Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell Death and Differentiation

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.cdd.4401651PMID 15905882
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Resveratrol-induced Autophagocytosis in Ovarian Cancer Cells

  2004cited by this paper
• Developmental cell death: morphological diversity and multiple mechanisms

  2004cited by this paper
• Role and regulation of starvation-induced autophagy in the Drosophila fat body.

  2004cited by this paper
• Multiple cell death pathways as regulators of tumour initiation and progression

  2004cited by this paper
• Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

  2004cited by this paper
• Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

  2004cited by this paper
• Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation

  2004cited by this paper
• Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

  2004cited by this paper
• Autophagy as a cell death and tumor suppressor mechanism

  2004cited by this paper
• Lysosomes in cell death

  2004cited by this paper
• Mild Heat Shock Induces Autophagic Growth Arrest, But Not Apoptosis in U251-MG and U87-MG Human Malignant Glioma Cells

  2004cited by this paper
• Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

  2003cited by this paper
• The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice.

  2003cited by this paper
• Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

  2003influential reference
• Endostatin induces autophagic cell death in EAhy926 human endothelial cells.

  2003cited by this paper
• Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

  2003cited by this paper
• Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B*

  2003cited by this paper
• DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

  2002cited by this paper
• Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells*

  2002cited by this paper
• Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.

  2002cited by this paper
• Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

  2001cited by this paper
• Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29.

  2001cited by this paper
• Sensitization to TNF‐induced apoptosis by 1,25‐dihydroxy vitamin D3 involves up‐regulation of the TNF receptor 1 and cathepsin B

  2001cited by this paper
• Vitamin D and cancer: effects of 1,25(OH)2D3 and its analogs on growth control and tumorigenesis.

  2001cited by this paper
• A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

  2001cited by this paper
• Four deaths and a funeral: from caspases to alternative mechanisms

  2001cited by this paper
• Sphingosine-induced apoptosis is dependent on lysosomal proteases.

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells

  2000cited by this paper
• Delayed micromolar elevation in intracellular calcium precedes induction of apoptosis in thapsigargin-treated breast cancer cells.

  2000cited by this paper
• 1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitize breast cancer cells to chemotherapy-induced cell death.

  2000cited by this paper
• Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution.

  1999cited by this paper
• Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

  1999cited by this paper
• Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.

  1999cited by this paper
• Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53.

  1999cited by this paper
• Induction of autophagy and inhibition of tumorigenesis by beclin 1

  1999cited by this paper
• Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast*

  1998cited by this paper
• Inhibition of autophagy abrogates tumour necrosis factor α induced apoptosis in human T‐lymphoblastic leukaemic cells

  1997cited by this paper
• Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

  1996cited by this paper
• Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles.

  1995cited by this paper
• Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

  1995cited by this paper
• Immunoelectron microscopy of the receptor for urokinase plasminogen activator and cathepsin D in the human breast cancer cell line MDA‐MB‐231

  1994cited by this paper
• Brefeldin A, thapsigargin, and AlF  4− stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

  1992cited by this paper
• Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

  1990cited by this paper
• Studies on the mechanisms of autophagy: formation of the autophagic vacuole

  1990cited by this paper
• 3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.

  1988cited by this paper
• 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.

  1982cited by this paper

• Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy

  2025cites this paper
• Vitamin D and cancer-related fatigue in elderly patients: mechanisms and therapeutic insights—a narrative review

  2025cites this paper
• Vitamin D in Cancer Prevention and Treatment: A Review of Epidemiological, Preclinical, and Cellular Studies

  2024cites this paper
• Autophagy in cancer development, immune evasion, and drug resistance.

  2024cites this paper
• Natural Activators of Autophagy

  2024cites this paper
• Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer

  2023cites this paper
• Ca2+ - and Zn2+ -dependent nucleases co-participate in nuclear DNA degradation during programmed cell death in secretory cavity development in Citrus fruits.

  2023cites this paper
• The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor

  2023cites this paper
• Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy

  2023cites this paper
• Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response.

  2023cites this paper
• Dual stimuli-responsive cross-linked nanoassemblies from an amphiphilic mannose-6-phosphate based tri-block copolymer for lysosomal membrane permeabilization.

  2023cites this paper
• Autophagy in the normal and diseased Cornea.

  2022cites this paper
• Autophagy in Cancer: A Metabolic Perspective.

  2022cites this paper
• Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells.

  2022cites this paper
• Relationship of blood 25-hydroxy vitamin D level with fibrocystic breast disease and breast density

  2022cites this paper
• Autophagy and Skin Diseases

  2022cites this paper
• Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor

  2021cites this paper
• Vitamin D3/phospholipid complex decorated caseinate nanomicelles for targeted delivery of synergistic combination therapy in breast cancer.

  2021cites this paper
• Molecular Mechanisms of Vitamin D-Mediated Immunomodulation

  2021cites this paper
• Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications

  2021cites this paper
• Evidence for lysosomal dysfunction within the epidermis in psoriasis and atopic dermatitis.

  2021cites this paper
• Breast cancer stem cells: A review of their characteristics and the agents that affect them

  2021cites this paper
• Pharmacological insights into autophagy modulation in autoimmune diseases

  2021cites this paper
• The effects of dietary vitamin D supplementation and in vitro 1,25 dihydroxyvitamin D3 treatment on autophagy in bone marrow-derived dendritic cells from high fat diet-induced obese mice.

  2021cites this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  2021cites this paper
• Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

  2021cites this paper
• Vitamin D-Induced Molecular Mechanisms to Potentiate Cancer Therapy and to Reverse Drug-Resistance in Cancer Cells

  2020cites this paper
• Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells

  2020cites this paper
• Sulfonamide phenylalanine (SPA) series of analogues as an antibacterial, antifungal, anticancer agents along with p53 tumor suppressor-DNA complex inhibitor – part 1

  2020cites this paper
• (+)-Bornyl p-Coumarate Extracted from Stem of Piper betle Induced Apoptosis and Autophagy in Melanoma Cells

  2020cites this paper
• Effect of vitamin D on malignant behavior of non-small cell lung cancer cells.

  2020cites this paper
• The Role of Vitamin D in Veterinary Oncology: A Literature Review

  2020cites this paper
• Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease

  2020cites this paper
• Molecular mechanism of Autophagy: Its role in the therapy of Alzheimer's disease.

  2020cites this paper
• Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro

  2020cites this paper
• Prion peptide-mediated calcium level alteration governs neuronal cell damage through AMPK-autophagy flux

  2020cites this paper
• Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications

  2020cites this paper
• Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation

  2019cites this paper
• VDR agonists down regulate PI3K/Akt/mTOR axis and trigger autophagy in Kaposi's sarcoma cells

  2019cites this paper
• Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor

  2019cites this paper
• Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo

  2019cites this paper
• Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism

  2019cites this paper
• Regulation of the Immune Balance During Allogeneic Hematopoietic Stem Cell Transplantation by Vitamin D

  2019cites this paper
• Autophagy: 'Self-Eating' Your Way to Longevity.

  2018cites this paper
• Overview of vitamin D actions in cancer

  2018cites this paper
• Diet-induced vitamin D deficiency triggers inflammation and DNA damage profile in murine myometrium

  2018cites this paper
• Exploring vitamin D metabolism and function in cancer

  2018cites this paper
• Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment

  2018cites this paper
• Autophagy-Driven Cancer Drug Development

  2018cites this paper
• Structural characterization, photoluminescence, computational studies and bioassay of newly synthesized N-(3-oxo-3-morpholino-1-phenyl-propyl) benzo sulfonamide with multifunctional application

  2018cites this paper
• Autophagy induced by vitamin D 3 inhibits the proliferation of human bladder cancer cells

  2017cites this paper
• Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography

  2017cites this paper
• Human cytomegalovirus infection downregulates vitamin-D receptor in mammalian cells.

  2017cites this paper
• Relationship between Vitamin D and Breast Cancer

  2017cites this paper
• [Potential of Using Vitamin D as an Adjuvant Treatment of Malignant Melanoma].

  2017cites this paper
• Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.

  2017cites this paper
• Trichosanthin inhibits human ovarian cancer cells growth due to apoptosis and autophagy

  2017cites this paper
• Combing oncolytic adenovirus expressing Beclin-1 with chemotherapy agent doxorubicin synergistically enhances cytotoxicity in human CML cells in vitro

  2017cites this paper
• Effect of 1,25(OH)2D3 on high glucose‑induced autophagy inhibition in peritoneum.

  2017cites this paper
• Current knowledge on the active form of Vitamin D synthesized in the skin and its effects on malignant melanoma.

  2017cites this paper
• Targeting Autophagy in ALK-Associated Cancers

  2017cites this paper
• Comparative Analysis of Cell Ultrastructure with Evidences of Programmed Death in Tissue Cultures of Cereals

  2017cites this paper
• Potential of Us ing Vitamin D as an Adjuvant Treatment of Malignant Melanoma

  2017cites this paper
• The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia

  2017cites this paper
• N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization

  2017cites this paper
• Vitamin D and breast cancer: Past and present.

  2017cites this paper
• Combination Therapy with AKT3 and PI3KCA siRNA Enhances the Antitumor Effect of Temozolomide and Carmustine in T98G Glioblastoma Multiforme Cells

  2016cites this paper
• Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

  2016cites this paper
• 1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells

  2016cites this paper
• Modulation of Autophagy by Calcium Signalosome in Human Disease

  2016cites this paper
• Molecular mechanisms of autophagy and its role in cancer development

  2016cites this paper
• Effect of Vitamin D Deficiency on Autophagy in the Intestine via MicroRNA Regulation

  2016cites this paper
• Mechanistic Insights of Vitamin D Anticancer Effects.

  2016cites this paper
• The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

  2016cites this paper
• Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

  2016cites this paper
• Extraskeletal actions of vitamin D

  2016cites this paper
• Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages

  2016cites this paper
• Regulation of Antimicrobial Peptide Gene Expression by Vitamin D

  2016cites this paper
• Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers

  2016cites this paper
• Targeting Programmed Cell Death Using Small‐Molecule Compounds to Improve Potential Cancer Therapy

  2016cites this paper
• A NBD-based simple but effective fluorescent pH probe for imaging of lysosomes in living cells.

  2016cites this paper
• Role of BEC-1/Beclin 1 and Autophagy Genes in C.elegans Germline Cell Proliferation

  2016cites this paper
• Nucleophagy: A New Look at Past Observations.

  2016cites this paper
• Autophagy Enhancers, are we there Yet?

  2016cites this paper
• Nucleotide Excision Repair and Vitamin D—Relevance for Skin Cancer Therapy

  2016cites this paper
• Development of autophagy inducers in clinical medicine.

  2015cites this paper
• Key autophagic targets and relevant small‐molecule compounds in cancer therapy

  2015cites this paper
• Vitamin D in cancer chemoprevention

  2015influential citation
• Novel Mechanism of Breast Cancer Prevention and Treatment Using Natural Extract of Pimenta Dioica

  2015cites this paper
• Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy

  2015cites this paper
• Current and emerging breast cancer biomarkers.

  2015cites this paper
• Biochemical protective effect of 1,25-dihydroxyvitamin D3 through autophagy induction in the MPTP mouse model of Parkinson’s disease

  2015cites this paper
• Autophagy : Moving Benchside Promises to Patient Bedsides.

  2015cites this paper
• Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency

  2015cites this paper
• Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

  2015cites this paper
• Unravelling the multifaceted roles of Atg proteins to improve cancer therapy

  2014cites this paper
• AUTOPHAGY IN TB

  2014cites this paper
• Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells.

  2014cites this paper
• Vitamin D and cancer: the promise not yet fulfilled

  2014cites this paper
• Review: Vitamin D3 deficiency results in dysfunctions of immunity with severe fatigue and depression in a variety of diseases.

  2014cites this paper