Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor

The results of this study show that lipoarabinomannans (LAM) isolated from a virulent strain and from an avirulent strain of Mycobacterium tuberculosis, which have recently been shown to differ markedly in terms of the structures of their nonreducing termini, also differ markedly in the capacity to induce the secretion of tumor necrosis factor from murine macrophages. It was found that LAM from the avirulent H37Ra strain was 100-fold more potent at inducing tumor necrosis factor secretion than LAM from the virulent Erdman strain, thus leading us to hypothesize that the structure of LAM from a given mycobacterial isolate may directly influence its ability to elicit, or avoid, cytokine-mediated mechanisms of host resistance.

• Publication year

  1992

• Venue

  Infection and Immunity

• Publication date

  1992-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/iai.60.3.1249-1253.1992PMID 1541542PMCID PMC257623
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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