Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Clinical Cancer Research

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10914728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy

  2005cited by this paper
• Suppression of Transforming Growth Factor-P (TGFP) and TGFp Receptor Messenger Ribonucleic Acid and Protein Expression in Leiomyomata in Women Receiving Gonadotropin-Releasing Hormone Agonist Therapy*

  2001cited by this paper
• Expression of adrenomedullin in the endometrium of the human uterus.

  1999cited by this paper
• Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.

  1999cited by this paper
• Hypoxia-induced adrenomedullin production in the kidney.

  1999cited by this paper
• Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-1beta and tumor necrosis factor-alpha.

  1998cited by this paper
• Validation of anti‐vascular endothelial growth factor (anti‐VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: expression of VEGF in the human endometrium

  1998cited by this paper
• PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

  1998influential reference
• Pathophysiology and medical treatment of uterine fibroids

  1998cited by this paper
• Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes*

  1998cited by this paper
• Production and secretion of adrenomedullin in cultured rat cardiac myocytes and nonmyocytes: stimulation by interleukin-1beta and tumor necrosis factor-alpha.

  1998cited by this paper
• Regulation of adrenomedullin production in rat endothelial cells.

  1998cited by this paper
• Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis.

  1998cited by this paper
• Expression of thymidine phosphorylase in uterine sarcoma and uterine leiomyoma: association with microvessel density and Doppler blood flow analysis

  1997cited by this paper
• Regulation of the Expression of the Angiogenic Enzyme Platelet-Derived Endothelial Cell Growth Factor/ Thymidine Phosphorylase in Endometrial Isolates by Ovarian Steroids and Cytokines.

  1997cited by this paper
• Regulation of the expression of the angiogenic enzyme platelet-derived endothelial cell growth factor/thymidine phosphorylase in endometrial isolates by ovarian steroids and cytokines.

  1997cited by this paper
• Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium.

  1997cited by this paper
• Expression of the fibroblast growth factor receptor in women with leiomyomas and abnormal uterine bleeding.

  1997cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• Adrenomedullin Expression in Human Tumor Cell Lines ITS POTENTIAL ROLE AS AN AUTOCRINE GROWTH FACTOR*

  1996cited by this paper
• Suppression of transforming growth factor-beta (TGF beta) and TGF beta receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotropin-releasing hormone agonist therapy.

  1996cited by this paper
• Microvascular density in conditions of endometrial atrophy.

  1996cited by this paper
• Growth Factors and Cytokines in Uterine Leiomyomas

  1996cited by this paper
• The production of tumour necrosis factor alpha (TNF-alpha) by human endometrial cells in culture.

  1996cited by this paper
• The production of tumour necrosis factor a (TNF-α) by human endometrial cells in culture

  1996cited by this paper
• Purification and partial sequencing of the major mitogen for human uterine smooth muscle-like cells in leiomyoma extracts.

  1995cited by this paper
• The isolation and long-term culture of normal human endometrial epithelium and stroma. Expression of mRNAs for angiogenic polypeptides basally and on oestrogen and progesterone challenges.

  1995cited by this paper
• Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells.

  1995cited by this paper
• Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium.

  1995cited by this paper
• Epidermal growth factor and transforming growth factor-beta in uterine fibroids and myometrium.

  1995cited by this paper
• Localization and quantification of vascular endothelial growth factor messenger ribonucleic acid in human myometrium and leiomyomata.

  1995cited by this paper
• Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count, and computer image analysis

  1995cited by this paper
• Familial predisposition to uterine leiomyomas

  1995cited by this paper
• Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha.

  1994cited by this paper
• Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction.

  1994cited by this paper
• Steroid receptor binding and messenger RNA expression in fibroids from untreated and gonadotrophin‐releasing hormone agonist pretreated women

  1994cited by this paper
• Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

  1993cited by this paper
• Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium.

  1993cited by this paper
• Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

  1993cited by this paper
• Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas.

  1993cited by this paper
• Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.

  1993cited by this paper
• Detection of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in the uterus during the second half of pregnancy in the mouse.

  1992cited by this paper
• Quantitative uterine histology during the menstrual cycle in relation to measured menstrual blood loss

  1984cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Suppression of Luteal Angiogenesis in the Primate after Neutralization of Vascular Endothelial Growth Factor*

  year unknowncited by this paper

• Identifying Shared Molecular Landscape between Uterine Fibroids and Recurrent Implantation Failure: An Integrated Bioinformatics Study

  2025cites this paper
• Relation of Endocan Serum Levels with Patient Characteristics and Morphological Features of Uterine Fibroids: A Case-Control Study

  2024cites this paper
• Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy.

  2024cites this paper
• Mechanism of Endometrial Receptivity Affected by Fibroids

  2024cites this paper
• Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review

  2023cites this paper
• Pathways of Hypoxia-Inducible Factor (HIF) in the Orchestration of Uterine Fibroids Development

  2023cites this paper
• Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth

  2022cites this paper
• Uterine Fibroids (Leiomyomata) and Heavy Menstrual Bleeding

  2022cites this paper
• Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway

  2022cites this paper
• Differential response to hypoxia in leiomyoma and myometrial cells.

  2021cites this paper
• Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy

  2021cites this paper
• Vascular Biology of Uterine Fibroids: Connecting Fibroids and Vascular Disorders.

  2021cites this paper
• Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses

  2021cites this paper
• Molecular Genetic Basis and Prospects of Gene Therapy of Uterine Leiomyoma

  2021cites this paper
• Uterine fibroid vascularization: from morphological evidence to clinical implications.

  2021cites this paper
• Effect of anesthetic technique on serum vascular endothelial growth factor C and prostaglandin E2 levels in women undergoing surgery for uterine leiomyomas

  2020cites this paper
• A prominent action of Insulin like growth factor I (IGF-I) in stimulation of uterine leiomyomata: a review

  2020cites this paper
• Adrenomedullin - Current Perspective on a Peptide Hormone with Significant Therapeutic Potential.

  2020cites this paper
• Pigment epithelium derived factor as a novel multi-target treatment for uterine fibroids.

  2020cites this paper
• A Review of the Molecular Basis for Reduced Endometrial Receptivity in Uterine Fibroids and Polyps

  2017cites this paper
• Generation and characterization of inducible knockout mice for adrenomedullin

  2017cites this paper
• Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids

  2017cites this paper
• Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1α and vascular endothelial growth factor

  2017cites this paper
• Differential expression of visfatin, leptin, stromal cell derived factor-1α, endothelial nitric oxide synthase, and vascular endothelial growth factor in human leiomyomas

  2017cites this paper
• Angiogenesis and Vascularization of Uterine Leiomyoma: Clinical Value of Pseudocapsule Containing Peptides and Neurotransmitters.

  2016cites this paper
• Uterine fibroids and effiency of in vitro fertilization programs

  2016cites this paper
• Expression of VEGF isoforms and their receptors in uterine myomas.

  2016cites this paper
• Myoma migration: an unexpected "effect" with Ulipristal acetate treatment.

  2016cites this paper
• Growth factors and pathogenesis.

  2016cites this paper
• Vascular density, angiogenesis and pro-angiogenic factors in uterine fibroids.

  2016cites this paper
• Angiogenesis and pro-angiogenic factors in uterine fibroids - facts and myths.

  2016influential citation
• Best Practice & Research Clinical Obstetrics and Gynaecology

  2016cites this paper
• Drug safety evaluation of ulipristal acetate in the treatment of uterine fibroids

  2015cites this paper
• Genetic and molecular basis of reproductive efficiency in swine

  2015cites this paper
• Uterine perfusion model for analyzing barriers to transport in fibroids.

  2015cites this paper
• The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of rapamycin complex 1/hypoxia-inducible factor-1α signaling pathway in ELT-3 cells.

  2015cites this paper
• Regulation and Neutralisation of Adrenomedullin in Cancer

  2014cites this paper
• Calcitonin gene related family peptides: importance in normal placental and fetal development.

  2014cites this paper
• Change of Plasma Adrenomedullin and Expression of Adrenomedullin and its Receptor in Villus of Normal Early Pregnancy

  2014cites this paper
• Antiangiogenic Agents in Natural Products for the Treatment of Gynecologic Disorders

  2014cites this paper
• Adrenomedullin and tumour microenvironment

  2014cites this paper
• The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy.

  2014influential citation
• The contribution of endothelin-1 in colorectal cancer & the efficacy of the novel endothelin receptor antagonist ZD4054

  2014cites this paper
• Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.

  2013cites this paper
• Uterine Leiomyomas

  2013cites this paper
• Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma

  2013cites this paper
• Vascular structure of outer myometrial uterine leiomyomata - a preliminary SEM and immunohistochemical study.

  2013cites this paper
• Blood vessels of the intratumoral septa in uterine leiomyomata.

  2013cites this paper
• Angioarchitecture of uterine cervical leiomyomata - a SEM study.

  2013cites this paper
• Ekspresja czynnika VEGF i receptora R1 w mięśniakach macicy kobiet w różnym wieku

  2013cites this paper
• The Endothelin Axis in Uterine Leiomyomas: New Insights1

  2012cites this paper
• Fertility and pregnancy Adrenomedullin and pregnancy : perspectives from animal models to humans

  2012cites this paper
• MINIREVIEW The Endothelin Axis in Uterine Leiomyomas: New Insights

  2012cites this paper
• An Angiogenic Role for Adrenomedullin in Choroidal Neovascularization

  2012cites this paper
• UNIWERSYTET JAGIELLOŃSKI COLLEGIUM MEDICUM WYDZIAŁ LEKARSKI

  2011cites this paper
• Adrenomedullin expression and regulation in human glioblastoma, cultured human glioblastoma cell lines and pilocytic astrocytoma.

  2011cites this paper
• Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications.

  2011cites this paper
• Regulation of endometrial repair and its impact on heavy menstrual bleeding

  2011cites this paper
• Lessons learned from the preclinical drug discovery of asoprisnil and ulipristal for non-surgical treatment of uterine leiomyomas

  2011cites this paper
• Hypoxia-inducible adrenomedullin in colorectal cancer.

  2011cites this paper
• Cell-Type Specific Actions of Progesterone Receptor Modulators in the Regulation of Uterine Leiomyoma Growth

  2010cites this paper
• Gene Expression Analysis Identifies Potential Biomarkers of Neurofibromatosis Type 1 Including Adrenomedullin

  2010cites this paper
• Subcutaneous leiomyosarcoma in an adrenomedullin heterozygous mouse.

  2010cites this paper
• Serum Vascular Endothelial Growth Factor Concentrations in Patients with Uterine Leiomyoma

  2010cites this paper
• Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin Running Title: Adrenomedullin as an NF1 serum biomarker

  2010cites this paper
• Expression of vascular endothelial growth factor mRNA in human leiomyomas

  2010cites this paper
• CORRELACIÓN ENTRE ECOGRAFÍA DOPPLER TRIDIMENSIONAL Y FACTORES DE NEOANGÍOGENESIS TUMORAL EN LOS MIOMAS UTERINOS.

  2009cites this paper
• Fibroids, Menstruation, Childbirth, and Evolution: The Fascinating Story of Uterine Blood Vessels

  2009cites this paper
• A leiomyoma presenting as an exophytic periurethral mass: a case report and review of the literature.

  2009cites this paper
• Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies.

  2008cites this paper
• Elevated level of plasma vascular endothelial growth factor after gonadotropin-releasing hormone agonist treatment for leiomyomata

  2008cites this paper
• The pathophysiology of dysfunctionaluterine bleeding

  2008cites this paper
• Adrenomedullin expression does not correlate with survival in lung cancer

  2007cites this paper
• Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

  2007cites this paper
• Nonclassic endogenous novel [corrected] regulators of angiogenesis.

  2007cites this paper
• Nonclassic Endogenous Novel Regulators of Angiogenesis

  2007cites this paper
• Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas.

  2007cites this paper
• Adrenomedullin: An Esoteric Juggernaut of Human Cancers

  2006cites this paper
• Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells.

  2006cites this paper
• Adrenomedullin: a tumor progression factor via angiogenic control.

  2006cites this paper
• Adrenomedullin increases the expr ession of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells

  2006cites this paper
• A Rapidly Growing Paraurethral Myoma with Profuse Bleeding from a Mucosal Vessel: Report of a Case

  2006cites this paper
• Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density

  2006cites this paper
• Adrenomedullin is a novel marker of tumor progression in neuroendocrine carcinomas.

  2006cites this paper
• Adrenomedullin is a Novel Marker of Tumor Progression in Neuroendocrine Carcinomas

  2006cites this paper
• The normal human myometrium has a vascular spatial gradient absent in small fibroids.

  2006influential citation
• Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells.

  2006cites this paper
• Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

  2006cites this paper
• The role of adrenomedullin in angiogenesis.

  2005cites this paper
• Changes of plasma vascular endothelial growth factor level after uterine artery embolisation for leiomyomata

  2005cites this paper
• Adrenomedullin Expression and Secretion

  2005cites this paper
• Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction.

  2005cites this paper
• Adrenomedullin and tumour angiogenesis

  2005influential citation
• Biological Action of Adrenomedullin

  2005cites this paper
• Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities.

  2005cites this paper
• Adrenomedullin: Multiple functions in human pregnancy

  2004cites this paper
• Sex steroidal regulation of uterine leiomyoma growth and apoptosis.

  2004cites this paper
• A case of generalised oedema secondary to uterine artery embolisation for leiomyomata

  2004cites this paper
• Two types of vascularisation of intramural uterine leiomyomata revealed by corrosion casting and immunohistochemical study.

  2004cites this paper
• Adrenomedullin and cancer.

  2003cites this paper