Increased Atherosclerosis in Mice Lacking Apolipoprotein A-I Attributable to Both Impaired Reverse Cholesterol Transport and Increased Inflammation

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Circulation Research

• Publication date

  2005-10-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.0000185320.82962.F7PMID 16151025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Enhancement of Scavenger Receptor Class B Type I-mediated Selective Cholesteryl Ester Uptake fromapoA-I−/− High Density Lipoprotein (HDL) by Apolipoprotein A-I Requires HDL Reorganization by Lecithin Cholesterol Acyltransferase*

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• Serum paraoxonase: effect of the apolipoprotein composition of HDL and the acute phase response.

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• Importance of different pathways of cellular cholesterol efflux.

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• Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol.

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• High-density lipoproteins and atherosclerosis.

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• C3H apoE(-/-) mice have less atherosclerosis than C57BL apoE(-/-) mice despite having a more atherogenic serum lipid profile.

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• Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1.

  2000cited by this paper
• Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool.

  1999cited by this paper
• Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice. Effects on lipoproteins and atherosclerosis.

  1999cited by this paper
• Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity.

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• Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors*

  1998cited by this paper
• Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

  1998cited by this paper
• Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice.

  1998cited by this paper
• Effect of streptozotocin-induced hyperglycemia on lipid profiles, formation of advanced glycation endproducts in lesions, and extent of atherosclerosis in LDL receptor-deficient mice.

  1997cited by this paper
• Novel Function of Lecithin-Cholesterol Acyltransferase

  1997cited by this paper
• Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

  1995cited by this paper
• Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

  1995cited by this paper
• Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.

  1994cited by this paper
• Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice.

  1993cited by this paper
• Generation of analytic plasma lipoprotein profiles using two prepacked superose 6B columns.

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• Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I.

  1992cited by this paper
• High-density lipoprotein--the clinical implications of recent studies.

  1989cited by this paper
• Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells.

  1988cited by this paper
• High-density lipoproteins and atherosclerosis.

  1982cited by this paper

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• Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics.

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