance of energetic factors.

  1995cites this paper
• Bone morphogenetic proteins induce differentiation in astrocyte lineage cells.

  1994cites this paper
• Pituitary adenylate cyclase-activating polypeptide (PACAP) mobilizes intracellular free calcium in cultured rat type-2, but not type-1, astrocytes

  1994cites this paper